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  • 1
    Language: English
    In: Journal of Pharmacological Sciences, 2011, Vol.115, Suppl. l.2, pp.132-132
    ISSN: 1347-8613
    Source: Medical*Online (Meteo, Inc.)
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  • 2
    Language: English
    In: Circulation, Nov 8, 2016, Vol.134(19)
    Keywords: Heart Transplantation -- Usage ; Heart Failure -- Care And Treatment ; Treatment Outcome -- Analysis
    ISSN: 0009-7322
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  • 3
    In: Circulation, 2016, Vol.134(Suppl_1 Suppl 1), pp.A17506-A17506
    Description: Background: Primary graft failure (PGF) is associated with poor outcome after heart transplantation (HTX). While donor factors have been intensively studied as a cause of PGF, recipient factors are not fully understood. We herein hypothesized that systemic inflammatory response in the recipient, triggered by operative intervention, may be associated with PGF post- HTX.Method: An institutional consecutive series of 57 patients undergoing adult HTX since 2007 were enrolled in this study. Blood plasma was sampled before cardiopulmonary bypass, at the time of donor heart reperfusion, at 1 hour and at 24 hours after reperfusion to measure interleukin (IL)-6 and IL-8. PGF was defined according to the severity scale by The International Society of Heart Lung Transplantation consensus meeting 2014. The cohort was divided into 14 patients (24.5%) developing moderate to severe PGF and the remaining 43 patients.Result: Donor factors, such as age, gender, cardiac function or ischemic time, were not significantly different between the 2 groups. In addition, background or characteristics of the recipients, including age, gender, assist device or preoperative status, was not significantly different between the 2 groups. Although IL-6 was not different between the 2 groups prior to the cardiopulmonary bypass, the PGF group exhibited a significantly higher IL-6 than the non-PGF group at the time of reperfusion, 1 hour and 24 hours after reperfusion. In contrast, IL-8 was not significantly different over the study period. Interestingly, hemoglobin level at the time of reperfusion was significantly lower in the PGF group (7.8±1.2 mg/dl) than that in the non-PGF group (9.3±1.1 mg/dl, P 〈0.0001). Among studied parameters, hemoglobin was a sole factor that was significantly correlated with plasma IL-6 at the time of reperfusion (r = -0.618, P = 0.0206) with areas under the receiver operating characteristic curves being 0.825. The cutoff level of hemoglobin was 9.1 mg/dl with a sensitivity and specificity of 100% and 56%, respectively.Conclusions: PGF after HTX was related to plasma IL-6 and hemoglobin levels of the recipient at the time of the reperfusion of the donor heart, suggesting that perioperative management of the recipient may be important to prevent PGF post-HTX.
    ISSN: 0009-7322
    Source: Copyright © 2013 Lippincott Williams & Wilkins. All rights reserved.〈img src=http://exlibris-pub.s3.amazonaws.com/LWW%20logo.png style="vertical-align:middle;margin-left:7px"〉
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  • 4
    Language: English
    In: Pharmacology, Biochemistry and Behavior, February 2018, Vol.165, pp.9-13
    Description: Trifluoperazine, a typical antipsychotic drug, not only antagonizes dopamine D receptors but also enhances serotonin 5-HT receptor-mediated behavior. Moreover, trifluoperazine suppresses human purinergic receptor P2X7 responses and calmodulin. However, the effect of trifluoperazine on marble-burying behavior, which has been considered an animal model of obsessive–compulsive disorder (OCD), has not been studied. Here, we examined the effect of trifluoperazine on marble-burying behavior in mice. Oral administration of paroxetine, a selective serotonin reuptake inhibitor, significantly reduced marble-burying behavior without affecting total locomotor activity. Similar results were obtained for trifluoperazine (3 mg/kg). The D receptor agonist, quinpirole (0.03 mg/kg, intraperitoneal [i.p.]), and 5-HT receptor antagonist, ketanserin (0.3 mg/kg, i.p.), significantly counteracted this reduction of marble-burying behavior by trifluoperazine. These results show that trifluoperazine reduces marble-burying behavior via D and 5-HT receptors, and may be a useful drug for the treatment of OCD.
    Keywords: Marble-Burying Behavior ; Trifluoperazine ; Obsessive–Compulsive Disorder ; Pharmacy, Therapeutics, & Pharmacology ; Psychology
    ISSN: 0091-3057
    E-ISSN: 1873-5177
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  • 5
    Language: English
    In: 2012, Vol.7(10), p.e48034
    Description: The astrocyte is a major glial cell type of the brain, and plays key roles in the formation, maturation, stabilization and elimination of synapses. Thus, changes in astrocyte condition and age can influence information processing at synapses. However, whether and how aging astrocytes affect synaptic function and maturation have not yet been thoroughly investigated. Here, we show the effects of prolonged culture on the ability of astrocytes to induce synapse formation and to modify synaptic transmission, using cultured autaptic neurons. By 9 weeks in culture, astrocytes derived from the mouse cerebral cortex demonstrated increases in β-galactosidase activity and glial fibrillary acidic protein (GFAP) expression, both of which are characteristic of aging and glial activation in vitro . Autaptic hippocampal neurons plated on these aging astrocytes showed a smaller amount of evoked release of the excitatory neurotransmitter glutamate, and a lower frequency of miniature release of glutamate, both of which were attributable to a reduction in the pool of readily releasable synaptic vesicles. Other features of synaptogenesis and synaptic transmission were retained, for example the ability to induce structural synapses, the presynaptic release probability, the fraction of functional presynaptic nerve terminals, and the ability to recruit functional AMPA and NMDA glutamate receptors to synapses. Thus the presence of aging astrocytes affects the efficiency of synaptic transmission. Given that the pool of readily releasable vesicles is also small at immature synapses, our results are consistent with astrocytic aging leading to retarded synapse maturation.
    Keywords: Research Article ; Biology ; Physiology ; Cell Biology ; Neuroscience ; Biochemistry
    E-ISSN: 1932-6203
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  • 6
    In: Circulation, 2015, Vol.132(Suppl_3 Suppl 3), pp.A13871-A13871
    Description: Introduction: The aim of this study was to evaluate and compare health-related quality of life (HRQoL) in patients waiting for heart transplantation (HTx) on inotropic support or on left ventricular assist device (LVAD) support and in patients after HTx.Methods: A prospective, comparative design was used to characterize changes over time in HRQoL (SF-36) in patients waiting for HTx on inotropic support (Group-Ino: n = 12) or on LVAD support (Group-LVAD: n = 16) and in patients after HTx (Group:HTx: n = 19).Results: LVAD or HTx free survivals at 1 and 2 years of Group-Ino, Group-LVAD, and Group-HTx were 44% and 33%, 100% and 82%, and 100% and 100%, respectively. Actuarial survivals at 1 and 5 year of the 3 groups were 100% and 89%, 100% and 100%, and 100% and 100%, respectively. The patients on inotropic support stayed hospitalized all through the waiting time, while 31% of patients on LVAD support went back to work or school, and 63% of patients did so after HTx. The SF-36 psychosocial component scores were unexpectedly high in all the 3 groups: 47.9±10.3 in Group-Ino, 51.4±12.5 in Group-LVAD, and 54.5±7.6 in Group-HTx (norm-based scoring, differences not significant among the 3 groups). On the other hand, the SF-36 physical component score was significantly higher in Group-HTx (45.7±11.7) than in Group-Ino (3.9±11.7, p 〈 0.01) and in Group-LVAD (25.2±18.9, p 〈 0.01). The changes of treatment status resulted in significant increase in the SF-36 physical component scores: Ino --〉 LVAD: 16.7±17.2 points, Ino --〉 HTx: 46.3±12.5 points, LVAD --〉 HTx: 19.6±28.2 points.Conclusion: Although the survival after LVAD implantation was as good as that after HTx, HRQoL in HTx recipients was significantly higher than that in LVAD recipients.
    ISSN: 0009-7322
    Source: Copyright © 2013 Lippincott Williams & Wilkins. All rights reserved.〈img src=http://exlibris-pub.s3.amazonaws.com/LWW%20logo.png style="vertical-align:middle;margin-left:7px"〉
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  • 7
    Language: English
    In: Circulation, Nov 10, 2015, Vol.132(19)
    Keywords: Heart Assist Devices – Usage ; Quality of Life – Analysis ; Heart Transplantation – Usage ; Coronary Heart Disease – Care and Treatment
    ISSN: 0009-7322
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  • 8
    Language: English
    In: Neuroscience Letters, 14 February 2018, Vol.666, pp.98-103
    Description: Perry syndrome is a rare neurodegenerative disease characterized by parkinsonism, depression/apathy, weight loss, and central hypoventilation. Our previously-conducted genome-wide association scan and subsequent studies identified nine mutations in , the largest protein subunit of the dynactin complex, in patients with Perry syndrome. These included G71A in the microtubule-binding cytoskeleton-associated protein Gly-rich domain of p150 . The dynactin complex is essential for function of the microtubule-based cytoplasmic retrograde motor dynein. To test the hypothesis that the G71A mutation in the gene is sufficient to cause Perry syndrome, we generated DCTN1 transgenic mice. These mice initially developed normally, but young animals showed decreased exploratory activity and aged animals showed impaired motor coordination. These behavioral defects parallel apathy-like symptoms and parkinsonism encountered in Perry syndrome. TDP-43 aggregates were not detected in the substantia nigra and cerebral cortex of the transgenic mice, although pathological aggregates of TDP-43 have been considered a major neuropathological feature of Perry syndrome. Our study reveals that a single mutation in the gene recapitulates symptoms of Perry syndrome patients, and provides evidence that DCTN1 transgenic mice represent a novel rodent model of Perry syndrome.
    Keywords: Perry Syndrome ; Distal Hereditary Motor Neuropathy 7b ; Mouse Model ; Dynactin ; Dynein ; Tdp-43 ; Medicine ; Anatomy & Physiology
    ISSN: 0304-3940
    E-ISSN: 1872-7972
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  • 9
    In: Journal of Neurochemistry, December 2017, Vol.143(6), pp.624-634
    Description: Astrocytes are the major glial cell type of the brain, and among their many roles are involved in amyloid β (Aβ) clearance and synapse function. Aβ‐exposed astrocytes lead to reduced glutamatergic synaptic transmission, but enhanced synapse function at the individual level. This suggests that astrocytic pathological changes induced by long‐term Aβ treatment may adversely affect neurotransmission in brain.
    Keywords: Amyloid Β ; Astrocyte ; In vitro ; Synapse ; Synaptic Release
    ISSN: 0022-3042
    E-ISSN: 1471-4159
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  • 10
    Language: English
    In: Journal of Pharmacological Sciences, 2013, Vol.121, Suppl. l, pp.75-75
    ISSN: 1347-8613
    Source: Medical*Online (Meteo, Inc.)
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