Format:
Online-Ressource (VIII, 200p. 18 illus., 4 illus. in color, digital)
ISBN:
9781441976567
Series Statement:
SpringerLink
Content:
The goal of this work is summarize the contribution that insertional mutagenesis has made to our understanding of cancer. A variety of insertional mutagens are presented that have been used to study a variety of tumor types in several model organisms. In addition, the impact of insertional mutagenesis in several gene therapy trials is discussed along with strategies to avoid such complications in future clinical trials.
Content:
The goal of this work is summarize the contribution that insertional mutagenesis has made to our understanding of cancer. A variety of insertional mutagens are presented that have been used to study a variety of tumor types in several model organisms. In addition, the impact of insertional mutagenesis in several gene therapy trials is discussed along with strategies to avoid such complications in future clinical trials
Note:
Description based upon print version of record
,
Contents; Contributors; 1 Insertional Mutagenesis: A Powerful Tool in Cancer Research; 2 Retroviral Insertional Mutagenesis in Mouse Models of Leukemia and Lymphoma; 3 Gene Discovery by MMTV Mediated Insertional Mutagenesis; 4 Chicken Models of Retroviral Insertional Mutagenesis; 5 Sleeping Beauty Models of Cancer; 6 Insertional Mutagenesis in Hematopoietic Cells: Lessons Learned from Adverse Events in Clinical Gene Therapy Trials; 7 Bioinformatics of High-Throughput Insertional Mutagenesis; Index;
Additional Edition:
ISBN 9781441976550
Additional Edition:
Buchausg. u.d.T. Insertional mutagenesis strategies in cancer genetics New York : Springer, 2011 ISBN 9781441976550
Additional Edition:
ISBN 1441976558
Language:
English
Subjects:
Medicine
Keywords:
Krebs
;
Mutagenese
;
Aufsatzsammlung
DOI:
10.1007/978-1-4419-7656-7
URL:
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