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  • 1
    Language: English
    In: Pediatrics, January 2011, Vol.127(1), pp.e245-9
    Description: Propylthiouracil, a drug commonly used to treat hyperthyroidism, is known to cause antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis as a rare complication. The wide clinical spectrum of propylthiouracil-induced vasculitis ranges from mild forms with rash and/or arthralgia to severe forms with renal or pulmonary involvement, which can be critical and life-threatening if left unrecognized and untreated. Given its rarity and exceedingly variable clinical presentations, diagnosis may be challenging, and delayed diagnosis is not uncommon without a high index of suspicion, as illustrated by this report of a 17-year-old girl with Graves' disease who developed occult pulmonary hemorrhage as an overlooked rare presentation of ANCA-associated vasculitis after administration of propylthiouracil. Associated clinical features included fever, fatigue, palpable purpura, polyarthritis, and nephritis. Positive findings on chest radiography prompted the bronchoalveolar lavage procedure, which led to the identification of pulmonary hemorrhage. Skin biopsy showed leukocytoclastic vasculitis. Serologic test results were positive for perinuclear ANCA, cytoplasmic ANCA, myeloperoxidase-ANCA, proteinase 3-ANCA, and cryoglobulins but negative for antinuclear antibody, anti-double-stranded DNA, rheumatoid factor, and anti-hepatitis C virus antibody. The symptoms resolved after discontinuation of propylthiouracil and a few months of corticosteroids and azathioprine. This report highlights the necessity for physicians to keep alert for the protean manifestations of propylthiouracil-induced vasculitis.
    Keywords: Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis -- Chemically Induced ; Antithyroid Agents -- Adverse Effects ; Hemorrhage -- Etiology ; Lung Diseases -- Etiology ; Propylthiouracil -- Adverse Effects
    ISSN: 00314005
    E-ISSN: 1098-4275
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  • 2
    Language: English
    In: The Journal of Allergy and Clinical Immunology, February 2018, Vol.141(2), pp.AB5-AB5
    Description: Furthermore, early-onset eczema appeared to show a significantly increased risk of allergic rhinitis [odds ratio (OR), 3.71; 95% confidence interval (CI), 1.37-10.02; P = 0.010] and asthma (OR, 3.80; 95% CI, 1.12-12.85; P = 0.032) at an age of 4 years. Conclusions Early-onset eczema appears not only...
    Keywords: Medicine
    ISSN: 0091-6749
    E-ISSN: 1097-6825
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  • 3
    Language: English
    In: The Journal of Allergy and Clinical Immunology, February 2018, Vol.141(2), pp.AB203-AB203
    Description: Rationale Cord blood soluble Fas ligand (sFasL), an innate immunity marker, was related to asthma, allergic rhinitis, and atopic dermatitis at some cross-sectional or short-term follow-up studies. Conclusions At this birth cohort, cord blood sFasL levels were associated with allergic rhinitis, obstructive-type lung function, FeNO, and house dust mite sensitization at 7 year-old children.
    Keywords: Medicine
    ISSN: 0091-6749
    E-ISSN: 1097-6825
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  • 4
    Language: English
    In: The Journal of Allergy and Clinical Immunology, February 2018, Vol.141(2), pp.AB183-AB183
    Description: At 7 years old, fractional exhaled nitric oxide (FeNO) and pulmonary function tests were conducted Results During 1~2 years old, 145 children were check their specific IgE to D. pteronyssinus. 42 (29%) children were sensitized to D. pteronyssinus, which...
    Keywords: Medicine
    ISSN: 0091-6749
    E-ISSN: 1097-6825
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  • 5
    Language: English
    In: PLoS ONE, 01 January 2015, Vol.10(6), p.e0128768
    Description: We aimed to determine the risk of tuberculosis in children with juvenile idiopathic arthritis (JIA) in Taiwan.We used the Taiwan National Health Insurance Research Database (NHIRD) to conduct a nested case-control study. We identified a JIA cohort and matched each JIA child with non-JIA children for comparison. Methotrexate (MTX), tumor necrosis factor (TNF) inhibitor administration, and new tuberculosis cases were determined during our study period. To compare tuberculosis (TB) risk among our study groups, Cox proportional regression models were used to determine adjusted hazard ratios (aHRs).We identified 1495 children with JIA and 11592 non-JIA children. Majority (68.7%) children with JIA had not received MTX or TNF inhibitors; 23.9% used MTX without TNF inhibitors, and 7.4% received TNF inhibitors, irrespective of MTX administration. In total, 43 children developed tuberculosis. The overall tuberculosis infection rate for children with JIA was two times higher than that for non-JIA children. Compared with non-JIA children, children with JIA who used MTX without TNF inhibitors revealed a significantly increased of tuberculosis infection rate (aHR = 4.67; 95% CI: 1.65-13.17; P = 0.004). Children with JIA who either received TNF inhibitors or never used MTX and TNF inhibitors revealed a tuberculosis infection rate comparable to that of non-JIA children.Analysis of nationwide data of Taiwan suggested that children with JIA were at higher risk of tuberculosis compared with those without JIA.
    Keywords: Sciences (General)
    E-ISSN: 1932-6203
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  • 6
    Language: English
    In: Biomedical Journal, 2012, Vol.35(1), p.1
    ISSN: 2319-4170
    Source: CrossRef
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  • 7
    Article
    Article
    In: Journal of Pediatrics & Neonatal Care, 8/17/2016, Vol.5(2)
    ISSN: Journal of Pediatrics & Neonatal Care
    E-ISSN: 23734426
    Source: CrossRef
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  • 8
    Language: English
    In: Arthritis & Rheumatism, September 2010, Vol.62(9), pp.2824-2824
    Keywords: Medicine;
    ISSN: 0004-3591
    ISSN: 2151464X
    E-ISSN: 1529-0131
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  • 9
    Language: English
    In: International Journal of Nursing Studies, August 2016, Vol.60, pp.133-144
    Description: Empowerment can be an effective strategy for changing an individual's health behaviours. However, how to empower whole families to manage their children's asthma is a challenge that requires innovative nursing intervention based on family-centred care. To evaluate the effectiveness of a family empowerment program on family function and pulmonary function of children with asthma compared to those receiving traditional self-management only. A randomized control trial. Sixty-five families were recruited from one asthma clinic in a medical centre in Taiwan. After random assignment, 34 families in the experimental group received the family empowerment program consisting of four counselling dialogues with the child and its family. We empowered the family caregiver's ability to manage their child's asthma problems through finding the problems in the family, discovery and discussion about the way to solve problems, and enabling the family's cooperation and asthma management. The other 31 families received the traditional care in asthma clinics. The Parental Stress Index and Family Environment Scale of family caregivers, and pulmonary function, and asthma signs of children with asthma were collected at pre-test, 3-month post-test, and one-year follow-up. We utilized the linear mixed model in SPSS (18.0) to analyze the effects between groups, across time, and the interaction between group and time. The family empowerment program decreased parental stress ( = 13.993, 〈 .0001) and increased family function (cohesion, expression, conflict solving, and independence) ( = 19.848, 〈 .0001). Children in the experimental group had better pulmonary expiratory flow (PEF) ( = 26.483, 〈 .0001) and forced expiratory volume in first second (FEV1) ( = 7.381, = .001) than children in the comparison group; however, no significant change in forced expiratory volume in first second (FEV1)/forced vital capacity (FVC) was found between the two groups. Sleep problems did not show significant changes but cough, wheezing, and dyspnoea were significantly reduced by family caregiver's observations. We empowered families by listening, dialogues, reflection, and taking action based on Freire's empowerment theory. Nurses could initiate the families’ life changes and assist children to solve the problems by themselves, which could yield positive health outcomes.
    Keywords: Asthma ; Caregivers ; Children ; Empowerment ; Family ; Family-Centred Nursing ; Nursing
    ISSN: 0020-7489
    E-ISSN: 1873-491X
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  • 10
    Language: English
    In: PLoS ONE, 01 January 2014, Vol.9(7), p.e102809
    Description: A correct interpretation of sensitization to common allergens is critical in determining susceptibility to allergic diseases. The aim of this study was to investigate the patterns of sensitization to food and inhalant allergens, and their relation to the development of atopic diseases in early childhood.Children aged 0 through 4 years from a birth cohort in the Prediction of Allergies in Taiwanese Children (PATCH) study were enrolled. Specific IgE antibody against food and inhalant allergens were measured and their association between total serum IgE levels and atopic diseases were assessed.A total of 182 children were regular followed up at clinics for a four-year follow-up period. The prevalence of food allergen sensitization increased markedly after 6 months of age, reaching up to 47% at 1.5 years of age and then declined significantly to 10% in parallel with a considerable increase in the prevalence of sensitization to inhalant allergens up to 25% at age 4. Food allergen sensitization appeared to be mainly associated with the elevation of serum total IgE levels before age 2. A combined sensitization to food and inhalant allergens had an additive effect on serum IgE levels after age 2, and was significantly associated with the risk of developing atopic diseases at age 4.Sensitization to food occurs early in life, in parallel with the rising prevalence of sensitization to inhalant allergens at older age. A combined sensitization to food and inhalant allergens not only has an additive increase in serum IgE antibody production but also increases the risk of developing allergic respiratory diseases in early childhood.
    Keywords: Sciences (General)
    E-ISSN: 1932-6203
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