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  • 1
    Language: English
    In: Nature, 21 August 2014, Vol.512(7514), pp.253
    Keywords: Aging -- Drug Effects ; Biomedical Research -- Trends ; Geriatrics -- Trends ; Longevity -- Drug Effects ; Preventive Medicine -- Trends ; Rejuvenation -- Physiology
    ISSN: 00280836
    E-ISSN: 1476-4687
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  • 2
    Article
    Article
    Language: English
    In: Journal of the Neurological Sciences, Oct 15, 2015, Vol.357, p.e490
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jns.2015.09.267 Byline: W. Howlett
    Keywords: HIV
    ISSN: 0022-510X
    E-ISSN: 18785883
    Source: Cengage Learning, Inc.
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  • 3
    In: Nature, 2014, Vol.512(7514), p.253
    ISSN: 0028-0836
    E-ISSN: 1476-4687
    Source: Nature Publishing Group
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  • 4
    Language: English
    In: Nature, Feb 19, 2009, Vol.457(7232), p.973(1)
    Keywords: Dimorphism (Biology) -- Research ; Fishes -- Physiological Aspects ; Fishes -- Research ; Metamorphosis (Biology) -- Research
    ISSN: 0028-0836
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  • 5
    Language: English
    In: Social Science & Medicine, March 2013, Vol.81, pp.34-41
    Description: The role of patients' organisations in shaping (medical) knowledge about particular health conditions and illnesses sheds light on notions of informed patienthood and the dynamics of lay-expert knowledge in the context of medicalisation. This paper considers dynamics of knowledge production in relation to a specific condition area, Attention Deficit Hyperactivity Disorder (ADHD), by investigating how parents of children with ADHD are intervening in knowledge creation about the effectiveness of different treatments for the disorder. It draws on qualitative research carried out between 2009 and 2011 with organisations representing parents of children with ADHD in Ireland, to explore how parents have commissioned evaluations of alternative interventions to medication. Drawing on analysis of 12 semi-structured interviews with both parents and professionals active in the arena of ADHD, documentary evidence, and observation at parent organisations' events, the study demonstrates how parents' interventions have sought to expand the therapeutic domain of ADHD beyond the exclusive realm of biopsychiatry, and the dilemmas they face in making their experiences count in a context where the need for evidence has become paramount in the governance of health. ► Explores how ADHD parent organisations shape knowledge about ADHD and its treatment. Parents commissioned evaluations of alternative therapies for ADHD beyond medication. ► Parents deploy research with a pragmatic goal of lobbying for improved, holistic services. ► Parents seek to create credentialised knowledge out of their own experiences. ► Illuminates how the context of evidence-based policy structures parents' knowledge work.
    Keywords: Ireland ; ADHD ; Patients' Organisations ; Parents ; Knowledge Production ; Medicalisation ; Medicine ; Social Sciences (General) ; Public Health
    ISSN: 0277-9536
    E-ISSN: 1873-5347
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  • 6
    Language: English
    In: Journal of the American College of Cardiology, 15 May 2012, Vol.59(20), pp.1796-1798
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jacc.2012.01.043 Byline: Jonathan G. Howlett Keywords: atrial fibrillation; ejection fraction; heart failure; heart rate; prognosis Author Affiliation: Division of Cardiology, Department of Cardiac Sciences, University of Calgary, Calgary, Alberta, Canada Article Note: (footnote) Dr. Howlett has reported that he has no relationships relevant to the contents of this paper to disclose.
    Keywords: Atrial Fibrillation ; Ejection Fraction ; Heart Failure ; Heart Rate ; Prognosis ; Medicine
    ISSN: 0735-1097
    E-ISSN: 1558-3597
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  • 7
    Language: English
    In: Australian & New Zealand Journal of Psychiatry, February 2015, Vol.49(2), pp.137-144
    Description: Objective: To investigate the ambulatory mental health service profile of persons with intellectual disability (ID) in a representative sample of New South Wales (NSW). Methods: A statistical linkage key was used to link the Disability Services Minimum Data Set (DS-MDS) and a community mental health services dataset (MH-COM) for a representative area of NSW for the period 2005–2010. Linkage was undertaken in four NSW local health districts (LHDs), covering 36.7% of the NSW population. The mental health profiles and service use characteristics of people with an ID were compared to mental health service users without an ID. Results: Of the 89,262 people in the MH-COM over this 6-year period, 1,459 people (1.6 %) were identified as having an ID. Compared to those without an ID, people with an ID were more likely to have psychotic disorders, developmental disorders and personality disorders, and more than twice as likely to have an ‘unknown’ diagnosis. Compared to those without an ID, people with an ID were less likely to have depressive disorders, adjustment disorders and other disorders. Service use profiles revealed that people with an ID had 1.6 times more face-to-face contacts, and a total face-to-face contact time which was 2.5 times longer than people without an ID. Conclusions: Ambulatory mental health data from NSW indicates that people with an ID receive care for a distinct range of mental disorders, and experience uncertainty regarding their diagnosis. People with an ID have higher service needs which require recognition and the allocation of specific resources. Such data provide a suitable baseline for future evaluation of the impact of ambulatory mental health reforms for people with an ID.
    Keywords: Ambulatory Mental Health Services ; Data Linkage ; Disability Services Minimum Dataset ; Intellectual Disability ; Mental Health Services ; Medicine
    ISSN: 0004-8674
    E-ISSN: 1440-1614
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  • 8
    Language: English
    In: Archives of Disease in Childhood, 02/2018, Vol.103(2), pp.e2.12-e2
    Description: Aims Health information technology (HIT) is increasingly being promoted as a medication error reduction strategy. Electronic prescribing and smart-pump technology are examples of HIT widely advocated in the hospital setting. In critical care, the risks associated with paediatric infusions have been specifically...
    Keywords: Computerized Physician Order Entry ; Chemotherapy ; Information Technology ; Taxonomy ; Intensive Care ; Human Error ; Medical Errors ; Analgesia ; Critical Care ; Pain Perception ; Intravenous Administration ; Pediatrics;
    ISSN: 0003-9888
    E-ISSN: 1468-2044
    Source: CrossRef
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  • 9
    Language: English
    In: Journal of the American Chemical Society, 29 June 2011, Vol.133(25), pp.9678-81
    Description: Gliotoxin, a major product of the gli non-ribosomal peptide synthetase gene cluster, is strongly associated with virulence of the opportunistic human pathogen Aspergillus fumigatus. Despite identification of the gli cluster, the pathway of gliotoxin biosynthesis has remained elusive, in part because few potential intermediates have been identified. In addition, previous studies suggest that knowledge of gli-dependent metabolites is incomplete. Here we use differential analysis by 2D NMR spectroscopy (DANS) of metabolite extracts derived from gli knock-out and wild-type (WT) strains to obtain a detailed inventory of gli-dependent metabolites. DANS-based comparison of the WT metabolome with that of ΔgliZ, a knock-out strain devoid of the gene encoding the transcriptional regulator of the gli cluster, revealed nine novel gliZ-dependent metabolites including unexpected structural motifs. Their identification provides insight into gliotoxin biosynthesis and may benefit studies of the role of the gli cluster in A. fumigatus virulence. Our study demonstrates the utility of DANS for correlating gene expression and metabolite biosynthesis in microorganisms.
    Keywords: Aspergillus Fumigatus -- Pathogenicity ; Gliotoxin -- Biosynthesis ; Magnetic Resonance Spectroscopy -- Methods ; Metabolomics -- Methods
    ISSN: 00027863
    E-ISSN: 1520-5126
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  • 10
    In: Journal of Applied Behavior Analysis, December 2011, Vol.44(4), pp.943-947
    Description: The effects of contriving motivating operations (MOs) and script fading on the acquisition of the mand “Where's [object]?” were evaluated in 2 boys with language delays. During each session, trials were alternated in which high‐preference items were present (abolishing operation [AO] trials) or missing (establishing operation [EO] trials) from their typical locations. Both participants learned to mand during EO trials and not to mand during AO trials during training. Generalization of manding was demonstrated across novel instructors, stimuli, and settings and maintained 3 to 4 weeks following the intervention.
    Keywords: Motivating Operations ; Mand ; Script Fading
    ISSN: 0021-8855
    E-ISSN: 1938-3703
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