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  • 1
    Online Resource
    Online Resource
    Cambridge :Cambridge University Press,
    UID:
    almahu_9948233423702882
    Format: 1 online resource (vii, 309 pages) : , digital, PDF file(s).
    ISBN: 9781107588660 (ebook)
    Series Statement: Cambridge medicine
    Content: This practical guide to the diagnosis of neurodegenerative diseases discusses modern molecular techniques, morphological classification, fundamentals of clinical symptomology, diagnostic pitfalls and immunostaining protocols. It is based on the proteinopathy concept of neurodegenerative disease, which has influenced classification and provides new strategies for therapy. Numerous high-quality images, including histopathology photomicrographs and neuroradiology scans, accompany the description of morphologic alterations and interpretation of immunoreactivities. Diagnostic methods and criteria are placed within recent developments in neuropathology, including the now widespread application of immunohistochemistry. To aid daily practice, the guide includes diagnostic algorithms and offers personal insights from experienced experts in the field. Special focus is given to the way brain tissue should be handled during diagnosis. This is a must-have reference for medical specialists and specialist medical trainees in the fields of pathology, neuropathology and neurology working with neuropathologic features of neurodegenerative diseases. The book is packaged with a password, giving the user online access to all the text and images.
    Note: Title from publisher's bibliographic system (viewed on 05 Oct 2015).
    Additional Edition: Print version: ISBN 9781107674202
    Language: English
    URL: Volltext  (URL des Erstveröffentlichers)
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Online Resource
    Online Resource
    Amsterdam ; Kidlington ; Cambridge, MA :Elsevier,
    UID:
    edoccha_BV045382611
    Format: 1 Online-Ressource (xvii, 619 Seiten).
    ISBN: 978-0-12-802615-1
    Series Statement: Handbook of clinical neurology volume 145
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-0-12-802395-2
    Language: English
    Keywords: Aufsatzsammlung
    URL: Volltext  (URL des Erstveröffentlichers)
    Library Location Call Number Volume/Issue/Year Availability
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  • 3
    UID:
    gbv_1014708044
    Format: xvii, 619 Seiten , Illustrationen
    ISBN: 9780128023952
    Series Statement: Handbook of clinical neurology volume 145
    Note: Literaturangaben
    Language: English
    Subjects: Medicine
    RVK:
    Library Location Call Number Volume/Issue/Year Availability
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  • 4
    Online Resource
    Online Resource
    Amsterdam ; Kidlington ; Cambridge, MA :Elsevier,
    UID:
    edocfu_BV045382611
    Format: 1 Online-Ressource (xvii, 619 Seiten).
    ISBN: 978-0-12-802615-1
    Series Statement: Handbook of clinical neurology volume 145
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-0-12-802395-2
    Language: English
    Keywords: Aufsatzsammlung
    URL: Volltext  (URL des Erstveröffentlichers)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Online Resource
    Online Resource
    Amsterdam, Netherlands :Elsevier,
    UID:
    edocfu_9961089710902883
    Format: 1 online resource (640 pages).
    ISBN: 0-12-802615-4 , 0-12-802395-3
    Series Statement: Handbook of Clinical Neurology ; Volume 145
    Note: Front Cover -- Neuropathology -- Copyright -- Handbook of Clinical Neurology 3rd Series -- Foreword -- Preface -- Contributors -- Contents -- Section I: Pathology of the central nervous system -- Chapter 1: Techniques in neuropathology -- Introduction -- Gross examination -- Neuroanatomy -- Light microscopy -- Histologic techniques -- Immunohistochemistry -- Electron microscopy -- Molecular biology -- Epigenetics -- Summary -- References -- Chapter 2: Banking brain tissue for research -- Human tissue for research -- The origin of collections of human tissue and fluids -- Transformation of collections into biobanks -- Conclusion -- Acknowledgments -- Disclaimer -- References -- Chapter 3: Cellular reactions of the central nervous system -- Introduction -- Neurons -- Definition and markers -- Pathologic reactions -- Astrocytes -- Definition and markers -- Pathologic reactions -- Oligodendroctyes -- Definition and markers -- Pathologic reactions -- Microglia -- Definition and markers -- Pathologic reactions -- Ependymal cells -- Definition and markers -- Pathologic reactions -- Choroid plexus -- Definition and markers -- Pathologic reactions -- References -- Chapter 4: Raised intracranial pressure and brain edema -- Classification -- Cytotoxic edema -- Ionic edema (osmotic edema) -- Vasogenic edema -- High-altitude cerebral edema -- Interstitial edema -- Epidemiology -- Clinical phenotypes and imaging -- Traumatic brain injury -- Hemorrhagic stroke -- Ischemic stroke -- Tumors -- Infections -- Chronically increased ICP -- Imaging -- Neuropathology -- Macroscopy -- Microscopy -- Pathogenesis, experimental models, and biochemistry -- References -- Chapter 5: Cerebrospinal fluid circulation and hydrocephalus -- CSF circulation -- Classification -- Chronic hydrocephalus -- Epidemiology -- Hydrocephalus in children -- Chronic hydrocephalus. , Idiopathic intracranial hypertension -- Clinical phenotypes and imaging -- Idiopathic intracranial hypertension -- Chronic hydrocephalus - normal-pressure hydrocephalus -- Long-standing overt ventriculomegaly in adults -- Neuropathology -- Macroscopy -- Microscopy/immunohistochemistry -- Overview of the diagnostic approach -- Diagnostic criteria -- Pathogenesis, experimental models, and biochemistry -- Secondary hydrocephalus -- References -- Chapter 6: Developmental and perinatal brain diseases -- Brain development -- Macroscopic examination -- Corticogenesis -- Development of the cerebellum -- Development of the spinal cord -- CNS manifestations of chromosomal change -- Forebrain patterning defects -- Neural tube defects -- Midline patterning defects -- Holoprosencephaly -- Atelencephaly/aprosencephaly -- Agenesis of the corpus callosum -- Septo-optic dysplasia -- Disorders of brain size -- Microcephaly -- Megalencephaly and hemimegalencephaly -- Thanatophoric dysplasia -- Cell migration and specification disorders -- Lissencephaly, type I -- Genetics -- Lissencephaly, type II (cobblestone lissencephaly) -- Polymicrogyria -- Cerebral heterotopia -- Diffuse nodular heterotopia -- Nodular heterotopia -- Laminar heterotopia -- Leptomeningeal glioneuronal heterotopia -- Tuberous sclerosis -- Cerebellum, hindbrain, and spinal patterning defects -- Chiari malformations -- Dandy-Walker malformation -- Joubert syndrome -- Cerebellar heterotopias -- Rhombencephalosynapsis -- Olivary heterotopia -- Dysplasias of the dentate and olivary nuclei -- Dentato-olivary dysplasia with intractable seizures in infancy -- Moebius syndrome -- Abnormalities of the pyramidal tracts -- Pontine tegmental cap dysplasia -- Pontocerebellar hypoplasia -- Spinal cord lesions -- Hydrocephalus -- Secondary malformations and destructive pathologies -- Antenatal disruptive lesions. , Hemorrhagic lesions -- White-matter lesions in the perinatal period -- Gray-matter lesions -- Cerebral cortex -- Hippocampus -- Basal nuclei and thalamus -- Cerebellum -- Brainstem and spinal cord -- Vascular malformations -- Aneurysmal malformation of the vein of Galen -- Sturge-Weber syndrome -- Fowler syndrome: proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome -- Arachnoid cysts -- Infectious diseases -- References -- Chapter 7: Neuropathology of cerebrovascular diseases -- Epidemiology -- Anatomy of the cerebral blood vessels -- Pathophysiology: ischemia, hypoxia, and related conditions -- Necrosis, apoptosis, necroptosis, and delayed neuronal death -- Necrosis -- Apoptosis -- Necroptosis -- Delayed neuronal death -- Hypoxia -- General responses to hypoxia -- Hypobaric hypoxia -- Clinical symptoms -- Neuropathology -- Hypoxemia and anemic hypoxia -- Histotoxic hypoxia: sulfide, cyanide, and azide -- Clinical symptoms -- Neuropathology -- Carbon monoxide damage -- Clinical symptoms -- Neuropathology -- Clinical outcome in surviving cases -- Hyperoxic brain damage and decompression sickness -- Hyperoxic brain damage -- Clinical symptoms -- Decompression sickness -- Clinical symptoms -- Neuropathology -- Other causes -- Patterns of cell injury: selective cell and regional vulnerability -- Selective regional vulnerability -- Reperfusion injury -- Diseases of the vessels -- Atherosclerosis -- Hypertensive angiopathy -- Small-vessel (degenerative) disease: arteriolosclerosis, arteriolar hyalinosis, lipohyalinosis, and fibrinoid necrosis -- Inflammatory vascular diseases -- Giant-cell arteritis (temporal arteritis, Horton arteritis: GCA) -- Primary cerebral angiitis -- Takayasu arteritis -- Systemic vasculitis in autoimmune diseases -- Infectious vasculitis -- Drug-induced vasculitis -- Cerebral amyloid angiopathies (CAA). , Aβ-related angiitis -- CADASIL -- CARASIL -- Cerebrovascular occlusive diseases with retinal involvement -- Other diseases that can lead to cerebrovascular occlusion -- Fibromuscular dysplasia -- Sneddon syndrome -- Moyamoya syndrome -- Hodgkin lymphomas -- Fabry disease -- Clinical manifestations of diseases of the blood vessels -- Complementary methods in the study of diseases of blood vessels, including neuropathologic examination -- Angiography and MRI angiography -- Peripheral nerve biopsies -- Intracranial (and intraspinal) aneurysms and vascular malformations -- Saccular aneurysms -- Dolichoectasia and fusiform aneurysms -- Capillary telangiectasias -- Cavernous angiomas (cavernous hemangiomas, cerebral cavernous malformations) -- Arteriovenous malformations -- Venous malformations -- Aneurysms of the vein of Galen -- Fistulas -- Hematologic disorders -- Brain ischemic damage -- Focal cerebral ischemia -- Infarct progression -- Morphologic changes -- Hemorrhagic infarcts -- Brain edema associated with infarction -- Neuroimaging correlates -- The penumbra -- Clinical and pathologic correlations -- Global cerebral ischemia -- Morphologic changes -- Permanent global ischemia -- Clinical and pathologic correlates -- Venous thrombosis and infarction -- Clinical aspects -- Other brain lesions related to ischemia -- Lacunas and lacunar state -- Status cribrosus -- Dilatation of the perivascular spaces of the perforant arteries -- Granular atrophy of the cerebral cortex -- Hippocampal sclerosis -- Vascular leukoencephalopathy: Binswanger-type leukoencephalopathy -- Multi-infarct encephalopathy -- Clinical manifestations -- Neuroimaging -- Spontaneous intracranial bleeding -- Subarachnoid hemorrhages -- Morphologic changes -- Parenchymal hemorrhages -- Morphologic changes -- Clinical symptoms and diagnosis by neuroimaging. , Vascular cognitive impairment -- References -- Chapter 8: Neurotrauma -- Introduction -- Epidemiology -- Classification of traumatic brain injury -- Diffuse traumatic axonal injury and diffuse vascular injuries -- Histopathologic identification of TAI -- Hemorrhagic lesions associated with rotational injury -- Causes of diffuse TAI -- Contusions and intracranial hemorrhages -- Contusions -- Intracranial hemorrhages -- Extradural (epidural) hematoma -- Subdural hematomas -- Acute subdural hematoma -- Chronic subdural hematoma -- Subarachnoid hemorrhage -- Intracerebral hemorrhage -- Other vascular lesions -- Traumatic intraventricular hemorrhage -- Focal vascular injuries -- Spinal cord trauma -- Long-term consequences of TBI -- Concussion -- Long-term cognitive problems -- Repetitive head injury and chronic traumatic encephalopathy -- Single episode of TBI -- Penetrating head injuries -- Blast injuries -- References -- Chapter 9: Neurometabolic and neurodegenerative diseases in children -- Introduction -- Lysosomal diseases -- Nonvacuolar lysosomal diseases -- Sphingolipidoses -- Definition -- Classification -- Clinical phenotypes -- Neuropathology -- Macroscopy -- Microscopy -- Diagnostic approach -- Pathogenesis -- Neuronal ceroid-lipofuscinoses -- Definition -- Epidemiology -- Classification -- Clinical phenotypes -- Neuropathology -- Macroscopy -- Microscopy -- Diagnostic approach -- Diagnostic criteria -- Pathogenesis -- Vacuolar lysosomal diseases -- Definition -- Classification -- Clinical phenotypes -- Neuropathology -- Macroscopy -- Microscopy -- Diagnostic approach -- Pathogenesis -- Other lysosomal diseases -- Peroxisomal disorders -- Definition -- Epidemiology -- Classification -- Peroxisome biogenesis defects -- Clinical phenotypes -- Neuropathology -- Macroscopy -- Microscopy -- Diagnostic approach -- Pathogenesis. , Single peroxisome enzyme/transporter defects.
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
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  • 6
    Online Resource
    Online Resource
    Amsterdam, Netherlands :Elsevier,
    UID:
    edoccha_9961089710902883
    Format: 1 online resource (640 pages).
    ISBN: 0-12-802615-4 , 0-12-802395-3
    Series Statement: Handbook of Clinical Neurology ; Volume 145
    Note: Front Cover -- Neuropathology -- Copyright -- Handbook of Clinical Neurology 3rd Series -- Foreword -- Preface -- Contributors -- Contents -- Section I: Pathology of the central nervous system -- Chapter 1: Techniques in neuropathology -- Introduction -- Gross examination -- Neuroanatomy -- Light microscopy -- Histologic techniques -- Immunohistochemistry -- Electron microscopy -- Molecular biology -- Epigenetics -- Summary -- References -- Chapter 2: Banking brain tissue for research -- Human tissue for research -- The origin of collections of human tissue and fluids -- Transformation of collections into biobanks -- Conclusion -- Acknowledgments -- Disclaimer -- References -- Chapter 3: Cellular reactions of the central nervous system -- Introduction -- Neurons -- Definition and markers -- Pathologic reactions -- Astrocytes -- Definition and markers -- Pathologic reactions -- Oligodendroctyes -- Definition and markers -- Pathologic reactions -- Microglia -- Definition and markers -- Pathologic reactions -- Ependymal cells -- Definition and markers -- Pathologic reactions -- Choroid plexus -- Definition and markers -- Pathologic reactions -- References -- Chapter 4: Raised intracranial pressure and brain edema -- Classification -- Cytotoxic edema -- Ionic edema (osmotic edema) -- Vasogenic edema -- High-altitude cerebral edema -- Interstitial edema -- Epidemiology -- Clinical phenotypes and imaging -- Traumatic brain injury -- Hemorrhagic stroke -- Ischemic stroke -- Tumors -- Infections -- Chronically increased ICP -- Imaging -- Neuropathology -- Macroscopy -- Microscopy -- Pathogenesis, experimental models, and biochemistry -- References -- Chapter 5: Cerebrospinal fluid circulation and hydrocephalus -- CSF circulation -- Classification -- Chronic hydrocephalus -- Epidemiology -- Hydrocephalus in children -- Chronic hydrocephalus. , Idiopathic intracranial hypertension -- Clinical phenotypes and imaging -- Idiopathic intracranial hypertension -- Chronic hydrocephalus - normal-pressure hydrocephalus -- Long-standing overt ventriculomegaly in adults -- Neuropathology -- Macroscopy -- Microscopy/immunohistochemistry -- Overview of the diagnostic approach -- Diagnostic criteria -- Pathogenesis, experimental models, and biochemistry -- Secondary hydrocephalus -- References -- Chapter 6: Developmental and perinatal brain diseases -- Brain development -- Macroscopic examination -- Corticogenesis -- Development of the cerebellum -- Development of the spinal cord -- CNS manifestations of chromosomal change -- Forebrain patterning defects -- Neural tube defects -- Midline patterning defects -- Holoprosencephaly -- Atelencephaly/aprosencephaly -- Agenesis of the corpus callosum -- Septo-optic dysplasia -- Disorders of brain size -- Microcephaly -- Megalencephaly and hemimegalencephaly -- Thanatophoric dysplasia -- Cell migration and specification disorders -- Lissencephaly, type I -- Genetics -- Lissencephaly, type II (cobblestone lissencephaly) -- Polymicrogyria -- Cerebral heterotopia -- Diffuse nodular heterotopia -- Nodular heterotopia -- Laminar heterotopia -- Leptomeningeal glioneuronal heterotopia -- Tuberous sclerosis -- Cerebellum, hindbrain, and spinal patterning defects -- Chiari malformations -- Dandy-Walker malformation -- Joubert syndrome -- Cerebellar heterotopias -- Rhombencephalosynapsis -- Olivary heterotopia -- Dysplasias of the dentate and olivary nuclei -- Dentato-olivary dysplasia with intractable seizures in infancy -- Moebius syndrome -- Abnormalities of the pyramidal tracts -- Pontine tegmental cap dysplasia -- Pontocerebellar hypoplasia -- Spinal cord lesions -- Hydrocephalus -- Secondary malformations and destructive pathologies -- Antenatal disruptive lesions. , Hemorrhagic lesions -- White-matter lesions in the perinatal period -- Gray-matter lesions -- Cerebral cortex -- Hippocampus -- Basal nuclei and thalamus -- Cerebellum -- Brainstem and spinal cord -- Vascular malformations -- Aneurysmal malformation of the vein of Galen -- Sturge-Weber syndrome -- Fowler syndrome: proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome -- Arachnoid cysts -- Infectious diseases -- References -- Chapter 7: Neuropathology of cerebrovascular diseases -- Epidemiology -- Anatomy of the cerebral blood vessels -- Pathophysiology: ischemia, hypoxia, and related conditions -- Necrosis, apoptosis, necroptosis, and delayed neuronal death -- Necrosis -- Apoptosis -- Necroptosis -- Delayed neuronal death -- Hypoxia -- General responses to hypoxia -- Hypobaric hypoxia -- Clinical symptoms -- Neuropathology -- Hypoxemia and anemic hypoxia -- Histotoxic hypoxia: sulfide, cyanide, and azide -- Clinical symptoms -- Neuropathology -- Carbon monoxide damage -- Clinical symptoms -- Neuropathology -- Clinical outcome in surviving cases -- Hyperoxic brain damage and decompression sickness -- Hyperoxic brain damage -- Clinical symptoms -- Decompression sickness -- Clinical symptoms -- Neuropathology -- Other causes -- Patterns of cell injury: selective cell and regional vulnerability -- Selective regional vulnerability -- Reperfusion injury -- Diseases of the vessels -- Atherosclerosis -- Hypertensive angiopathy -- Small-vessel (degenerative) disease: arteriolosclerosis, arteriolar hyalinosis, lipohyalinosis, and fibrinoid necrosis -- Inflammatory vascular diseases -- Giant-cell arteritis (temporal arteritis, Horton arteritis: GCA) -- Primary cerebral angiitis -- Takayasu arteritis -- Systemic vasculitis in autoimmune diseases -- Infectious vasculitis -- Drug-induced vasculitis -- Cerebral amyloid angiopathies (CAA). , Aβ-related angiitis -- CADASIL -- CARASIL -- Cerebrovascular occlusive diseases with retinal involvement -- Other diseases that can lead to cerebrovascular occlusion -- Fibromuscular dysplasia -- Sneddon syndrome -- Moyamoya syndrome -- Hodgkin lymphomas -- Fabry disease -- Clinical manifestations of diseases of the blood vessels -- Complementary methods in the study of diseases of blood vessels, including neuropathologic examination -- Angiography and MRI angiography -- Peripheral nerve biopsies -- Intracranial (and intraspinal) aneurysms and vascular malformations -- Saccular aneurysms -- Dolichoectasia and fusiform aneurysms -- Capillary telangiectasias -- Cavernous angiomas (cavernous hemangiomas, cerebral cavernous malformations) -- Arteriovenous malformations -- Venous malformations -- Aneurysms of the vein of Galen -- Fistulas -- Hematologic disorders -- Brain ischemic damage -- Focal cerebral ischemia -- Infarct progression -- Morphologic changes -- Hemorrhagic infarcts -- Brain edema associated with infarction -- Neuroimaging correlates -- The penumbra -- Clinical and pathologic correlations -- Global cerebral ischemia -- Morphologic changes -- Permanent global ischemia -- Clinical and pathologic correlates -- Venous thrombosis and infarction -- Clinical aspects -- Other brain lesions related to ischemia -- Lacunas and lacunar state -- Status cribrosus -- Dilatation of the perivascular spaces of the perforant arteries -- Granular atrophy of the cerebral cortex -- Hippocampal sclerosis -- Vascular leukoencephalopathy: Binswanger-type leukoencephalopathy -- Multi-infarct encephalopathy -- Clinical manifestations -- Neuroimaging -- Spontaneous intracranial bleeding -- Subarachnoid hemorrhages -- Morphologic changes -- Parenchymal hemorrhages -- Morphologic changes -- Clinical symptoms and diagnosis by neuroimaging. , Vascular cognitive impairment -- References -- Chapter 8: Neurotrauma -- Introduction -- Epidemiology -- Classification of traumatic brain injury -- Diffuse traumatic axonal injury and diffuse vascular injuries -- Histopathologic identification of TAI -- Hemorrhagic lesions associated with rotational injury -- Causes of diffuse TAI -- Contusions and intracranial hemorrhages -- Contusions -- Intracranial hemorrhages -- Extradural (epidural) hematoma -- Subdural hematomas -- Acute subdural hematoma -- Chronic subdural hematoma -- Subarachnoid hemorrhage -- Intracerebral hemorrhage -- Other vascular lesions -- Traumatic intraventricular hemorrhage -- Focal vascular injuries -- Spinal cord trauma -- Long-term consequences of TBI -- Concussion -- Long-term cognitive problems -- Repetitive head injury and chronic traumatic encephalopathy -- Single episode of TBI -- Penetrating head injuries -- Blast injuries -- References -- Chapter 9: Neurometabolic and neurodegenerative diseases in children -- Introduction -- Lysosomal diseases -- Nonvacuolar lysosomal diseases -- Sphingolipidoses -- Definition -- Classification -- Clinical phenotypes -- Neuropathology -- Macroscopy -- Microscopy -- Diagnostic approach -- Pathogenesis -- Neuronal ceroid-lipofuscinoses -- Definition -- Epidemiology -- Classification -- Clinical phenotypes -- Neuropathology -- Macroscopy -- Microscopy -- Diagnostic approach -- Diagnostic criteria -- Pathogenesis -- Vacuolar lysosomal diseases -- Definition -- Classification -- Clinical phenotypes -- Neuropathology -- Macroscopy -- Microscopy -- Diagnostic approach -- Pathogenesis -- Other lysosomal diseases -- Peroxisomal disorders -- Definition -- Epidemiology -- Classification -- Peroxisome biogenesis defects -- Clinical phenotypes -- Neuropathology -- Macroscopy -- Microscopy -- Diagnostic approach -- Pathogenesis. , Single peroxisome enzyme/transporter defects.
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
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  • 7
    Online Resource
    Online Resource
    Amsterdam, Netherlands :Elsevier,
    UID:
    almahu_9948025343902882
    Format: 1 online resource (640 pages).
    ISBN: 0-12-802615-4 , 0-12-802395-3
    Series Statement: Handbook of Clinical Neurology ; Volume 145
    Note: Front Cover -- Neuropathology -- Copyright -- Handbook of Clinical Neurology 3rd Series -- Foreword -- Preface -- Contributors -- Contents -- Section I: Pathology of the central nervous system -- Chapter 1: Techniques in neuropathology -- Introduction -- Gross examination -- Neuroanatomy -- Light microscopy -- Histologic techniques -- Immunohistochemistry -- Electron microscopy -- Molecular biology -- Epigenetics -- Summary -- References -- Chapter 2: Banking brain tissue for research -- Human tissue for research -- The origin of collections of human tissue and fluids -- Transformation of collections into biobanks -- Conclusion -- Acknowledgments -- Disclaimer -- References -- Chapter 3: Cellular reactions of the central nervous system -- Introduction -- Neurons -- Definition and markers -- Pathologic reactions -- Astrocytes -- Definition and markers -- Pathologic reactions -- Oligodendroctyes -- Definition and markers -- Pathologic reactions -- Microglia -- Definition and markers -- Pathologic reactions -- Ependymal cells -- Definition and markers -- Pathologic reactions -- Choroid plexus -- Definition and markers -- Pathologic reactions -- References -- Chapter 4: Raised intracranial pressure and brain edema -- Classification -- Cytotoxic edema -- Ionic edema (osmotic edema) -- Vasogenic edema -- High-altitude cerebral edema -- Interstitial edema -- Epidemiology -- Clinical phenotypes and imaging -- Traumatic brain injury -- Hemorrhagic stroke -- Ischemic stroke -- Tumors -- Infections -- Chronically increased ICP -- Imaging -- Neuropathology -- Macroscopy -- Microscopy -- Pathogenesis, experimental models, and biochemistry -- References -- Chapter 5: Cerebrospinal fluid circulation and hydrocephalus -- CSF circulation -- Classification -- Chronic hydrocephalus -- Epidemiology -- Hydrocephalus in children -- Chronic hydrocephalus. , Idiopathic intracranial hypertension -- Clinical phenotypes and imaging -- Idiopathic intracranial hypertension -- Chronic hydrocephalus - normal-pressure hydrocephalus -- Long-standing overt ventriculomegaly in adults -- Neuropathology -- Macroscopy -- Microscopy/immunohistochemistry -- Overview of the diagnostic approach -- Diagnostic criteria -- Pathogenesis, experimental models, and biochemistry -- Secondary hydrocephalus -- References -- Chapter 6: Developmental and perinatal brain diseases -- Brain development -- Macroscopic examination -- Corticogenesis -- Development of the cerebellum -- Development of the spinal cord -- CNS manifestations of chromosomal change -- Forebrain patterning defects -- Neural tube defects -- Midline patterning defects -- Holoprosencephaly -- Atelencephaly/aprosencephaly -- Agenesis of the corpus callosum -- Septo-optic dysplasia -- Disorders of brain size -- Microcephaly -- Megalencephaly and hemimegalencephaly -- Thanatophoric dysplasia -- Cell migration and specification disorders -- Lissencephaly, type I -- Genetics -- Lissencephaly, type II (cobblestone lissencephaly) -- Polymicrogyria -- Cerebral heterotopia -- Diffuse nodular heterotopia -- Nodular heterotopia -- Laminar heterotopia -- Leptomeningeal glioneuronal heterotopia -- Tuberous sclerosis -- Cerebellum, hindbrain, and spinal patterning defects -- Chiari malformations -- Dandy-Walker malformation -- Joubert syndrome -- Cerebellar heterotopias -- Rhombencephalosynapsis -- Olivary heterotopia -- Dysplasias of the dentate and olivary nuclei -- Dentato-olivary dysplasia with intractable seizures in infancy -- Moebius syndrome -- Abnormalities of the pyramidal tracts -- Pontine tegmental cap dysplasia -- Pontocerebellar hypoplasia -- Spinal cord lesions -- Hydrocephalus -- Secondary malformations and destructive pathologies -- Antenatal disruptive lesions. , Hemorrhagic lesions -- White-matter lesions in the perinatal period -- Gray-matter lesions -- Cerebral cortex -- Hippocampus -- Basal nuclei and thalamus -- Cerebellum -- Brainstem and spinal cord -- Vascular malformations -- Aneurysmal malformation of the vein of Galen -- Sturge-Weber syndrome -- Fowler syndrome: proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome -- Arachnoid cysts -- Infectious diseases -- References -- Chapter 7: Neuropathology of cerebrovascular diseases -- Epidemiology -- Anatomy of the cerebral blood vessels -- Pathophysiology: ischemia, hypoxia, and related conditions -- Necrosis, apoptosis, necroptosis, and delayed neuronal death -- Necrosis -- Apoptosis -- Necroptosis -- Delayed neuronal death -- Hypoxia -- General responses to hypoxia -- Hypobaric hypoxia -- Clinical symptoms -- Neuropathology -- Hypoxemia and anemic hypoxia -- Histotoxic hypoxia: sulfide, cyanide, and azide -- Clinical symptoms -- Neuropathology -- Carbon monoxide damage -- Clinical symptoms -- Neuropathology -- Clinical outcome in surviving cases -- Hyperoxic brain damage and decompression sickness -- Hyperoxic brain damage -- Clinical symptoms -- Decompression sickness -- Clinical symptoms -- Neuropathology -- Other causes -- Patterns of cell injury: selective cell and regional vulnerability -- Selective regional vulnerability -- Reperfusion injury -- Diseases of the vessels -- Atherosclerosis -- Hypertensive angiopathy -- Small-vessel (degenerative) disease: arteriolosclerosis, arteriolar hyalinosis, lipohyalinosis, and fibrinoid necrosis -- Inflammatory vascular diseases -- Giant-cell arteritis (temporal arteritis, Horton arteritis: GCA) -- Primary cerebral angiitis -- Takayasu arteritis -- Systemic vasculitis in autoimmune diseases -- Infectious vasculitis -- Drug-induced vasculitis -- Cerebral amyloid angiopathies (CAA). , Aβ-related angiitis -- CADASIL -- CARASIL -- Cerebrovascular occlusive diseases with retinal involvement -- Other diseases that can lead to cerebrovascular occlusion -- Fibromuscular dysplasia -- Sneddon syndrome -- Moyamoya syndrome -- Hodgkin lymphomas -- Fabry disease -- Clinical manifestations of diseases of the blood vessels -- Complementary methods in the study of diseases of blood vessels, including neuropathologic examination -- Angiography and MRI angiography -- Peripheral nerve biopsies -- Intracranial (and intraspinal) aneurysms and vascular malformations -- Saccular aneurysms -- Dolichoectasia and fusiform aneurysms -- Capillary telangiectasias -- Cavernous angiomas (cavernous hemangiomas, cerebral cavernous malformations) -- Arteriovenous malformations -- Venous malformations -- Aneurysms of the vein of Galen -- Fistulas -- Hematologic disorders -- Brain ischemic damage -- Focal cerebral ischemia -- Infarct progression -- Morphologic changes -- Hemorrhagic infarcts -- Brain edema associated with infarction -- Neuroimaging correlates -- The penumbra -- Clinical and pathologic correlations -- Global cerebral ischemia -- Morphologic changes -- Permanent global ischemia -- Clinical and pathologic correlates -- Venous thrombosis and infarction -- Clinical aspects -- Other brain lesions related to ischemia -- Lacunas and lacunar state -- Status cribrosus -- Dilatation of the perivascular spaces of the perforant arteries -- Granular atrophy of the cerebral cortex -- Hippocampal sclerosis -- Vascular leukoencephalopathy: Binswanger-type leukoencephalopathy -- Multi-infarct encephalopathy -- Clinical manifestations -- Neuroimaging -- Spontaneous intracranial bleeding -- Subarachnoid hemorrhages -- Morphologic changes -- Parenchymal hemorrhages -- Morphologic changes -- Clinical symptoms and diagnosis by neuroimaging. , Vascular cognitive impairment -- References -- Chapter 8: Neurotrauma -- Introduction -- Epidemiology -- Classification of traumatic brain injury -- Diffuse traumatic axonal injury and diffuse vascular injuries -- Histopathologic identification of TAI -- Hemorrhagic lesions associated with rotational injury -- Causes of diffuse TAI -- Contusions and intracranial hemorrhages -- Contusions -- Intracranial hemorrhages -- Extradural (epidural) hematoma -- Subdural hematomas -- Acute subdural hematoma -- Chronic subdural hematoma -- Subarachnoid hemorrhage -- Intracerebral hemorrhage -- Other vascular lesions -- Traumatic intraventricular hemorrhage -- Focal vascular injuries -- Spinal cord trauma -- Long-term consequences of TBI -- Concussion -- Long-term cognitive problems -- Repetitive head injury and chronic traumatic encephalopathy -- Single episode of TBI -- Penetrating head injuries -- Blast injuries -- References -- Chapter 9: Neurometabolic and neurodegenerative diseases in children -- Introduction -- Lysosomal diseases -- Nonvacuolar lysosomal diseases -- Sphingolipidoses -- Definition -- Classification -- Clinical phenotypes -- Neuropathology -- Macroscopy -- Microscopy -- Diagnostic approach -- Pathogenesis -- Neuronal ceroid-lipofuscinoses -- Definition -- Epidemiology -- Classification -- Clinical phenotypes -- Neuropathology -- Macroscopy -- Microscopy -- Diagnostic approach -- Diagnostic criteria -- Pathogenesis -- Vacuolar lysosomal diseases -- Definition -- Classification -- Clinical phenotypes -- Neuropathology -- Macroscopy -- Microscopy -- Diagnostic approach -- Pathogenesis -- Other lysosomal diseases -- Peroxisomal disorders -- Definition -- Epidemiology -- Classification -- Peroxisome biogenesis defects -- Clinical phenotypes -- Neuropathology -- Macroscopy -- Microscopy -- Diagnostic approach -- Pathogenesis. , Single peroxisome enzyme/transporter defects.
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
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  • 8
    Online Resource
    Online Resource
    Amsterdam ; Kidlington ; Cambridge, MA :Elsevier,
    UID:
    almafu_BV045382611
    Format: 1 Online-Ressource (xvii, 619 Seiten).
    ISBN: 978-0-12-802615-1
    Series Statement: Handbook of clinical neurology volume 145
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-0-12-802395-2
    Language: English
    Keywords: Aufsatzsammlung
    URL: Volltext  (URL des Erstveröffentlichers)
    Library Location Call Number Volume/Issue/Year Availability
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  • 9
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