Format:
1 Online-Ressource (xvii, 171 Seiten, 9431 KB)
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Illustrationen, Diagramme
Content:
Monoclonal antibodies (mAbs) are an innovative group of drugs with increasing clinical importance in oncology, combining high specificity with generally low toxicity. There are, however, numerous challenges associated with the development of mAbs as therapeutics. Mechanistic understanding of factors that govern the pharmacokinetics (PK) of mAbs is critical for drug development and the optimisation of effective therapies; in particular, adequate dosing strategies can improve patient quality life and lower drug cost. Physiologically-based PK (PBPK) models offer a physiological and mechanistic framework, which is of advantage in the context of animal to human extrapolation. Unlike for small molecule drugs, however, there is no consensus on how to model mAb disposition in a PBPK context. Current PBPK models for mAb PK hugely vary in their representation of physiology and parameterisation. Their complexity poses a challenge for their applications, e.g., translating knowledge from animal species to humans. In this thesis, we developed ...
Note:
Dissertation Universität Potsdam 2018
Additional Edition:
Erscheint auch als Druck-Ausgabe Fuhrmann, Saskia Physiologically-based pharmacokinetic and mechanism-based pharmacodynamic modelling of monoclonal antibodies with a focus on tumour targeting Potsdam, 2018
Language:
English
Keywords:
Hochschulschrift
URN:
urn:nbn:de:kobv:517-opus4-418861
URL:
https://nbn-resolving.org/urn:nbn:de:kobv:517-opus4-418861
URL:
https://d-nb.info/1265011834/34
Author information:
Meibohm, Bernd
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