Kooperativer Bibliotheksverbund

Berlin Brandenburg

and
and

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Language
Year
  • 1
    Language: German
    In: Info Onkologie, 3/2013, Vol.16(2), pp.36-37
    ISSN: 1613-3633
    Source: Springer (via CrossRef)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Language: English
    In: Patient Education and Counseling, June 2011, Vol.83(3), pp.367-374
    Description: This study was conducted to define the task allocation in multiprofessional cancer medication management (MCMM) with a special focus on the role of the pharmacist as well as patient education and counseling. The acceptance of the proposed task allocation and the perceptions on multiprofessional teamwork were explored on a national level. We held local focus group meetings (University of Bonn with collaboration partners) to identify MCMM tasks. With the Delphi technique the tasks were allocated to physicians, pharmacists and nurses. Professionals (members of the German Cancer Society) were approached nationwide via an online questionnaire to evaluate the acceptance of the MCMM model and explore their perceptions on multiprofessional teamwork. The MCMM model comprised 38 tasks including 11 on patient education and counseling. It was rated to be reasonable (79%) and feasible (68%). Barriers and benefits of multiprofessional teamwork stated were patient-, team-, therapy-, structure-, and resources-related. The MCMM model integrates the pharmacist with responsibilities in patient education and counseling as well as prevention of drug-related problems. The approach was generally appreciated nationwide by the professions. The proposed model can serve as a tool to trigger changes in cancer medication management.
    Keywords: Medication Management ; Cancer Care ; Teamwork ; Oncology Pharmacist ; Medicine ; Public Health
    ISSN: 0738-3991
    E-ISSN: 1873-5134
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Language: English
    In: 2012, Vol.7(9), p.e46015
    Description: Elevated homocysteine concentrations have been associated with methotrexate-induced neurotoxicity. Based on methotrexate and homocysteine plasma concentrations of 494 children with acute lymphoblastic leukemia treated with high-dose methotrexate in the TOTAL XV study, a pharmacokinetic/pharmacodynamic (PK/PD) model was built with NONMEM. Several compartment and indirect response models were investigated. The pharmacokinetic disposition of methotrexate was best described by a two-compartment model. Homocysteine concentrations were included by an indirect response model where methotrexate inhibition of the homocysteine elimination rate was described by an E max model. The homocysteine baseline level was found to be age-dependent. Simulations revealed that folinate rescue therapy does not affect peak concentrations of homocysteine but leads to a modestly reduced homocysteine exposure. In conclusion, our PK/PD model describes the increase of methotrexate-induced HCY concentrations with satisfactory precision and can be applied to assess the effect of folinate regimens on the HCY concentration-time course.
    Keywords: Research Article ; Medicine ; Hematology ; Oncology ; Pharmacology
    E-ISSN: 1932-6203
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    In: ELECTROPHORESIS, February 2015, Vol.36(4), pp.509-517
    Description: Pt‐based anticancer drugs, such as cisplatin, are known to undergo several (bio‐)chemical transformation steps after administration. Hydrolysis and adduct formation with small nucleophiles and larger proteins are their most relevant reactions on the way to the final reaction site (DNA), but there are still many open questions regarding the identity and pharmacological relevance of various proposed adducts and intermediates. Furthermore, the role of buffer components or additives, which are inevitably added to samples during any type of analytical measurement, has been frequently neglected in previous studies. Here, we report on adduct formation reactions of the fluorescent cisplatin analogue carboxyfluorescein diacetate platinum (CFDA‐Pt) in commonly used buffers and cell culture medium. Our results indicate that chelation reactions with noninnocent buffers (e.g., Tris) and components of the cell culture/cell lysis medium must be taken into account when interpreting results. Adduct formation kinetics was followed up to 60 h at nanomolar concentrations of CFDA‐Pt by using CE‐LIF. CE‐MS enabled the online identification of such unexpected adducts down to the nanomolar concentration range. By using an optimized sample preparation strategy, unwanted adducts can be avoided and several fluorescent adducts of CFDA‐Pt are detectable in sensitive and cisplatin‐resistant cancer cell lines. By processing samples rapidly after incubation, we could even identify the initial, but transient, Pt species in the cells as deacetylated CFDA‐Pt with unaltered complexing environment at Pt. Overall, the proposed procedure enables a very sensitive and accurate analysis of low molecular mass Pt species in cancer cells, involving a fast CE‐LIF detection within 5 min.
    Keywords: Cancer Cell Lines ; Ce‐Lif ; Fluorescent Cisplatin Analogue ; Platinum Adducts
    ISSN: 0173-0835
    E-ISSN: 1522-2683
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Language: German
    In: Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz, 2018, Vol.61(9), pp.1111-1118
    Description: Bedingt durch den demografischen Wandel nimmt die Anzahl an älteren, pflegebedürftigen Menschen in Deutschland stetig zu. Ältere und hochbetagte Menschen in Heimen leiden häufig an mehreren chronischen Erkrankungen, was zur Verordnung einer Vielzahl von Arzneimitteln und einem hohen Risiko für unerwünschte Arzneimittelwirkungen (UAW) führt. Vor allem ZNS-wirksame Arzneistoffe sind in diesem Zusammenhang kritisch. Hinzu kommt der komplexe Medikationsprozess in Heimen mit zahlreichen Schnittstellen und Fehlerquellen. Arzneimitteltherapiesicherheit (AMTS) in der Versorgung von Heimbewohnern wird daher heute als multiprofessionelle Herausforderung verstanden. In Deutschland wurde in den letzten Jahren eine Reihe von Modellprojekten zur Verbesserung der AMTS in Heimen durchgeführt bzw. begonnen. Mit dem AMTS-AMPEL-Projekt ist es gelungen, die bisher größte Interventionsstudie zur AMTS in deutschen Einrichtungen der Langzeitpflege durchzuführen. Mit einer multiprofessionellen Intervention bestehend aus edukativen und strukturellen Maßnahmen konnten die Prävalenz und Inzidenz vermeidbarer UAW signifikant reduziert werden. Dieses und andere Projekte liefern Hinweise darauf, dass die AMTS in der Versorgung von Heimbewohnern durch gezielte multiprofessionelle Interventionen verbessert werden kann. Auch wenn es bereits Evidenz gibt, dass durch AMTS-fördernde Interventionen die Qualität der Medikation verbessert und arzneimittelbezogene Probleme gelöst werden können, ist der Nachweis der Beeinflussung klinischer Endpunkte wie der Hospitalisierungsrate und der Mortalität noch zu erbringen. Die Modellprojekte tragen aber schon jetzt durch die Sensibilisierung für Risiken im Medikationsprozess zu einer höheren Patientensicherheit in Einrichtungen der Langzeitpflege bei. Due to demographic change, the number of elderly patients in need of long-term care is continuously increasing. Residents in nursing homes often suffer from various chronic diseases leading to the prescription of a plethora of drugs and a high risk for adverse drug reactions (ADR). Particularly, CNS-active drugs are critical in this context. Moreover, the medication process in nursing homes is complex with numerous interfaces and error sources. Therefore, medication safety for long-term care residents is regarded as a multiprofessional challenge. In Germany, several model projects have been conducted and initiated that aim at enhancing medication safety in nursing homes. The AMTS-AMPEL project is the largest intervention study so far dealing with medication safety in German long-term care facilities. After implementation of a complex multiprofessional intervention consisting of educative and structural measures, prevalence and incidence of preventable ADR could be significantly reduced. This and other projects suggest that medication safety in long-term care residents can be improved by targeted multiprofessional interventions. Although there is already evidence that interventions enhancing medication safety can improve medication appropriateness and solve drug-related problems, they still lack evidence of affecting clinical endpoints like hospitalization rate and mortality. Nevertheless, the model projects already enhance patient safety by increasing the awareness for risks in the medication process in long-term care facilities.
    Keywords: Elderly patients ; Long-term care ; Medication process ; Polymedication ; Adverse drug reactions
    ISSN: 1436-9990
    E-ISSN: 1437-1588
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Language: English
    In: International Journal of Pharmaceutics, 2010, Vol.389(1), pp.10-17
    Description: The clinical application of cisplatin to treat solid tumours is often limited by the development of tumour cell resistance against this cytostatic agent. Although liposomal carriers of cisplatin are currently in clinical development, approaches to functionally overcome cisplatin resistance by liposomes have hardly been reported. We prepared PEGylated cisplatin-containing liposomes with diameters of about 110 nm and targetability to transferrin receptors (TfR) to correlate cisplatin cell uptake with cytotoxicity in sensitive and cisplatin resistant ovarian cancer cells A2780 compared to the free drug. Whereas the cell entry of free cisplatin was reduced by factor 4 after 24 h in resistant cells, liposomal uptake was similar in both cell lines and not affected by resistance. Cytotoxicity was clearly related to intracellular platinum levels, which were even higher for liposomal vs. free cisplatin in the resistant cells after 24, 48, and 72 h and slightly lower in the sensitive cells. However, TfR targeting was of less impact on activity in comparison to non-targeted liposomes. Detection of cellular ATP levels within 24 h allowed postulations on the intracellular fate of the liposomes. Altogether, this study strongly supports approaches to overcome cisplatin resistance by a liposomal application of the drug.
    Keywords: Cisplatin ; Pegylated Liposomes ; Targeting ; Tumour Cell Resistance ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 0378-5173
    E-ISSN: 1873-3476
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Language: English
    In: Electrophoresis, 2018, Vol.39(12)
    Description: Byline: Sandra Kotz, Maximilian Kullmann, Ganna V. Kalayda, Nadine Dyballa-Rukes, Ulrich Jaehde, Sabine Metzger ***** No abstract is available for this article. *****
    Keywords: Ovarian Cancer ; Antineoplastic Agents
    ISSN: 0173-0835
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Language: English
    In: Electrophoresis, 2015, Vol.36(21), pp.2811-2819
    Description: Cisplatin is one of the most widely used anticancer agents, but a major problem for successful chemotherapy is the development of drug resistance of tumor cells against cisplatin. Resistance to cisplatin is a multifactorial problem. A method to detect and identify intracellular cisplatin–protein adducts was developed using a fluorescent carboxyfluorescein‐diacetate‐labeled cisplatin analogue (CFDA–cisplatin), 2DE, and ESI‐MS/MS. We identified several CFDA–cisplatin–protein adducts including members of the protein disulfide isomerase family (PDI). These are the first results of the detection of intracellular CFDA–cisplatin–protein adducts, which may help to understand the resistance mechanism of cisplatin. ; p. 2811-2819.
    Keywords: Fluorescence ; Drug Resistance ; Cisplatin ; Drug Therapy ; Two-Dimensional Gel Electrophoresis ; Neoplasm Cells ; Protein Disulfide-Isomerase
    ISSN: 0173-0835
    Source: AGRIS (Food and Agriculture Organization of the United Nations)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    In: ELECTROPHORESIS, November 2015, Vol.36(21-22), pp.2811-2819
    Description: Cisplatin is one of the most widely used anticancer agents, but a major problem for successful chemotherapy is the development of drug resistance of tumor cells against cisplatin. Resistance to cisplatin is a multifactorial problem. A method to detect and identify intracellular cisplatin–protein adducts was developed using a fluorescent carboxyfluorescein‐diacetate‐labeled cisplatin analogue (CFDA–cisplatin), 2DE, and ESI‐MS/MS. We identified several CFDA–cisplatin–protein adducts including members of the protein disulfide isomerase family (PDI). These are the first results of the detection of intracellular CFDA–cisplatin–protein adducts, which may help to understand the resistance mechanism of cisplatin.
    Keywords: Carboxyfluorescein‐Diacetate‐Labeled Cisplatin Analogue ; Cisplatin ; Cisplatin–Protein Adducts ; Protein Marker Grid ; Two‐Dimensional Gel Electrophoresis
    ISSN: 0173-0835
    ISSN: ELECTROPHORESIS
    E-ISSN: 1522-2683
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Language: English
    In: Electrophoresis, November 2015, Vol.36(21-22), pp.2811-2819
    Description: Cisplatin is one of the most widely used anticancer agents, but a major problem for successful chemotherapy is the development of drug resistance of tumor cells against cisplatin. Resistance to cisplatin is a multifactorial problem. A method to detect and identify intracellular cisplatin-protein adducts was developed using a fluorescent carboxyfluorescein-diacetate-labeled cisplatin analogue (CFDA-cisplatin), 2DE, and ESI-MS/MS. We identified several CFDA-cisplatin-protein adducts including members of the protein disulfide isomerase family (PDI). These are the first results of the detection of intracellular CFDA-cisplatin-protein adducts, which may help to understand the resistance mechanism of cisplatin.
    Keywords: Carboxyfluorescein-Diacetate-Labeled Cisplatin Analogue ; Cisplatin ; Cisplatin-Protein Adducts ; Protein Marker Grid ; Two-Dimensional Gel Electrophoresis
    ISSN: 01730835
    E-ISSN: 1522-2683
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages