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Berlin Brandenburg

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  • 1
    Language: English
    In: The Journal of biological chemistry, 18 July 2014, Vol.289(29), pp.19855-61
    Description: Work over the past 4 years indicates that multiple proteins associated with neurodegenerative diseases, especially Tau and α-synuclein, can propagate aggregates between cells in a prion-like manner. This means that once an aggregate is formed it can escape the cell of origin, contact a connected cell, enter the cell, and induce further aggregation via templated conformational change. The prion model predicts a key role for extracellular protein aggregates in mediating progression of disease. This suggests new therapeutic approaches based on blocking neuronal uptake of protein aggregates and promoting their clearance. This will likely include therapeutic antibodies or small molecules, both of which can be developed and optimized in vitro prior to preclinical studies.
    Keywords: Aggregate Propagation ; Alpha-Synuclein (a-Synuclein) ; Chemoprevention ; Neurodegenerative Disease ; Prion ; Tau Protein (Tau) ; Therapy ; Prions -- Metabolism ; Tauopathies -- Metabolism ; Tau Proteins -- Metabolism
    E-ISSN: 1083-351X
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  • 2
    Language: English
    In: Journal of Nutrition Education and Behavior, 2011, Vol.43(3), pp.157-164
    Description: Describe lay food group categories of low-income African American women and assess the overlap of lay food groups and MyPyramid food groups. A convenience sample of African American mothers from a low-income Chicago neighborhood performed a card-sorting task in which they grouped familiar food items into food groups. One-on-one interviews in a neighborhood community center. Twenty-eight African American mothers. A hierarchical taxonomy of food groups for each participant, represented as a matrix of distances among food items in the individual sort of each participant. Cultural consensus analysis, hierarchical cluster analysis, and coding of food group category labels and sorting justifications. Consensus analysis revealed a consistent cultural model of lay food groups among the women. Lay food groups were systematically different from MyPyramid food groups. Lay food groups were more influenced by how food items are prepared or when and how food items are eaten than are MyPyramid food group categories. Nutrition messages framed using lay food group categories of low-income African Americans may be more effective for that population than messages using MyPyramid food group categories.
    Keywords: Culture ; Needs Assessment ; African Americans ; Food ; Health Behavior ; Education ; Anatomy & Physiology ; Diet & Clinical Nutrition
    ISSN: 1499-4046
    E-ISSN: 1878-2620
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  • 3
    Language: English
    In: Neuroimage, Nov 1, 2013, Vol.81, p.8(7)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.neuroimage.2013.05.003 Byline: Robin B. Holmes, Sandra M.A. Hoffman, Paul M. Kemp Abstract: Traditional interpretation of rCBF SPECT data is of a qualitative nature and is dependent on the observer's understanding of the normal distribution of the tracer. The use of a normal database in quantitative regional analysis facilitates the detection of functional abnormality in individual and group studies by accounting for inter-subject variability. The ability to simulate realistic images would allow various important areas related to the use of normal databases to be studied. These include the optimisation of the detection of abnormal blood flow and the portability of normal databases between gamma camera systems. To investigate this further we have constructed a hardware phantom and scanned various configurations of radioactive brain patterns and simulated skull configurations. Article History: Accepted 3 May 2013
    Keywords: Single Photon Emission Computed Tomography -- Usage ; Single Photon Emission Computed Tomography -- Analysis ; Import Regulations -- Usage ; Import Regulations -- Analysis
    ISSN: 1053-8119
    Source: Cengage Learning, Inc.
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  • 4
    Language: English
    In: Forest Ecology and Management, May 1, 2012, Vol.271, p.132(8)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.foreco.2012.02.001 Byline: Stephen B. Holmes (a), Douglas G. Pitt (b), Ken A. McIlwrick (a), Michael K. Hoepting (b) Keywords: Partial harvest; Selection silvicultural system; Northern tolerant hardwood forest; Breeding bird community composition Abstract: a* We studied the effects of partial harvesting on birds in a northern hardwood forest. a* Bird communities had not fully recovered by 10-12years post-harvest. a* Populations of some early successional species remained elevated. a* Ovenbird numbers were reduced. a* Repeated applications of selection cutting could have cumulative effects on birds. Author Affiliation: (a) Natural Resources Canada, Canadian Forest Service, Great Lakes Forestry Centre, 1219 Queen Street East, Sault Ste. Marie, Ont., Canada P6A 2E5 (b) Natural Resources Canada, Canadian Forest Service, Canadian Wood Fibre Centre, 1219 Queen Street East, Sault Ste. Marie, Ont., Canada P6A 2E5 Article History: Received 16 December 2011; Revised 1 February 2012; Accepted 2 February 2012
    Keywords: Deciduous Forests
    ISSN: 0378-1127
    Source: Cengage Learning, Inc.
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  • 5
    Language: English
    In: Journal of Nutrition Education and Behavior, March 2012, Vol.44(2), pp.154-159
    Description: Describe beliefs about what makes foods healthful among low-income African American women. In one-on-one interviews, 28 low-income African American mothers viewed 30 pairs of familiar foods and explained which food in the pair was more healthful and why. Responses were grouped into codes describing concepts of food healthfulness. Nutrient content, physical effects of food, and food categories were used to judge the healthfulness of foods. Fruits, vegetables, and dairy foods were considered the most healthful and starchy foods the least healthful because they were believed to cause weight gain. Beliefs about which foods contain which nutrients and which foods have particular physical effects varied widely across participants. Participants demonstrated awareness of which foods are healthful but lacked understanding of why those foods are more healthful than others. Knowledge about the health effects of foods may be necessary to motivate individuals to choose healthful foods.
    Keywords: African American ; Food Choice ; Low Income ; Nutrition Knowledge ; Nutrition Beliefs ; Nutrition Education ; Education ; Anatomy & Physiology ; Diet & Clinical Nutrition
    ISSN: 1499-4046
    E-ISSN: 1878-2620
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  • 6
    Language: English
    In: European journal of clinical nutrition, April 2011, Vol.65(4), pp.538-45
    Description: To investigate the influence of social and physical factors on diet quality in materially deprived (low income) older people in the United Kingdom. A diet quality index was obtained for 222 men and 440 women aged 65 and over living alone or with other adults of retirement age from the United Kingdom Low Income Diet and Nutrition Survey (2003-2005). The association between diet quality and social and physical factors was investigated by logistic regression analysis. Analysis revealed several barriers to an adequate diet in the older low-income population. For both men and women, having the best quality diet was inversely associated with usually eating meals on one's lap as opposed to at the table (Adjusted odds ratio (ORs)=0.3, 95% confidence interval: 0.12-0.77 (men), 0.3, 0.17-0.56 (women)). For men, difficulty chewing was inversely associated with the best quality diet (OR=0.4; 0.13-0.99), whereas for women, current smoking and being 75 years or over were inversely associated with the best quality diet (OR=0.2; 0.06-0.42 and 0.5; 0.27-0.87, respectively); P value for all associations was 〈0.05. Results suggest that the social setting is an important determinant of diet quality in this group and future studies should collect details on where and with whom meals are taken to fully investigate the extent of this influence.
    Keywords: Eating ; Energy Intake ; Nutritional Status ; Poverty ; Socioeconomic Factors
    ISSN: 09543007
    E-ISSN: 1476-5640
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  • 7
    Language: English
    In: Journal of the American College of Cardiology, 21 March 2017, Vol.69(11), pp.2328-2328
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/S0735-1097(17)35717-0 Byline: Benjamin B. Holmes, Kristopher Swiger, Juan Estrada Author Affiliation: Vanderbilt Heart & Vascular Institute, Nashville, TN, USA Article Note: (footnote) Poster Contributions Poster Hall, Hall C Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m. Session Title: FIT Clinical Decision-Making: Arrhythmias and Electrophysiology Abstract Category: Arrhythmias and Clinical EP Presentation Number: 1206-416
    Keywords: Medicine
    ISSN: 0735-1097
    E-ISSN: 1558-3597
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  • 8
    Language: English
    In: Biological Conservation, 2011, Vol.144(5), pp.1560-1566
    Description: Objective evaluations of wildlife reintroductions are vital for increasing the success of future efforts to re-establish endangered species. Attempts to reintroduce one of the most endangered mammals in North America, the black-footed ferret ( ), have been ongoing for 18 years with no quantitative assessment of factors related to reintroduction success. We examined relationships between ferret reintroduction success and factors associated with disease outbreaks, release strategies, and the distribution and abundance of their primary prey, prairie dogs ( sp.), at 11 reintroduction sites. The most important factor related to ferret reintroduction success was a cumulative metric incorporating both size of the area occupied by prairie dogs and density of prairie dog burrows within that area. Each of the four successful sites had prairie dog populations that occupied an area of at least 4300 ha. No sites with 〈4300 ha of prairie dogs were successful in maintaining ⩾30 adult individual ferrets over multiple years without augmentation even if they had a high prairie dog burrow density. The overarching importance of the availability of high-quality habitat suggests managers should prioritize actions that maintain and enhance the availability of large areas with high prairie dog burrow density, which are becoming increasingly rare due to anthropogenic impacts and disease outbreaks.
    Keywords: Carnivore ; Endangered Species ; Mustela Nigripes ; Prairie Dogs ; Recovery ; Reintroduction Biology ; Agriculture ; Biology ; Ecology
    ISSN: 0006-3207
    E-ISSN: 18732917
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  • 9
    Language: English
    In: The Journal of biological chemistry, 01 March 2013, Vol.288(9), pp.6063-71
    Description: Huntington disease is a dominantly inherited neurodegenerative condition caused by polyglutamine expansion in the N terminus of the huntingtin protein (Htt). The first 17 amino acids (N17) of Htt play a key role in regulating its toxicity and aggregation. Both nuclear export and cytoplasm retention functions have been ascribed to N17. We have determined that N17 acts as a nuclear export sequence (NES) within Htt exon and when fused to yellow fluorescent protein. We have defined amino acids within N17 that constitute the nuclear export sequence (NES). Mutation of any of the conserved residues increases nuclear accumulation of Htt exon 1. Nuclear export of Htt is sensitive to leptomycin B and is reduced by knockdown of exportin 1. In HEK293 cells, NES mutations decrease overall Htt aggregation but increase the fraction of cells with nuclear inclusions. In primary cultured neurons, NES mutations increase nuclear accumulation and increase overall aggregation. This work defines a bona fide nuclear export sequence within N17 and links it to effects on protein aggregation. This may help explain the important role of N17 in controlling Htt toxicity.
    Keywords: Exons ; Nuclear Export Signals ; Cell Nucleus -- Metabolism ; Cytoplasm -- Metabolism ; Nerve Tissue Proteins -- Metabolism
    E-ISSN: 1083-351X
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  • 10
    Language: English
    In: The International Journal of Human Resource Management, 01 January 2011, Vol.22(3), pp.746-761
    Description: The purpose of this article is to develop a theoretical framework for governing an organization's relationships with customers engaged as contributors to the organization's business processes (i.e. customers as quasi-employees). Based on our suggested framework, we explain how appropriate customer-centric...
    Keywords: Customer Participation ; Customer Relationship Management ; Governance ; Ihrm ; Business ; Economics
    ISSN: 0958-5192
    E-ISSN: 1466-4399
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