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  • 1
    In: Nature, 2011, Vol.471(7340), p.602
    Description: CRISPR/Cas systems constitute a widespread class of immunity systems that protect bacteria and archaea against phages and plasmids, and commonly use repeat/spacer-derived short crRNAs to silence foreign nucleic acids in a sequence-specific manner. Although the maturation of crRNAs represents a key event in CRISPR activation, the responsible endoribonucleases (CasE, Cas6, Csy4) are missing in many CRISPR/Cas subtypes. Here, differential RNA sequencing of the human pathogen Streptococcus pyogenes uncovered tracrRNA, a trans-encoded small RNA with 24-nucleotide complementarity to the repeat regions of crRNA precursor transcripts. We show that tracrRNA directs the maturation of crRNAs by the activities of the widely conserved endogenous RNase III and the CRISPR-associated Csn1 protein; all these components are essential to protect S. pyogenes against prophage-derived DNA. Our study reveals a novel pathway of small guide RNA maturation and the first example of a host factor (RNase III) required for bacterial RNA-mediated immunity against invaders. [PUBLICATION ]
    Keywords: Bacterial Proteins–Chemistry ; Bacterial Proteins–Genetics ; Bacterial Proteins–Immunology ; Bacterial Proteins–Metabolism ; Conserved Sequence–Genetics ; DNA, Viral–Metabolism ; DNA, Viral–Genetics ; Escherichia Coli–Genetics ; Models, Biological–Metabolism ; Prophages–Biosynthesis ; RNA Precursors–Genetics ; RNA Precursors–Immunology ; RNA Processing, Post-Transcriptional–Metabolism ; RNA, Bacterial–Genetics ; RNA, Bacterial–Metabolism ; RNA, Bacterial–Genetics ; RNA, Bacterial–Immunology ; RNA, Guide–Metabolism ; Ribonuclease III–Virology ; Streptococcus Pyogenes–Virology ; Streptococcus Pyogenes–Virology ; Streptococcus Pyogenes–Virology ; Streptococcus Pyogenes–Virology ; E Coli ; Bacteria ; Bacteriology ; Plasmids ; Proteins ; Bacterial Proteins ; DNA, Viral ; RNA Precursors ; RNA, Bacterial ; RNA, Guide ; Ribonuclease III;
    ISSN: 0028-0836
    E-ISSN: 14764687
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  • 2
    Language: English
    In: Archives of Sexual Behavior, 2017, Vol.46(8), pp.2511-2511
    Description: To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s10508-016-0864-6 Byline: Maria Ines Rodrigues Lobato (1,2), Alexandre Saadeh (3), Desiree Monteiro Cordeiro (3), Daniel Augusto Mori Gagliotti (3), Angelo Costa Brandelli (2,4), Anna Martha V. Fontanari (1,2), Cesar Bridi Filho (2), Claudia Correa Garcia Garcia (1,2), Dhiordan Cardoso Silva (1,2), Jaqueline Salvador (1,2), Karine Schwarz (1,2), Maiko Abel Schneider (1,2), Marcia Ivani Brambila (1,2), Aline Giardin (1,2), Lisia Maya Monteiro (1,2), Bianca Machado Borba Soll (1,2), Andre Gonzales Real (2) Author Affiliation: (1) Graduate Program in Medical Sciences: Psychiatry, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2400, Porto Alegre, RS, 90035-003, Brazil (2) Gender Identity Disorder Program, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (3) Hospital de Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil (4) Pontificia Universidade Catolica, Porto Alegre, RS, Brazil Article History: Registration Date: 09/09/2016 Received Date: 01/09/2016 Accepted Date: 08/09/2016 Online Date: 22/09/2016
    Keywords: Sex Differences (Psychology) – Health Aspects ; Pediatric Diseases – Psychological Aspects ; Pediatric Diseases – Diagnosis;
    ISSN: 0004-0002
    E-ISSN: 1573-2800
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  • 3
    In: Sistemas & Gestão, 09/05/2017, Vol.12(3), p.295
    Description: This study approaches the view of representative entities of the Brazilian textile and clothing industry on its role of support and encouragement for cooperation among the companies that these entities represent as a means to foster the competitiveness of the sector. With reference to a conceptual model built on the foundations found in the literature concerning strategies of competitiveness and cooperation, a qualitative study of an exploratory nature was carried out. At the empirical level, data was collected through documentary analysis and interviews with seven managers working in five different institutions representing the sector. The results show that the class entities of the researched sector see themselves as agents that promote cooperation actions between the companies that they represent, between these companies and government and between other institutions, besides being of fundamental importance to providing support services and to carry out projects of Innovation and development of the sector as a means of achieving competitiveness at the international level.
    Keywords: Business;
    ISSN: Sistemas & Gestão
    E-ISSN: 1980-5160
    Source: CrossRef
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  • 4
    Language: English
    In: The Journal of neuroscience : the official journal of the Society for Neuroscience, 13 January 2010, Vol.30(2), pp.523-33
    Description: A unilateral activation of the mesencephalic locomotor region (MLR) produces symmetrical bilateral locomotion in all vertebrate species tested to date. How this occurs remains unresolved. This study examined the possibility that the symmetry occurred at the level of the inputs from the MLR to reticulospinal (RS) cells. In lamprey semi-intact preparations, we recorded intracellular responses of pairs of large, homologous RS cells on both sides to stimulation of the MLR on one side. The synaptic responses on both sides were very similar in shape, amplitude, and threshold intensity. Increasing MLR stimulation intensity produced a symmetrical increase in the magnitude of the responses on both sides. Ca(2+) imaging confirmed the bilateral activation of smaller-sized RS cells as well. In a high-divalent cation solution, the synaptic responses of homologous RS cells persisted and exhibited a constant latency during high-frequency stimulation. Moreover, during gradual replacement of normal Ringer's solution with a Ca(2+)-free solution, the magnitude of responses showed a gradual reduction with a similar time course in the homologous RS cells. These results support the idea that the MLR projects monosynaptically to RS cells on both sides with symmetrical inputs. During locomotion of the semi-intact preparation, the discharge pattern was also very similar in homologous bilateral RS cells. Anatomical experiments confirmed the presence of MLR neurons projecting ipsilaterally to the reticular formation intermingled with neurons projecting contralaterally. We conclude that the bilaterally symmetrical MLR inputs to RS cells are likely contributors to generating symmetrical locomotor activity.
    Keywords: Brain Stem -- Physiology ; Excitatory Postsynaptic Potentials -- Physiology ; Functional Laterality -- Physiology ; Locomotion -- Physiology
    ISSN: 02706474
    E-ISSN: 1529-2401
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  • 5
    Language: English
    In: Journal of Volcanology and Geothermal Research, 2014, Vol.276, pp.132-144
    Description: Ubinas volcano, the historically most active volcano in Peru straddles a low-relief high plateau and the flank of a steep valley. A multidisciplinary geophysical study has been performed to investigate the internal structure and the fluids flow within the edifice. We conducted 10 self-potential (SP) radial (from summit to base) profiles, 15 audio magnetotelluric (AMT) soundings on the west flank and a detailed survey of SP and soil temperature measurements on the summit caldera floor. The typical “V” shape of the SP radial profiles has been interpreted as the result of a hydrothermal zone superimposed on a hydrogeological zone in the upper parts of the edifice, and depicts a sub-circular SP positive anomaly, about 6 km in diameter. The latter is centred on the summit, and is characterised by a larger extension on the western flank located on the low-relief high plateau. The AMT resistivity model shows the presence of a conductive body beneath the summit at a depth comparable to that of the bottom of the inner south crater in the present-day caldera, where intense hydrothermal manifestations occur. The lack of SP and temperature anomalies on the present caldera floor suggests a self-sealed hydrothermal system, where the inner south crater acts as a pressure release valve. Although no resistivity data exists on the eastern flank, we presume, based on the asymmetry of the basement topography, and the amplitude of SP anomalies on the east flank, which are approximately five fold that on the west flank, that gravitational flow of hydrothermal fluids may occur towards the deep valley of Ubinas. This hypothesis, supported by the presence of hot springs and faults on the eastern foot of the edifice, reinforces the idea that a large part of the southeast flank of the Ubinas volcano may be altered by hydrothermal activity and will tend to be less stable. One of the major findings that stems from this study is that the slope of the basement on which a volcano has grown plays a major role in the geometry of the hydrothermal systems.Another case of asymmetrical composite cone edifice, built on a steep topography, is observed on El Misti volcano (situated 70 km west of Ubinas), which exhibits a similar SP pattern. These types of edifices have a high potential of spreading and sliding along the slope owing to the thicker accumulation of low cohesion and hydrothermally altered volcanic products.
    Keywords: Sciences of the Universe ; Earth Sciences ; Volcanology ; Edifice Stability ; Ubinas Volcano ; Hydrothermal System ; Soil Temperature ; Self-Potential ; Audio-Magnetotelluric Soundings ; Geology
    ISSN: 0377-0273
    E-ISSN: 1872-6097
    Source: Hyper Article en Ligne (CCSd)
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  • 6
    In: Liver International, February 2018, Vol.38(2), pp.358-364
    Description: Byline: Claude Besmond, Dominique Valla, Laurence Hubert, Karine Poirier, Brigitte Grosse, Catherine Guettier, Olivier Bernard, Emmanuel Gonzales,Emmanuel Jacquemin Keywords: exome analysis; genetics; idiopathic portal hypertension; non-cirrhotic portal hypertension Abstract Background & Aims Obliterative portal venopathy (OPV) is characterized by lesions of portal vein intrahepatic branches and is thought to be responsible for many cases of portal hypertension in the absence of cirrhosis or obstruction of large portal or hepatic veins. In most cases the cause of OPV remains unknown. The aim was to identify a candidate gene of OPV. Methods Whole exome sequencing was performed in two families, including 6 patients with OPV. Identified mutations were confirmed by Sanger sequencing and expression of candidate gene transcript was studied by real time qPCR in human tissues. Results In both families, no mutations were identified in genes previously reported to be associated with OPV. In each family, we identified a heterozygous mutation (c.1783G〉A, p.Gly595Arg and c.4895C〉T, p.Thr1632Ile) in a novel gene located on chromosome 4, that we called FOPV (Familial Obliterative Portal Venopathy), and having a cDNA coding for 1793 amino acids. The FOPV mutations segregated with the disease in families and the pattern of inheritance was suggestive of autosomal dominant inherited OPV, with incomplete penetrance and variable expressivity. In silico analysis predicted a deleterious effect of each mutant and mutations concerned highly conserved amino acids in mammals. A deleterious heterozygous FOPV missense mutation (c.4244T〉C, p.Phe1415Ser) was also identified in a patient with non-familial OPV. Expression study in liver veins showed that FOPV transcript was mainly expressed in intrahepatic portal vein. Conclusions This report suggests that FOPV mutations may have a pathogenic role in some cases of familial and non-familial OPV. Article Note: Handling Editor: Luca Valenti Supporting information: Additional Supporting Information may be found in the online version of this article Additional Supporting Information may be found at onlinelibrary.wiley.com/doi/10.1111/liv.13547/suppinfo CAPTION(S):
    Keywords: Exome Analysis ; Genetics ; Idiopathic Portal Hypertension ; Non‐Cirrhotic Portal Hypertension
    ISSN: 1478-3223
    E-ISSN: 1478-3231
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  • 7
    Language: French
    In: Perspectives Psy, 10 August 2015, Issue 1, pp.20-29
    Description: L'anorexie mentale de l'adolescente anorexique engage la patiente et sa famille dans une dynamique où se côtoient amaigrissement, cristallisation des interactions et des comportements familiaux et nécessité, chez certains cas sévères, d'une hospitalisation.L'unité de médecine et de psychopathologie de l'adolescent du CHU de Rouen accueille des adolescent(e)s anorexiques en hospitalisation et propose comme cadre thérapeutique un contrat de soin articulant progression pondérale et objectifs motivationnels après un temps introductif de séparation entre les parents et leur adolescent malade.Un des constats de cette modalité thérapeutique est l'angoisse, redondante et partagée par les parents et leurs enfants, des temps de repas au sortir d'une hospitalisation souvent longue.En réponse à cette préoccupation, nous avons élaboré un programme thérapeutique de « repas familiaux » associant la patiente, sa famille, un binôme de soignants et une supervision par un thérapeute familial dont un des supports de travail est la lecture des enregistrements vidéo de ces repas.Nous proposons, après un rappel des approches familiales de l'adolescente anorexique, de présenter ce programme thérapeutique dont a pu bénéficier, depuis deux ans, près d'une quinzaine de famille et de transmettre les premiers retours de cet outil de soin innovant.
    Keywords: Anorexie Mentale ; Adolescence ; Famille ; Traitement ; Thérapie Familiale ; Anorexia Nervosa ; Family ; Treatment ; Family Therapy
    ISSN: 0031-6032
    Source: Cairn.info
    Source: Cairn.info - Revues
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  • 8
    Language: French
    In: Perspectives Psy, 2015, Vol.54(1), pp.20-29
    Description: L'anorexie mentale de l'adolescente anorexique engage la patiente et sa famille dans une dynamique où se côtoient amaigrissement, cristallisation des interactions et des comportements familiaux et nécessité, chez certains cas sévères, d'une hospitalisation.L'unité de médecine et de psychopathologie de l'adolescent du CHU de Rouen accueille des adolescent(e)s anorexiques en hospitalisation et propose comme cadre thérapeutique un contrat de soin articulant progression pondérale et objectifs motivationnels après un temps introductif de séparation entre les parents et leur adolescent malade.Un des constats de cette modalité thérapeutique est l'angoisse, redondante et partagée par les parents et leurs enfants, des temps de repas au sortir d'une hospitalisation souvent longue.En réponse à cette préoccupation, nous avons élaboré un programme thérapeutique de « repas familiaux » associant la patiente, sa famille, un binôme de soignants et une supervision par un thérapeute familial dont un des supports de travail est la lecture des enregistrements vidéo de ces repas.Nous proposons, après un rappel des approches familiales de l'adolescente anorexique, de présenter ce programme thérapeutique dont a pu bénéficier, depuis deux ans, près d'une quinzaine de famille et de transmettre les premiers retours de cet outil de soin innovant.
    Keywords: Anorexie Mentale ; Adolescence ; Famille ; Traitement ; Thérapie Familiale
    ISSN: 0031-6032
    E-ISSN: 2118-4038
    Source: Cairn.info
    Source: Cairn.info - Revues
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  • 9
    Language: English
    In: Journal of Volcanology and Geothermal Research, 15 April 2014, Vol.276, pp.132-144
    Description: Ubinas volcano, the historically most active volcano in Peru straddles a low-relief high plateau and the flank of a steep valley. A multidisciplinary geophysical study has been performed to investigate the internal structure and the fluids flow within the edifice. We conducted 10 self-potential (SP) radial (from summit to base) profiles, 15 audio magnetotelluric (AMT) soundings on the west flank and a detailed survey of SP and soil temperature measurements on the summit caldera floor. The typical “V” shape of the SP radial profiles has been interpreted as the result of a hydrothermal zone superimposed on a hydrogeological zone in the upper parts of the edifice, and depicts a sub-circular SP positive anomaly, about 6 km in diameter. The latter is centred on the summit, and is characterised by a larger extension on the western flank located on the low-relief high plateau. The AMT resistivity model shows the presence of a conductive body beneath the summit at a depth comparable to that of the bottom of the inner south crater in the present-day caldera, where intense hydrothermal manifestations occur. The lack of SP and temperature anomalies on the present caldera floor suggests a self-sealed hydrothermal system, where the inner south crater acts as a pressure release valve. Although no resistivity data exists on the eastern flank, we presume, based on the asymmetry of the basement topography, and the amplitude of SP anomalies on the east flank, which are approximately five fold that on the west flank, that gravitational flow of hydrothermal fluids may occur towards the deep valley of Ubinas. This hypothesis, supported by the presence of hot springs and faults on the eastern foot of the edifice, reinforces the idea that a large part of the southeast flank of the Ubinas volcano may be altered by hydrothermal activity and will tend to be less stable. One of the major findings that stems from this study is that the slope of the basement on which a volcano has grown plays a major role in the geometry of the hydrothermal systems. Another case of asymmetrical composite cone edifice, built on a steep topography, is observed on El Misti volcano (situated 70 km west of Ubinas), which exhibits a similar SP pattern. These types of edifices have a high potential of spreading and sliding along the slope owing to the thicker accumulation of low cohesion and hydrothermally altered volcanic products.
    Keywords: Ubinas Volcano ; Hydrothermal System ; Self-Potential ; Audio-Magnetotelluric Soundings ; Soil Temperature ; Edifice Stability ; Geology
    ISSN: 0377-0273
    E-ISSN: 1872-6097
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  • 10
    Language: English
    In: World journal of oncology, June 2010, Vol.1(3), pp.111-117
    Description: Epidemiological studies have reported positive associations between anthropometric measures and risk for developing breast cancers that express hormone receptors and associated mortality. However, the impact of nutritional status on the molecular response to endocrine therapy has yet to be described. Body mass index (BMI), waist circumference (WC), hip circumference (HP), and waist-to-hip ratio (WHR) were measured in patients with invasive ductal carcinoma (IDC) before and after neoadjuvant treatment with either tamoxifen or anastrozole, and a possible correlation with prognostic factors, as estrogen receptor (ER), progesterone receptor (PgR), and proliferative index (Ki-67), was analyzed. Fifty-seven patients with palpable ER-positive IDC were randomized into three neoadjuvant treatment groups and received anastrozole or placebo or tamoxifen for twenty-one days. Biomarker status was obtained by comparing the immunohistochemical evaluation of samples collected before and after treatment, using the Allred scoring system. Statistical analysis was performed using the Statistical Package for the Social Sciences (SPSS). After treatment, the anastrozole group showed reduced ER and PgR expression (p 〈 0.05), and both the anastrozole and tamoxifen groups showed lower Ki-67 status. A significant reduction in PgR positivity (p 〈 0.05) was found in women with large WC and HC who were treated with anastrozole. Reduction in PgR positivity also tended to be associated with BMI (p = 0.09) in the anastrozole group. BMI, WC, HC and WHR correlated neither with biomarker levels in the tamoxifen and placebo groups nor with ER and Ki-67 status in the anastrozole group after primary endocrine treatment.
    Keywords: Anastrozole ; Anthropometry ; Breast Cancer ; Postmenopause ; Tamoxifen
    ISSN: 19204531
    E-ISSN: 1920-454X
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