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  • 1
    Language: German
    In: Psychotherapeut, 2011, Vol.56(5), pp.386-393
    Description: Byline: Susanne Singer (1,859,5,859), Sylvia Hohlfeld (2,859), Daniel Muller-Briel (3,859), Andreas Dietz (4,859), Elmar Brahler (5,859), Katharina Schroter (5,859), Antje Lehmann-Laue (5,859) Keywords: Gewebsneubildung; Versorgungsforschung; Universitatskrankenhauser; Beratung; Konsil-/Liaisondienst; Neoplasm; Health services research; University hospitals; Counseling; Consultation-Liaison-Service Abstract (German): Ziel Ziel dieser Studie war es, Daten zur psychoonkologischen Versorgungssituation von Krebspatienten im ambulanten und im stationaren Bereich unter Routinebedingungen zu gewinnen. Dabei interessierten vorrangig die Versorgungsdichte sowie der Bedarf an und der Wunsch nach psychosozialer Versorgung. Methode Die Versorgungsdichte wurde anhand des Vergleichs von Inzidenzzahlen des Tumorregisters Leipzig, der Zahl der durch den psychoonkologischen Konsil-/Liaisondienst des Universitatsklinikums Leipzig betreuten Patienten und der Zahl der Ratsuchenden in der an der Universitat angesiedelten ambulanten Krebsberatungsstelle im Jahr 2008 ermittelt. Bedarf an und Wunsch nach psychosozialer Hilfe wurden anhand von Daten einer Patientenbefragung am gleichen Klinikum untersucht. Ergebnisse Im stationaren und im ambulanten Bereich wurden jeweils 11% der Krebspatienten psychoonkologisch betreut. Demgegenuber stehen ein sozialer Hilfebedarf bei 37% und ein psychologischer Hilfebedarf bei 52% der Patienten wahrend des Krankenhausaufenthalts (1/2 Jahr spater: je 42%). Insgesamt 41% der Befragten wunschten sich zu Beginn des Krankenhausaufenthalts Hilfe von einem Sozialarbeiter und 29% von einem Psychologen. Zwischen Patienten verschiedener Tumorentitaten bestanden grosse Unterschiede hinsichtlich der Versorgungssituation. Schlussfolgerung Im Vergleich zum Hilfebedarf und ihren Versorgungswunschen waren die Krebspatienten unter Routinebedingungen in einem Krankenhauses der Maximalversorgung als psychoonkologisch deutlich unterversorgt einzuschatzen. Abstract: Objectives The aim of this study was to determine rates of psychooncological care for cancer inpatients and outpatients under routine conditions in a large University hospital. The percentage of patients who received care was analyzed and compared with self-rated and expert rated supportive care needs. Methods The percentage of inpatients who received psychooncological care was calculated by comparing the number of cancer patients treated at the hospital as documented by the local tumor registry (n=1,979) with the number of patients treated by a psychooncologist in that hospital as documented by the hospital's psychooncological consultation liaison service. The percentage of outpatients who received psychooncological care was calculated by comparing the number of incident cancer cases as documented by the local tumor registry (n=5,886) with the number of patients who received at least one consultation at the local tumor counseling centre. Supportive care needs were estimated by analyzing data of a prospective patient survey in the same hospital (n=1,803) using the Hospital Anxiety and Depression Scale and single items to determine social burden and the wish for emotional support. Results The results showed that 11% of inpatients and outpatients (n=234 and n=638, respectively) received psychooncological care. Social care needs were prevalent in 37% and psychological care needs in 52% of the patients during the stay in hospital and in 42% (social and psychological) 6 months later. Of the patients 41% expressed the need to see a social worker and 29% to see a psychologist. Large differences were found between patients with different tumor entities. Conclusion Psychooncological care delivered to cancer patients under routine conditions was below the actual rate required as estimated by screening instruments and as expressed by the patients. Author Affiliation: (1859) Abt. Gesundheitspsychologie und Angewandte Diagnostik, Bergische Universitat Wuppertal, Gaussstr. 20, 42119, Wuppertal, Deutschland (2859) Tumorzentrum, Universitatsklinikum Leipzig, Leipzig, Deutschland (3859) Bereich Informationsmanagement, Universitatsklinikum Leipzig, Leipzig, Deutschland (4859) Klinik und Poliklinik fur Hals-Nasen-Ohrenheilkunde, Universitatsklinikum Leipzig, Leipzig, Deutschland (5859) Abteilung Medizinische Psychologie und Medizinische Soziologie, Universitat Leipzig, Leipzig, Deutschland Article History: Registration Date: 04/08/2011 Online Date: 27/08/2011
    Keywords: Neoplasm ; Health services research ; University hospitals ; Counseling ; Consultation-Liaison-Service
    ISSN: 0935-6185
    E-ISSN: 1432-2080
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  • 2
    Language: German
    In: Psychotherapie Psychosomatik Medizinische Psychologie, 2011, Vol.61(08), pp.377-382
    Description: Der vorliegende Beitrag geht der Frage nach, in welchem Umfang Brustkrebspatientinnen an medizinischen Entscheidungen bei Behandlungen in zertifizierten Brustzentren vs. nicht-zertifizierten Krankenhäusern beteiligt sind. Es werden retrospektiv erhobene Daten von 652 Brustkrebspatientinnen zur Teilhabe an medizinischen Entscheidungen in 9 verschiedenen Entscheidungsbereichen analysiert. In der deskriptiven Analyse findet sich lediglich ein signifikanter Unterschied zwischen Zentren vs. nicht-Zentren (Entscheidungsbereich: Zeitpunkt der Behandlung). Multivariate Analysen zeigen, dass die Behandlung in einem Zentrum eine Prädiktorvariable für höhere Patientenmitwirkung in 3 Entscheidungsbereichen ist (p〈0,05). Insbesondere auch jüngeres Alter und ein guter Gesundheitszustand sind von statistischer Bedeutung für die Entscheidungsteilhabe. Eine höhere Patientenbeteiligung ist in Zentren für einige Entscheidungsbereiche zu konstatieren, aber nicht generell zu beobachten.
    Keywords: Psychoonkologie ; Zentrumsmedizin ; Shared decision-making ; Krebs ; Psycho-oncology ; Centre care ; Shared decision-making ; Cancer
    ISSN: 0937-2032
    E-ISSN: 1439-1058
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  • 3
    Language: English
    In: Brain Pathology, Sept, 2012, p.(1)
    Description: To purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1111/j.1750-3639.2012.00564.x/abstract Byline: Sylvia Eisele(1)(2), Markus Krumbholz(1)(2), Marie-Therese Fischer(3), Hema Mohan(2), Andreas Junker(1)(2)(*), Thomas Arzberger(4), Reinhard Hohlfeld(1)(2), Monika Bradl(3), Hans Lassmann(3), Edgar Meinl(1)(2) Keywords: FFPE; microRNA; molecular analysis; multiple sclerosis; quantitative PCR; transcriptome Abstract The elaboration of novel pathogenic aspects of multiple sclerosis (MS) requires the analysis of well-defined stages of lesion development. However, specimens of certain stages and lesion types are either present in small brain biopsies, insufficient in size for further molecular studies or available as formalin-fixed and paraffin-embedded (FFPE) material only. Therefore, application of current molecular biology techniques to FFPE tissue is warranted. We compared FFPE and frozen tissue by using quantitative polymerase chain reaction and report: (1) FFPE material is highly heterogeneous regarding the utility for transcript profiling of mRNAs; well-preserved FFPE samples had about a 100-fold reduced sensitivity compared with frozen tissue, but gave similar results for genes of sufficient abundance; (2) FFPE samples not suitable for mRNA analysis are still highly valuable for miRNA quantification; (3) the length of tissue fixation greatly affects utility for mRNA but not for miRNA analysis; (4) FFPE samples can be processed via a hot water bath for dissection of defined lesion areas; and (5) in situ hybridization for proteolipid protein (PLP) helps to identify samples not suitable for mRNA amplification. In summary, we present a detailed protocol how to use autoptic FFPE tissue for transcript profiling in dissected tissue areas. Author Affiliation: (1)Institute of Clinical Neuroimmunology, University Hospital Gro[sz]hadern, Ludwig-Maximilians-University, Munich (2)Department of Neuroimmunology, Max-Planck-Institute of Neurobiology, Martinsried, Germany (3)Center for Brain Research, Medical University of Vienna, Vienna, Austria (4)Center for Neuropathology and Prion Research, Ludwig-Maximilians-University, Munich, Germany Correspondence: (*) Edgar Meinl, MD, Department of Neuroimmunology, Max-Planck-Institute of Neurobiology, Am Klopferspitz 18, 82152 Martinsried, Germany (E-mail: meinl@neuro.mpg.de) Article Note: (*) Present address: Institute of Neuropathology, University Medical Center, Robert-Koch-Str. 40, 37099 Gottingen, Germany. ([dagger]) Grants and Support: The Deutsche Forschungsgemeinschaft (SFB 571), Herrmann and Lilly Schilling Foundation, Verein zur Therapieforschung fur Multiple-Sklerose-Kranke, the Bundesministerium fur Bildung und Forschung (aKrankheitsbezogenes Kompetenznetz Multiple Sklerosea), the Excellency Initiative of the Ludwig Maximilians University Munich and the scholarship program aForderung fur Forschung und Lehre (FoFoLe)a of the Ludwig Maximilians University Munich, Germany. Received 29 September 2011; Accepted 28 November 2011; Published Online Article Accepted 10 January 2012 Supporting information: Additional Supporting Information may be found in the online version of this article Table S1. Analyzed tissue specimens. Table S2. Extracellular matrix and extracellular matrix related genes and corresponding TaqManA[R] PCR assays used for TaqManA[R] Low Density Array (LDA) analysis (Applied Biosystems, Darmstadt, Germany). Table S3. Protocol for using archival FFPE specimen.
    Keywords: Messenger Rna -- Analysis ; Scholarships (Financial aid) -- Analysis ; Medical Schools -- Analysis ; Genes -- Analysis ; Microrna -- Analysis ; Multiple Sclerosis -- Analysis
    ISSN: 1015-6305
    Source: Cengage Learning, Inc.
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  • 4
    Language: English
    In: Brain Pathology, Sept, 2012, p.(1)
    Keywords: Messenger Rna -- Analysis ; Scholarships (Financial aid) -- Analysis ; Medical Schools -- Analysis ; Genes -- Analysis ; Microrna -- Analysis ; Multiple Sclerosis -- Analysis
    ISSN: 1015-6305
    Source: Cengage Learning, Inc.
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  • 5
    Language: English
    In: Advanced Engineering Materials, 2018, Vol.20(12), p.n/a(8)
    Description: Byline: Kai Hohlfeld, Sebastian Rhein, Markus Flossel, Alexander Michaelis,Sylvia E. Gebhardt Piezoelectric sensors and actuators have gained increasing interest in lightweight engineering for shape control, vibration damping, condition, and structural health monitoring. In combination with complementary control units, these adaptive structures become more relevant as cost-effective technologies and mass production of suitable piezoelectric components are available. The authors investigate serial and cost-effective fabrication of piezoceramic components and composites, which allow for direct integration into lightweight structures. To succeed functional integration, layout, structure, and composition of the piezoelectric components need to be adjusted to the lightweight material and to the constraints of the entire manufacturing process. Examples of robust piezoelectric components for integration into fiber-reinforced plastics and light metal parts are given. Manufacturing, properties, and influence of structure integration on physical characteristics are described and discussed in detail.
    Keywords: Aktor ; Verbundwerkstoff ; Niedertemperatureinbrandkeramik ; Piezokeramik ; Sensor ; Leichtbaustruktur ; Piezoelektrischer Sensor ; Vibrationsdämpfung ; Massenproduktion ; Regelarmatur ; Steuereinrichtung ; Verstärkter Kunststoff ; Leichtmetalle ; Physikalische Eigenschaft ; Engineering;
    ISSN: 1438-1656
    E-ISSN: 15272648
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  • 6
    Language: English
    In: Advances in Applied Ceramics, Vol.114 (2015), No.4, pp.231-237
    Description: The present paper deals with the development of lead zirconate titanate (PZT) fibres, pearls and fibre fragments, for their use as active phase in piezocomposites. As new a approach, the green ceramic components are shaped by polysulphone spinning, allowing for effective and flexible forming over a wide range of different geometries and sizes.1 The correlation between processing parameters, e.g. the slurry composition, nozzle size and operation velocity, and the resultant shape of ceramic components is analysed. Sintered piezoceramic parts show a dense microstructure. Performance data are evaluated on PZT/epoxy composites. Measurement results of strain, polarisation and piezoelectric coupling are given and discussed. The developed PZT components are seen as key for the creation of smart and lightweight structural components. Further, free formed PZT components open new design approaches for sensing and actuating devices and ultrasound transducers.
    Keywords: Pzt ; Fibre ; Pearl ; Piezocomposite ; Smart Structure ; Electromechanical Transducer ; Lightweight Material
    Source: Fraunhofer ePrints (Fraunhofer Gesellschaft)
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  • 7
    Language: English
    In: 2013 Joint IEEE International Symposium on Applications of Ferroelectric and Workshop on Piezoresponse Force Microscopy (ISAF/PFM), July 2013, pp.279-282
    Description: Structural devices with integrated adaptive functions are demanded in lightweight engineering especially in automotive and aerospace industries and mechanical engineering. As base of such systems, piezocomposites are of high interest. They can be made from piezoceramic components, e.g. plates, fibers, or more complex three-dimensional structures, integrated into matrix materials. We developed the polysulfone spinning process as an appropriate technique to produce dense piezoceramic components with different shapes. The paper reports on fabrication and properties of PZT fibers, fiber fragments and spherical samples (pearls). Potential applications of customized PZT components for smart structures and ultrasonic transducers are shown.
    Keywords: Optical Fiber Sensors ; Shape ; Microstructure ; Optical Fiber Polarization ; Materials ; Electrodes ; Pzt ; Piezocomposite ; Fiber ; Pearl ; Piezoelectric Transducer ; Adaptive Structure ; Engineering
    ISSN: 1099-4734
    E-ISSN: 2375-0448
    Source: IEEE Conference Publications
    Source: IEEE Xplore
    Source: IEEE Journals & Magazines 
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  • 8
    Language: English
    In: Advanced Engineering Materials, 2018, Vol.20(12), p.n/a(8)
    Description: Byline: Michael Zapf, Kai Hohlfeld, Nicole V. Ruiter, Patrick Pfistner, Koen W. A. van Dongen, Hartmut Gemmeke, Alexander Michaelis, Sylvia E. Gebhardt Ultrasound Computer Tomography (USCT) medical imaging is a promising approach for early detection of breast cancer. At Karlsruhe Institute of Technology (KIT) a 3-D USCT system is developed. The region-of-interest (ROI) of 10x10x10cm.sup.3 volume is surrounded by a aperture of 2014 semi-spherical positioned ultrasound transducers. Results from a first patient study reveals the requirement of a significantly increased ROI to cover bodily variations. Design considerations and simulations show a demand for circular transducers with a diameter of ca. 500A[micro]m, increasing the opening angle of the transducers to ca. 60[degrees]. Piezofiber composite technology is predestinated to simply provide circular transducers of the required dimensions. Moreover, piezocomposites based on single PZT (lead zirconate titanate Pb[Zr.sub.xTi.sub.1-x]O.sub.3) fibers enable a cost-effective and series-production alternative to currently used dice-and-fill composites. A transducer design is presented which utilizes individually arranged single piezoceramic fibers with 460[MU]m in diameter within piezocomposite discs. As a result, fibers are independently addressable as single transducer elements allowing for the desired transducer arrangement. The electrical performance of each piezoceramic fiber is determined proofing a strong dependence both of the coupling coefficient and the resonance frequency from the transducer thickness. In further processing, the piezocomposite discs are connected to printed circuits, integrated into a cylindrical housing, and backfilled with polyurethane. Ultrasound characteristics such as sound pressure and opening angle are evaluated quantitatively. The results show that the transducer opening angles lie in the expected range, that the desired center frequency is achieved and that the bandwidth could be preserved compared to former dice-and-fill transducers.
    Keywords: Biomedizinische Bildgebung ; Ultraschallabbildung ; Ultraschallwandler ; Ultraschall ; Computertomographie ; Konstruktive Gestaltung ; Bleizirkonattitanat ; Komposit ; Gefüllter Verbundwerkstoff ; Technische Hochschule ; Brustkrebs ; Piezoelektrischer Werkstoff ; Gedruckte Schaltung ; Polyurethan ; Schalldruck ; Engineering;
    ISSN: 1438-1656
    E-ISSN: 15272648
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  • 9
    In: Brain Pathology, September 2012, Vol.22(5), pp.607-618
    Description: The elaboration of novel pathogenic aspects of multiple sclerosis (MS) requires the analysis of well‐defined stages of lesion development. However, specimens of certain stages and lesion types are either present in small brain biopsies, insufficient in size for further molecular studies or available as formalin‐fixed and paraffin‐embedded (FFPE) material only. Therefore, application of current molecular biology techniques to FFPE tissue is warranted. We compared FFPE and frozen tissue by using quantitative polymerase chain reaction and report: (1) FFPE material is highly heterogeneous regarding the utility for transcript profiling of mRNAs; well‐preserved FFPE samples had about a 100‐fold reduced sensitivity compared with frozen tissue, but gave similar results for genes of sufficient abundance; (2) FFPE samples not suitable for mRNA analysis are still highly valuable for miRNA quantification; (3) the length of tissue fixation greatly affects utility for mRNA but not for miRNA analysis; (4) FFPE samples can be processed via a hot water bath for dissection of defined lesion areas; and (5) hybridization for proteolipid protein (PLP) helps to identify samples not suitable for mRNA amplification. In summary, we present a detailed protocol how to use autoptic FFPE tissue for transcript profiling in dissected tissue areas.
    Keywords: Ffpe ; Microrna ; Molecular Analysis ; Multiple Sclerosis ; Quantitative Pcr ; Transcriptome
    ISSN: 1015-6305
    E-ISSN: 1750-3639
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  • 10
    Language: English
    In: Sensors & Actuators: A. Physical, 01 February 2018, Vol.270, pp.231-239
    Description: Integration of piezoceramic particles into polymers is considered to meet current and future challenges of function integration in lightweight engineering. Especially composites with integrated piezoceramic transducers for sensory tasks such as condition or structural health monitoring are gaining importance. A possible, mass production compatible manufacturing approach is the direct formation of a piezoceramic particle-electrode-assembly during the processing by integrating the ceramic and its electrodes into the polymer matrix. The piezoelectric particles are then fully surrounded by the polymer matrix, forming a so-called 0–3 composite (Newnham et al., 1978). However, it is unpoled and inactive and thus requires poling to activate the piezoelectric properties. It is known that poling of piezoelectric particles in a polymer matrix is difficult due to the misfit in dielectric constants of polymer and ceramic. To overcome this obstacle, a poling process that is conducted during the uncured stage of the polymer matrix is introduced in the present paper, making use of the relatively low electrical resistance of the selected polymer in the uncured state. In a first step, the method is modelled and experimentally verified using specimen made of PZT pearls embedded in epoxy resin. In these preliminary experiments, effective piezoelectric charge coefficients up to 28.6 pC/N were achieved. The method is transferred and integrated into the production of fibre-reinforced polyurethane composites. Effective piezoelectric charge coefficients of 5.5 pC/N are obtained for the polyurethane based composites.
    Keywords: Poling Method ; Piezoceramic Sensors ; Piezocomposite ; Long Fibre Injection ; Lightweight Engineering ; Engineering
    ISSN: 0924-4247
    E-ISSN: 1873-3069
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