Format:
Online-Ressource (digital)
ISBN:
9780387788876
Series Statement:
SpringerLink
Content:
Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during both developmental stages and in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may serve as therapeutic treatment for a number of neurodegenerative diseases.
Note:
Description based upon print version of record
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Title Page; Copyright Page; Preface; Table of Contents; Contributors; About the Editors; Cdk5/p35 Regulates Neuronal Migration; Expression of Cdk5, p35, and p39 During Brain Development; Cdk5/p35 Deficiency Causes Neuronal Migration Defects in CNS; Normal Migration of Cortical Neurons and Alterationby Cdk5/ p35 Deficiency; Molecular Mechanism of the Regulatory Function of Cdk5/p35in Neuronal Migration; Summary; References; CRMP Family Protein: Novel Targets for Cdk5That Regulates Axon Guidance, SynapseMaturation, and Cell Migration; Introduction; Fyn and Cdk5 Are Involved in Sema3A Signaling
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Plex-A2 Associates with Cdk5 via Interaction with Active Fyn,and Fyn Activates Cdk5 via Tyr15 PhosphorylationSema3A-Induced Growth Cone Collapse Is Mediated ThroughCdk5 Activation via Tyr15 Phosphorylation; CRMP2 Is an In Vivo Substrate of Cdk5; Cdk5-Primed GSK3b Phosphorylation of CRMP2; The Phosphorylation of CRMPs Disrupts Association of CRMPswith Tubulin; Sema3A-Induced Growth Cone Collapse Through Phosphorylationof CRMP2, and Evidence for Both CRMP1 and CRMP2Are Involved in Sema3A Signaling; CRMP1 Regulates Spine Maturation Through Mediating Sema3ASignaling In Vivo
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CRMP1 Mediates Reelin Signaling in Cortical Neuronal MigrationThe Phosphorylation of CRMPs in Mediating Extacellular Signals; Conclusion; References; Cdk5 in Presynapses; Cdk5 in Presynapses; Cdk5 in Exocytosis; Cdk5 and Synapsin; Cdk5 and Munc-18; Cdk5 and Voltage-Gated Calcium Channels; Role of Cdk5 in Exocytosis; Cdk5 in Endocytosis; Cdk5 and Dynamin 1; Cdk5 and Amphiphysin; Cdk5 and Synaptojanin; Concluding Remarks; References; Cyclin-Dependent Kinase 5: A Critical Regulatorof Neurotransmitter Release; Introduction
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Effect of Cdk5 on the Exocytosis of Synaptic Vesiclesin Presynaptic TerminalsPhosphorylation of Munc18-1 by Cdk5; Phosphorylation of Sept5 by Cdk5; Untitled; Phosphorylation of Pctaire1, a Kinase to Phosphorylate NSFby Cdk5; Effect of Cdk5 on Endocytosis in Presynaptic Terminals; Phosphorylation of Dynamin 1 by Cdk5; Phosphorylation of Amphiphysin I by Cdk5; Phosphorylation of Synaptojanin 1 by Cdk5; Effect of Cdk5 on Neurotransmitter Synthesis; Phosphorylation of Tyrosine Hydroxylase by Cdk5; Control of Presynaptic Ca++ and Lipid Signaling by Cdk5
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Phosphorylation of P/Q-Type Calcium Channels by Cdk5Phosphorylation of PIPKIg by Cdk5; Conclusion; References; Cdk5 in Dendrite and Synapse Development:Emerging Role as a Modulator of ReceptorTyrosine Kinase Signaling; Dendrite, Spine, and Synapse Development; Cdk5: an Atypical Cyclin-Dependent Kinase; Regulation of Dendrite Development by Cdk5; Cdk5 as a Modulator of Extracellular Cues; Neurotrophins; Semaphorin 3A; Cdk5: Regulator of Cytoskeletal Components; Regulation of Actin Dynamics Through Modulation of Rho GTPases; Regulation of Microtubule Dynamics
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Regulation of Synapse Formation by Cdk5
Additional Edition:
ISBN 9780387788869
Additional Edition:
Buchausg. u.d.T. Cyclin dependent kinase 5 (Cdk5) New York : Springer, 2008 ISBN 9780387788869
Additional Edition:
ISBN 0387788867
Language:
English
Subjects:
Biology
DOI:
10.1007/978-0-387-78887-6
URL:
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