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  • 1
    UID:
    (DE-627)859586588
    Format: XI, 64 Seiten , 21 cm
    Note: Im Titel ist "2+" hochgestellt , Dissertation Eberhard Karls Universität Tübingen 2016
    Language: English
    Keywords: Hochschulschrift
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  • 2
    UID:
    (DE-627)884978028
    Format: 1 Online-Ressource (394 pages)
    ISBN: 9780128034996
    Content: Network Functions and Plasticity: Perspectives from Studying Neuronal Electrical Coupling in Microcircuitsfocuses on the specific roles of electrical coupling in tractable, well-defined circuits, highlighting current research that offers novel insights for electrical coupling's roles in sensory and motor functions, neural computations, decision-making, regulation of network activity, circuit development, and learning and memory. Bringing together a diverse group of international experts and their contributions using a variety of approaches to study different invertebrate and vertebrate model systems with a focus on the role of electrical coupling/gap junctions in microcircuits, this book presents a timely contribution for students and researchers alike.Provides an easy-to-read introduction on neural circuits of the model systemFocuses on the specific roles of electrical coupling in tractable, well-defined circuitsIncludes recent discoveries and findings that are presented in the context of historical backgroundOutlines outstanding issues and future research in the field
    Additional Edition: 9780128034712
    Additional Edition: Print version Jing, Jian Network Functions and Plasticity : Perspectives from Studying Neuronal Electrical Coupling in Microcircuits Saint Louis : Elsevier Science,c2017 9780128034712
    Language: English
    URL: Volltext  (lizenzpflichtig)
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  • 3
    Book
    Book
    London, United Kingdom : Elsevier/Academic Press
    UID:
    (DE-602)b3kat_BV044728853
    Format: xxii, 370 Seiten , Illustrationen, Diagramme , 25 cm
    ISBN: 9780128034712 , 0128034718
    Note: Includes bibliographical references and index
    Language: English
    Subjects: Biology , Psychology
    RVK:
    RVK:
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  • 4
    UID:
    (DE-627)1813329346
    ISBN: 9780128034712
    Content: Network Functions and Plasticity: Perspectives from Studying Neuronal Electrical Coupling in Microcircuits focuses on the specific roles of electrical coupling in tractable, well-defined circuits, highlighting current research that offers novel insights for electrical coupling's roles in sensory and motor functions, neural computations, decision-making, regulation of network activity, circuit development, and learning and memory. Bringing together a diverse group of international experts and their contributions using a variety of approaches to study different invertebrate and vertebrate model systems with a focus on the role of electrical coupling/gap junctions in microcircuits, this book presents a timely contribution for students and researchers alike
    Language: English
    Keywords: Electronic books
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  • 5
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : [Verlag nicht ermittelbar]
    UID:
    (DE-627)1803894598
    Content: Liver fatty acid binding protein (L-FABP) binds and translocates many lipophilic substrates within the cytoplasm including long chain fatty acids. Moreover it was reported that L-FABP possesses antioxidative properties within hepatocytes. However, the mechanism of L-FABP's antioxidative activity remains to be determined. Peroxisome proliferator activated receptor (PPAR) agonists and antagonists can regulate L-FABP levels. However, it needs to be investigated how PPAR agonists and antagonists regulate L-FABP expression. And whether the altered expression of L-FABP by these agents will affect its antioxidative properties within hepatocytes remains unclear. In this thesis we employed clofibrate (PPARα agonist), MK886 (PPARα antagonist), and GW9662 (PPARγ antagonist) to elucidate the mechanism whereby PPAR regulate L-FABP expression and what effect such expression has on the antioxidant activity of L-FABP in CRL-1548 hepatoma cells. Clofibrate served to upregulate L-FABP expression while MK886 and GW9662 were employed to inhibit L-FABP expression. The principal findings revealed that clofibrate treatment enhanced L-FABP mRNA stability and transcription, which resulted in increased L-FABP levels, while MK866 and GW9662 reduced these levels. We also demonstrated that increases in L-FABP levels were associated with reduced cytosolic reactive oxygen species (ROS), while L-FABP siRNA knockdown resulted in a decrease in L-FABP expression and an associated increase in ROS levels. The antioxidant mechanism of recombinant rat L-FABP in the presence of a hydrophilic (AAPH) and lipophilic (AMVN) free radical generators was also evaluated. Recombinant rat L-FABP was produced in E. coli and its amino acid sequence was confirmed by MALDI QqTOF MS. Antioxidant activity was assayed using the thiobarbituric acid method. Ascorbic acid served as a positive control for the AAPH reaction while α-tocopherol was used as a positive control for the AMVN reaction. The antioxidant activity of recombinant L-FABP was greater when free radicals were generated with AAPH than AMVN. Oxidative modification of L-FABP included up to five methionine oxidative peptides with a total of 80 Da mass shift compared to native L-FABP. These findings suggest that the mechanism of L-FABP's antioxidant activity involved the reaction of methionine with free radicals. In conclusion, L-FABP expression is regulated by PPAR agonists and antagonists through transcription and mRNA stability. Moreover, methionine residues appear to play an important role in the antioxidative activity of L-FABP. ; October 2010
    Note: Dissertation 2010
    Language: English
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  • 6
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : The University of Hong Kong (Pokfulam, Hong Kong)
    UID:
    (DE-627)1803894601
    Content: published_or_final_version ; Chemistry ; Doctoral ; Doctor of Philosophy
    Note: Dissertation The University of Hong Kong (Pokfulam, Hong Kong)
    Language: English
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  • 7
    UID:
    (DE-627)885668073
    Format: 1 Online-Ressource , illustrations
    Edition: Online-Ausg.]
    ISBN: 9780128034996 , 0128034998
    Content: Network Functions and Plasticity: Perspectives from Studying Neuronal Electrical Coupling in Microcircuits focuses on the specific roles of electrical coupling in tractable, well-defined circuits, highlighting current research that offers novel insights for electrical coupling's roles in sensory and motor functions, neural computations, decision-making, regulation of network activity, circuit development, and learning and memory. Bringing together a diverse group of international experts and their contributions using a variety of approaches to study different invertebrate and vertebrate model systems with a focus on the role of electrical coupling/gap junctions in microcircuits, this book presents a timely contribution for students and researchers alike
    Additional Edition: 0128034718
    Additional Edition: 9780128034712
    Additional Edition: Erscheint auch als Druck-Ausgabe Network Functions and Plasticity London : Academic Press, 2017 0128034718
    Additional Edition: 9780128034712
    Language: English
    Keywords: Electronic books
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  • 8
    UID:
    (DE-101)1084810328
    Format: XI, 64 Seiten , Illustrationen, Diagramme , 21 cm
    Note: Im Titel ist "2+" hochgestellt , Dissertation Eberhard Karls Universität Tübingen 2016
    Language: English
    Keywords: Hochschulschrift
    Library Location Call Number Volume/Issue/Year Availability
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  • 9
    UID:
    (DE-604)BV044988837
    Format: 1 online resource (394 pages)
    ISBN: 9780128034996
    Note: Description based on publisher supplied metadata and other sources
    Additional Edition: Erscheint auch als Druck-Ausgabe Jing, Jian Network Functions and Plasticity : Perspectives from Studying Neuronal Electrical Coupling in Microcircuits San Diego : Elsevier Science & Technology,c2017 ISBN 9780128034712
    Language: English
    Subjects: Biology , Psychology
    RVK:
    RVK:
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  • 10
    UID:
    (DE-605)HT007405761
    Format: IV, 209 S.
    ISBN: 0612007901
    Note: Kopie von University Microfilms International, Ann Arbor, Mich , Kingston, Queen's Univ., Diss., 1995
    Language: Undetermined
    Keywords: China ; Frauenbewegung ; Familie
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