Format:
Online-Ressource ()
Edition:
2nd ed
Edition:
Online-Ausg.
ISBN:
9780123942968
,
0123946336
Content:
"This book highlights new principles of immune suppression that drive cancer, and offers radically new ideas about how therapy can be improved by attacking these principles. It provides an overview of immune escape as a critical trait in cancer and how applying specific combinations of immunotherapy and chemotherapy to attack this trait may radically improve the treatment of advanced disease"--Publisher's description
Content:
There has been major growth in understanding immune suppression mechanisms and their relationships to cancer progression and therapy. Following work that firmly establishes immune escape as an essential trait of cancer, recent studies have now defined specific mechanisms of tumoral immune suppression. The second edition of Cancer Immunotherapy highlights emerging principles of immune suppression that drive cancer and offers new ideas about how therapy can be improved by attacking these principles. Beginning by reviewing current understanding of cancer immunobiology and therap
Note:
Description based upon print version of record
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Front Cover; Cancer Immunotherapy: Immune Suppressionand Tumor Growth; Copyright; Contents; List of Contributors; Chapter 1 - Introduction; I. SUMMARY; II. HISTORICAL BACKGROUND; III. THE CHALLENGE OF CANCER; IV. PARTS OF THE BOOK; References; Section 1 - Principles of Basic Immunology; Chapter 2 - Components of the Immune System; I. OVERVIEW; II. PRINCIPAL TISSUES AND ORGANS; III. CELLS OF THE IMMUNE SYSTEM; IV. IMMUNE RESPONSES; V. LYMPHOCYTE RECOGNITION OF ANTIGEN; VI. EFFECTOR FUNCTIONS; References; Chapter 3 - Adaptive Immunity: B Cells and Antibodies; I. INTRODUCTION TO B CELLS
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II. B-CELL DEVELOPMENTIII. MATURE B CELLS; IV. ANTIBODY FUNCTION; V. B CELLS AND CANCER; VI. CONCLUSIONS; References; Chapter 4 - Adaptive Immunity: T Cells and Cytokines; I. AN OVERVIEW OF THE EVENTS THAT INITIATE AN ADAPTIVE IMMUNE RESPONSE; II. T-CELL ACTIVATION: A DEEPER LOOK; III. THE DIFFERENTIATION OF NAÏVE T CELLS INTO EFFECTOR T CELLS; IV. THE SIGNIFICANCE OF POLARIZING CYTOKINES; V. CD8+ T CELLS DEVELOP INTO CYTOTOXIC LYMPHOCYTES; VI. THE ACTIVITIES OF EFFECTOR AND MEMORY T CELLS IN TISSUES; VII. TWO MAJOR TYPES OF MEMORY T CELLS REMAIN AFTER ANTIGEN IS CLEARED
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VIII. THE CHALLENGES FACED BY THE ADAPTIVE IMMUNE SYSTEM WHEN RESPONDING TO TUMORSFurther Reading; Chapter 5 - Dendritic Cells: Antigen Processing and Presentation; I. DENDRITIC CELLS: INTRODUCTION; II. ANTIGEN PROCESSING AND PRESENTATION; III. MHC CLASS I; IV. MHC CLASS II; V. ALTERNATE PATHWAYS OF ANTIGEN PRESENTATION; VI. DENDRITIC CELL SUBSETS AND SPECIALIZED FUNCTIONS; VII. HUMAN DC SUBSETS; VIII. CONCLUSIONS; References; Chapter 6 - Mucosal Immunity; I. OVERVIEW; II. MUCOSAL SURFACES ARE THE MAJOR PORTALS OF ENTRY FOR ANTIGEN; III. EPITHELIAL BARRIER
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IV. INDUCTIVE AND EFFECTOR SITES IN THE MUCOSA-ASSOCIATED LYMPHOID TISSUEV. THE MICROBIOME AND MUCOSAL SURFACES; VI. TOLERANCE TO DIETARY ANTIGEN AND THE MICROBIOME; References; Section 2 - Principles of Cancer Immunobiology; Chapter 7 - Cancer Immunoediting: From Surveillance to Escape; I. INTRODUCTION; II. HISTORY OF CANCER IMMUNE SURVEILLANCE AND CANCER IMMUNOEDITING; III. MOUSE MODELS OF CANCER USED IN THE ESTABLISHMENT OF THE THREE ES; IV. CANCER IMMUNOEDITING IN HUMANS; References; Chapter 8 - Immunosurveillance: Innate and Adaptive Antitumor Immunity; I. INTRODUCTION
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II. INNATE ANTITUMOR RESPONSESIII. INNATE IMMUNE CELLS∗; IV. ADAPTIVE ANTITUMOR RESPONSES; V. ADAPTIVE IMMUNITY IN IMMUNOSURVEILLANCE; VI. TARGETS OF ANTITUMOR T-CELL RESPONSES; VII. ANTITUMOR EFFECTOR MECHANISMS: CYTOKINES∗; VIII. ANTITUMOR EFFECTOR MECHANISMS: CYTOTOXIC MECHANISMS; IX. THE INTERPLAY OF INNATE AND ADAPTIVE ANTITUMOR IMMUNITY; X. CONCLUSION; References; Chapter 9 - Immunological Sculpting: Natural Killer-Cell Receptors and Ligands; I. INTRODUCTION; II. NK EDUCATION, LICENSING, AND PRIMING; III. HOW RECEPTOR: LIGAND INTERACTIONS TRIGGER CELL LYSIS
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IV. RECEPTORS FOR MHC I AND MHC I-RELATED MOLECULES
Additional Edition:
ISBN 9780123946331
Additional Edition:
ISBN 0123942969
Additional Edition:
Print version Cancer Immunotherapy Immune Suppression and Tumor Growth
Language:
English
Keywords:
Electronic books
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