Kooperativer Bibliotheksverbund

Berlin Brandenburg

and
and

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Type of Medium
Language
Year
  • 1
    Language: English
    In: Biochemistry, 12 September 2017, Vol.56(36), pp.4871-4878
    Description: Short chain fatty acids (SCFAs) are postulated to modulate the immune development of neonates via epigenetic regulations such as histone deacetylase (HDAC) inhibition. In the context of atopic diseases, the inhibition of HDAC maintains T-cell homeostasis and induces naïve T-cell differentiation into adaptive Treg, which regulates the production of anti-inflammatory cytokines and suppression of Th2 immune responses. We investigated the structure-inhibition relationships of SCFAs with class I HDAC3 and class IIa HDAC7 using in silico docking simulation and the in vitro human recombinant HDAC inhibition assay. In silico docking simulation demonstrated that the lower binding energy of SCFAs toward HDACs was associated with the longer aliphatic chain length of SCFAs. Conversely, branching of SCFAs increased their binding energies toward both HDAC3 and HDAC7. The in vitro HDAC inhibition assay revealed that SCFAs more potently inhibit HDAC3 than HDAC7, with butyric acid being the most potent HDAC3 inhibitor among SCFAs (IC = 0.318 mM). In conclusion, our findings inform novel structural relationships between SCFAs and HDAC3 versus HDAC7. Future investigation of human disposition of SCFAs is important to establish their effects on innate versus adaptive immunity.
    Keywords: Fatty Acids, Volatile -- Chemistry ; Histone Deacetylases -- Metabolism
    ISSN: 00062960
    E-ISSN: 1520-4995
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    In: Journal of Paediatrics and Child Health, October 2011, Vol.47(10), pp.723-727
    Description: The study aims to examine recent childhood asthma hospitalisation rates in the Asia Pacific countries of Australia, Hong Kong and Singapore. On the background of reported decline in many countries with high asthma prevalence during late 1990s. Annual asthma hospitalisation (ICD9‐CM: 493 or ICD10‐AM: J45‐46) and population data from 1994 to 2008, of children aged 0–14 years old, were obtained from the Australian National Hospital Morbidity Database, from the Hospital Authority in Hong Kong and from the Ministry of Health in Singapore. Data were stratified in two age groups: 0–4 and 5–14 years old, and also in different periods of calendar years. Time‐series regression analyses were used to examine temporal trends. Diagnostic transfer was addressed by examining bronchitis hospitalisations. Significant decreases of up to 6.5% per annum in childhood asthma hospitalisation rates were found over the study period. However, the latter half of the study period showed increases in hospitalisation rates in all countries studied. No evidence of diagnostic transfer was found. Although there has been a decrease in childhood asthma hospitalisation rates since the 1990s, a modest increase was observed from 2003 to 2008. Ongoing monitoring is required.
    Keywords: Asthma ; Child ; Hospitalisation
    ISSN: 1034-4810
    E-ISSN: 1440-1754
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Language: English
    In: Food Allergy: Molecular Basis and Clinical Practice, 2015, Vol.101, p.152-161
    Description: Abstract Fish and shellfish consumption has increased worldwide, and there are increasing reports of adverse reactions to fish and shellfish, with an approximate prevalence of 0.5-5%. Fish allergy often develops early in life, whilst shellfish allergy tends to develop later, from adolescence onwards. Little is known about the natural history of these allergies, but both are thought to be persistent. The clinical manifestations of shellfish allergy, in particular, may vary from local to life-threatening ‘anaphylactic' reactions within an individual and between individuals. Parvalbumin and tropomyosin are the two major allergens, but several other allergens have been cloned and described. These allergens are highly heat and biochemically stable, and this may in part explain the persistence of these allergies. Diagnosis requires a thorough history, skin prick and in-vitro-specific IgE tests, and oral challenges may be needed for diagnostic confirmation. Strict avoidance of these allergens is the current standard of clinical care for allergic patients, and when indicated, an anaphylactic plan with an adrenaline auto-injector is prescribed. There are no published clinical trials evaluating specific oral immunotherapy for fish or shellfish allergy. © 2015 S. Karger AG, Basel
    Keywords: Food Hypersensitivity -- Diagnosis ; Seafood -- Adverse Effects;
    ISBN: 978-3-318-02340-4
    ISSN: 1660-2242
    E-ISSN: 1662-2898
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Language: English
    In: The Journal of infectious diseases, 01 January 2014, Vol.209(1), pp.12-23
    Description: Children are highly vulnerable to infection with novel influenza viruses. It is essential to develop candidate pandemic influenza vaccines that are safe and effective in the pediatric population. Infants and children aged 6-35 months and 3-8 years, respectively, were randomized to receive 2 immunizations with a 7.5-µg or 3.75-µg hemagglutinin (HA) dose of a nonadjuvanted whole-virus A/Vietnam(H5N1) vaccine; adolescents aged 9-17 years received a 7.5-µg dose only. A subset of participants received a booster immunization with an A/Indonesia(H5N1) vaccine approximately 1 year later. HA and neuraminidase antibody responses were assessed. Vaccination was safe and well tolerated; adverse reactions were transient and predominantly mild. Two immunizations with the 7.5-µg dose of A/Vietnam vaccine induced virus microneutralization (MN) titers of ≥1:20 against the A/Vietnam strain in 68.8%-85.4% of participants in the different age groups. After the booster, 93.1%-100% of participants achieved MN titers of ≥1:20 against the A/Vietnam and A/Indonesia strains. Neuraminidase-inhibiting antibodies were induced in ≥90% of participants after 2 immunizations with the 7.5 µg A/Vietnam vaccine and in 100% of participants after the booster. A whole-virus influenza A(H5N1) vaccine is suitable for prepandemic or pandemic immunization in a pediatric population. NCT01052402.
    Keywords: Ha ; Na ; Vero ; Cell Culture ; Children ; Heterosubtypic Immunity ; Immunological Priming ; Neuraminidase ; Pediatric ; Whole-Virus H5n1 Vaccine ; Influenza A Virus, H5n1 Subtype -- Immunology ; Influenza Vaccines -- Administration & Dosage
    ISSN: 00221899
    E-ISSN: 1537-6613
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    In: Journal of Paediatrics and Child Health, August 2013, Vol.49(8), pp.629-634
    Description: Byline: Jethro Wu, Alison Joanne Lee, Anne Eng-Neo Goh, Moira Chia, Christopher Ho, Jackelyn Laycano Bugarin, Lynette Pei-Chi Shek, Yiong-Huak Chan, Bee-Wah Lee Keywords: FDA approved; indication; intravenous immunoglobulin (IVIG); Kawasaki disease; trend Aims There is a paucity of data on the pattern of intravenous immunoglobulin (IVIG) usage in the paediatric population. This study aimed to assess the prevalence, trends, indications and burden of cost of IVIG usage in the Singaporean paediatric population. Methods Pharmacy data of all IVIG prescriptions between 2000 and 2009 in the two major paediatric public hospitals in Singapore were retrospectively reviewed. Each prescription was cross-referenced with the patient's hospital records to confirm the administration of IVIG and indication of use. Results Over the 10-year period, a total 78155g of IVIG valued at an estimated $5.2 million was prescribed. There was an increasing trend of 445.6g/year (P = 0.02) over this period. Analysis of patients showed that the most common indication for IVIG use was Kawasaki disease, both in terms of the proportion of patients (60%) and amount of IVIG used (34%). Kawasaki disease was also the only indication where there were significant increasing trends in both patient numbers (7.4 patients/year) and amount of IVIG used (247.5g/year). The indications with the highest amount of IVIG used per patient were for conditions related to primary immunodeficiency diseases and stem cell transplantation, where repeat transfusions were required. More than 75% of indications were Food and Drug Administration approved. Conclusion Albeit substantial and increasing, the use of IVIG in Singaporean children is mostly evidence based. Author Affiliation: Article Note: Conflict of interest: No conflict of interest to declare.
    Keywords: Approved ; Indication ; Intravenous Immunoglobulin ; Awasaki Disease ; Trend
    ISSN: 1034-4810
    E-ISSN: 1440-1754
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Language: English
    In: PLoS ONE, 2010, Vol.5(4), p.e9964
    Description: Eczema is a chronic form of childhood disorder that is gaining in prevalence in affluent societies. Previous studies hypothesized that the development of eczema is correlated with changes in microbial profile and composition of early life endemic microbiota, but contradictory conclusions were obtained, possibly due to the lack of minimization of apparent non-health related confounders (e.g., age, antibiotic consumption, diet and mode of delivery). In this study, we recruited seven caesarean-delivered and total formula-fed infants, and comparatively examined the early-life endemic microbiota in these infants with and without eczema. Using 16S pyrosequencing, infants' fecal microbiota were observed to comprise Proteobacteria, Firmicutes, Actinobacteria and Bacteroidetes as the four main phyla, and the presence and absence of specific populations within these four phyla are primarily mediated by ageing. Quantitative analysis of bacterial targets on a larger sample size (n = 36 at 1, 3, and 12 months of age) revealed that the abundances of Bifidobacterium and Enterobacteriaceae were different among caesarean-delivered infants with and without eczema, and the bacterial targets may be potential biomarkers that can correlate to the health status of these infants. Our overall findings suggest that the minimization of possible confounders is essential prior to comparative evaluation and correlation of fecal microbiota to health status, and that stool samples collected from caesarean-delivered infants at less than 1 year of age may represent a good cohort to study for potential biomarkers that can distinguish infants with eczema from those without. These findings would greatly facilitate future efforts in understanding the possible pathogenesis behind certain bacterial targets, and may lead to a timely intervention that reduces the occurrence of early life eczema and possibly allergic disorders in later life.
    Keywords: Research Article ; Ecology -- Environmental Microbiology ; Microbiology -- Applied Microbiology ; Microbiology -- Environmental Microbiology ; Microbiology -- Medical Microbiology
    E-ISSN: 1932-6203
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Language: English
    In: The Journal of infectious diseases, 01 December 2014, Vol.210(11), pp.1800-10
    Description: Protecting young children from pandemic influenza should also reduce transmission to susceptible adults, including pregnant women. An open study assessed immunogenicity and reactogenicity of a heterologous booster dose of A/turkey/Turkey/1/2005(H5N1)-AS03B (AS03B is an Adjuvant System containing α-tocopherol and squalene in an oil-in-water emulsion [5.93 mg tocopherol]) in infants and children aged 6 to 〈36 months that was given 6 months following 2-dose primary vaccination with A/Indonesia/05/2005(H5N1)-AS03B. Vaccines contained 1.9 µg of hemagglutinin antigen and AS03B. Hemagglutinin inhibition (HI) responses, microneutralization titers, and antineuraminidase antibody levels were assessed for 6 months following the booster vaccination. For each age stratum (defined on the basis of the subject's age at first vaccination as 6 to 〈12 months, 12 to 〈24 months, and 24 to 〈36 months) and overall (n=113), European influenza vaccine licensure criteria were fulfilled for responses to A/turkey/Turkey/1/2005(H5N1) 10 days following the booster vaccination. Local pain and fever increased with consecutive doses. Anamnestic immune responses were demonstrated for HI, neutralizing, and antineuraminidase antibodies against vaccine-homologous/heterologous strains. Antibody responses to vaccine-homologous/heterologous strains persisted in all children 6 months following the booster vaccination. Prevaccination of young children with a clade 2 strain influenza A(H5N1) AS03-adjuvanted vaccine followed by heterologous booster vaccination boosted immune responses to the homologous strain and a related clade, with persistence for at least 6 months. The results support a prime-boost vaccination approach in young children for pandemic influenza preparedness. NCT01323946.
    Keywords: H5n1 ; Booster ; Children ; Influenza ; Pandemic ; Adjuvants, Immunologic -- Administration & Dosage ; Influenza A Virus, H5n1 Subtype -- Immunology ; Influenza Vaccines -- Immunology ; Influenza, Human -- Prevention & Control
    ISSN: 00221899
    E-ISSN: 1537-6613
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Language: English
    In: Asia Pacific allergy, January 2013, Vol.3(1), pp.1-2
    Description: Asia is the world's most populous region consisting of highly diverse populations with respect to ancestry and cultural background. It may not be obvious at the outset, but this region is probably an important resource for lessons in allergic disorders. With growing affluence and westernization, the global trends in allergic diseases have increased at tandem, albeit at different rates. In the 1960's to 1990's, several populations [1] including Asian communities [2] have documented increases in asthma prevalence, particularly in children. The International Study of Asthma and Allergies in Childhood (ISAAC), is a highly quoted research initiative that has provided us with a standardized means of comparing global asthma, allergic rhinitis and eczema prevalence. The Phase One ISAAC studies showed us that none of the Asian countries were ranked amongst the top in terms of asthma symptom prevalence [3]. Instead, the United Kingdom, New Zealand, Australia, Republic of Ireland and Canada had the highest prevalence for asthma symptoms. Japan, Thailand, Hong Kong, Philippines, Singapore and Malaysia were ranked midway. Most interestingly, China had one of the lowest prevalence and Indonesia was ranked the lowest for asthma symptom prevalence. The ISAAC Phase 3 study was a repeat of Phase 1 study performed 7 to 10 years later. The data showed that asthma prevalence had plateaued in several populations, with modest increases in some centers. Only 4 of 8 Asia Pacific countries recorded an increase in asthma symptom prevalence, and increases for Hong Kong, Japan and Taiwan were very modest (〈1%) [4]. Taken together, the ISAAC Phase 1 and 3 data indicate that childhood asthma prevalence in Asia is likely to have stabilized and would not reach the proportions seen in the western world.
    Keywords: Medicine;
    ISSN: 2233-8276
    E-ISSN: 22338268
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Language: English
    In: Nutrition, January 2013, Vol.29(1), pp.184-194
    Description: In early infancy, various gastrointestinal symptoms (e.g., constipation, regurgitation, crying/fussiness, infantile colic, and excessive gas) are common problems and may result in numerous visits to pediatricians. Worldwide, this often results in switching infant formulas because parents (and sometimes doctors) believe these symptoms reflect a formula intolerance. However, in many cases, these infants are growing and developing normally. This study was performed to offer family pediatricians consensus-based algorithms on the management of the most common gastrointestinal symptoms in infants. A group of pediatric gastroenterologists and pediatric allergists from Europe, USA, Latin America, and Asia developed guidelines and practical algorithms to assist general pediatricians in addressing this challenge. Five such practice recommendations were developed after a thorough literature review. These algorithms should not be considered as an “evidence-based guideline”; on the contrary, the authors are convinced that challenging these proposals will result in updated and improved versions. To date, these algorithms, based on the published literature, are the result of a broad consensus of pediatric gastroenterologists from different continents.
    Keywords: Constipation ; Colic ; Crying ; Functional Disorder ; Formula ; Fussiness ; Gastrointestinal Symptoms ; Gassiness ; Infant ; Regurgitation ; Anatomy & Physiology ; Diet & Clinical Nutrition
    ISSN: 0899-9007
    E-ISSN: 1873-1244
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Language: English
    In: PLoS ONE, 01 January 2017, Vol.12(10), p.e0184955
    Description: Gut microbiota play an important role in human immunological processes, potentially affecting allergic diseases such as eczema. The diversity and structure of gut microbiota in infants with eczema have been previously documented. This study aims to evaluate by comparative metagenomics differences in genetic content in gut microbiota of infants with eczema and their matched controls. Stools were collected at the age of one month old from twelve infants from an at risk birth cohort in a case control manner. Clinical follow up for atopic outcomes were carried out at the age of 12 and 24 months. Microbial genomic DNA were extracted from stool samples and used for shotgun sequencing. Comparative metagenomic analysis showed that immune-regulatory TCAAGCTTGA motifs were significantly enriched in the six healthy controls (C) communities compared to the six eczema subjects (E), with many encoded by Bifidobacterium (38% of the total motifs in the C communities). Draft genomes of five Bifidobacterium species populations (B. longum, B. bifidum, B. breve, B. dentium, and B. pseudocatenulatum) were recovered from metagenomic datasets. The B. longum BFN-121-2 genome encoded more TCAAGCTTGA motifs (4.2 copies per one million genome sequence) than other Bifidobacterium genomes. Additionally, the communities in the stool of controls (C) were also significantly enriched in functions associated with tetrapyrrole biosynthesis compared to those of eczema (E). Our results show distinct immune-modulatory genomic properties of gut microbiota in infants associated with eczema and provide new insights into potential role of gut microbiota in affecting human immune homeostasis.
    Keywords: Sciences (General)
    E-ISSN: 1932-6203
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages