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  • 1
    Language: German
    In: Tierärztliche Praxis Ausgabe G: Großtiere / Nutztiere, 2011, Vol.39(03), pp.186-187
    ISSN: 1434-1220
    E-ISSN: 2567-5834
    Source: Thieme Publishing Group (via CrossRef)
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  • 2
    Language: English
    In: PLoS ONE, 01 January 2018, Vol.13(2), p.e0192171
    Description: The treatment of patients with multiple trauma including blunt chest/thoracic trauma (TxT) and hemorrhagic shock (H) is still challenging. Numerous studies show detrimental consequences of TxT and HS resulting in strong inflammatory changes, organ injury and mortality. Additionally, the reperfusion (R) phase plays a key role in triggering inflammation and worsening outcome. Ethyl pyruvate (EP), a stable lipophilic ester, has anti-inflammatory properties. Here, the influence of EP on the inflammatory reaction and liver injury in a double hit model of TxT and H/R in rats was explored.Female Lewis rats were subjected to TxT followed by hemorrhage/H (60 min, 35±3 mm Hg) and resuscitation/R (TxT+H/R). Reperfusion was performed by either Ringer`s lactated solution (RL) alone or RL supplemented with EP (50 mg/kg). Sham animals underwent all surgical procedures without TxT+H/R. After 2h, blood and liver tissue were collected for analyses, and survival was assessed after 24h.Resuscitation with EP significantly improved haemoglobin levels and base excess recovery compared with controls after TxT+H/R, respectively (p〈0.05). TxT+H/R-induced significant increase in alanine aminotransferase levels and liver injury were attenuated by EP compared with controls (p〈0.05). Local inflammation as shown by increased gene expression of IL-6 and ICAM-1, enhanced ICAM-1 and HMGB1 protein expression and infiltration of the liver with neutrophils were also significantly attenuated by EP compared with controls after TxT+H/R (p〈0.05). EP significantly reduced TxT+H/R-induced p65 activation in liver tissue. Survival rates improved by EP from 50% to 70% after TxT+H/R.These data support the concept that the pronounced local pro-inflammatory response in the liver after blunt chest trauma and hemorrhagic shock is associated with NF-κB. In particular, the beneficial anti-inflammatory effects of ethyl pyruvate seem to be regulated by the HMGB1/NF-κB axis in the liver, thereby, restraining inflammatory responses and liver injury after double hit trauma in the rat.
    Keywords: Sciences (General)
    E-ISSN: 1932-6203
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  • 3
    Language: German
    In: Tierarztliche Praxis. Ausgabe G, Grosstiere/Nutztiere, 10 August 2017, Vol.45(4), pp.237-243
    Description: Two cases of an innate hyperplastic goiter in foals as well as the sonographic evaluation of the hyperplastic gland are presented. One foal displayed skeletal deformities in the form of a mandibular prognathism and forelimb contractures in addition to the swollen thyroid gland. Because of a poor prognosis, the animal was euthanized. The second foal was premature and displayed respiratory signs. Under symptomatic therapy, the goiter regressed within a few weeks.
    Keywords: Neonate ; Congenital Goiter ; Horse ; Sonography ; Thyroid Gland ; Goiter -- Veterinary ; Horse Diseases -- Congenital
    ISSN: 14341220
    E-ISSN: 2567-5834
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  • 4
    In: Tierärztliche Praxis K: Kleintiere/Heimtiere, 2018, Vol.46(02)
    In: Tierärztliche Praxis K: Kleintiere/Heimtiere, 2018, Vol.46(02), pp.119-125
    Description: Die Kasuistik beschreibt ein sehr seltenes kutanes nichtepitheliotropes B-Zell-Lymphom bei einem 11 Jahre alten Weimaraner-Rüden, der mit multiplen kutanen Umfangsvermehrungen vorgestellt wurde. Die zytologische Untersuchung eines aus einem Hautknoten entnommenen Feinnadelaspirats ergab neben zahlreichen Zytoplasmafragmenten lymphatischer Zellen eine Population pleomorpher plumper bis spindelförmiger Zellen mit runden bis ovalen Nuklei, feiner Chromatinstruktur, mittleren Mengen eines hellbasophilen Zytoplasmas sowie überwiegend undeutlichen Zellgrenzen. Der Befund war verdächtig für ein spindelzelliges kutanes Lymphom, sodass eine Biopsie erfolgte. Bei der histopathologischen Untersuchung zeigten die Zellen keinen Epitheliotropismus und waren immunhistologisch für mehrere B-ZellMarker positiv. Neben der Seltenheit kutaner nichtepitheliotroper B-Zell-Lymphome an sich ist die Besonderheit dieses Falls in der atypischen Spindelzellmorphologie der lymphatischen Zellen zu sehen. Eine spindelzellige Variante eines kutanen B-Zell-Lymphoms wurde bisher lediglich beim Menschen beschrieben.
    Keywords: Kutanes lymphom ; Spindelzelliges b-zell-lymphosarkom ; Haut ; Tumor ; Cutaneous lymphoma ; Spindle-cell b-cell lymphoma ; Skin ; Neoplasia
    ISSN: 1434-1239
    E-ISSN: 2567-5842
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  • 5
    Language: English
    In: Journal of veterinary science, 30 November 2018, Vol.19(6), pp.725-734
    Description: Ovaries of 21 bitches presented with gynecopathies were surgically removed and histologically examined. Standard histological, as well as immunohistochemical, classification of 193 cystic structures resulted in the classification of 72 cysts of subsurface epithelial structures (SES), 61 follicular cysts (FCs), 38 cystic rete ovarii (CRO), 13 lutein cysts (LCs), and 9 non-classifiable cysts (NCCs). In addition to the histological classification, results were interpreted according to subject medical history, clinical examination outcome, and macroscopic observations during ovariohysterectomy. Dogs with ovarian cysts (OCs) and associated reproductive perturbations were mostly nulliparous, of large breed, and had an average of 9.5 ± 3 years. Prolonged or shortened inter-estrus intervals of past heats, however, seemed to be relatively low-risk factors for the development of OCs in dogs. Furthermore, we provide histological observations of a rarely seen canine LC including a degenerated oocyte in the central cavity.
    Keywords: Dogs ; Histology ; Immunohistochemistry ; Medical History Taking ; Ovarian Cysts ; Dog Diseases -- Classification ; Ovarian Cysts -- Veterinary
    ISSN: 1229845X
    E-ISSN: 1976-555X
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  • 6
    Language: English
    In: Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, December 2016, Vol.47(4), pp.1090-1092
    Description: A 48-yr-old captive white rhinoceros ( Ceratotherium simum ) was euthanized due to old age, pododermatitis, and progressive laminitis of the middle toe of the left fore- and hindlimbs. Severe chronic necrotizing periodontitis and dental loss was diagnosed, although food intake prior to death had not decreased. In addition, extensive ulceration of the tongue was noted. Histologically, squamous cell carcinoma of the tongue was diagnosed with chronic severe ulcerative glossitis. Metastatic lesions were not detected. Clinicians should monitor the oral health of aging rhinoceros due to the occult nature of these lesions.
    Keywords: Ceratotherium Simum ; Rhinoceros ; Squamous Cell Carcinoma ; Tongue ; Ulceration ; Perissodactyla ; Carcinoma, Squamous Cell -- Veterinary ; Tongue Neoplasms -- Veterinary
    ISSN: 1042-7260
    E-ISSN: 19372825
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  • 7
    Language: English
    In: Veterinary Pathology, November 2017, Vol.54(6), pp.922-932
    Description: Feline herpesvirus type 1 (FeHV-1) is one of the etiological agents of feline respiratory disease. FeHV-1 is an epitheliotropic and cytopathic virus that mainly causes rhinitis and conjunctivitis, although pneumonia is also occasionally seen. In this study, the authors investigated the pathogenesis of FeHV-1-associated pneumonia, comparing natural cases with viral infection of tracheal ring and cell cultures in vitro, using histology, immunohistology, double immunofluorescence, and transmission electron microscopy as investigative tools. The results confirm that FeHV-1 targets both respiratory epithelial cells and pneumocytes and indicate that FeHV-1 pneumonia is the consequence of continuous cell-to-cell viral spread from the upper airways via the trachea into the lungs. They provide strong evidence that FeHV-1–infected cells die primarily via apoptosis, following loss of cell-to-cell contact, rounding, and detachment. However, virus-induced lesions in vivo are dominated by marked neutrophil infiltration and extensive necrosis with less prominent apoptosis; in the airways, the tissue necrosis can extend into the submucosa. The necrosis appears to result from virus-induced neutrophil influx and release of proteolytic enzymes, such as matrix metalloproteinase-9, from the neutrophils.
    Keywords: Apoptosis ; Cell-to-Cell Spread ; Feline Herpesvirus 1 ; Feline Viral Rhinotracheitis ; Pathogenesis ; Necrosis ; Neutrophil Influx ; Pneumonia ; Respiratory Diseases ; Cats ; Veterinary Medicine
    ISSN: 0300-9858
    E-ISSN: 1544-2217
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  • 8
    Language: English
    In: Pediatric Rheumatology Online Journal, 01 April 2017, Vol.15(1), pp.1-9
    Description: Abstract Background Although it is common clinical practice to treat children with Juvenile Idiopathic Arthritis (JIA) with functional appliances, the scientific evidence for this is limited. The aim of this study was to study the histologic effects of mandibular protrusion splints in temporomandibular joint (TMJ) arthritis in rabbits. Methods Twenty-eight ten-week old New Zealand white rabbits were randomly divided into four groups: AO (TMJ arthritis, no splint), AS (TMJ arthritis, mandibular splint advancement), OS (no arthritis, mandibular splint advancement) and OO (no arthritis, no splint). TMJ arthritis was induced in the groups AO and AS; 1 week later mandibular protrusion splints were placed on the upper incisors of the AS and OS animals. After 60 days the animals were sacrificed and a semiquantitative histologic evaluation of each TMJ was carried out to analyze the amount of inflammation and bone modeling. Results AO and AS animals had a higher inflammation score (AO = 1.3; AS = 1.8) than the non-arthritis groups (OO = 0.6; OS = 0.4). Whereas in the untreated control (OO) the amount of apposition and resorption was almost in balance (+1), OS animals displayed significantly more apposition (+9) and AO animals significantly more resorption (−3) than the untreated control. Arthritis animals with protrusion appliances (AS), however, had remarkably more bone apposition (+3) than resorption, indicating a similar bony reaction as in healthy animals, although reduced in extent. Conclusions Mandibular advancement in rabbits with TMJ arthritis is possible without detrimental histologic reactions and appears to partially compensate for the bone loss seen in rabbits with TMJ arthritis but without protrusion splints.
    Keywords: Jia ; Arthritis ; Tmj Morphology ; Functional Mandibular Advancement ; Medicine
    E-ISSN: 1546-0096
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  • 9
    Language: German
    In: Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere, 19 April 2017, Vol.45(2), pp.109-114
    Description: In a 9-year-old Yorkshire terrier a cyst of the respiratory epithelium of the nasopharynx was diagnosed. A complete obstruction of the nasopharynx leading to dyspnea was detected by computed tomography and endoscopy. A minimally invasive ablation of the cystic wall was performed under endoscopic guidance, followed by a pathohistological examination. Immediately after resection of the cyst, the clinical symptoms resolved. The follow-up endoscopical examination 3 months postoperatively was unremarkable. In the presented case the minimally invasive endoscopic ablation of the cystic wall was a successful treatment method.
    Keywords: Endoscopy ; Tornwaldt-Like Cyst ; Computed Tomography ; Histology ; Minimally Invasive Ablation ; Cysts -- Veterinary ; Dog Diseases -- Diagnostic Imaging ; Nasopharyngeal Neoplasms -- Veterinary
    ISSN: 14341239
    E-ISSN: 2567-5842
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  • 10
    Language: English
    In: Journal of Feline Medicine and Surgery Open Reports, 10 December 2015, Vol.1(2)
    Description: Case summary A 10-year-old male neutered British Shorthair cat was presented with a 6 month history of lethargy, weight loss and alopecia. Clinical examination revealed widespread alopecia of the ventral abdomen and hindlimbs. The skin in these areas was smooth and shiny and hairs could be easily epilated. Spontaneous pruritus was observed. Cytological examination of superficial impression smears showed a severe Malassezia species dermatitis and pyoderma. Ectoparasites could not be detected and no sign of dermatophytosis was visible in trichograms and Wood’s lamp analysis. Abdominal ultrasound found a focally thickened wall of the large intestine and multiple nodules in the liver. Fine-needle aspirates from lymph nodes, liver and altered colonic wall were consistent with an undifferentiated malignant neoplasia. The cat was euthanased at the owners’ request, owing to potential neoplasia with metastatic spread. At necropsy a metastasising carcinoma of the colonic wall was found, as well as a paraneoplastic alopecia. Relevance and novel information Feline paraneoplastic alopecia has been reported in association with pancreatic carcinoma, bile duct carcinoma and hepatocellular carcinoma, as well as with neuroendocrine pancreatic carcinoma and hepatosplenic plasma cell tumour. This is the first reported case of feline paraneoplastic alopecia associated with a colon carcinoma.
    Keywords: Veterinary Medicine
    E-ISSN: 2055-1169
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