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Berlin Brandenburg

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  • 1
    Language: English
    In: Astrophysics and Space Science, 2014, Vol.350(2), p.701(5)
    Description: Byline: N. Koning (1), D. Leahy (1), R. Ouyed (1) Keywords: Stars: neutron; Stars: individual (1E 2259+586); X-Rays: bursts Abstract: We investigate the "antiglitch" AXP 1E 2259+586 experienced between MJD=56031 and 56045 in the context of the Quark-Nova model in which an AXP is a quark star surrounded by a degenerate Keplerian disk. In a companion paper we assumed the "anti-glitch" to be instantaneous, whereas in this paper we consider the quark star to undergo a period of enhanced spin-down over several days. We find that the Quark-Nova model can account for the spin-down and at the same time the enhanced 2--10 keV observed flux without introducing any new physics to the model. Author Affiliation: (1) Department of Physics and Astronomy, University of Calgary, Calgary, AB, T2N1N4, Canada Article History: Registration Date: 06/01/2014 Received Date: 13/11/2013 Accepted Date: 06/01/2014 Online Date: 15/01/2014
    ISSN: 0004-640X
    Source: Cengage Learning, Inc.
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  • 2
    In: Medicine & Science in Sports & Exercise, 2018, Vol.50(5S Suppl 1), pp.736-736
    ISSN: 0195-9131
    Source: Copyright © 2013 Lippincott Williams & Wilkins. All rights reserved.〈img src=http://exlibris-pub.s3.amazonaws.com/LWW%20logo.png style="vertical-align:middle;margin-left:7px"〉
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  • 3
    Language: English
    In: Bioresource Technology, Dec, 2013, Vol.149, p.216(9)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.biortech.2013.09.006 Byline: K. Dussan, B. Girisuta, D. Haverty, J.J. Leahy, M.H.B. Hayes Abstract: acents Experiments with Miscanthus at 150, 175 and 200[degrees]C; and 0.10, 0.21 and 0.53M H.sub.2SO.sub.4. acents Low temperatures improve levulinic acid selectivity but increase the reaction time. acents High temperatures favour the formation of furfural (27%mol at 185[degrees]C, 0.5M H.sub.2SO.sub.4). acents A two-stage process was proposed to maximise furfural and optimise levulinic acid. acents Yields between 58-72%-mol levulinic acid are obtained at 160-200[degrees]C. Article History: Received 30 July 2013; Revised 28 August 2013; Accepted 1 September 2013
    ISSN: 0960-8524
    Source: Cengage Learning, Inc.
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  • 4
    Language: English
    In: Psychology & Health, 02 November 2015, Vol.30(11), pp.1346-1360
    Description: Objective: We assess the association between conscientiousness and adherence to the oral contraceptive pill (OCP), and examine if such a relationship is independent of a measure of prospective memory and a range of social cognitive variables. Method: Data were collected from...
    Keywords: Oral Contraceptive Pill ; Adherence ; Conscientiousness ; Planning ; Prospective Memory ; Intention ; Beliefs ; Psychology
    ISSN: 0887-0446
    E-ISSN: 1476-8321
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  • 5
    Language: English
    In: Proceedings of the National Academy of Sciences, 07/03/2012, Vol.109(27), pp.10861-10866
    Description: Crystal structures of human epidermal growth factor receptor (EGFR) with bound ligand revealed symmetric, doubly ligated receptor dimers thought to represent physiologically active states. Such complexes fail to rationalize negative cooperativity of epidermal growth factor (EGF) binding to EGFR and the behavior of the ligandless EGFR homolog ErbB2/HER2, however. We report cell-based assays that provide evidence for active, singly ligated dimers of human EGFR and its homolog, ErbB4/HER4. We also report crystal structures of the ErbB4/HER4 extracellular region complexed with its ligand Neuregulin-l[beta] that resolve two types of ErbB dimer when compared to EGFR:Ligand complexes. One type resembles the recently reported asymmetric dimer of Drosophila EGFR with a single high-affinity ligand bound and provides a model for singly ligated human ErbB dimers. These results unify models of vertebrate and invertebrate EGFR/ErbB signaling, imply that the tethered conformation of unliganded ErbBs evolved to prevent crosstalk among ErbBs, and establish a molecular basis for both negative cooperativity of ligand binding to vertebrate ErbBs and the absence of active ErbB2/HER2 homodimers in normal conditions. doi/10.1073/pnas.1201114109
    Keywords: Ligands (Biochemistry) -- Physiological Aspects ; Dimer Acids -- Physiological Aspects ; Epidermal Growth Factor Receptors -- Physiological Aspects ; Biophysics -- Research;
    ISSN: 0027-8424
    E-ISSN: 1091-6490
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  • 6
    Language: English
    In: Proceedings of the National Academy of Sciences, 08/09/2011, Vol.108(32), pp.13112-13117
    Description: Glypicans are heparan sulfate proteoglycans that modulate the signaling of multiple growth factors active during animal development, and loss of glypican function is associated with widespread developmental abnormalities. Glypicans consist of a conserved, approximately 45-kDa N-terminal protein core region followed by a stalk region that is tethered to the cell membrane by a glycosyl-phosphatidylinositol anchor. The stalk regions are predicted to be random coil but contain a variable number of attachment sites for heparan sulfate chains. Both the N-terminal protein core and the heparan sulfate attachments are important for glypican function. We report here the 2.4-[Angstrom] crystal structure of the N-terminal protein core region of the Drosophila glypican Dally-like (Dip). This structure reveals an elongated, [alpha]-helical fold for glypican core regions that does not appear homologous to any known structure. The Dip core protein is required for normal responsiveness to Hedgehog (Hh) signals, and we identify a localized region on the Dip surface important for mediating its function in Hh signaling. Purified Dip protein core does not, however, interact appreciably with either Hh or an Hh:lhog complex. doi/ 10.1073/pnas.1109877108
    Keywords: Proteoglycans -- Physiological Aspects ; Proteoglycans -- Research ; Hedgehog Proteins -- Physiological Aspects ; Hedgehog Proteins -- Research ; Cellular Signal Transduction -- Research;
    ISSN: 0027-8424
    E-ISSN: 1091-6490
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  • 7
    Language: English
    In: Journal of Biological Chemistry, 11/07/2014, Vol.289(45), pp.31361-31372
    Description: S-Adenosylhomocysteine hydrolase (SAHH) is an NAD(+)-dependent tetrameric enzyme that catalyzes the breakdown of S-adenosylhomocysteine to adenosine and homocysteine and is important in cell growth and the regulation of gene expression. Loss of SAHH function can result in global inhibition of cellular methyltransferase enzymes because of high levels of S-adenosylhomocysteine. Prior proteomics studies have identified two SAHH acetylation sites at Lys(401) and Lys(408) but the impact of these post-translational modifications has not yet been determined. Here we use expressed protein ligation to produce semisynthetic SAHH acetylated at Lys(401) and Lys(408) and show that modification of either position negatively impacts the catalytic activity of SAHH. X-ray crystal structures of 408-acetylated SAHH and dually acetylated SAHH have been determined and reveal perturbations in the C-terminal hydrogen bonding patterns, a region of the protein important for NAD(+) binding. These crystal structures along with mutagenesis data suggest that such hydrogen bond perturbations are responsible for SAHH catalytic inhibition by acetylation. These results suggest how increased acetylation of SAHH may globally influence cellular methylation patterns.
    Keywords: Enzyme ; Peptides ; Post-Translational Modification (Ptm) ; Protein Structure ; X-Ray Crystallography ; Adenosylhomocysteinase -- Metabolism ; Lysine -- Metabolism;
    ISSN: 0021-9258
    E-ISSN: 1083-351X
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  • 8
    Language: English
    In: Proceedings of the National Academy of Sciences, 03/30/2010, Vol.107(13), pp.5869-5874
    Description: The distribution and activities of morphogenic signaling proteins such as Hedgehog (Hh) and Wingless (Wg) depend on heparan sulfate proteoglycans (HSPGs). HSPGs consist of a core protein with covalently attached heparan sulfate glycosaminoglycan (GAG) chains. We report that the unmodified core protein of Dally-like (Dlp), an HSPG required for cell-autonomous Hh response in Drosophila embryos, alone suffices to rescue embryonic Hh signaling defects. Membrane tethering but not specifically the glycosylphosphatidylinositol linkage characteristic of glypicans is critical for this cell-autonomous activity. Our studies further suggest divergence of the two Drosophila and six mammalian glypicans into two functional families, an activating family that rescues cell-autonomous Dip function in Hh response and a family that inhibits Hh response. Thus, in addition to the previously established requirement for HSPG GAG chains in Hh movement, these findings demonstrate a positive cell-autonomous role for a core protein in morphogen response in vivo and suggest the conservation of a network of antagonistic glypican activities in the regulation of Hh response. glypicans | heparan sulfate proteoglycans doi/10.1073/pnas.1001777107
    Keywords: Cell Regulation -- Research ; Developmental Biology -- Research ; Hedgehog Proteins -- Properties;
    ISSN: 0027-8424
    E-ISSN: 1091-6490
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  • 9
    In: Proceedings of the International Astronomical Union, 2013, Vol.9(S296), pp.374-375
    Description: Abstract We study several TeV Supernova Remnants (SNRs W51C, CTB 37A, CTB 37B and G353.6-0.7) by radio and X-ray observations. We utilize neutral hydrogen (\HI) 21 cm line data to measure their kinematic distances, and use the CO line survey sensitive to molecular hydrogen clouds to validate these distance measurements and understand their relation to the TeV SNRs. Our study show that the TeV γ-ray emission from W51C should not be associated with the high-velocity HI clouds; CTB 37A and CTB 37B are at different distances and are only by chance nearby each other on the sky; the extended TeV emission from G353.6-0.7 possibly originates from the interaction between the SNR shock and the adjacent CO clouds.
    Keywords: Contributed Papers; Ism:supernova Remnants - Ism: Hii Regions - Ism:lines And Bands - Cosmic Rays
    ISBN: 9781107044777
    ISSN: 1743-9213
    E-ISSN: 1743-9221
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  • 10
    In: Proceedings of the International Astronomical Union, 2013, Vol.9(S297), pp.229-231
    Description: Abstract TeV gamma ray emissions have been detected at the directions of supernova remnants (SNRs) W51C and Tycho SNR. We analyze the H i absorption spectra towards W51C, Tycho SNR and their nearby compact sources. We conclude that W51C is at a distance of about 4.3 kpc and Tycho SNR has a distance of 2.5 ~ 3.0 kpc. Our study detects high-velocity H i clouds which coincide with star formation region W51B, but finds that the clouds are behind W51B which argues against previous claims that W51C has shocked the high velocity H i clouds. We argue that Tycho SNR is naked Ia SNR (lack of evidence of interacting with adjacent neutral and molecular cloud). This gives two examples that the very high gamma ray emission from SNRs does not likely originate from SNR-cloud interaction.
    Keywords: Contributed Papers; Ism: Kinematics And Dynamics; Ism: Supernova Remnants; Ism: Cosmic Rays
    ISSN: 1743-9213
    E-ISSN: 1743-9221
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