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  • 1
    Article
    Article
    Analysis of electronic structure, binding, and vibrations in biotin-streptavidin complexes based on density functional theory and molecular mechanics (2013)
    Details
    Language: English
    In: The journal of physical chemistry. B, 10 January 2013, Vol.117(1), pp.25-37
    Description: In this work, the biotin-streptavidin complex was studied with density functional theory (DFT), molecular mechanical methods (MM), and a hybrid DFT/MM approach in order to obtain the theoretical predictions for electronic structures, binding, optical transitions, harmonic vibrations, and absorption spectra. It was demonstrated that biotin solvation in water can reduce the binding strength to streptavidin by more than half. All studied properties, including the biotin binding and the UV absorption of the biotin-streptavidin complex, are predicted to be protonation state dependent. The absorption edge of the complex calculated with TDDFT/MM was found to be virtually insensitive to the choice of the MM force field and strongly dependent on the type of embedding of the DFT partition. Both UV and terahertz light absorption spectra are predicted to be sensitive to the presence of biotin in the streptavidin tetramer.
    Keywords: Biotin -- Chemistry ; Streptavidin -- Chemistry
    ISSN: 15206106
    E-ISSN: 1520-5207
    DOI: 10.1021/jp3075833
    URL: View this record in MEDLINE/PubMed
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  • 2
    Article
    Article
    Regulatory hurdles, economics cloud prospects for US LNG exports.(Transportation) (2012)
    Details
    Language: English
    In: The Oil and Gas Journal, August 6, 2012, Vol.110(8), p.92(5)
    Description: The growth of United States liquefied natural gas (LNG) exports is seen to be hampered by the weak economy and government regulations. Federal and state approvals are required for exporting LNG. Statistics on US LNG exports are also included.
    Keywords: Gas Industry -- Exports ; Gas Industry -- Laws, Regulations And Rules ; Gas Industry -- Economic Aspects
    ISSN: 0030-1388
    Source: Cengage Learning, Inc.
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  • 3
    Article
    Article
    Preformulation stability of trans-resveratrol and trans-resveratrol glucoside (Piceid) (2010)
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    Language: English
    In: Journal of agricultural and food chemistry, 10 February 2010, Vol.58(3), pp.1685-90
    Description: Resveratrol and resveratrol glucoside (piceid) were evaluated in a preformulation stability study. An HPLC assay was used for the analysis of stressed/reference samples. Samples of solid, crystalline material were held under the following conditions: 40 degrees C/75% RH (both open and protected), ambient fluorescent light (open), 70 degrees C (open), and exposed using a light cabinet to achieve ICH conditions for UV/fluorescent light. Both compounds were found to be stable out to 3 months for both accelerated and ambient conditions with negligible degradation. Exposure to UV and fluorescent light under ICH conditions did not significantly degrade the solid materials for UV exposure at 3 times the ICH limit and for fluorescent light exposure at 1 times the ICH limit. The results presented demonstrate crystalline resveratrol and piceid are stable solids. No evidence of oxidation of either material by atmospheric oxidants was seen. The data reported may help to clarify widely held beliefs that resveratrol is unstable and extremely sensitive to oxidation/degradation.
    Keywords: Chromatography, High Pressure Liquid -- Methods ; Fallopia Japonica -- Chemistry ; Glucosides -- Chemistry ; Plant Extracts -- Chemistry ; Stilbenes -- Chemistry
    ISSN: 00218561
    E-ISSN: 1520-5118
    DOI: 10.1021/jf903009f
    URL: View this record in MEDLINE/PubMed
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  • 4
    Article
    Article
    A solution to the educational crisis in Nevada (2012)
    Details
    Language: English
    In: Distance Learning, April, 2012, Vol.9(2), p.42(6)
    ISSN: 1547-4712
    Source: Cengage Learning, Inc.
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  • 5
    Article
    Article
    TCT-768 Comparative Branch And Distally Focused Main Renal Artery Denervation With Two Radio Frequency Catheters In A Preclinical Model (2015)
    Details
    Language: English
    In: Journal of the American College of Cardiology, 13 October 2015, Vol.66(15), pp.B312-B313
    Description: Methods Sixteen swine were treated unilaterally with either 8 lesions in the branch renal arteries (BA) or 8 in the branch + 4 in the main renal artery (MA) with the Medtronic Spyral(TM) catheter (SP) or in the MA alone with the St. Jude Medical EnligHTN(TM) catheter (EN) in one of four arms: 1) SP8 - 8 BA lesions, 2) SP12 - 8 BA + 4 MA lesions, 3) EN8 - 8 MA lesions, or 4) EN12 - 12 MA lesions.
    Keywords: Medicine
    ISSN: 0735-1097
    E-ISSN: 1558-3597
    DOI: 10.1016/j.jacc.2015.08.792
    URL: View record in ScienceDirect (Access to full text may be restricted)
    URL: View full text in ScienceDirect
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  • 6
    Article
    Article
    Real-Time UV Imaging of Nicotine Release from Transdermal Patch (2010)
    Details
    Language: English
    In: Pharmaceutical Research, 2010, Vol.27(12), pp.2614-2623
    Description: Byline: Jesper Astergaard (1), Emil Meng-Lund (1), Susan Weng Larsen (1), Claus Larsen (1), Karsten Petersson (2), James Lenke (3), Henrik Jensen (1) Keywords: diffusion; in vitro release; transdermal delivery; UV imaging Abstract: Purpose This study was conducted to characterize UV imaging as a platform for performing in vitro release studies using Nicorette(r) nicotine patches as a model drug delivery system. Methods The rate of nicotine release from 2 mm diameter patch samples (Nicorette(r)) into 0.067 M phosphate buffer, pH 7.40, was studied by UV imaging (Actipix SDI300 dissolution imaging system) at 254 nm. The release rates were compared to those obtained using the paddle-over-disk method. Results Calibration curves were successfully established which allowed temporally and spatially resolved quantification of nicotine. Release profiles obtained from UV imaging were in qualitative agreement with results from the paddle-over-disk release method. Conclusion Visualization as well as quantification of nicotine concentration gradients was achieved by UV imaging in real time. UV imaging has the potential to become an important technology platform for conducting in vitro drug release studies. Author Affiliation: (1) Department of Pharmaceutics and Analytical Chemistry Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark (2) New Products, LEO Pharma A/S, Ballerup, Denmark (3) Paraytec Ltd., York, UK Article History: Registration Date: 19/08/2010 Received Date: 21/06/2010 Accepted Date: 19/08/2010 Online Date: 02/09/2010 Article note: Electronic Supplementary Material The online version of this article (doi: 10.1007/s11095-010-0257-9) contains supplementary material, which is available to authorized users.
    Keywords: diffusion ; release ; transdermal delivery ; UV imaging
    ISSN: 0724-8741
    E-ISSN: 1573-904X
    DOI: 10.1007/s11095-010-0257-9
    URL: View full text in Springer (Subscribers only)
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  • 7
    Article
    Article
    Toward precision medulloblastoma treatment through integrated functional and genomic analysis of realistic preclinical models (2017)
    Details
    Description: The past decade has brought a wealth of information about the genetic and molecular characteristics of medulloblastoma, a cancer of the cerebellum. This should enable more targeted therapy better adapted to the diversity of the disease. However, barriers remain to translating this knowledge into improved therapeutic outcomes. Bridging the gap between genomics and treatment will require realistic preclinical models and integration of functional and genomic data. To this end, we performed in vitro screening of 7729 drugs on 20 patient-derived xenografts (PDXs) from the three most common medulloblastoma subgroups. One drug, actinomycin D, was shown to be effective in vivo in PDXs of Group 3 medulloblastoma, the molecular subgroup with the worst outcomes. Screening results were analyzed alongside mutational, transcriptional, and epigenetic data. I illustrate how this data could be used to provide personalized therapy recommendations and to shed light on molecular mechanisms underlying differences in drug response.
    Keywords: Bioinformatics; Oncology; Applied mathematics; actinomycin D; drug screen; medulloblastoma; patient-derived xenograft; precision medicine
    Source: eScholarship
    URL: View Full-text in eScholarship
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  • 8
    Article
    Article
    Disinfection model based on excess inactivation sites: implications for linear disinfection curves and the Chick-Watson dilution coefficient (2010)
    Details
    Language: English
    In: Environmental science & technology, 01 November 2010, Vol.44(21), pp.8162-8
    Description: Current disinfection models generally are either empirical modifications of Chick's law (linear survivor curves) or hit or site models modified from the radiation literature. In this paper, a general disinfection model is developed that assumes a large number of inactivation sites. From a probabilistic model of damaged site distribution, the normalized number of surviving organisms is described as the cumulative distribution function (cdf) of the normal distribution, with the independent variable equal to a measure of damage and the mean and variance equal and determined by dose-response submodels. Submodels were developed for chemical disinfectants without disinfectant demand, ultraviolet radiation, and chemical disinfectants with first-order disinfectant demand. This infinite site model reproduces linear, shouldering, and tailing survivor curves from literature data. In addition, it predicts Chick-Watson dilution coefficients in the range observed in the literature. The infinite site model offers the interpretation that linear, shoulder, tailing, and biphasic survivor curves and the apparent Chick-Watson dilution coefficient are ramifications of the normal cdf, rather than mechanistic laws.
    Keywords: Models, Biological ; Bacteria -- Drug Effects ; Disinfectants -- Pharmacology ; Disinfection -- Statistics & Numerical Data
    ISSN: 0013936X
    E-ISSN: 1520-5851
    DOI: 10.1021/es101818z
    URL: View this record in MEDLINE/PubMed
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  • 9
    Article
    Article
    Market changes vex Russian gas policies.(General Interest) (2010)
    Details
    Language: English
    In: The Oil and Gas Journal, August 2, 2010, Vol.108(28), p.24(5)
    Description: Changes in the international gas market have impacted Russia's gas policies. Many of the country's gas policy problems are linked to gas pricing issues. Russia is also seen to need to retain Gazprom's export monopoly, affecting its relations with the European Union.
    Keywords: Gas Industry -- Laws, Regulations And Rules ; Gas Industry -- Prices And Rates ; Gas Industry -- Market Share ; Russian Foreign Relations -- Economic Aspects ; Oao Gazprom
    ISSN: 0030-1388
    Source: Cengage Learning, Inc.
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  • 10
    Article
    Article
    System and method for encoding and decoding digital data using acoustical tones (2007)
    Details
    Language: English
    In: The Journal of the Acoustical Society of America, 2007, Vol.122(2), p.702
    ISSN: 00014966
    DOI: 10.1121/1.2771330
    Source: CrossRef
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