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  • 1
    Language: English
    In: Eastern Journal of European Studies, 2011, Vol.2(2), pp.49-60
    Description: The main aim of the paper is to analyse the impact of the EU accession on the New Member States’ agriculture with special regard to production, employment, farmers’ income and intra-EU trade in agricultural goods on the basis of the latest statistical data of Eurostat. According to our findings,...
    Keywords: Politics / Political Sciences ; Eu Accession ; Nms Agriculture ; Farmers’ Income ; Intraeu Agricultural Trade ; History & Archaeology
    ISSN: 2068-651X
    E-ISSN: 2068-6633
    Source: Central and Eastern European Online Library (C.E.E.O.L.)
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  • 2
    Language: English
    In: MATEC Web of Conferences, 01 January 2018, Vol.184, p.04018
    Description: The economic role of knowledge, education and research as investments in individuals‘ human capital has become a real focus of attention among researchers and policy makers in Europe over the last few decades. Individuals‘ high level skills and the versatile knowledge acquired in a formal or informal educational context have become extremely important factors in evolving knowledge-based economies. In this article we primarily analyze fiscal expenditures on education, and on research and development among OECD countries, and examine the change over time of state expenditures on education.
    Keywords: Engineering
    E-ISSN: 2261-236X
    Source: Directory of Open Access Journals (DOAJ)
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  • 3
    In: ANNALS OF THE ORADEA UNIVERSITY. Fascicle of Management and Technological Engineering., 2015, Vol.XXIV (XIV), 2015/1(1)
    Description: According to the human capital theory, education can be seen as an investment into individual human capital. The profitability of human capital investment is partly determined by the individuals’ work-related earnings. The study examines how work-related earnings and the gap between gross earnings at different educational level changed in Hungary, between 2004 and 2013. An indicator is defined and presented to measure the change in gross earnings and net earnings caused by the education as the human capital investment. Moreover, we examine the change in earnings surplus by educational level, look for the answer to the question whether the gap between earnings for individuals with different educational attainment increased or decreased in Hungary from 2004 to 2013.
    ISSN: ANNALS OF THE ORADEA UNIVERSITY. Fascicle of Management and Technological Engineering.
    E-ISSN: 15830691
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  • 4
    In: ANNALS OF THE ORADEA UNIVERSITY. Fascicle of Management and Technological Engineering., 2013, Vol.XXII (XII), 2013/1(1)
    ISSN: ANNALS OF THE ORADEA UNIVERSITY. Fascicle of Management and Technological Engineering.
    E-ISSN: 15830691
    Source: CrossRef
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  • 5
    Language: English
    In: Annals of the Oradea University: Fascicle Management and Technological Engineering, 01 May 2015, Vol.XXIV (XIV)
    Description: According to the human capital theory, education can be seen as an investment into individual human capital. The profitability of human capital investment is partly determined by the individuals’ work-related earnings. The study examines how work-related earnings and the gap between gross earnings at different educational level changed in Hungary, between 2004 and 2013. An indicator is defined and presented to measure the change in gross earnings and net earnings caused by the education as the human capital investment. Moreover, we examine the change in earnings surplus by educational level, look for the answer to the question whether the gap between earnings for individuals with different educational attainment increased or decreased in Hungary from 2004 to 2013.
    Keywords: Educationallevel ; Marginalearningrate ; Investmentinhumancapital ; Taxburden
    ISSN: 1583-0691
    E-ISSN: 1583-0691
    Source: Directory of Open Access Journals (DOAJ)
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  • 6
    In: ANNALS OF THE ORADEA UNIVERSITY. Fascicle of Management and Technological Engineering., 2012, Vol.XXI (XI), 2012/1(1)
    ISSN: ANNALS OF THE ORADEA UNIVERSITY. Fascicle of Management and Technological Engineering.
    E-ISSN: 15830691
    Source: CrossRef
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  • 7
    Language: English
    In: Annals of the Oradea University: Fascicle Management and Technological Engineering, 01 May 2013, Vol.XXII (XII)
    ISSN: 1583-0691
    E-ISSN: 1583-0691
    Source: Directory of Open Access Journals (DOAJ)
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  • 8
    Language: English
    In: Langenbeck's Archives of Surgery, 2012, Vol.397(4), pp.603-610
    Description: Byline: Judit Kiss (1), Johanna Kirchberg (1), Martin Schneider (1) Keywords: HIF prolyl hydroxylases; Hypoxia inducible factors; Reactive oxygen species; Prolyl hydroxylase inhibitors; Ischemia/reperfusion; Inflammation; Tumor hypoxia Abstract: Background Since mammalian cells rely on the availability of oxygen, they have devised mechanisms to sense environmental oxygen tension, and to efficiently counteract oxygen deprivation (hypoxia). These adaptive responses to hypoxia are essentially mediated by hypoxia inducible transcription factors (HIFs). Three HIF prolyl hydroxylase enzymes (PHD1, PHD2 and PHD3) function as oxygen sensing enzymes, which regulate the activity of HIFs in normoxic and hypoxic conditions. Many of the compensatory functions exerted by the PHD--HIF system are of immediate surgical relevance since they regulate the biological response of ischemic tissues following ligation of blood vessels, of oxygen-deprived inflamed tissues, and of tumors outgrowing their vascular supply. Purpose Here, we outline specific functions of PHD enzymes in surgically relevant pathological conditions, and discuss how these functions might be exploited in order to support the treatment of surgically relevant diseases. Author Affiliation: (1) Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany Article History: Registration Date: 15/02/2012 Received Date: 13/02/2012 Accepted Date: 14/02/2012 Online Date: 07/03/2012
    Keywords: HIF prolyl hydroxylases ; Hypoxia inducible factors ; Reactive oxygen species ; Prolyl hydroxylase inhibitors ; Ischemia/reperfusion ; Inflammation ; Tumor hypoxia
    ISSN: 1435-2443
    E-ISSN: 1435-2451
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  • 9
    Language: English
    In: PLoS ONE, 01 January 2017, Vol.12(2), p.e0172020
    Description: Hepatocyte nuclear factor 4 alpha (HNF4α) nuclear receptor is a master regulator of hepatocyte development, nutrient transport and metabolism. HNF4α is regulated both at the transcriptional and post-transcriptional levels by different mechanisms. Several kinases (PKA, PKC, AMPK) were shown to phosphorylate and decrease the activity of HNF4α. Activation of the ERK1/2 signalling pathway, inducing proliferation and survival, inhibits the expression of HNF4α. However, based on our previous results we hypothesized that HNF4α is also regulated at the post-transcriptional level by ERK1/2. Here we show that ERK1/2 is capable of directly phosphorylating HNF4α in vitro at several phosphorylation sites including residues previously shown to be targeted by other kinases, as well. Furthermore, we also demonstrate that phosphorylation of HNF4α leads to a reduced trans-activational capacity of the nuclear receptor in luciferase reporter gene assay. We confirm the functional relevance of these findings by demonstrating with ChIP-qPCR experiments that 30-minute activation of ERK1/2 leads to reduced chromatin binding of HNF4α. Accordingly, we have observed decreasing but not disappearing binding of HNF4α to the target genes. In addition, 24-hour activation of the pathway further decreased HNF4α chromatin binding to specific loci in ChIP-qPCR experiments, which confirms the previous reports on the decreased expression of the HNF4a gene due to ERK1/2 activation. Our data suggest that the ERK1/2 pathway plays an important role in the regulation of HNF4α-dependent hepatic gene expression.
    Keywords: Sciences (General)
    E-ISSN: 1932-6203
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  • 10
    Language: Hungarian
    In: Korunk, 2014, Issue 7, pp.61-65
    Keywords: Social Sciences ; Psychology ; Psychology
    ISSN: 1222-8338
    Source: Central and Eastern European Online Library (C.E.E.O.L.)
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