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  • 1
    Language: English
    In: Analytical and bioanalytical chemistry, February 2013, Vol.405(6), pp.1789-90
    Description: For many years, the function and fate of metals and their species in biological systems has been of increasing interest to the scientific community, because of their important physiological effects and toxic properties. Although different groups of scientists, including biologists, inorganic chemists, physicians, and analytical chemists, have all attempted to answer questions related to metal species in the body by use of their established scientific methods and instrumentation, it has become clear that much more intense interdisciplinary cooperation between scientists of all these disciplines is required to successfully address the highly complex questions arising from their research. The subject “metallomics” has emerged with the objective of providing a deep understanding of the kind, concentration, and function of metal species in biology. Although “omics” is typically understood to mean a comprehensive approach to the target analytes, it is more realistic to include all methods le ...
    Keywords: Metalloproteins -- Metabolism ; Metals -- Metabolism
    ISSN: 16182642
    E-ISSN: 1618-2650
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  • 2
    Language: English
    In: Journal of Chromatography A, Oct 12, 2012, Vol.1259, p.16(34)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.chroma.2012.05.066 Byline: Sandra Jahn, Uwe Karst Keywords: Electrochemistry; Mass spectrometry; Liquid chromatography; Drug metabolism; Oxidative degradation; Electrochemical synthesis; Peptide cleavage; Protein adducts; Electrochemical derivatization; DNA oxidation; Xenobiotics Abstract: a* Electrochemistry/LC/MS is an emerging analytical technique. a* A major application is the simulation of the oxidative metabolism of drugs. a* Protein cleavage and chemical modification of biomacromolecules can be carried out. a* Various technical arrangements are applied. Author Affiliation: University of Munster, Institute of Inorganic and Analytical Chemistry and NRW Graduate School of Chemistry, Corrensstr. 30, 48149 Munster, Germany
    Keywords: Peptides ; Mass Spectrometry ; Xenobiotics ; Proteases ; Liquid Chromatography ; Electrochemistry ; Electrochemical Reactions
    ISSN: 0021-9673
    Source: Cengage Learning, Inc.
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  • 3
    Language: English
    In: Analytical and Bioanalytical Chemistry, 2012, Vol.403(2), p.333(2)
    Keywords: Mass Spectrometry – Methods ; Electrochemistry – Methods ; Electrochemical Reactions – Methods
    ISSN: 1618-2642
    Source: Cengage Learning, Inc.
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  • 4
    Language: English
    In: Analytical and Bioanalytical Chemistry, April, 2012, Vol.403(2), p.333(2)
    Description: Byline: Martin Vogel (1), Uwe Karst (1) Author Affiliation: (1) Institut fur Anorganische und Analytische Chemie, Westfalische Wilhelms-Universitat Munster, Wilhelm-Klemm-Str. 8, 48149, Munster, Germany Article History: Registration Date: 11/02/2012 Online Date: 28/02/2012 Article note: Published in the special paper collection Electrochemistry--Mass Spectrometry with guest editors Uwe Karst and Martin Vogel.
    Keywords: Mass Spectrometry -- Methods ; Spectroscopy -- Methods ; Electrochemistry -- Methods
    ISSN: 1618-2642
    ISSN: 16182650
    E-ISSN: 16182650
    Source: Cengage Learning, Inc.
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  • 5
    Language: English
    In: Journal of Chromatography A, 12 October 2012, Vol.1259, pp.16-49
    Description: ► Electrochemistry/LC/MS is an emerging analytical technique. ► A major application is the simulation of the oxidative metabolism of drugs. ► Protein cleavage and chemical modification of biomacromolecules can be carried out. ► Various technical arrangements are applied. The coupling of electrochemistry (EC) to different mass spectrometric (MS) techniques in off-line and especially in on-line approaches is a quickly growing research field in analytical chemistry with numerous distinct objectives. Depending on the analytical problem, a separation step can be further integrated according to the instrumental set-up and, most frequently, liquid chromatography (LC) is selected for this purpose. In this review, various scientific areas of application for this EC/(LC/)MS hybrid method are presented and discussed in detail. Therefore, one major division is made between those applications which are already successfully used on a large scale (current state), and those which have shown promising results for future utilization (future perspectives). The reader shall be provided with a thorough overview on the capabilities of the combination of EC/(LC/)MS and the drawbacks which result in further optimization and exploration of this technique. The major topics addressed in this review include the role of EC/(LC/)MS for drug metabolism studies, peptide, protein and DNA (deoxyribonucleic acid) research and quantification strategies. Promising future applications that are presented and evaluated comprise the fields of toxicology and forensics, targeted product synthesis and environmental analysis.
    Keywords: Electrochemistry ; Mass Spectrometry ; Liquid Chromatography ; Drug Metabolism ; Oxidative Degradation ; Electrochemical Synthesis ; Peptide Cleavage ; Protein Adducts ; Electrochemical Derivatization ; DNA Oxidation ; Xenobiotics ; Chemistry
    ISSN: 0021-9673
    E-ISSN: 18733778
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  • 6
    Language: English
    In: Journal of chromatography, 2012, Vol.1259, pp.16-49
    Description: The coupling of electrochemistry (EC) to different mass spectrometric (MS) techniques in off-line and especially in on-line approaches is a quickly growing research field in analytical chemistry with numerous distinct objectives. Depending on the analytical problem, a separation step can be further integrated according to the instrumental set-up and, most frequently, liquid chromatography (LC) is selected for this purpose. In this review, various scientific areas of application for this EC/(LC/)MS hybrid method are presented and discussed in detail. Therefore, one major division is made between those applications which are already successfully used on a large scale (current state), and those which have shown promising results for future utilization (future perspectives). The reader shall be provided with a thorough overview on the capabilities of the combination of EC/(LC/)MS and the drawbacks which result in further optimization and exploration of this technique. The major topics addressed in this review include the role of EC/(LC/)MS for drug metabolism studies, peptide, protein and DNA (deoxyribonucleic acid) research and quantification strategies. Promising future applications that are presented and evaluated comprise the fields of toxicology and forensics, targeted product synthesis and environmental analysis. ; p. 16-49.
    Keywords: Liquid Chromatography ; Mass Spectrometry ; Analytical Chemistry ; Toxicology ; Dna ; Environmental Assessment ; Forensic Sciences ; Pharmacokinetics ; Electrochemistry
    ISSN: 0021-9673
    Source: AGRIS (Food and Agriculture Organization of the United Nations)
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  • 7
    Language: English
    In: Analytical and bioanalytical chemistry, August 2010, Vol.397(8), pp.3431-2
    Description: Byline: Jorg Bettmer (1), Uwe Karst (2) Author Affiliation: (1) Departamento de Quimica Fisica y Analitica, Universidad de Oviedo, C/ Julian Claveria 8, 33006, Oviedo, Spain (2) Institut fur Anorganische und Analytische Chemie, Westfalische Wilhelms-Universitat Munster, Corrensstr. 30, 48149, Munster, Germany Article History: Registration Date: 22/05/2010 Online Date: 12/06/2010
    Keywords: Biopolymers -- Chemistry ; Staining and Labeling -- Trends
    ISSN: 16182642
    E-ISSN: 1618-2650
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  • 8
    Language: English
    In: Analytical and bioanalytical chemistry, April 2012, Vol.403(2), pp.333-4
    Keywords: Electrochemistry -- Methods ; Mass Spectrometry -- Methods
    ISSN: 16182642
    E-ISSN: 1618-2650
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  • 9
    Language: English
    In: Analytical and Bioanalytical Chemistry, 2013, Vol.405(15), pp.5249-5258
    Description: Melarsoprol is the only currently available drug for treatment of the late stage of African trypanosomiasis (sleeping sickness). Unfortunately, the arsenic-containing drug causes serious side effects, for which the mechanisms have not been elucidated so far. This investigation describes the study of the melarsoprol biotransformation processes by electrochemical (EC) techniques. Based on EC, potential oxidation reactions of melarsoprol are examined. Moreover, the reactivity of melarsoprol, its metabolite melarsen oxide, and their oxidation products toward the tripeptide glutathione and the proteins hemoglobin and human serum albumin is evaluated. The combination of different analytical techniques allows the identification as well as the quantification of the biotransformation products. The hyphenation of liquid chromatography (LC) and electrospray ionization mass spectrometry (ESI–MS) is applied for identification and structure elucidation, which implies the determination of exact masses and fragmentation patterns. For the selective detection of arsenic containing metabolites, LC coupled to inductively coupled plasma mass spectrometry is utilized. Based on the obtained data, the oxidative biotransformation of melarsoprol can be predicted, revealing novel species which have been suspected, but not been identified up to now. The results of the protein studies prove that melarsen oxide, the active derivative of melarsoprol, strongly binds to human hemoglobin and forms different adducts via the free cysteinyl groups of the hemoglobin α- and β-chain.
    Keywords: Electrochemistry ; Mass spectrometry ; Phase-I metabolism ; Sleeping sickness
    ISSN: 1618-2642
    E-ISSN: 1618-2650
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  • 10
    Language: English
    In: Analytica Chimica Acta, Feb 18, 2013, Vol.764, p.1(16)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.aca.2012.12.007 Byline: Lena Telgmann (a), Michael Sperling (a)(b), Uwe Karst (a) Keywords: MRI contrast agents; Biomedical analysis; Environmental analysis; Separation techniques; Mass spectrometry; Hyphenated techniques; Speciation analysis Abstract: Display Omitted Author Affiliation: (a) University of Munster, Institute of Inorganic and Analytical Chemistry, Munster, Germany (b) European Virtual Institute for Speciation Analysis (EVISA), Munster, Germany Article History: Received 25 July 2012; Revised 2 December 2012; Accepted 3 December 2012
    Keywords: Mass Spectrometry -- Analysis ; Magnetic Resonance Imaging -- Analysis
    ISSN: 0003-2670
    Source: Cengage Learning, Inc.
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