Format:
Online-Ressource (VIII, 250p, digital)
ISBN:
9789048190690
Series Statement:
Subcellular Biochemistry 52
Content:
Transcription factors are - in the most common use of the term - proteins that possess sequence-specific DNA-binding activity, and either directly or indirectly influence the transcription of genes in proximity to the binding site. Transcription factors are the primary interface between the cell and the genome, and in aggregate control not only regulation of transcription but also genome organization, and play a central role in many aspects of physiology and evolution. This book will provide a reference for the major aspects of transcription factor biochemistry, function, and evolution. Conten
Note:
Includes bibliographical references and index
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Preface; Contents; Contributors; 1 Introduction to A Handbook of Transcription Factors; 1.1 Overview; 1.2 Families of DNA-Binding Domains; 1.3 DNA-Binding Activity, TF Targeting, and the Influence of Chromatin; 1.4 Transcriptional Regulatory Activity; 1.5 Conclusion and Perspective; References; 2 An Overview of Prokaryotic Transcription Factors; 2.1 Introduction: Regulation of Transcription Initiation in Bacteria; 2.2 Core Regulatory Members of the RNA Polymerase: The -Factors; 2.3 Transcription Factors; 2.3.1 Identification and Genomic Distribution of Transcription Factors
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2.3.2 Classification of Transcription Factors Based on Their Regulatory Scope: Global and Local Regulators2.3.3 Signal Dependent Activity of Global Regulators: CRP and LRP; 2.3.3.1 Lrp: The Feast or Famine Global Transcription Factor; 2.3.3.2 Crp and Transcriptional Responses to Carbon-Source Nutrition; 2.3.4 Expression and Protein--Protein Interaction Dependent Activity of Global Regulators: FIS and H-NS; 2.3.4.1 Fis: An Enigmatic Transcriptional Regulator; 2.3.4.2 H-NS: ''The Genome Sentinel''; 2.3.5 Local Transcription Factors and Specific Responses
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2.4 Structure and Evolution of Bacterial Transcriptional Regulatory Networks2.4.1 Modular Architecture of the Transcriptional Regulatory Network; 2.4.2 Subnetwork Architectures for Different Gene Functions; 2.4.3 Evolution of Transcription Networks: Implications for Regulatory Networks; 2.5 Conclusions; References; 3 A Catalogue of Eukaryotic Transcription Factor Types, Their Evolutionary Origin, and Species Distribution; 3.1 Introduction; 3.2 A Catalogue of Eukaryotic Transcription Factor Families; 3.2.1 Metazoan Transcription Factor Families
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3.2.1.1 Metazoan Basic Superfamily Transcription Factors3.2.1.2 Metazoan Zinc-Coordinating Transcription Factors; 3.2.1.3 Metazoan Helix-Turn-Helix Transcription Factors; 3.2.1.4 Metazoan -Scaffold Transcription Factors; 3.2.1.5 Other Metazoan Transcription Factor Families; 3.2.2 Plant Transcription Factor Families; 3.2.2.1 Plant -Scaffold Transcription Factors; 3.2.2.2 Plant Zinc-Coordinating Transcription Factors; 3.2.2.3 Additional Plant Transcription Factor Families; 3.2.3 Fungal Transcription Factors; 3.2.4 Transcription Factors in Protists
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3.3 A Brief History of Eukaryotic Transcription Factor Families3.3.1 Events Pre-dating the Emergence of Metazoans; 3.3.2 The Evolution of Metazoan Transcription Factor Families; 3.3.3 The Evolution of Plant Transcription Factor Families; 3.3.4 Evolutionary Contributions of Transcription Factor Family Expansions; 3.3.5 The Contribution of TF Dimerization; 3.4 Summary and Future Directions; References; 4 Function and Evolution of C2H2 Zinc Finger Arrays; 4.1 Introduction; 4.2 Zinc FingerDNA Interactions; 4.2.1 Predicting a Zinc-Finger Code; 4.2.2 Experimental Data on KZNF--DNA Interactions
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4.3 Evolutionary History: The Rise and Fall of Lineage-Specific KZNF Families
Additional Edition:
ISBN 9789048190683
Additional Edition:
Buchausg. u.d.T. A handbook of transcription factors Dordrecht : Springer, 2011 ISBN 9789048190683
Language:
English
Subjects:
Biology
Keywords:
Transkriptionsfaktor
;
Transkriptionsfaktor
;
Transkription
DOI:
10.1007/978-90-481-9069-0
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