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  • 1
    Language: German
    In: DNP - Der Neurologe und Psychiater, 10/2014, Vol.15(10), pp.38-49
    ISSN: 1616-2455
    E-ISSN: 2196-6427
    Source: Springer (via CrossRef)
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  • 2
    Language: English
    In: The Journal of Urology, April 2013, Vol.189(4), pp.e389-e389
    Keywords: Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
    Source: ScienceDirect Journals (Elsevier)
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  • 3
    Language: English
    In: Geriatric Mental Health Care, 9/2013, Vol.1(3), pp.56-62
    ISSN: 22129693
    Source: Elsevier (via CrossRef)
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  • 4
    Language: English
    In: PLoS ONE, 01 January 2014, Vol.9(9), p.e108328
    Description: PURPOSE: Attenuation correction (AC) based on low-dose computed tomography (CT) could be more accurate in brain single-photon emission computed tomography (SPECT) than the widely used Chang method, and, therefore, has the potential to improve both semi-quantitative analysis and visual image...
    Keywords: Sciences (General)
    E-ISSN: 1932-6203
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  • 5
    Language: English
    In: Journal of Neural Transmission, 2015, Vol.122(Supplement 1), pp.19-23
    Description: Major self-mutilation is one of the most hazardous complications encountered in psychiatric patients, and is generally associated with auditory verbal hallucinations as part of a psychotic syndrome. This case report exemplarily discusses the treatment of such hallucinations with repeated (20 sessions) low-frequency (1 Hz) transcranial magnetic stimulation targeting areas of elevated metabolic activity in the temporo-parietal cortex (‘neuronavigated rTMS’), drawing upon experience concerning treatment of a patient with chronic auditory verbal hallucinations that had proved intractable to antipsychotic medication combined with cognitive behavioural therapy, and who had severed a forearm because of the content of these hallucinations. This example of major self-mutilation underscores the urgent requirement for effective management of chronic auditory verbal hallucinations in patients suffering from psychiatric disease, and neuronavigated rTMS represents an approach that deserves further exploration in this regard.
    Keywords: rTMS ; Major self-mutilation ; Chronic verbal hallucinations
    ISSN: 0300-9564
    E-ISSN: 1435-1463
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  • 6
    Language: English
    In: NeuroImage: Clinical, 2015, Vol.8, pp.583-593
    Description: Selecting a set of relevant markers to predict conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD) has become a challenging task given the wealth of regional pathologic information that can be extracted from multimodal imaging data. Here, we used regularized regression approaches with an elastic net penalty for best subset selection of multiregional information from AV45-PET, FDG-PET and volumetric MRI data to predict conversion from MCI to AD. The study sample consisted of 127 MCI subjects from ADNI-2 who had a clinical follow-up between 6 and 31 months. Additional analyses assessed the effect of partial volume correction on predictive performance of AV45- and FDG-PET data. Predictor variables were highly collinear within and across imaging modalities. Penalized Cox regression yielded more parsimonious prediction models compared to unpenalized Cox regression. Within single modalities, time to conversion was best predicted by increased AV45-PET signal in posterior medial and lateral cortical regions, decreased FDG-PET signal in medial temporal and temporobasal regions, and reduced gray matter volume in medial, basal, and lateral temporal regions. Logistic regression models reached up to 72% cross-validated accuracy for prediction of conversion status, which was comparable to cross-validated accuracy of non-linear support vector machine classification. Regularized regression outperformed unpenalized stepwise regression when number of parameters approached or exceeded the number of training cases. Partial volume correction had a negative effect on the predictive performance of AV45-PET, but slightly improved the predictive value of FDG-PET data. Penalized regression yielded more parsimonious models than unpenalized stepwise regression for the integration of multiregional and multimodal imaging information. The advantage of penalized regression was particularly strong with a high number of collinear predictors.
    Keywords: Medicine
    ISSN: 2213-1582
    E-ISSN: 2213-1582
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  • 7
    In: Nuclear Medicine Communications, 2018, Vol.39(3), pp.236-246
    Description: OBJECTIVES: Peptide receptor radionuclide therapy (PRRT) with lutetium-177 (Lu)-DOTATATE is regarded as a safe treatment option with promising results for patients with neuroendocrine neoplasia (NEN). We aimed to study the absorbed organ and tumor doses, the renal and hematological toxicity as well as their mutual interaction. Another aim was the identification of adverse effects as possible predictors which may affect survival. METHODS: A total of 30 (14 female and 16 male) patients with inoperable/metastatic NEN were treated with 7.4 GBq of Lu-DOTATATE. Occurrence of renal and hematological toxicity wasretrospectively studied. Morever, we examined the effects of hematological toxicity on survival after Lu-DOTATATE-PRRT. RESULTS: In 49 treatment cycles, the mean absorbed dose to the kidneys was 5.13±2.12, 4.49±2.49 Gy to the liver, and 14.44±8.97 Gy to the spleen, whereas tumor lesions absorbed a mean dose of 31.43±36.86 Gy. Comparing different localizations of metastases, no significant differences in absorbed dose were observed. Clinical response status revealed regressive disease in 47.6%, stable disease in 38.1%, and progressive disease in 14.3% of cases (n=21). Biochemically, 81.3% of patients showed reduced serotonin values (n=16; P〈0.05) following Lu-DOTATATE-PRRT. No severe subacute renal or hematological toxicity occurred (one Common Terminology Criteria for Adverse Events-grade 3 for thrombocytopenia and another one for leukocytopenia). No statistically significant relation between baseline kidney function and post-therapeutic hematological changes was identified. CONCLUSION: The findings indicate that Lu-DOTATATE-PRRT is a safe and effective treatment method for patients with NEN. Moreover, these data strongly suggest that hematological parameters may affect survival so a further re-evaluation in prospective studies is warranted.
    Keywords: Lutetium Lu 177 Dotatate – Health Aspects ; Neuroendocrine Tumors – Care and Treatment ; Peptide Receptor Radionuclide Therapy – Usage ; Peptide Receptor Radionuclide Therapy – Health Aspects;
    ISSN: 0143-3636
    E-ISSN: 14735628
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  • 8
    Language: English
    In: European Radiology, 2015, Vol.25(9), pp.2709-2717
    Description: Byline: Catharina Lange (1), Jens Kurth (2), Anita Seese (3), Sarah Schwarzenbock (2), Karen Steinhoff (3), Bert Umland-Seidler (4), Bernd J. Krause (2), Winfried Brenner (1), Osama Sabri (3), Swen Hesse (3), Ralph Buchert (1) Keywords: I-123-ioflupane; Attenuation correction; Chang; Contour delineation; Stereotactical normalization Abstract: Objectives Chang's method, the most widely used attenuation correction (AC) in brain single-photon emission computed tomography (SPECT), requires delineation of the outer contour of the head. Manual and automatic threshold-based methods are prone to errors due to variability of tracer uptake in the scalp. The present study proposes a new method for fully automated delineation of the head based on stereotactical normalization. The method was validated for SPECT with I-123-ioflupane. Methods The new method was compared to threshold-based delineation in 62 unselected patients who had received I-123-ioflupane SPECT at one of 3 centres. The impact on diagnostic power was tested for semi-quantitative analysis and visual reading of the SPECT images (six independent readers). Results The two delineation methods produced highly consistent semi-quantitative results. This was confirmed by receiver operating characteristic analyses in which the putamen specific-to-background ratio achieved highest area under the curve with negligible effect of the delineation method: 0.935 versus 0.938 for stereotactical normalization and threshold-based delineation, respectively. Visual interpretation of DVR images was also not affected by the delineation method. Conclusions Delineation of the head contour by stereotactical normalization appears useful for Chang AC in I-123-ioflupane SPECT. It is robust and does not require user interaction. Key Points acentsChang attenuation correction in brain SPECT requires delineation of the head contour. acentsManual and threshold-based methods are prone to errors. acentsThe study proposes a fully-automated method for delineation based on stereotactical normalization. acentsThe method is shown to work reliably in I-123-ioflupane SPECT. acentsIt might improve the workflow of I-123-ioflupane SPECT in everyday patient care. Author Affiliation: (1) Department of Nuclear Medicine, Charite - Universitatsmedizin Berlin, Chariteplatz 1, 10117, Berlin, Germany (2) Department of Nuclear Medicine, Universitatsmedizin Rostock, 18057, Rostock, Germany (3) Department of Nuclear Medicine, Universitatsklinikum Leipzig, 04103, Leipzig, Germany (4) GE Healthcare Buchler GmbH & Co. KG, 80807, Munich, Germany Article History: Registration Date: 12/02/2015 Received Date: 29/09/2014 Accepted Date: 12/02/2015 Online Date: 26/02/2015
    Keywords: I-123-ioflupane ; Attenuation correction ; Chang ; Contour delineation ; Stereotactical normalization
    ISSN: 0938-7994
    E-ISSN: 1432-1084
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  • 9
    Language: English
    In: Molecules, 01 March 2018, Vol.23(3), p.587
    Description: Intrastriatal injection of botulinum neurotoxin A (BoNT-A) results in improved motor behavior of hemiparkinsonian (hemi-PD) rats, an animal model for Parkinson’s disease. The caudate–putamen (CPu), as the main input nucleus of the basal ganglia loop, is fundamentally involved in motor function...
    Keywords: D2/D3 Receptors ; Hemiparkinsonian Rat Model ; Botulinum Neurotoxin A ; Basal Ganglia ; Striatum ; Parkinson’s Disease ; Small Animal Imaging ; Pet/CT ; [18f]Fallypride ; Mri ; Chemistry
    E-ISSN: 1420-3049
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  • 10
    Language: English
    In: Journal of neural transmission (Vienna, Austria : 1996), August 2015, Vol.122 Suppl 1, pp.S19-23
    Description: Major self-mutilation is one of the most hazardous complications encountered in psychiatric patients, and is generally associated with auditory verbal hallucinations as part of a psychotic syndrome. This case report exemplarily discusses the treatment of such hallucinations with repeated (20 sessions) low-frequency (1 Hz) transcranial magnetic stimulation targeting areas of elevated metabolic activity in the temporo-parietal cortex ('neuronavigated rTMS'), drawing upon experience concerning treatment of a patient with chronic auditory verbal hallucinations that had proved intractable to antipsychotic medication combined with cognitive behavioural therapy, and who had severed a forearm because of the content of these hallucinations. This example of major self-mutilation underscores the urgent requirement for effective management of chronic auditory verbal hallucinations in patients suffering from psychiatric disease, and neuronavigated rTMS represents an approach that deserves further exploration in this regard.
    Keywords: Hallucinations -- Etiology ; Schizophrenia -- Complications ; Self-Injurious Behavior -- Therapy ; Transcranial Magnetic Stimulation -- Methods
    ISSN: 03009564
    E-ISSN: 1435-1463
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
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