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Berlin Brandenburg

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  • 1
    Language: English
    In: Mineral Law Series: Rocky Mountain Mineral Law Foundation, Sept 13, 2012, Vol.2012(3), p.CH4(10)
    Keywords: Water Reuse -- Management ; Water Treatment -- Management
    ISSN: 0897-0122
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  • 2
    In: Medical Education, May 2015, Vol.49(5), pp.533-534
    Description: To purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1111/medu.12701/abstract Byline: Guadalupe Martinez, Kenneth Knox ***** No abstract is available for this article. *****
    Keywords: Algorithms–Psychology ; Faculty, Medical–Psychology ; Humans–Psychology ; Interprofessional Relations–Psychology ; Mentors–Psychology ; Physicians–Psychology;
    ISSN: 0308-0110
    E-ISSN: 1365-2923
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  • 3
    Language: English
    In: The Journal of infectious diseases, 01 September 2013, Vol.208(5), pp.857-63
    Description: The specific cellular immunological characteristics of bronchoalveolar lavage (BAL) fluid in acute pulmonary coccidioidomycosis have not been defined. BAL fluid from patients living in a coccidioidomycosis-endemic region of Arizona who were undergoing bronchoscopy because of pulmonary infiltrates was analyzed. Mononuclear cells from BAL fluid and peripheral blood mononuclear cells (PBMCs) were incubated with the coccidioidal antigen T27K in vitro, and cellular immunological assays were performed. Forty-six patients were studied. Twelve received a diagnosis of acute pulmonary coccidioidomycosis, 17 received other diagnoses, and 17 had no diagnosis established. There was an increased proportion of polyfunctional CD8(+) T cells after antigen stimulation from subjects with coccidioidomycosis as compared to those with another diagnosis (P = .025). In cells collected from BAL fluid and in PBMCs, the concentrations of interferon γ, tumor necrosis factor α, and interleukin 17 (IL-17) were all significantly increased in samples from those with acute pulmonary coccidioidomycosis, compared with the other 2 groups (for all, P〈.05). When incubated in vitro with a coccidioidal antigen preparation, cells from both BAL fluid and peripheral blood obtained from patients with pulmonary coccidioidomycosis demonstrated specific cellular immune responses, including expression of IL-17.
    Keywords: Bronchoalveolar Lavage ; Cellular Immunity ; Coccidioidomycosis ; Human ; Bronchoalveolar Lavage Fluid -- Immunology ; Coccidioidomycosis -- Immunology ; Lung Diseases, Fungal -- Immunology
    ISSN: 00221899
    E-ISSN: 1537-6613
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  • 4
    Language: English
    In: Chest, 23 October 2011, Vol.140(4), pp.647A-647A
    Keywords: Medicine
    ISSN: 0012-3692
    E-ISSN: 1931-3543
    Source: ScienceDirect Journals (Elsevier)
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  • 5
    Language: English
    In: American journal of respiratory and critical care medicine, 15 March 2014, Vol.189(6), pp.752-3
    Keywords: Coccidioidomycosis -- Diagnosis ; Histoplasmosis -- Diagnosis ; Lung Diseases, Fungal -- Diagnosis
    ISSN: 1073449X
    E-ISSN: 1535-4970
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  • 6
    In: Southwest Journal of Pulmonary and Critical Care, 02/04/2015, Vol.10(2), pp.79-80
    Description: No abstract available. Article truncated at 150 words. Magnussen H, Disse B, Rodriguez-Roisin R, et al. Withdrawal of inhaled glucocorticoids and exacerbations of COPD. N Engl J Med. 2014;371(14):1285-94. GOLD guidelines recommend various combinations of inhaled corticosteroids (ICS), long-acting beta-agonists (LABA), and long-acting muscarinic agonists (LAMA) to treat patients with chronic obstructive pulmonary disease (COPD) who are at high risk of exacerbation. A substantial portion of patients are ultimately prescribed triple-therapy at some point. The WISDOM trial examined the risk of exacerbation among patients taking triple therapy who were subsequently weaned from their ICS treatment. The present WISDOM trial was a randomized, double-blind, non-inferiority trial sponsored by Boehringer Ingelheim Pharma. Over 4 years, approximately 2500 participants in 23 non-US countries with severe or very severe COPD were randomized. Participants were eligible if they were 〉40 years of age, were current or former smokers with ≥10 pack-year history, and had at least one exacerbation within the year prior to ...
    Keywords: Inhaled Corticosteroids ; Inhaled Glucocorticoids ; Copd ; Exacerbation of Copd ; Chronic Obstructive Pulmonary Disease ; Treatment ; Medicine;
    ISSN: Southwest Journal of Pulmonary and Critical Care
    E-ISSN: 21606773
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  • 7
    Language: English
    In: Chest, October 2010, Vol.138(4), pp.875A-875A
    Keywords: Medicine
    ISSN: 0012-3692
    E-ISSN: 1931-3543
    Source: ScienceDirect Journals (Elsevier)
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  • 8
    Language: English
    In: 2012, Vol.7(9), p.e44818
    Description: Sarcoidosis, a systemic granulomatous syndrome invariably affecting the lung, typically spontaneously remits but in ∼20% of cases progresses with severe lung dysfunction or cardiac and neurologic involvement (complicated sarcoidosis). Unfortunately, current biomarkers fail to distinguish patients with remitting (uncomplicated) sarcoidosis from other fibrotic lung disorders, and fail to identify individuals at risk for complicated sarcoidosis. We utilized genome-wide peripheral blood gene expression analysis to identify a 20-gene sarcoidosis biomarker signature distinguishing sarcoidosis (n = 39) from healthy controls (n = 35, 86% classification accuracy) and which served as a molecular signature for complicated sarcoidosis (n = 17). As aberrancies in T cell receptor (TCR) signaling, JAK-STAT (JS) signaling, and cytokine-cytokine receptor (CCR) signaling are implicated in sarcoidosis pathogenesis, a 31-gene signature comprised of T cell signaling pathway genes associated with sarcoidosis (TCR/JS/CCR) was compared to the unbiased 20-gene biomarker signature but proved inferior in prediction accuracy in distinguishing complicated from uncomplicated sarcoidosis. Additional validation strategies included significant association of single nucleotide polymorphisms (SNPs) in signature genes with sarcoidosis susceptibility and severity (unbiased signature genes - CX3CR1 , FKBP1A , NOG , RBM12B , SENS3 , TSHZ2 ; T cell/JAK-STAT pathway genes such as AKT3 , CBLB , DLG1 , IFNG , IL2RA , IL7R , ITK , JUN , MALT1 , NFATC2 , PLCG1 , SPRED1 ). In summary, this validated peripheral blood molecular gene signature appears to be a valuable biomarker in identifying cases with sarcoidoisis and predicting risk for complicated sarcoidosis.
    Keywords: Research Article ; Biology ; Medicine ; Genetics And Genomics ; Public Health And Epidemiology ; Computational Biology ; Evolutionary Biology ; Pathology ; Respiratory Medicine
    E-ISSN: 1932-6203
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  • 9
    Language: English
    In: Circulation, Nov 8, 2016, Vol.134(19)
    Keywords: Exome Sequencing -- Research ; Pulmonary Hypertension -- Care And Treatment ; Pulmonary Hypertension -- Genetic Aspects ; Gene Mutation -- Research
    ISSN: 0009-7322
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  • 10
    Description: In this paper we prove weak L^{1,p} (and thus C^{\alpha}) compactness for the class of uniformly mean-convex Riemannian n-manifolds with boundary satisfying bounds on curvature quantities, diameter, and (n-1)-volume of the boundary. We obtain two stability theorems from the compactness result. The first theorem applies to 3-manifolds (contained in the aforementioned class) that have Ricci curvature close to 0 and whose boundaries are Gromov-Hausdorff close to a fixed metric on S^2 with positive curvature. Such manifolds are C^{\alpha} close to the region enclosed by a Weyl embedding of the fixed metric into \R^3. The second theorem shows that a 3-manifold with Ricci curvature close to 0 (resp. -2, 2) and mean curvature close to 2 (resp. 2\sqrt 2, 0) is C^{\alpha} close to a metric ball in the space form of constant curvature 0 (resp -1, 1), provided that the boundary is a topological sphere. Comment: 17 pages; comments welcome
    Keywords: Mathematics - Differential Geometry ; 53c20, 53c21
    Source: Cornell University
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