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Berlin Brandenburg

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  • 1
    In: Inflammatory Bowel Diseases, 2017, Vol. 23(suppl1), pp.S79-S79
    Keywords: Medicine;
    ISSN: 1078-0998
    E-ISSN: 1536-4844
    Source: Oxford University Press
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  • 2
    Language: English
    In: Landscape & Irrigation, Jan, 2010, Vol.34(1), p.14(3)
    Keywords: Landscaping Industry
    ISSN: 0745-3795
    Source: Cengage Learning, Inc.
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  • 3
    Language: English
    In: Landscape Management, March, 2010, Vol.49(3), p.51(2)
    Keywords: Landscaping Industry
    ISSN: 0894-1254
    Source: Cengage Learning, Inc.
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  • 4
    In: The Journal of Infectious Diseases, 2017, Vol. 215(4), pp.653-657
    Description: Staphylococcus aureus, a metabolically flexible gram-positive pathogen, causes infections in a variety of tissues. Recent evidence implicates S. aureus as an emerging cause of chorioamnionitis and premature rupture of membranes, which are associated with preterm birth and neonatal disease. We demonstrate here that S. aureus infects and forms biofilms on the choriodecidual surface of explanted human gestational membranes. Concomitantly, S. aureus elicits the production of proinflammatory cytokines, which could ultimately perturb maternal-fetal tolerance during pregnancy. Therefore, targeting the immunological response to S. aureus infection during pregnancy could attenuate disease among infected individuals, especially in the context of antibiotic resistance.
    Keywords: 〈Kwd〉 〈Italic Toggle="Yes"〉Staphylococcus Aureus〈/Italic〉 〈/Kwd〉 ; Gestational Membranes ; Cytokine
    ISSN: 0022-1899
    E-ISSN: 1537-6613
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  • 5
    Language: English
    In: Medical Teacher, 01 November 2013, Vol.35(11), pp.915-919
    Description: Background: Test-enhanced learning has gained popularity because it is an effective way to increase retention of knowledge; provided the student receives the correct answer soon after the test is taken. Aim: To determine whether detailed feedback provided to test-enhanced...
    Keywords: Medicine ; Education
    ISSN: 0142-159X
    E-ISSN: 1466-187X
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  • 6
    Language: English
    In: Landscape & Irrigation, April, 2009, Vol.33(4), p.18(4)
    Keywords: Landscaping Industry
    ISSN: 0745-3795
    Source: Cengage Learning, Inc.
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  • 7
    Language: English
    In: Landscape & Irrigation, Sept, 2008, Vol.32(7), p.26(4)
    Keywords: Landscaping Industry
    ISSN: 0745-3795
    Source: Cengage Learning, Inc.
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  • 8
    Language: English
    In: PLoS ONE, 01 January 2013, Vol.8(8), p.e71221
    Description: The mechanisms underlying latent-virus-mediated heterologous immunity, and subsequent transplant rejection, especially in the setting of T cell costimulation blockade, remain undetermined. To address this, we have utilized MHV68 to develop a rodent model of latent virus-induced heterologous alloimmunity. MHV68 infection was correlated with multimodal immune deviation, which included increased secretion of CXCL9 and CXCL10, and with the expansion of a CD8(dim) T cell population. CD8(dim) T cells exhibited decreased expression of multiple costimulation molecules and increased expression of two adhesion molecules, LFA-1 and VLA-4. In the setting of MHV68 latency, recipients demonstrated accelerated costimulation blockade-resistant rejection of skin allografts compared to non-infected animals (MST 13.5 d in infected animals vs 22 d in non-infected animals, p〈.0001). In contrast, the duration of graft acceptance was equivalent between non-infected and infected animals when treated with combined anti-LFA-1/anti-VLA-4 adhesion blockade (MST 24 d for non-infected and 27 d for infected, p = n.s.). The combination of CTLA-4-Ig/anti-CD154-based costimulation blockade+anti-LFA-1/anti-VLA-4-based adhesion blockade led to prolonged graft acceptance in both non-infected and infected cohorts (MST〉100 d for both, p〈.0001 versus costimulation blockade for either). While in the non-infected cohort, either CTLA-4-Ig or anti-CD154 alone could effectively pair with adhesion blockade to prolong allograft acceptance, in infected animals, the prolonged acceptance of skin grafts could only be recapitulated when anti-LFA-1 and anti-VLA-4 antibodies were combined with anti-CD154 (without CTLA-4-Ig, MST〉100 d). Graft acceptance was significantly impaired when CTLA-4-Ig alone (no anti-CD154) was combined with adhesion blockade (MST 41 d). These results suggest that in the setting of MHV68 infection, synergy occurs predominantly between adhesion pathways and CD154-based costimulation, and that combined targeting of both pathways may be required to overcome the increased risk of rejection that occurs in the setting of latent-virus-mediated immune deviation.
    Keywords: Sciences (General)
    E-ISSN: 1932-6203
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  • 9
    Language: English
    In: Future Microbiology, 09/2018, Vol.13(11), pp.1271-1281
    ISSN: 1746-0913
    E-ISSN: 1746-0921
    Source: CrossRef
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  • 10
    Language: English
    In: Future microbiology, September 2018, Vol.13, pp.1271-1281
    Description: To evaluate the effect on the nonsteroidal anti-inflammatory drug indomethacin on Clostridium difficile infection (CDI) severity. Indomethacin was administered in two different mouse models of antibiotic-associated CDI in two different facilities, using a low and high dose of indomethacin. Indomethacin administration caused weight loss, increased the signs of severe infection and worsened histopathological damage, leading to 100% mortality during CDI. Indomethacin-treated, antibiotic-exposed mice infected with C. difficile had enhanced intestinal inflammation with increased expression of KC, IL-1β and IL-22 compared with infected mice unexposed to indomethacin. These results demonstrate a negative impact of nonsteroidal anti-inflammatory drugs on antibiotic-associated CDI in mice and suggest that targeting the synthesis or signaling of prostaglandins might be an approach to ameliorating the severity of CDI.
    Keywords: C. Difficile Infection Severity ; Nsaid ; Antibiotic-Associated CDI ; Indomethacin ; Prostaglandins ; Clostridium Difficile ; Severity of Illness Index ; Anti-Inflammatory Agents, Non-Steroidal -- Adverse Effects ; Clostridium Infections -- Drug Therapy ; Indomethacin -- Adverse Effects ; Intestines -- Pathology
    E-ISSN: 1746-0921
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
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