Journal of Chromatography A, June 1, 2012, Vol.1240, p.156(9)
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.chroma.2012.03.072 Byline: Song Yang (a), Jeremy S. Nadeau (c), Elizabeth M. Humston-Fulmer (c), Jamin C. Hoggard (c), Mary E. Lidstrom (a)(b), Robert E. Synovec (c) Keywords: GC-MS; PARAFAC; Peak deconvolution;.sup.12C/.sup.13C isotopomer determination; Metabolomics;.sup.13C flux analysis Abstract: a* GC-MS with chemometrics for analyzing coeluting.sup.12C and.sup.13C labeled contributions. a* The stacked samples in GC-MS create a three-dimensional data cube. a* PARAFAC is utilized for mathematical peak deconvolution and isotopic isolation. a* The accuracy and precision of metabolomics and.sup.13C flux analysis are enhanced. Author Affiliation: (a) Department of Chemical Engineering, University of Washington, Seattle, WA 98195-2180, USA (b) Department of Microbiology, University of Washington, Seattle, WA 98195-2180, USA (c) Department of Chemistry, University of Washington, Seattle, WA 98195-1700, USA Article History: Received 25 January 2012; Revised 17 March 2012; Accepted 21 March 2012
Mass Spectrometry ; Chromatography
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