Format:
12
ISSN:
1791-7530
Content:
Background/Aim: Malignant rhabdoid tumor (MRT) is a rare, aggressive neoplasm found in young children, caused by inactivation of a single gene, SNF5 (INI1, SMARCB1). MRT cases with multifocal tumors at diagnosis are categorized as synchronous MRT, often with a germline mutation of SNF5. The aim of this study was to establish new models useful in clarifying the biological basis of synchronous MRT. Materials and Methods: We established two novel MRT cell lines, designated as KP-MRT-KS and KP-MRT-KSa, derived from different lesions and at a different time from a synchronous multifocal 7-month-old female MRT patient. Results: Both cells showed typical morphology of MRT, with a compound genomic mutation in exons 2 and 5 of the SNF5 gene. The exon 2 mutation was found in the germline. Conclusion: These cell lines could serve as powerful tools for unveiling the molecular mechanism of refractory synchronous MRT.
Note:
Gesehen am 04.01.2021
In:
Anticancer research, Attiki, 2004, 40(2020), 11, Seite 6159-6170, 1791-7530
In:
volume:40
In:
year:2020
In:
number:11
In:
pages:6159-6170
In:
extent:12
Language:
English
DOI:
10.21873/anticanres.14636
URL:
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