Format:
Online-Ressource (XX, 263 p. 49 illus., 42 illus. in color, digital)
ISBN:
9783642330995
,
1283945967
,
9781283945967
Series Statement:
Current Topics in Microbiology and Immunology 363
Content:
In this volume, a wide-ranging series of reviews reveal how systems biology-a holistic and inter-disciplinary approach requiring the combined talents of biologists, mathematicians, and computer scientists-is changing the face of infectious disease research. Leading experts discuss how the use of high-throughput and computational approaches are generating exciting-and often unexpected-new insights into the microbial-host interactions of a variety of bacterial and viral pathogens, including Salmonella, Yersinia, Mycobacterium, influenza virus, human and simian immunodeficiency virus, and hepatitis C virus. Additional chapters focus on systems approaches to innate immunity, intra- and inter-cellular signaling, biomarker discovery, and the evaluation and rational development of improved vaccines. Systems biology has both been hailed as a paradigm shift that will revolutionize biological science and criticized as overly expensive and complex. While the truth no doubt lies somewhere in between, the approach is yielding increasingly detailed and comprehensive views of biological systems and processes, including those that dictate the host response to infection and disease outcome. Systems Biology of Infectious Diseaseis highly informative reading for investigators already engaged in systems biology research as well as for those scientists and clinicians who may be seeking an introduction to the field
Note:
Description based upon print version of record
,
Systems Biology; Preface; Introduction: Embracing Complexity in Infectious Disease Research; Contents; Contributors; 246 Systems Approaches to Dissecting Immunity; Abstract; 1…Systems Biology; 1.1 Basic Concepts Crucial in Understanding Complex Biological Systems: Emergence, Robustness, and Modularity; 1.1.1 Emergence; 1.1.2 Robustness; 1.1.3 Modularity; 1.2 A Systems Biology Approach to Studying Immunity; 2…Innate Immune Receptors; 2.1 Crosstalk Between Phagocytic Receptors and PRRs; 2.2 Crosstalk Between PRRs; 2.3 Robustness and Modularity in Innate Immunity
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3…Network Analysis of Innate Immune Responses3.1 A Network that Enables Innate Immune Cells to Discriminate Between Transient and Persistent Activation; 3.2 Unraveling Complexity in Innate Immune Signaling; 4…Systems Vaccinology; 4.1 An Iterative, Multistep Approach; 4.2 Accelerating Efficacy Trials; References; 247 Studying Salmonellae and Yersiniae Host--Pathogen Interactions Using Integrated 'Omics and Modeling; Abstract; 1…Introduction; 2…Elements of a Systems Approach; 2.1 Experimental Considerations for a Biological Perspective; 2.2 Foundational Omics Technologies
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2.3 Computational Framework for Integrating Biological Information3…Pathogen Perspective: Salmonella; 3.1 Proteogeonomics; 3.2 Genome-Scale Metabolic Reconstruction; 3.3 Metabolic Model-Guided Analysis of Omics Data; 3.4 Inference-Based Analysis of Omics Data; 3.5 Integrated Inference- and Knowledge-Based Analysis of Omics Data; 4…Pathogen Perspective: Yersinia; 4.1 Proteogeonomics; 4.2 Genome-Scale Metabolic Reconstruction; 5…Host Perspective; 6…Host--Pathogen Interaction; 6.1 Integrated Host--Pathogen Model of Metabolism; 6.2 The Host--Pathogen Interface
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6.3 Host--Pathogen Interactions in the Gut Microbiome7…Conclusion and Future Prospects; Acknowledgments; References; 257 ChIP-Seq and the Complexity of Bacterial Transcriptional Regulation; Abstract; 1…Introduction; 2…The Canonical Model of Bacterial Transcriptional Regulation: The Lac Operon; 3…Chromatin Immunoprecipitation for Mapping DNA Binding Sites; 4…Large-Scale Mapping of MTB Transcription Factor Binding Sites; 5…Diverse Binding Locations; 6…Extensive Weak Binding; 7…MTB Binding Data Available at TBDB; References
,
248 The Role and Contributions of Systems Biology to the Non-Human Primate Model of Influenza Pathogenesis and VaccinologyAbstract; 1…Introduction: How Systems Biology Helps us See the Covert but Far-Reaching Effects of One Infected Cell; 2…How 'Omics' Can Assist as Early Prognostic Tools; 3…The Immune Response to Low and High-Path Influenza Viruses: Role of Systems Biology in the Study of Very Early yet Critical Differences in Host Response; 4…Pathology of Influenza Infections: Systems Biology Enhances Findings of Conventional Analyses
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5…From Diagnosis to Prevention: Is There a Role for Systems Biology?
Additional Edition:
ISBN 9783642330988
Additional Edition:
Buchausg. u.d.T. Systems biology Berlin : Springer, 2013 ISBN 3642330983
Additional Edition:
ISBN 9783642330988
Language:
English
Subjects:
Biology
,
Medicine
Keywords:
Infektionskrankheit
;
Systembiologie
;
Systembiologie
;
Infektionskrankheit
;
Aufsatzsammlung
DOI:
10.1007/978-3-642-33099-5
URL:
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