PLoS ONE, 2010, Vol.5(9), p.e12925
Vitamin D 3 , the most physiologically relevant form of vitamin D, is an essential organic compound that has been shown to have a crucial effect on the immune responses. Vitamin D 3 ameliorates the onset of the experimental autoimmune encephalomyelitis (EAE); however, the direct effect of vitamin D 3 on T cells is largely unknown. ; In an system using cells from mice, the active form of vitamin D (1,25-dihydroxyvitamin D) suppresses both interleukin (IL)-17-producing T cells (T17) and regulatory T cells (Treg) differentiation via a vitamin D receptor signal. The ability of 1,25-dihydroxyvitamin D (1,25(OH)D) to reduce the amount of IL-2 regulates the generation of Treg cells, but not T17 cells. Under T17-polarizing conditions, 1,25(OH)D helps to increase the numbers of IL-10-producing T cells, but 1,25(OH)D's negative regulation of T17 development is still defined in the IL-10 T cells. Although the STAT1 signal reciprocally affects the secretion of IL-10 and IL-17, 1,25(OH)D inhibits IL-17 production in STAT1 T cells. Most interestingly, 1,25(OH)D negatively regulates CCR6 expression which might be essential for T17 cells to enter the central nervous system and initiate EAE. ; Our present results in an experimental murine model suggest that 1,25(OH)D can directly regulate T cell differentiation and could be applied in preventive and therapeutic strategies for T17-mediated autoimmune diseases.
Research Article ; Immunology -- Autoimmunity ; Immunology -- Immune Response ; Immunology -- Leukocyte Development