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  • 1
    Language: English
    In: Current hematologic malignancy reports, December 2013, Vol.8(4), pp.333-41
    Description: Although the revised World Health Organization (WHO) criteria for the diagnosis and classification of myeloproliferative neoplasms (MPN) were defined by a panel of expert hematopathologists and clinicians, controversy has been repeatedly expressed questioning the clinical usefulness and reproducibility of these diagnostic guidelines. In particular, the distinction between essential thrombocythemia (ET), early/prefibrotic primary myelofibrosis (PMF) and initial stages of polycythemia vera (PV) is still a matter of debate. In this context, it has been argued that clinical correlations with histological features were not firmly substantiated. On the other hand, recently published data from independently performed studies have repeatedly validated the reproducibility of the WHO criteria and provided persuasive evidence that discrimination of early/prefibrotic PMF has a significant impact on the risk of myelofibrotic and leukemic transformation. However, as has been explicitly required, the WHO concept is based on the recognition of characteristic bone marrow patterns and a consensus of clinical and molecular data.
    Keywords: Polycythemia -- Classification ; Primary Myelofibrosis -- Classification ; Thrombocythemia, Essential -- Classification
    ISSN: 15588211
    E-ISSN: 1558-822X
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  • 2
    Language: English
    In: The Lancet Haematology, July 2017, Vol.4(7), pp.e305-e306
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/S2352-3026(17)30102-3 Byline: Hans Michael Kvasnicka (a) Author Affiliation: (a) Senckenberg Institute of Pathology, University of Frankfurt, Frankfurt, 60590, Germany
    Keywords: Medicine
    ISSN: 2352-3026
    E-ISSN: 2352-3026
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  • 3
    Language: English
    In: Cancer Research, 07/01/2018, Vol.78(13 Supplement), pp.1500-1500
    ISSN: 0008-5472
    E-ISSN: 1538-7445
    Source: CrossRef
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  • 4
    In: LaboratoriumsMedizin, 01/1/2015, Vol.39(5)
    ISSN: 0342-3026
    E-ISSN: 1439-0477
    Source: Walter de Gruyter (via CrossRef)
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  • 5
    Language: English
    In: Managing Myeloproliferative Neoplasms: A Case-Based Approach, pp.22-36
    Keywords: Medicine
    ISBN: 9781107444430
    ISBN: 1107444438
    Source: Cambridge Core All Books (Cambridge University Press)〈img src=https://exlibris-pub.s3.amazonaws.com/CUP%20logo%20%282%29.gif style="vertical-align:middle;margin-left:7px"〉
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  • 6
    In: Circulation: Journal of the American Heart Association, 2003, Vol.108(8), pp.e60-e60
    Description: To the Editor: We have read with interest the recently reported results of Deb et al,1 in which the authors claim that for the first time, human bone marrow was established as a source of extracardiac progenitor cells capable of de novo cardiomyocyte formation. In this context, we would like to refer to a previously published paper from our laboratory2 reporting that gender-mismatched transplantation of unmanipulated bone marrow from female donors generated chimeric cardiomyocytes and endothelial cells in cadaver hearts of 5 male patients. Controversy arises concerning quantification of this phenomenon, which is of great clinical importance concerning myocardial regeneration and revascularization.3 Recognition of chimeric cardiomyocytes in sections of heart muscle tissue is hampered by several obstacles, among which are the technique of fluorescence in situ hybridization (FISH), method of counting, influence of a certain section plane, and autolytic changes in postmortem tissue. Unfortunately, in the study by Deb et …
    Keywords: Medicine ; Anatomy & Physiology;
    ISSN: 0009-7322
    ISSN: 15244539
    E-ISSN: 15244539
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  • 7
    Language: English
    In: Blood, 26 May 2011, Vol.117(21), pp.5710-8
    Description: Controversy persists regarding the role of histopathology in the distinction between essential thrombocythemia (ET) and early-prefibrotic primary myelofi-brosis (PMF) presenting with thrombocythemia. To investigate the impact and reproducibility of bone marrow (BM) morphology according to the World Health Organization classification, 295 patients with the presumptive clinical diagnosis of either ET or early PMF were studied. Data of this cohort (Vienna group) were compared with 732 corresponding patients (Cologne group). Evaluating blindly (only age and gender known) BM specimens, the 2 groups of pathologists achieved an overall consensus of 78% regarding the total series and 88% concerning the discrimination between ET versus PMF. In 126 ET and 81 early PMF patients without pretreatment and complete documentation, a 90% concordance with the independently established clinical diagnosis was found. In 12 patients, overlapping of histopathology and some clinical findings between ET and polycythemia vera occurred. Contrasting ET, early PMF showed significant differences of presenting hematologic data and an unfavorable prognosis (estimated mean survival, 14 vs 21 years). Comparison of clinical and survival data of the Vienna cohort with the historical Cologne series revealed an overall congruence. This study highlights the impact of BM morphology for the differentiation between true vs false ET.
    Keywords: Bone Marrow -- Pathology ; Primary Myelofibrosis -- Classification ; Thrombocythemia, Essential -- Classification
    ISSN: 00064971
    E-ISSN: 1528-0020
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  • 8
    In: Cancer, August 15, 1997, Vol.80(4), p.708(12)
    Description: Prognostic variables for idiopathic (primary) osteomyelofibrosis (IMF) are ill-defined because of the lack of large control studies based on uniform diagnostic criteria. A retrospective clinicopathologic study was performed on 250 consecutively recruited patients (115 males and 135 females) with an established diagnosis of IMF. In contrast to previous studies, the current study cohort encompassed the full spectrum of initial to advanced stages of the disease process according to laboratory data and particularly histology. Because of the relatively high patient age on admission (median, 66.5 years), relative survival rates with corresponding life expectancies and disease specific life loss were calculated. Moreover, a classification and regression tree (CART) analysis was performed to segregate the study patients into subgroups with significantly different prognosis. Analysis of the life expectancy and the proportion of deaths attributable to IMF showed a global reduction in life expectancy of 31%. Further calculation disclosed a consistently greater impact of disease in older patients. Age, hemoglobin level on admission, and leukocyte and thrombocyte counts remained as the most relevant parameters for prognosis in multivariate consideration (CART analysis) and facilitated a clear-cut separation into three risk groups. The life expectancy of low risk patients was approximately 10 times higher than that of high risk patients (22.07 years vs. 2.25 years). These results are in keeping with the assumption that features signaling bone marrow insufficiency are associated with a worsening of survival. Generalization, indicated by myeloid metaplasia, can occur at every stage, even in so-called hypercellular phases of IMF. Conversely, myelofibrosis alone is not necessarily predictive of poor survival.
    Keywords: Myelofibrosis -- Prognosis
    ISSN: 0008-543X
    E-ISSN: 10970142
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  • 9
    Language: English
    In: American Journal of Hematology, February 2012, Vol.87(2), pp.203-204
    Description: Byline: Alessandra Carobbio, Guido Finazzi, Juergen Thiele, Hans-Michael Kvasnicka, Francesco Passamonti, Elisa Rumi, Marco Ruggeri, Francesco Rodeghiero, Maria Luigia Randi, Irene Bertozzi, Alessandro M. Vannucchi, Elisabetta Antonioli, Heinz Gisslinger, Veronika Buxhofer-Ausch, Naseema Gangat, Alessandro Rambaldi, Ayalew Tefferi, Tiziano Barbui ***** No abstract is available for this article. ***** Author Affiliation: Division of Hematology, Ospedali Riuniti di Bergamo, Bergamo, Italy Institute of Pathology, University of Cologne, Cologne, Germany Senckenberg Institute of Pathology, University of Frankfurt, Frankfurt Germany Division of Hematology, Ospedale di Circolo e Fondazione Macchi, Polo Universitario, Varese Italy Division of Hematology, University of Pavia, I.R.C.C.S. Policlinico San Matteo, Pavia Italy Division of Hematology, S. Bortolo Hospital, Vicenza, Italy Department of Internal Medicine, University of Padua, Padua Italy Section of Hematology, University of Florence, Florence, Italy Department of Internal Medicine I, Section of Hematology, Medical University of Vienna Vienna, Austria Division of Hematology, Mayo Clinic, Rochester, Minnesota Ospedali Riuniti di Bergamo, Bergamo, Italy Division of Hematology, Ospedali Riuniti di Bergamo, Bergamo, Italy Institute of Pathology, University of Cologne, Cologne, Germany Senckenberg Institute of Pathology, University of Frankfurt, Frankfurt Germany Division of Hematology, Ospedale di Circolo e Fondazione Macchi, Polo Universitario, Varese Italy Division of Hematology, University of Pavia, I.R.C.C.S. Policlinico San Matteo, Pavia Italy Division of Hematology, S. Bortolo Hospital, Vicenza, Italy Department of Internal Medicine, University of Padua, Padua Italy Section of Hematology, University of Florence, Florence, Italy Department of Internal Medicine I, Section of Hematology, Medical University of Vienna Vienna, Austria Division of Hematology, Mayo Clinic, Rochester, Minnesota Article Note: (*) Conflict of interest: Nothing to report.
    Keywords: Medical Research ; Blood Tests;
    ISSN: 0361-8609
    E-ISSN: 1096-8652
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  • 10
    Language: English
    In: Oncology Reports, March, 2016, Vol.35(3), p.1629(7)
    Keywords: Testicular Cancer -- Genetic Aspects ; Testicular Cancer -- Development And Progression ; Cellular Proteins -- Health Aspects ; Autophagy (Cytology) -- Genetic Aspects ; Autophagy (Cytology) -- Health Aspects
    ISSN: 1021-335X
    Source: Cengage Learning, Inc.
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