UID:
edoccha_9960074111202883
Format:
1 online resource (714 p.)
ISBN:
0-12-803345-2
,
0-12-803309-6
Series Statement:
Translational Epigenetics Series
Content:
Genome Stability: From Virus to Human Application covers the genome stability of DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, with the latter including major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, as well as changes in genome stability in response to aging. Every species has to preserve the integrity of its genome to ensure faithful passage of genetic information to the progeny. At the same time, there are times during the life of the organism and population in general when a fine balance in genome stability and diversification has to be made to benefit the survival of the species. This book teaches the reader how various species maintain this fine balance in genome stability and genome diversification in response to their environments. The book also covers how epigenetic factors contribute to genome stability and how species pass the memory of the encounters to the progeny, thus influencing the genome of the progeny in an indirect manner.
Note:
Description based upon print version of record.
,
Front Cover; Genome Stability; Translational Epigenetics Series; Genome Stability: From Virus to Human Application; Copyright; Contents; List of Contributors; Introduction; 1 - Genome Stability: An Evolutionary Perspective ; 1. INTRODUCTION; 2. EVOLUTION THEORIES AND MY REFLECTION ON THEM; 3. THE ROLE OF SYMBIOSIS IN GENOME EVOLUTION; 3.1 Changes in the Structure of the Organellar Genome Over Time; 3.2 Mutation Rates in Organellar Genomes and Adaptive Evolution; 3.3 Symbiotic Interactions Between Viruses, Prokaryotes, and Eukaryotes: The Role of Transposable Elements
,
5. THE VIRAL POLYMERASE AS A SOURCE OF ERROR6. OTHER VIRAL DETERMINANTS OF MUTATION RATE; 7. RECOMBINATION; 8. THE EFFECT OF REPLICATION MODE ON MUTATION FREQUENCY; 9. THE EFFECT OF CELLULAR FACTORS ON VIRUS MUTATION RATE; 10. MECHANISMS UNDERLYING GENETIC ROBUSTNESS IN RNA VIRUSES; 11. RNA VIRUSES ON THE EDGE; 12. VIRUS GENETIC VARIABILITY AND THE VIRUS-HOST "ARMS RACE"; 13. TAKING ADVANTAGE OF THE MUTABILITY OF RNA VIRUSES; 14. CONCLUSION; GLOSSARY; LIST OF ABBREVIATIONS; REFERENCES; 3 - Genome Instability in DNA Viruses ; 1. OVERVIEW
Language:
English
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