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  • 1
    Language: English
    In: Tetrahedron, 25 November 2012, Vol.68(47), pp.9694-9700
    Description: Nine new steroids, sclerosteroids A–I ( , , , – ), along with 18 known metabolites ( – , , – ), were isolated from the soft coral These structures were elucidated on the basis of detailed spectroscopic analysis. The absolute configurations of sugar moieties in steroidal glycosides – were determined by HPLC analysis of the -tolylthiocarbamate derivatives of the liberated sugars from hydrolysis of these steroidal giycosides. Cytotoxic and anti-inflammatory activities of these compounds were measured in vitro.
    Keywords: Scleronephthya Gracillimum ; Sclerosteroids ; O-Tolylthiocarbamate ; Cytotoxic Activity ; Anti-Inflammatory Activity ; Chemistry
    ISSN: 0040-4020
    E-ISSN: 1464-5416
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  • 2
    Language: English
    In: Journal of the Chinese Medical Association, June 2014, Vol.77(6), pp.333-336
    Description: We describe in this paper the current status of ophthalmic plastic and orbital surgery in Taiwan. Data were collected from the Bureau of National Health Insurance of Taiwan, the Bulletin of the Taiwan Ophthalmic Plastic and Reconstructive Society, and the by the Taiwan Medical Association. We ascertained that 94 ophthalmologists were oculoplastic surgeons and accounted for 5.8% of 1621 ophthalmologists in Taiwan. They had their fellowship training abroad (most ophthalmologists trained in the United States of America) or in Taiwan. All ophthalmologists were well trained and capable of performing major oculoplastic surgeries. The payment rates by our National Health Insurance for oculoplastic and orbital surgeries are relatively low, compared to Medicare payments in the United States. Ophthalmologists should promote the concept that oculoplastic surgeons specialize in periorbital plastic and aesthetic surgeries. However, general ophthalmologists should receive more educational courses on oculoplastic and cosmetic surgery.
    Keywords: Manpower ; Operation Fee ; Ophthalmic Plastic Surgery ; Orbital Surgery ; Taiwan ; Medicine
    ISSN: 1726-4901
    E-ISSN: 1728-7731
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  • 3
    Language: English
    In: Bioorganic & Medicinal Chemistry, 2010, Vol.18(10), pp.3379-3386
    Description: Chemical investigations of the soft coral resulted in the isolation of six new norcembranolides, gyrosanolides A–F ( – ), a new norcembrane, gyrosanin A ( ), and 11 known norditerpenoids – . The structures of the isolated compounds were elucidated through extensive spectroscopic data and by comparison with reported data in the literature. Compounds – , – , , and at concentration of 10 μM did not inhibit the COX-2 protein expression, but significantly reduced the levels of the iNOS protein (55.2 ± 14.6%, 18.6 ± 6.7%, 10.6 ± 4.6%, 66.9 ± 5.2%, 10.2 ± 5.1%, 17.4 ± 7.2%, 47.2 ± 11.9%, and 56.3 ± 5.1%, respectively) by LPS stimulation. Compound showed significant antiviral activity against HCMV (human cytomegalovirus) cells with an IC of 1.9 μg/mL.
    Keywords: Sinularia Gyrosa ; Norcembranoids ; Norditerpenoids ; Anti-Inflammatory Activity ; Cytotoxicity ; Anti-Hcmv (Human Cytomegalovirus) ; Antibacterial Activity ; Medicine ; Chemistry ; Anatomy & Physiology
    ISSN: 0968-0896
    E-ISSN: 1464-3391
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  • 4
    Language: English
    In: Journal of Experimental & Clinical Medicine, 2011, Vol.3(6), pp.278-282
    Description: To analyze clinical features and treatment results of 42 patients with cavernous hemangioma of orbit. A retrospective chart review of cases. Between 1976 and 2011, 42 patients with pathologically proven cavernous hemangioma of the orbit were referred to, and treated by, the authors. The clinical features and treatment outcomes were analyzed. The retrospective study included 42 cases of symptomatic tumors that were completely removed by means of anterior orbitotomy (8/42, 19%), lateral orbitotomy (30/42, 71%), and transcranial approach (4/42, 10%). There were more female cases than male cases (29:13). Ages ranged from 17 years to 71 years (mean 46.2 years ± 6.8 years). Most of the tumors (32/42, 76%) were located in the muscle cone. The left orbit was affected in 18 cases, and the right orbit in 24 cases, no case was bilaterally involved. Painless, gradually progressive proptosis (exophthalmos) and visual disturbance were the main clinical signs. Of the cases, 90% (38/42) could be accurately diagnosed preoperatively based on ultrasound scan and computed tomography/magnetic resonance imaging examination. Improvement (or no change) of visual function (35 cases, 83%) was achieved in the 42 cases who received surgical treatment. No recurrence was noted during a 6 month to 136 month follow-up period. Nearly 90% of 42 patients with cavernous hemangioma of orbit could be correctly diagnosed preoperatively. The location of tumor determined the choice of surgical approach. Orbitotomies with careful dissection and cryoprobe extraction of the tumor have been successfully used in 32 cases. Among the 42 patients who received surgical treatment, good outcome of visual function (83%) was achieved. All patients were regularly followed up at least 6 months (range, 6–136 months; mean 16.4 months) and no recurrence was noted.
    Keywords: Cavernous Hemangioma ; Exophthalmos ; Orbit ; Orbitotomy ; Proptosis ; Medicine
    ISSN: 1878-3317
    E-ISSN: 1878-3325
    Source: ScienceDirect Journals (Elsevier)
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  • 5
    In: Current Opinion in Ophthalmology, 2015, Vol.26(2), pp.90-95
    Description: PURPOSE OF REVIEW: The aim of the present review was to summarize the evidence implicating the association between myopia and glaucoma, the possible underlying mechanisms for this relation, and the controversies surrounding detection of glaucomatous changes in coexisting myopia. RECENT FINDINGS: Numerous studies have shown that increasing categories of myopia are associated with a higher risk for optic neuropathy and glaucoma-like visual field defects. Recently, some high-resolution imaging modalities have been developed that aid further detection of the microanatomical changes of the optic nerve head and thus may provide a new insight to explain the association between myopia and glaucoma. Although the highly myopic eye usually shows many structural and functional defects that are difficult to distinguish from those caused by glaucoma, some new methods have been introduced to better differentiate between these changes. SUMMARY: The interaction of myopia with glaucoma risk remains complex, largely because of the retinal and nerve fiber layer damage that occurs in myopia alone. Whether to treat for glaucoma relies on the suspicion level of the clinician who must consider other risk factors for vision loss. Ultimately, it is the progression of glaucoma-like findings that determines whether a myopic patient has glaucoma.
    Keywords: Axial Length, Eye–Pathology ; Glaucoma, Open-Angle–Diagnosis ; Humans–Etiology ; Myopia, Degenerative–Complications ; Optic Disk–Pathology ; Optic Nerve Diseases–Diagnosis ; Risk Factors–Etiology;
    ISSN: 1040-8738
    E-ISSN: 15317021
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  • 6
    In: PLoS ONE, 2014, Vol.9(10)
    Description: Objective There is limited epidemiological data on the seasonality of respiratory syncytial virus (RSV) infection in subtropical climates, such as in Taiwan. This study aimed to assess RSV seasonality among children ≤24 months of age in Taiwan. We also assessed factors (gestational age [GA], chronologic age [CA], and bronchopulmonary dysplasia [BPD]) associated with RSV-associated hospitalization in preterm infants to confirm the appropriateness of the novel Taiwanese RSV prophylactic policy. Study Design From January 2000 to August 2010, 3572 children aged ≤24-months were admitted to Taipei Mackay Memorial Hospital due to RSV infection. The monthly RSV-associated hospitalization rate among children aged ≤24 months was retrospectively reviewed. Among these children, 378 were born preterm. The associations between GA, CA, and BPD and the incidence of RSV-associated hospitalization in the preterm infants were assessed. Results In children aged ≤24 months, the monthly distribution of RSV-associated hospitalization rates revealed a prolonged RSV season with a duration of 10 months. Infants with GAs ≤32 weeks and those who had BPD had the highest rates of RSV hospitalization ( P 〈0.001). Preterm infants were most vulnerable to RSV infection within CA 9 months. Conclusions Given that Taiwan has a prolonged (10-month) RSV season, the American Academy of Pediatrics' recommendations for RSV prophylaxis are not directly applicable. The current Taiwanese guidelines for RSV prophylaxis, which specify palivizumab injection (a total six doses until CA 8–9 months) for preterm infants (those born before 28 6/7 weeks GA or before 35 6/7 weeks GA with BPD), are appropriate. This prophylaxis strategy may be applicable to other countries/regions with subtropical climates.
    Keywords: Research Article ; Medicine And Health Sciences
    E-ISSN: 1932-6203
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  • 7
    Language: English
    In: Journal of Experimental & Clinical Medicine, October 2013, Vol.5(5), pp.201-202
    Keywords: Medicine
    ISSN: 1878-3317
    E-ISSN: 1878-3325
    Source: ScienceDirect Journals (Elsevier)
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  • 8
    Language: English
    In: Journal of the Formosan Medical Association, June 2014, Vol.113(6), pp.356-363
    Description: Hemangiopericytoma is a very rare orbital tumor. The purpose of this study was to report the clinical and histopathological features of six cases of orbital hemangiopericytoma in an Asian population. Clinical and histopathological features were reviewed in six patients who were histopathologically confirmed as having primary orbital hemangiopericytoma in National Taiwan University Hospital between May 2001 and December 2010. Among the six cases who were diagnosed as having primary orbital hemangiopericytoma, all lesions were reported as vascular tumors and featured branching “staghorn appearance” vessels. All patients, including one male and five females, presented with progressive proptosis and some associated symptoms such as extraocular motility limitation with diplopia, displacement of the globe, afferent pupillary defect, congested vessels of conjunctiva, or decreased visual acuity. On computed tomography, the orbital tumors tended to manifest as circumscribed masses with homogeneous medium-to-high enhancement with contrast studies. All six patients received surgical treatments, and four of them had additional radiotherapy. Three patients had recurrence after surgeries, and one of them had multiple metastases to lung and liver. All patients were still alive after a follow-up period of 5–10 years. Orbital hemangiopericytoma has malignant potential, which may lead to local recurrence and/or metastasis. Histopathological findings alone are insufficient to predict the behavior of this tumor. Therefore, both clinical and histopathological findings are important to evaluate the treatment outcomes. Total excision accompanied with radiotherapy is suggested and long-term follow-up is required.
    Keywords: Asian Population ; Orbital Hemangio-Pericytoma ; Medicine
    ISSN: 0929-6646
    E-ISSN: 1876-0821
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  • 9
    Language: English
    In: Mitochondrial DNA Part A, 03 March 2016, Vol.27(2), pp.1229-1230
    Description: In this article, the complete mitogenome of the Octocorallia, zooxanthellate, Junceella fragilis has been amplified and sequenced. This mitochondrial genome consists of 18,724 bp, with 14 protein-coding genes, 2 ribosomal RNA genes, 1 transfer RNA genes, no intron was observed. It has been...
    Keywords: Gorgonian Coral ; Junceella Fragilis ; Mitochondrial Genome ; Anatomy & Physiology
    ISSN: 2470-1394
    E-ISSN: 2470-1408
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  • 10
    Language: English
    In: PLoS ONE, 01 January 2014, Vol.9(6), p.e100981
    Description: Respiratory syncytial virus (RSV) circulates year round in Taiwan. A novel six consecutive monthly doses of palivizumab for RSV prevention protocol has been approved for high risk preterm infants since December 2010. This study aimed to determine...
    Keywords: Sciences (General)
    E-ISSN: 1932-6203
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