Format:
Online-Ressource
ISSN:
1613-6829
Content:
Abstract: The rapid development of engineered nanomaterials (ENMs) causes humans to become increasingly exposed to them. Therefore, a better understanding of the health impact of ENMs is highly demanded. Considering the 3Rs (Replacement, Reduction, and Refinement) principle, in vitro and computational methods are excellent alternatives for testing on animals. Among computational methods, nano‐quantitative structure‐activity relationship (nano‐QSAR), which links the physicochemical and structural properties of EMNs with biological activities, is one of the leading method. The nature of toxicological experiments has evolved over the last decades; currently, one experiment can provide thousands of measurements of the organism's functioning at the molecular level. At the same time, the capacity of the in vitro systems to mimic the human organism is also improving significantly. Hence, the authors would like to discuss whether the nano‐QSAR approach follows modern toxicological studies and takes full advantage of the opportunities offered by modern toxicological platforms. Challenges and possibilities for improving data integration are underlined narratively, including the need for a consensus built between the in vitro and the QSAR domains.
In:
day:29
In:
month:09
In:
year:2023
In:
extent:13
In:
Small, Weinheim : Wiley-VCH, [2005]-, (29.09.2023) (gesamt 13), 1613-6829
Language:
English
DOI:
10.1002/smll.202305581
URN:
urn:nbn:de:101:1-2023093015105694004342
URL:
https://doi.org/10.1002/smll.202305581
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023093015105694004342
URL:
https://d-nb.info/1304602842/34
URL:
https://doi.org/10.1002/smll.202305581
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