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Consortium
  • 1
    Book
    Book
    London [u.a.] :Routledge,
    UID:
    (DE-602)almahu_BV041241271
    Format: XIV, 206 S. : , Ill., graph. Darst., Kt.
    Edition: 1. publ.
    ISBN: 978-0-415-82508-5
    Series Statement: Ontological explorations
    Note: Includes bibliographical references and index
    Additional Edition: Erscheint auch als Online-Ausgabe ISBN 978-1-315-88739-5
    Language: English
    Subjects: Economics
    RVK:
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  • 2
    UID:
    (DE-627)1637807678
    ISSN: 1750-8916
    In: The Chinese journal of international politics, Oxford : Oxford Univ. Press, 2006, 9(2016), 4, Seite 459-485, 1750-8916
    In: volume:9
    In: year:2016
    In: number:4
    In: pages:459-485
    Language: English
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  • 3
    UID:
    (DE-604)BV046260083
    Format: Illustrationen
    ISSN: 0007-6287
    In: The Burlington magazine / ed. Benedict Nicolson, London, 2019, Volume 161, number 1399 (October 2019), Seite 820-829, 0007-6287
    Language: English
    Keywords: China ; Sogdiana ; Einwanderer ; Grab ; Ausstattung ; Sofa ; Geschichte 518-579
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  • 4
    Online Resource
    Online Resource
    [S.l.] : SSRN
    UID:
    (DE-627)1781152667
    Format: 1 Online-Ressource (58 p)
    Content: I find that firms experiencing increases in import competition significantly reduce their leverage ratios by issuing equity and selling assets to repay debt. Using import tariffs and foreign exchange rates as instrumental variables for import penetration, I show that these results are not manifestations of endogenous relations between import competition and leverage. The results are consistent with traditional tradeoff models of capital structure that predict a positive relation between book leverage and future expected profitability. Further evidence suggests that import competition affects leverage through changes in the tradeoff between the tax benefits of debt and the costs of financial distress
    Note: In: Journal of Financial Economics 106(2), November 2012, pages 427-446 , Nach Informationen von SSRN wurde die ursprüngliche Fassung des Dokuments October 24, 2011 erstellt
    Language: Undetermined
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  • 5
    Online Resource
    Online Resource
    New Haven : Yale University Press | Ann Arbor, Michigan : ProQuest
    UID:
    (DE-603)475866479
    Format: 1 Online-Ressource (385 pages)
    ISBN: 9780300258271
    Note: Description based on publisher supplied metadata and other sources
    Additional Edition: 9780300250046
    Language: English
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  • 6
    UID:
    (DE-627)719566959
    Format: graph. Darst.
    ISSN: 1225-0279
    In: Seoul journal of economics, Seoul : Univ., 1988, 25(2012), 2, Seite 153-175, 1225-0279
    In: volume:25
    In: year:2012
    In: number:2
    In: pages:153-175
    Language: English
    Keywords: Aufsatz in Zeitschrift
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  • 7
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : [Verlag nicht ermittelbar]
    UID:
    (DE-627)1803180854
    Content: Most deciduous trees drop their leaves before winter, a process which is referred to as leaf abscission. Leaf abscission is thought to be regulated by the action of auxin and ethylene. In order to test the function of auxin in leaf abscission, an experimental system in Populus was established to induce leaf shedding synchronously under controlled greenhouse conditions. Exogenous auxin and an auxin transport inhibitor delayed the abscission of dark-induced leaves and a new auxin response maximum preceded the formation of an abscission zone. The analysis of microarray results revealed that several genes encoding auxin transporters were strongly down-regulated during abscission, suggesting their involvement in the formation of the auxin maximum in the leaf axil. In ethylene-insensitive trees, leaf abscission could be delayed by the application of auxin and ethylene signaling was not required for the regulation of gene expression of auxin transporters during abscission. Thus, auxin and ethylene act partly independently of each other on leaf abscission in Populus. In order to study the effects of auxin on cell separation, isolated from its action on the development of an abscission zone, we examined root cap abscission in Arabidopsis. An auxin response gradient, spanning the root cap, was found to be established prior to the separation of the outermost root cap layer. Inhibition of polar auxin transport abolished the auxin response gradient in the root cap and disrupted abscission. Intriguingly, auxin efflux carriers of the PIN family were not expressed in the cell layer proximal to the abscising layer indicating that the outermost columella tier is disconnected from the auxin source in the quiescent center. A Populus homolog of the Arabidopsis WALLS ARE THIN1 (WAT1) was among the most strongly regulated genes during abscission. We found that WAT1 localizes to the tonoplast and facilitates auxin export from the vacuole. Whereas, WAT1-mediated auxin homeostasis is needed for secondary wall deposition, wat1 mutants do not display any phenotype related to abscission. While auxin gradients have been implicated in various growth-related processes our work provides novel data in support of a regulatory role of distinct auxin maxima and minima in organ and tissue abscission.
    Note: Dissertation 2015
    Language: English
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  • 8
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : [Verlag nicht ermittelbar]
    UID:
    (DE-627)1803892315
    Content: 2020 ; Biochemistry ; University of Maryland, Baltimore ; Ph.D. ; Background: Drug resistance is one of the most prevalent causes of death in advanced prostate cancer patients. Combination therapies that target cancer cells via different mechanisms to overcome resistance have gained increased attention in recent years. However, the optimal drug combinations and the underlying mechanisms are yet to be fully explored. Aim and methods: The aim of this study is to investigate drugs that inhibit the growth of cells that are resistant to standard chemo and androgen deprivation therapy, and determine the underlying mechanisms of their action. To achieve this aim, we established cell lines that are resistant to this standard combination drug treatment and tested new compounds to overcome this double drug" resistance. Results: Our results show that combination of enzalutamide (ENZ) and docetaxel (DTX) effectively inhibit the growth of prostate cancer cells that are resistant to either DTX or ENZ alone. The downregulation of transcription factor E2F1 plays a crucial role in cellular inhibition in response to the combined therapy. Notably, the androgen receptor (AR) variant AR3 (a.k.a. AR-V7), but not AR full length (AR-FL), positively regulates E2F1 expression in these cells. Specifically, E2F1 regulates AR3 and forms a positive regulatory feed-forward loop. Moreover, this drug combination treatment also results in DNA double strand break via the E2F1-AR3 signaling axis. Importantly, we established new drug-resistant cell lines that are resistant to ENZ+DTX combination therapy and found that the expression of both AR3 and E2F1 was restored in these double drug-resistant cells. Furthermore, we identified that auranofin, an FDA-approved drug for the treatment of rheumatoid arthritis, overcame the drug resistance and inhibited the growth of drug-resistant prostate cancer cells both in vitro and in vivo. Conclusion and significance: This proof-of-principle study demonstrates that targeting the E2F1/AR3 feedforward loop via a combination therapy or a multi-targeting drug could circumvent castration resistance in prostate cancer."
    Note: Dissertation 2020
    Language: English
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  • 9
    UID:
    (DE-627)1792787693
    Format: 1 Online-Ressource (24 p)
    Content: In this paper, we measured the total factor productivity (TFP) of all Chinese publicly listed firms by micro-level, that is, by industry and firm levels, from 1999 to 2005. Financial data from the China Stock Market (CSMAR) database were used and capital (K), labor (L), and material (M) were employed as input factors. China's TFP showed some increase but remained relatively stagnant, mainly because of the low TFP of big firms, which could potentially drive the country's overall productivity. We used four patterns of catch-up method (i.e., overtaking, convergence, slow catch-up, and reverse catch-up) developed by Jung and Lee (2010) to classify the catch-up patterns present in Chinese and Korean manufacturing industries. Two labor input methods, man hour and wage, were adopted for this purpose. The overall TFP catch-up level depended on the different labor input methods. Using man hour as labor input, no catch-up occurred in the overall industry level. Only “slow catch-up” and “reverse catch-up” manifested, indicating a huge gap between the overall industry TFPs of the two countries. Meanwhile, using wage as labor input, all of the four catch-up patterns occurred. The apparel industry particularly showed an “overtaking,” and four industries, namely, electrical machinery, textile mill products, instruments, and petroleum and coal products, showed a “convergence” pattern. The catch-up level of Chinese manufacturing firms approached that of Korean firms when wage was used as labor input
    Note: In: Seoul Journal of Economics Vol. 25, No. 2, pp. 153-175, 2012 , Nach Informationen von SSRN wurde die ursprüngliche Fassung des Dokuments 2012 erstellt
    Language: English
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  • 10
    Online Resource
    Online Resource
    Milton Park, Abingdon, Oxon ; : Routledge
    UID:
    (DE-627)1779201265
    Format: 1 online resource (xiv, 206 pages) , illustrations, maps
    ISBN: 9781315887395 , 1315887398
    Series Statement: Ontological explorations
    Content: pt. 1. Meta-theories, methodology and sustainable housing studies -- pt. 2. Transcendental critique : theoretical conditions of decoupling -- pt. 3. Immanent critique : empirical studies -- pt. 4. Explanatory critique : paradigm shift.
    Language: English
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