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  • 1
    In: Plastic and Reconstructive Surgery Global Open, 2017, Vol.5(2 Suppl)
    Keywords: Aaps 2017 Abstract Supplement
    E-ISSN: 2169-7574
    Source: U.S. National Library of Medicine (NIH/NLM)
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  • 2
    In: Plastic and Reconstructive Surgery, 2018, Vol.141(1), pp.192e-192e
    Keywords: Surgical Flaps ; Pectoralis Muscles -- Surgery;
    ISSN: 0032-1052
    E-ISSN: 15294242
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  • 3
    Language: English
    In: Brain Research, Oct 18, 2011, Vol.1418, p.1(11)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.brainres.2011.08.044 Byline: Katarzyna D. Kania, Hasini C. Wijesuriya, Stephen B. Hladky, Margery A. Barrand Keywords: Human brain endothelial cell; ABCB1; ABCG2; ABCC4; Wnt/[beta]-catenin signalling; [beta]-Amyloid Abbreviations: A[beta], [beta]-amyloid; ABC, ATP-Binding Cassette; AD, Alzheimer's disease; BIO, 6-bromoindirubin-3'-oxime; Dkk-1, Dickkopf-1; Fzd-1, Frizzled-1; GSK-3[beta], glycogen synthase kinase-3[beta]; LEF, lymphoid enhancer-binding factor; LRP, low density lipoprotein receptor-related protein; MTT, 3-(4,5-dimethylthiazol-2-)-2,5-diphenyl tetrazolium bromide; ROS, reactive oxygen species; SEAP, secreted alkaline phosphatase; TCF, T-cell factor Abstract: ABC (ATP Binding Cassette) efflux transporters at the blood-brain barrier, P-glycoprotein (ABCB1), multidrug resistance associated protein 4 (ABCC4) and breast cancer resistance protein (ABCG2), are important for protecting the brain from circulating xenobiotics. Their expression is regulated by signals from surrounding brain tissue that may alter in CNS pathologies. Differences have been reported in transporter expression on brain vasculature of Alzheimer's subjects where raised levels of [beta]-amyloid (A[beta]) occur. The present study examines in vitro the effects of A[beta] using immortalised brain endothelial cells (hCMEC/D3). Significantly lower expression of ABCB1 but not ABCC4 or ABCG2 was found following exposure to A[beta].sub.1-42 peptide but not its scrambled equivalent. This was evident at both protein and transcript level and was reflected in lower transcriptional activity of the ABCB1 promoter as judged from the luciferase reporter gene assay and in decreases in ABCB1-mediated efflux of rhodamine 123. A[beta] exposure also affected Wnt/[beta]-catenin signalling, decreasing levels of [beta]-catenin protein, reducing activation of TOPFLASH and increasing transcript levels of endogenous inhibitor, Dkk-1. Application of Wnt3a reversed the A[beta]-induced changes to ABCB1 protein. These results suggest that A[beta] may impair Wnt/[beta]-catenin signalling at the blood-brain barrier but that activation of this pathway may restore ABCB1. Article History: Accepted 17 August 2011
    Keywords: Bromine Compounds ; Genetic Research ; Endothelium ; Glycogen ; Phosphatases ; Alzheimer's Disease ; Glycogen Synthesis
    ISSN: 0006-8993
    Source: Cengage Learning, Inc.
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  • 4
    Language: English
    In: Brain research, 2011, Vol.1418, pp.1-11
    Description: ABC (ATP Binding Cassette) efflux transporters at the blood–brain barrier, P-glycoprotein (ABCB1), multidrug resistance associated protein 4 (ABCC4) and breast cancer resistance protein (ABCG2), are important for protecting the brain from circulating xenobiotics. Their expression is regulated by signals from surrounding brain tissue that may alter in CNS pathologies. Differences have been reported in transporter expression on brain vasculature of Alzheimer's subjects where raised levels of β-amyloid (Aβ) occur. The present study examines in vitro the effects of Aβ using immortalised brain endothelial cells (hCMEC/D3). Significantly lower expression of ABCB1 but not ABCC4 or ABCG2 was found following exposure to Aβ₁–₄₂ peptide but not its scrambled equivalent. This was evident at both protein and transcript level and was reflected in lower transcriptional activity of the ABCB1 promoter as judged from the luciferase reporter gene assay and in decreases in ABCB1-mediated efflux of rhodamine 123. Aβ exposure also affected Wnt/β-catenin signalling, decreasing levels of β-catenin protein, reducing activation of TOPFLASH and increasing transcript levels of endogenous inhibitor, Dkk-1. Application of Wnt3a reversed the Aβ-induced changes to ABCB1 protein. These results suggest that Aβ may impair Wnt/β-catenin signalling at the blood–brain barrier but that activation of this pathway may restore ABCB1. ; p. 1-11.
    Keywords: Endothelial Cells ; Blood-Brain Barrier ; Transporters ; Multiple Drug Resistance ; Reporter Genes ; Alzheimer Disease ; Xenobiotics ; Transcription (Genetics) ; Brain ; Amyloid ; Luciferase ; Breast Neoplasms
    ISSN: 0006-8993
    Source: AGRIS (Food and Agriculture Organization of the United Nations)
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  • 5
    Language: English
    In: Brain Research, 2011, Vol.1418, pp.1-11
    Description: ABC (ATP Binding Cassette) efflux transporters at the blood–brain barrier, P-glycoprotein (ABCB1), multidrug resistance associated protein 4 (ABCC4) and breast cancer resistance protein (ABCG2), are important for protecting the brain from circulating xenobiotics. Their expression is regulated by signals from surrounding brain tissue that may alter in CNS pathologies. Differences have been reported in transporter expression on brain vasculature of Alzheimer's subjects where raised levels of β-amyloid (Aβ) occur. The present study examines in vitro the effects of Aβ using immortalised brain endothelial cells (hCMEC/D3). Significantly lower expression of ABCB1 but not ABCC4 or ABCG2 was found following exposure to Aβ peptide but not its scrambled equivalent. This was evident at both protein and transcript level and was reflected in lower transcriptional activity of the ABCB1 promoter as judged from the luciferase reporter gene assay and in decreases in ABCB1-mediated efflux of rhodamine 123. Aβ exposure also affected Wnt/β-catenin signalling, decreasing levels of β-catenin protein, reducing activation of TOPFLASH and increasing transcript levels of endogenous inhibitor, Dkk-1. Application of Wnt3a reversed the Aβ-induced changes to ABCB1 protein. These results suggest that Aβ may impair Wnt/β-catenin signalling at the blood–brain barrier but that activation of this pathway may restore ABCB1. ► Can raised β-amyloid levels affect efflux transporters in brain endothelial cells? ► Lower expression of ABCB1 but not ABCC4 or ABCG2 seen following exposure to Aβ . ► Aβ effects reflected in decreased ABCB1-mediated efflux capacity. ► Aβ exposure also decreased Wnt/β-catenin signalling. ► Application of Wnt3a reversed the Aβ-induced changes to ABCB1 protein.
    Keywords: Human Brain Endothelial Cell ; Abcb1 ; Abcg2 ; Abcc4 ; Wnt/Β-Catenin Signalling ; Β-Amyloid ; Anatomy & Physiology
    ISSN: 0006-8993
    E-ISSN: 1872-6240
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  • 6
    Language: English
    In: Cancer Research, 10/15/2014, Vol.74(20 Supplement), pp.B47-B47
    ISSN: 0008-5472
    E-ISSN: 1538-7445
    Source: CrossRef
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  • 7
    In: Real Estate Management and Valuation, 03/1/2014, Vol.22(1), pp.36-43
    Description: In a development project, land is the key factor of production. The concepts of its identification, selection and development are fundamental to the pre-investment phase. The purpose of the article is to present a definition of a land bank and identify the factors which have an impact on creating land banks by developers. If the length of time between the actual acquisition of land and the commencement of construction work is difficult to predict, developers will increase the size of their land banks. The author assumes that one of the most important premises for developers to accumulate land resources is the land development system which creates land availability.
    Keywords: Land ; Land Banks ; Developer ; Land Development System;
    ISSN: Real Estate Management and Valuation
    E-ISSN: 1733-2478
    Source: CrossRef
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  • 8
    Language: Polish
    In: Świat Nieruchomości, 2017, Vol.1(99), pp.27-34
    Description: Developed real estate markets distinguish developers working both in the residential and commercial segment (office, retail, warehouse, etc.) as well as land developers. Land developers are focused on activities which increase the value of land by preparing it for investment (the purchase of...
    Keywords: Economy ; Land Developer ; Land, Developer ; Investment Project
    ISSN: 1231-8841
    E-ISSN: 2450-534X
    Source: Central and Eastern European Online Library (C.E.E.O.L.)
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  • 9
    Language: English
    In: Annales zoologici, 2013, Vol.63(4), pp.537-540
    Description: A new species of the genus Cheilotrichia Rossi, 1848 (Diptera: Limoniidae) from Bitterfeld amber is described. Bitterfeld amber (Saxonian amber) is contemporaneous with the Baltic amber deposited in Gdańsk Amber Bay area. The representatives of the same species are often found among inclusions of Bitterfeld and Baltic amber but the species described herein Cheiliotrichia (Empeda) weitschati sp. nov. have been found only in Bitterfeld amber. ; p. 537-540.
    Keywords: New Species ; Eocene ; Bitterfeld Amber ; Amber ; Taxonomy ; Limoniidae ; Cheilotrichia (Empeda) Weitschati Sp. Nov ; Diptera
    ISSN: 0003-4541
    E-ISSN: 17341833
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  • 10
    In: Plastic and Reconstructive Surgery, 2017, Vol.139(6), pp.1474-1477
    Description: BACKGROUND:: The pectoralis major is a versatile flap used as an advancement or turnover flap for sternal wound treatment. The advancement flap provides suboptimal inferior sternal coverage and poorly fills mediastinal dead space. The turnover flap covers the inferior sternum and fills dead space but requires disinsertion of the muscle from the humerus, resulting in functional loss and cosmetic deformity. METHODS:: The authors describe a new technique of splitting the pectoralis muscle along its fibers, using the superior portion as an advancement flap and the inferior portion as a turnover flap. RESULTS:: Eleven patients underwent the described technique. Nine patients healed without complications or repeated operations. One patient had a recurrent aortic graft infection requiring reoperation. One patient had a postoperative seroma requiring incision and drainage. CONCLUSION:: Using the pectoralis as an advancement and turnover flap allows inferior sternum and mediastinum coverage using one donor site and maintaining the function of the muscle and preventing cosmetic deformity.
    Keywords: Pectoralis Muscles -- Transplantation ; Reconstructive Surgical Procedures -- Methods ; Surgical Flaps -- Transplantation ; Surgical Wound -- Surgery;
    ISSN: 0032-1052
    E-ISSN: 15294242
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