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Predicting the functional repertoire of an organism from unassembled RNA–seq data (2014)

Landesfeind, Manuel [Verfasser] ; Meinicke, Peter [Mitwirkender] ; SpringerLink (Online service)

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UID:

(DE-101)1108862241

Format: Online-Ressource , online resource.

ISSN: 1471-2164 , 1471-2164

In: volume:15

In: number:1

In: day:20

In: month:11

In: year:2014

In: pages:1-11

In: date:12.2014

In: BMC genomics, London : BioMed Central, 2000-, 15, Heft 1 (20.11.2014), 1-11, 12.2014, 1471-2164

Language: English

DOI: 10.1186/1471-2164-15-1003

URN: urn:nbn:de:1111-2016072854039

URL: https://doi.org/10.1186/1471-2164-15-1003

URL: https://nbn-resolving.org/urn:nbn:de:1111-2016072854039

URL: https://d-nb.info/1108862241/34

URL: http://dx.doi.org/10.1186/1471-2164-15-1003

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2

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MarVis-Pathway : integrative and exploratory pathway analysis of non-targeted metabolomics data (2015)

Kaever, Alexander [VerfasserIn] ; Landesfeind, Manuel [VerfasserIn] ; Feussner, Kirstin [VerfasserIn] ; [et al.]

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UID:

(DE-627)1699190658

Format: Diagramme

ISSN: 1573-3890

Content: Metabolomics, Metabolic fingerprinting, Mass spectrometry, Metabolic pathways, Set enrichment analysis, Transcriptomics

In: Metabolomics, Berlin : Springer, 2005, 11(2015), 3, Seite 764-777, 1573-3890

In: volume:11

In: year:2015

In: number:3

In: pages:764-777

Language: English

DOI: 10.1007/s11306-014-0734-y

URL: kostenfrei

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3

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Patient derived renal cell carcinoma xenografts exhibit distinct sensitivity patterns in response to antiangiogenic therapy and constitute a suitable tool for biomarker development (2018)

Schüler, Julia [Verfasser] ; Klingner, Kerstin [Verfasser] ; Bug, Daniel [Verfasser] ; [et al.]

Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg

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UID:

(DE-101)1165868601

Format: Online-Ressource

In: In: OncoTarget, 9.2018, Nr. 57, S. 30946-30961, doi:10.18632/oncotarget.25697

Language: English

URN: urn:nbn:de:hebis:30:3-465395

URL: https://nbn-resolving.org/urn:nbn:de:hebis:30:3-465395

URL: https://d-nb.info/1165868601/34

URL: kostenfrei

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4

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Evaluation of molecular subtypes and clonal selection during establishment of patient-derived tumor xenografts from gastric adenocarcinoma (2020)

Peille, Anne Lise [Verfasser] ; Vuaroqueaux, Vincent [Verfasser] ; Wong, Swee-Seong [Verfasser] ; [et al.]

Freiburg : Universität

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UID:

(DE-603)468686053

Format: Online-Ressource

Content: Abstract: Patient-derived xenografts (PDX) have emerged as an important translational research tool for understanding tumor biology and enabling drug efficacy testing. They are established by transfer of patient tumor into immune compromised mice with the intent of using them as Avatars; operating under the assumption that they closely resemble patient tumors. In this study, we established 27 PDX from 100 resected gastric cancers and studied their fidelity in histological and molecular subtypes. We show that the established PDX preserved histology and molecular subtypes of parental tumors. However, in depth investigation of the entire cohort revealed that not all histological and molecular subtypes are established. Also, for the established PDX models, genetic changes are selected at early passages and rare subclones can emerge in PDX. This study highlights the importance of considering the molecular and evolutionary characteristics of PDX for a proper use of such models, particularly for Avatar trials

Note: Communications biology , 3, 1 (2020) , 367, ISSN: 2399-3642

Language: English

DOI: 10.1038/s42003-020-1077-z

URN: urn:nbn:de:bsz:25-freidok-1667684

URL: https://doi.org/10.1038/s42003-020-1077-z

URL: https://nbn-resolving.org/urn:nbn:de:bsz:25-freidok-1667684

URL: kostenfrei

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5

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Author correction: Evaluation of molecular subtypes and clonal selection during establishment of patient-derived tumor xenografts from gastric adenocarcinoma (2020)

Peille, Anne-Lise [VerfasserIn] ; Vuaroqueaux, Vincent [VerfasserIn] ; Wong, Swee-Seong [VerfasserIn] ; [et al.]

London : Springer Nature | Freiburg : Albert-Ludwigs-Universität Freiburg

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UID:

(DE-627)1736170481

Format: 1 Online-Ressource (1 Seite)

ISSN: 2399-3642

In: Communications biology, 3, 1 (2020), 400, 2399-3642

Language: English

DOI: 10.1038/s42003-020-01135-5

URN: urn:nbn:de:bsz:25-freidok-1667915

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6

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Evaluation of molecular subtypes and clonal selection during establishment of patient-derived tumor xenografts from gastric adenocarcinoma (2020)

Peille, Anne Lise [Verfasser] ; Vuaroqueaux, Vincent [Verfasser] ; Wong, Swee-Seong [Verfasser] ; [et al.]

Freiburg : Universität

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UID:

(DE-101)1215499256

Format: Online-Ressource

Content: Abstract: Patient-derived xenografts (PDX) have emerged as an important translational research tool for understanding tumor biology and enabling drug efficacy testing. They are established by transfer of patient tumor into immune compromised mice with the intent of using them as Avatars; operating under the assumption that they closely resemble patient tumors. In this study, we established 27 PDX from 100 resected gastric cancers and studied their fidelity in histological and molecular subtypes. We show that the established PDX preserved histology and molecular subtypes of parental tumors. However, in depth investigation of the entire cohort revealed that not all histological and molecular subtypes are established. Also, for the established PDX models, genetic changes are selected at early passages and rare subclones can emerge in PDX. This study highlights the importance of considering the molecular and evolutionary characteristics of PDX for a proper use of such models, particularly for Avatar trials

Note: Communications biology. - 3, 1 (2020) , 367, ISSN: 2399-3642

Language: English

DOI: 10.1038/s42003-020-1077-z

URN: urn:nbn:de:bsz:25-freidok-1667684

URL: https://doi.org/10.1038/s42003-020-1077-z

URL: https://nbn-resolving.org/urn:nbn:de:bsz:25-freidok-1667684

URL: https://d-nb.info/1215499256/34

URL: kostenfrei

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7

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Author correction: Evaluation of molecular subtypes and clonal selection during establishment of patient-derived tumor xenografts from gastric adenocarcinoma (2020)

Peille, Anne-Lise [Verfasser] ; Vuaroqueaux, Vincent [Verfasser] ; Wong, Swee-Seong [Verfasser] ; [et al.]

Freiburg : Universität

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UID:

(DE-603)468686142

Format: Online-Ressource

Note: Communications biology , 3, 1 (2020) , 400, ISSN: 2399-3642

Language: English

DOI: 10.1038/s42003-020-01135-5

URN: urn:nbn:de:bsz:25-freidok-1667915

URL: https://doi.org/10.1038/s42003-020-01135-5

URL: https://nbn-resolving.org/urn:nbn:de:bsz:25-freidok-1667915

URL: kostenfrei

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8

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Author correction: Evaluation of molecular subtypes and clonal selection during establishment of patient-derived tumor xenografts from gastric adenocarcinoma (2020)

Peille, Anne-Lise [Verfasser] ; Vuaroqueaux, Vincent [Verfasser] ; Wong, Swee-Seong [Verfasser] ; [et al.]

Freiburg : Universität

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UID:

(DE-101)1215499418

Format: Online-Ressource

Note: Communications biology. - 3, 1 (2020) , 400, ISSN: 2399-3642

Language: English

DOI: 10.1038/s42003-020-01135-5

URN: urn:nbn:de:bsz:25-freidok-1667915

URL: https://doi.org/10.1038/s42003-020-01135-5

URL: https://nbn-resolving.org/urn:nbn:de:bsz:25-freidok-1667915

URL: https://d-nb.info/1215499418/34

URL: kostenfrei

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9

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Evaluation of molecular subtypes and clonal selection during establishment of patient-derived tumor xenografts from gastric adenocarcinoma (2020)

Peille, Anne Lise [VerfasserIn] ; Vuaroqueaux, Vincent [VerfasserIn] ; Wong, Swee-Seong [VerfasserIn] ; [et al.]

London : Springer Nature | Freiburg : Albert-Ludwigs-Universität Freiburg

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UID:

(DE-627)1733245200

Format: 1 Online-Ressource (14 Seiten) , Diagramme , 1 Datei (Supplementary information)

ISSN: 2399-3642

Note: Enthält eine pdf-Datei und eine zip-Datei

In: Communications biology, 3, 1 (2020), 367, 2399-3642

Language: English

DOI: 10.1038/s42003-020-1077-z

URN: urn:nbn:de:bsz:25-freidok-1667684

URL: kostenfrei

URL: kostenfrei

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10

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Evaluation of molecular subtypes and clonal selection during establishment of patient-derived tumor xenografts from gastric adenocarcinoma (2020)

Peille, Anne-Lise [Verfasser] ; Vuaroqueaux, Vincent [Verfasser] ; Wong, Swee-Seong [Verfasser] ; [et al.]

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UID:

(DE-101)1226200338

Format: Online-Ressource , online resource.

ISSN: 2399-3642 , 2399-3642

In: volume:3

In: number:1

In: day:9

In: month:7

In: year:2020

In: pages:1-14

In: date:12.2020

In: Communications biology, London : Springer Nature, [2018]-, 3, Heft 1 (9.7.2020), 1-14, 12.2020, 2399-3642

Language: English

DOI: 10.1038/s42003-020-1077-z

URN: urn:nbn:de:101:1-2021020218191064675557

URL: https://doi.org/10.1038/s42003-020-1077-z

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2021020218191064675557

URL: https://d-nb.info/1226200338/34

URL: https://doi.org/10.1038/s42003-020-1077-z

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