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  • 1
    Language: English
    In: Clinical chemistry, October 2013, Vol.59(10), pp.1538-9
    Description: In a recent issue of Science , Lacetera, Macis, and Slonim summarize new information regarding the impact that economic rewards have on the blood supply and safety (1). For many years, the WHO has taken the stance that economic incentives decrease the safety of the blood supply. In support of the WHO position, the establishment of an all-volunteer blood supply led to a dramatic decrease in the incidence of posttransfusion hepatitis C. The authors submit, however, that the position of the WHO is based on studies that failed to control for several confounding variables (percentage of first-time donors, location of donation, and use of prisoners). Recent randomized field surveys reviewed by the authors found that economic incentives increase …
    Keywords: Guidelines As Topic ; Blood Donors -- Ethics ; Reimbursement, Incentive -- Ethics
    ISSN: 00099147
    E-ISSN: 1530-8561
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  • 2
    Language: English
    In: The Journal of Applied Laboratory Medicine: An AACC Publication, 09/2017, Vol.2(2), pp.286-287
    Description: 〉 If you bring forth what is within you, what you bring forth will save you. If you do not bring forth what is within you, what you do not bring forth will destroy you. 〉 〉 —Gospel of Thomas I did a rotation with the inpatient hematology service near …
    Keywords: Medicine;
    ISSN: The Journal of Applied Laboratory Medicine: An AACC Publication
    E-ISSN: 2475-7241
    Source: CrossRef
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  • 3
    In: Anesthesia & Analgesia, 2018, Vol.127(2), pp.349-357
    Description: BACKGROUND:: Plasma transfusion is commonly performed for the correction of abnormal coagulation screening tests. The goal of this investigation was to assess the relationship between the dose of plasma administered and changes in coagulation test results in a large and diverse cohort of patients with varying levels of coagulation abnormalities and comorbid disease and in a variety of clinical settings. METHODS:: In this single-center historical cohort study, all plasma transfusion episodes in adult patients with abnormal coagulation screening tests were extracted between 2011 and 2015. The primary outcome was the proportion of patients attaining normal posttransfusion international normalized ratio (INR ≤ 1.1) with secondary outcomes including the proportion of patients attaining partial normalization of INR (INR ≤ 1.5) or at least 50% normalization in pretransfusion values with respect to an INR of 1.1. RESULTS:: In total, 6779 unique patients received plasma with a median (quartiles) pretransfusion INR of 1.9 (1.6–2.5) and a median transfusion volume of 2 (2–3) units. The majority (85%) of transfusions occurred perioperatively, with 20% of transfusions administered prophylactically before a procedure. The median decrease in INR was 0.4 (0.2–0.8). Complete INR normalization was obtained in 12%. Reductions in INR were modest with pretransfusion INR values 〈3. Patients receiving ≥3 units of plasma were more likely to achieve at least 50% normalization in INR than those receiving ≤2 units (68% vs 60%; P 〈 .001). CONCLUSIONS:: Changes in INR after plasma transfusion were modest at typically used clinical doses, particularly in those with less severely deranged baseline coagulation screening tests. Further studies are necessary to assess the relationships between plasma-mediated changes in INR and clinical outcomes.
    Keywords: Blood Transfusion -- Analysis ; Comorbidity -- Research;
    ISSN: 0003-2999
    E-ISSN: 15267598
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  • 4
    In: Transfusion, February 2016, Vol.56(2), pp.285-289
    Description: Byline: James R. Stubbs, Justin D. Kreuter ***** No abstract is available for this article. *****
    Keywords: Blood Transfusion;
    ISSN: 0041-1132
    E-ISSN: 1537-2995
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  • 5
    Language: English
    In: Transfusion Medicine Reviews, April 2018, Vol.32(2), pp.123-124
    Keywords: Medicine
    ISSN: 0887-7963
    E-ISSN: 1532-9496
    Source: ScienceDirect Journals (Elsevier)
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  • 6
    Language: English
    In: Human Immunology, Oct, 2014, Vol.75, p.128
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.humimm.2014.08.174 Byline: Laurie Voit, Crystal Keso, Lisa Hallaway, Justin D. Kreuter, Manish J. Gandhi Abstract: Presence of HLA-B27 (associated with ankylosing spondylitis, juvenile rheumatoid arthritis, and Reiter's syndrome) on leukocytes in whole blood can be detected with monoclonal antibodies by a rapid qualitative two-color direct immunofluorescence flow cytometric method. In this method cross-reacting glycoproteins can provide a positive result; thus, some samples need to be confirmed by an alternate test method. We present an overview of our reagent quality control as well as observations requiring modification to the laboratory process.
    ISSN: 0198-8859
    Source: Cengage Learning, Inc.
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  • 7
    Language: English
    In: Human Immunology, 2015, Vol.76, p.62
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.humimm.2015.07.087 Byline: Deborah K. Falbo, Nisar A. Baig, Steven R. De Goey, Laurie L. Wakefield, Justin D. Kreuter, Manish J. Gandhi Abstract: A negative flow crossmatch (FXM) is considered as a "go ahead" to transplant solid organs at many centers. FXM is a biologic assay where donor lymphocytes are reacted with recipient sera to identify donor specific antibodies (DSA). Lymphocytes can be derived from different sources like peripheral blood (PB), lymph node or spleen. Mix of cellular components from all three sources are different and also may have different HLA expression depending on the age of the sample. We present our data to understand this variability.
    Keywords: Lymphocytes
    ISSN: 0198-8859
    Source: Cengage Learning, Inc.
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  • 8
    In: Transfusion, October 2013, Vol.53(10), pp.2307-2313
    Description: Byline: Nancy M. Dunbar, Justin D. Kreuter, Cynthia R. Marx-Wood, Larry J. Dumont, Zbigniew M. Szczepiorkowski Background The platelet (PLT) Pan Genera Detection test (PGD) is a rapid bacterial detection system used to screen PLTs for bacterial contamination. We report a single center 46-month experience with secondary screening of apheresis PLTs by PGD testing. Study Design and Methods Existing testing records of apheresis PLTs screened by PGD from July 2008 to April 2012 were reviewed. All PLT units were initially screened by routine postcollection culture methods. Secondary screening using PGD was performed for indated PLTs on PLT storage Day 4 and for outdated PLTs on Day 8. Results A total of 8535 apheresis PLTs were available in inventory during the study period. Of these, 5030 (58.9%) were dispensed and transfused before PGD testing and 3505 (41.1%) underwent PGD testing on Day 4. Twenty-five units tested on Day 4 were PGD initial reactive (0.71%). All were confirmed to be false positive by repeat PGD testing in triplicate (n=20) or by confirmatory culture (n=5). An additional 364 units that were PGD nonreactive on Day 4 were approved for transfusion on Day 6 or Day 7 due to urgent clinical need. A total of 371 outdated units underwent repeat PGD testing before discard on Day 8; all were nonreactive. Conclusion Secondary PGD testing of culture-screened apheresis PLTs results in low yield in a medium-sized transfusion service. Use of PGD testing on Day 4 may allow for extension of the apheresis PLT shelf life to Day 7 for hospitals that face supply constraints. Article Note: These authors contributed equally.
    Keywords: Detection Equipment -- Usage;
    ISSN: 0041-1132
    E-ISSN: 1537-2995
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  • 9
    In: Journal of Clinical Apheresis, June 2015, Vol.30(3), pp.147-153
    Description: Transplant‐associated thrombotic microangiopathy (TA‐TMA) is a rare clinical syndrome associated with significant mortality. Although the use of plasma exchange (PE) in TA‐TMA continues to be explored, evidence for its efficacy is debated. We performed a single institution, retrospective study to evaluate the efficacy of PE in treating TA‐TMA patients. Special attention was given to efficacy in relation to the timing of presentation with TA‐TMA since transplant. Thirty‐three patients diagnosed with TA‐TMA and treated with PE between January 1999 and December 2010 were included in the study. Clinical improvement was seen in eight patients (24%); four patients achieved complete resolution while the remaining four achieved partial resolution. All‐cause day‐30 and day‐100 mortality was 33 and 55%, respectively. There was a trend toward a better outcome (complete/partial) for those presenting ≥ 100 days after transplantation (42%) vs. 〈 100 days after transplantation (14%; ‐value = 0.15). Similarly, those presenting at ≥ 100 days had better, but not significantly, 30‐day and 100‐day all‐cause mortality rates (17 and 33%, respectively) than those presenting at 〈 100 days (43 and 67%, respectively) (‐value = 0.25 and 0.08, for 30‐ and 100‐day all‐cause mortality, respectively). This is the first study looking at the efficacy of PE while considering the time of presentation since transplantation and is one of the largest single institution series of TA‐TMA. The overall efficacy of PE is poor; however, patients who present with TA‐TMA ≥100 days after transplant may have better outcome and lower mortality. J. Clin. Apheresis 30:147–153, 2015. © 2014 Wiley Periodicals, Inc.
    Keywords: Microangiopathic Hemolytic Anemia ; Thrombotic Thrombocytopenic Purpura ; Adamts13
    ISSN: 0733-2459
    E-ISSN: 1098-1101
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  • 10
    In: Transfusion, June 2016, Vol.56(6), pp.1258-1258
    Description: Byline: Gavin W. Roddy, Justin D. Kreuter, Brian D. Koh, Andrew J. Barkmeier ***** No abstract is available for this article. ***** Article Note: Funded by an unrestricted grant from Research to Prevent Blindness.
    Keywords: Fluorescein Angiography–Adverse Effects ; Humans–Adverse Effects ; Male–Diagnosis ; Middle Aged–Etiology ; Platelet Transfusion–Pathology ; Plateletpheresis–Diagnosis ; Retinal Vein Occlusion–Etiology ; Risk Factors–Pathology ; Thrombosis–Pathology;
    ISSN: 0041-1132
    E-ISSN: 1537-2995
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