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  • 1
    UID:
    b3kat_BV001246101
    Format: 168 S.
    Note: Göttingen, Univ., Diss., 1985
    Language: German
    Keywords: CARS-Spektroskopie ; Cycloheptatrienderivate ; Flugzeitmassenspektrometer ; Hochschulschrift
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  • 2
  • 3
    UID:
    gbv_1022318993
    Format: xvi, 120 Seiten , Illustrationen, Diagramme
    Content: In Germany more than 200.000 persons die of cancer every year, which makes it the second most common cause of death. Chemotherapy and radiation therapy are often combined to exploit a supra-additive effect, as some chemotherapeutic agents like halogenated nucleobases sensitize the cancerous tissue to radiation. The radiosensitizing action of certain therapeutic agents can be at least partly assigned to their interaction with secondary low energy electrons (LEEs) that are generated along the track of the ionizing radiation. In the therapy of cancer DNA is an important target, as severe DNA damage like double strand breaks induce the cell death. As there is only a limited number of radiosensitizing agents in clinical practice, which are often strongly cytotoxic, it would be beneficial to get a deeper understanding of the interaction of less toxic potential radiosensitizers with secondary reactive species like LEEs. Beyond that LEEs can be generated by laser illuminated nanoparticles that are applied in photothermal therapy (PTT) of […]
    Note: Enthält 5 Publikationen , Dissertation University of Potsdam, Mathematisch-Naturwissenschaftliche Fakultät 2017
    Additional Edition: Erscheint auch als Online-Ausgabe Schürmann, Robin Interaction of the potential DNA-radiosensitizer 8-bromoadenine with free and plasmonically generated electrons Potsdam, 2018
    Language: English
    Keywords: Krebs ; Strahlentherapie ; Chemotherapie ; Radiosensibilisator ; Langsames Elektron ; DNS ; Bromorganische Verbindungen ; Elektronenanlagerungsreaktion ; Nanostruktur ; Hochschulschrift
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  • 4
    UID:
    gbv_871684322
    Format: 143 Seiten , Illustrationen, Diagramme
    Content: The aim of this thesis was the elucidation of different ionization methods (resonance-enhanced multiphoton ionization – REMPI, electrospray ionization – ESI, atmospheric pressure chemical ionization – APCI) in ion mobility (IM) spectrometry. In order to gain a better understanding of the ionization processes, several spectroscopic, mass spectrometric and theoretical methods were also used. Another focus was the development of experimental techniques, including a high resolution spectrograph and various combinations of IM and mass spectrometry.The novel high resolution 2D spectrograph facilitates spectroscopic resolutions in the range of commercial echelle spectrographs. The lowest full width at half maximum of a peak achieved was 25 pm. The 2D spectrograph is based on the wavelength separation of light by the combination of a prism and a grating in one dimension, and an etalon in the second dimension. This instrument was successfully employed for the acquisition of Raman and laser-induced breakdown spectra.Different spectroscopic …
    Note: Dissertation Universität Potsdam 2016
    Additional Edition: Erscheint auch als Online-Ausgabe Riebe, Daniel Experimental and theoretical investigations of molecular ions by spectroscopy as well as ion mobility and mass spectrometry Potsdam, 2016
    Language: English
    Keywords: Ionenbeweglichkeitsspektroskopie ; Ionenbeweglichkeit ; Ionenfallen-Massenspektrometrie ; Hochschulschrift
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  • 5
    UID:
    gbv_1818949024
    Format: 1 Online-Ressource (IX, 96 Seiten ; 20348 KB) , Illustrationen, Diagramme
    Content: The doctoral thesis presented provides a comprehensive view of laser-based ablation techniques promoted to new fields of operation, including, but not limited to, size, composition, and concentration analyses. It covers various applications of laser ablation techniques over a wide range of sizes, from single molecules all the way to aerosol particles. The research for this thesis started with broadening and deepening the field of application and the fundamental understanding of liquid-phase IR-MALDI. Here, the hybridization of ion mobility spectrometry and microfluidics was realized by using IR-MALDI as the coupling technique for the first time. The setup was used for monitoring the photocatalytic performance of the E-Z isomerization of olefins. Using this hybrid, measurement times were so drastically reduced that such photocatalyst screenings became a matter of minutes rather than hours. With this on hand, triple measurements screenings could not only be performed within ten minutes, but also with a minimum amount of resources ...
    Note: kumulative Dissertation , Dissertation Universität Potsdam 2022
    Additional Edition: Erscheint auch als Druck-Ausgabe Prüfert, Christian Laser ablation and matter sizing Potsdam, 2022
    Language: English
    Keywords: Hochschulschrift
    Author information: Sielemann, Stefanie 1970-
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  • 6
    UID:
    gbv_1817197096
    Format: 1 Online-Ressource (v, 68 Seiten, 3332 KB) , Illustrationen, Diagramme
    Content: One aspect of achieving a more sustainable chemical industry is the minimization of the usage of solvents and chemicals. Thus, optimization and development of chemical processes for large-scale production is favourably performed in small batches. The critical step in this approach is upscaling the batches from the small reaction systems to the large reactors mandatory for cost efficient production in an industrial environment. Scaling up the bulk volume always goes along with increasing the surface where the reaction medium is in contact with the confining vessel. Since volume scales proportional with the cubic dimension while the surface scales quadratic, their ratio is size-dependent. The influence of reaction vessel walls can change the reaction performance. A number of phenomena occurring at the surface-liquid interface can affect reaction rates and yields, resulting in possible difficulties in predicting and extrapolating from small size production scale to large industrial processes. The application of levitated droplets as a ...
    Note: kumulative Dissertation , Dissertation Universität Potsdam 2022
    Additional Edition: Erscheint auch als Druck-Ausgabe Michalik-Onichimowska, Aleksandra Real-time monitoring of (photo)chemical reactions in micro flow reactors and levitated droplets by IR-MALDI ion mobility and mass spectrometry Potsdam, 2022
    Language: English
    Keywords: Hochschulschrift
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  • 7
    UID:
    gbv_272821594
    Format: 168 S , Ill., graph. Darst
    Note: Göttingen, Univ., Diss., 1985
    Language: Undetermined
    Keywords: Hochschulschrift
    Library Location Call Number Volume/Issue/Year Availability
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  • 8
    UID:
    gbv_1022318098
    Format: 1 Online-Ressource (xvi, 120 Seiten, 6887 KB) , Illustrationen, Diagramme
    Content: In Germany more than 200.000 persons die of cancer every year, which makes it the second most common cause of death. Chemotherapy and radiation therapy are often combined to exploit a supra-additive effect, as some chemotherapeutic agents like halogenated nucleobases sensitize the cancerous tissue to radiation. The radiosensitizing action of certain therapeutic agents can be at least partly assigned to their interaction with secondary low energy electrons (LEEs) that are generated along the track of the ionizing radiation. In the therapy of cancer DNA is an important target, as severe DNA damage like double strand breaks induce the cell death. As there is only a limited number of radiosensitizing agents in clinical practice, which are often strongly cytotoxic, it would be beneficial to get a deeper understanding of the interaction of less toxic potential radiosensitizers with secondary reactive species like LEEs. Beyond that LEEs can be generated by laser illuminated nanoparticles that are applied in photothermal therapy (PTT) of […]
    Note: Dissertation Universität Potsdam, Mathematisch-Naturwissenschaftliche Fakultät 2017
    Additional Edition: Erscheint auch als Druck-Ausgabe Schürmann, Robin Interaction of the potential DNA-radiosensitizer 8-bromoadenine with free and plasmonically generated electrons Potsdam, 2017
    Language: English
    Keywords: Krebs ; Strahlentherapie ; Chemotherapie ; Radiosensibilisator ; Langsames Elektron ; DNS ; Bromorganische Verbindungen ; Elektronenanlagerungsreaktion ; Nanostruktur ; Hochschulschrift
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  • 9
    UID:
    gbv_1772558850
    Format: 102, xviii Seiten , Illustrationen, Diagramme
    Content: Die vorgelegte Arbeit besteht aus drei Teilprojekten, der Realisierung eines Multiparametersensors (Temperatur, pH-Wert und Sauerstoffkonzentration), der Konzipierung und Untersuchung eines optischen Atemgassensors und Untersuchungen zur Anwendung des Konzeptes der Sauerstofflöschung in der Immuntechnologie. Zur Realisierung des Multiparametersensors wurden die einzelnen Sensorfarbstoffe, sofern notwendig, synthetisiert und anschließend einzeln unter Laborbedingungen charakterisiert. Im weiteren Verlauf wurde ein Versuchsaufbau konzipiert mit dem es möglich ist, alle verwendeten Sensorfarbstoffe mit einer Anregungsquelle anzuregen. Dabei erfolgte die Detektion der Parameter Temperatur und Sauerstoffkonzentration mittels Phasenmodulationsspektroskopie und die pH-Wert-bestimmung mittels stationärer Fluoreszenzspektroskopie. So konnte ein Multiparametersensor konzipiert werden, mit dem es möglich ist, die drei genannten Parameter simultan, in Echtzeit und ohne externe Temperaturmessung zu detektieren. Im Rahmen der Entwicklung eines optischen Atemgassensors konnte zunächst eine neue Sensorform entwickelt werden. [...]
    Note: Dissertation Universität Potsdam 2020
    Language: German
    Keywords: Sauerstoffsensor ; Phasenmodulation ; Spektroskopie ; Hochschulschrift
    Author information: Kumke, Michael Uwe 1963-
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  • 10
    UID:
    gbv_1817197266
    Format: v, 68 Seiten , Illustrationen, Diagramme
    Content: One aspect of achieving a more sustainable chemical industry is the minimization of the usage of solvents and chemicals. Thus, optimization and development of chemical processes for large-scale production is favourably performed in small batches. The critical step in this approach is upscaling the batches from the small reaction systems to the large reactors mandatory for cost efficient production in an industrial environment. Scaling up the bulk volume always goes along with increasing the surface where the reaction medium is in contact with the confining vessel. Since volume scales proportional with the cubic dimension while the surface scales quadratic, their ratio is size-dependent. The influence of reaction vessel walls can change the reaction performance. A number of phenomena occurring at the surface-liquid interface can affect reaction rates and yields, resulting in possible difficulties in predicting and extrapolating from small size production scale to large industrial processes. The application of levitated droplets as a ...
    Note: kumulative Dissertation , Dissertation Universität Potsdam 2022
    Additional Edition: Erscheint auch als Online-Ausgabe Michalik-Onichimowska, Aleksandra Real-time monitoring of (photo)chemical reactions in micro flow reactors and levitated droplets by IR-MALDI ion mobility and mass spectrometry Potsdam, 2022
    Language: English
    Keywords: Hochschulschrift
    Library Location Call Number Volume/Issue/Year Availability
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