Kooperativer Bibliotheksverbund

UID:

Format: 1 online resource (705 p.)

Edition: 2nd ed.

ISBN: 1-4377-3778-1

Content: Pediatric Allergy supplies the comprehensive guidance you need to diagnose, manage, and treat virtually any type of allergy seen in children. Drs. Leung, Sampson, Geha, and Szefler present the new full-color second edition, with coverage of the diagnosis and management of anaphylaxis, the immune mechanisms underlying allergic disease, the latest diagnostic tests, and more...in print and online at expertconsult.com. Treat the full range of pediatric allergic and immunologic diseases through clinically focused coverage relevant to both allergists and pediatricians. Unders

Note: "Expert Consult."--Cover. , section a. General concepts -- section b. Immunologic diseases -- section c. Immune-directed therapies -- section d. Diagnosis and treatment of allergic diseases -- section e. Upper airway disease -- section f. Asthma -- section g. Food allergy -- section h. Allergic skin and eye diseases -- section i. Drug allergy and anaphylaxis. , English

Additional Edition: ISBN 1-336-23681-7

Additional Edition: ISBN 1-4377-0271-6

Language: English

UID:

Format: 226 Seiten , Ill., graph. Darst.

Edition: 1

ISBN: 3540604073 , 0412101912

Series Statement: Medical intelligence unit

Note: engl.

Language: English

Keywords: Endogenes Ekzem ; Aufsatzsammlung ; Aufsatzsammlung ; Aufsatzsammlung

UID:

Format: 1 online resource (727 p.)

Edition: 3rd ed.

ISBN: 0-323-33946-8

Content: The third edition of Pediatric Allergy continues this title's steadfast tradition of providing comprehensive, authoritative guidance on the day-to-day diagnosis and management of pediatric allergic and immunologic diseases. You'll have the most up-to-date research at hand thanks to an easily accessible full-color format that highlights a host of new chapters, extensive updates, and clinically focused coverage. Whether you're a student, resident, pediatrician or allergist, you'll appreciate this user-friendly and versatile source for providing optimal care! Includes diagnostic tests available

Note: Description based upon print version of record. , Front cover -- Half title page -- Dedication -- Pediatric Allergy: Principles and Practice -- Copyright page -- Table of Contents -- List of Contributors -- Preface -- A General Concepts -- 1 Epidemiology of Allergic Diseases -- Key Points -- Introduction -- Prevalence of Childhood Asthma and Allergies -- Western versus Developing Countries -- The East-West Gradient across Europe -- Differences between Rural and Urban Populations -- Inner City Areas of the USA -- Time Trends in the Prevalence of Allergic Diseases -- Environmental Risk Factors for Allergic Diseases -- Air Pollution -- Environmental Tobacco Smoke -- Water Hardness and Dampness -- Nutrition -- Allergen Exposure -- Family Size, Infections and Hygiene -- Gene-Environment Interactions -- Conclusions -- Key References -- References -- 2 Natural History of Allergic Diseases and Asthma -- Key Points -- Allergic March of Childhood -- Early Immune Development Underlying Allergies -- Total Serum IgE Levels -- Allergen-Specific IgE -- Allergen-Specific Th2 Lymphocytes, and Their Regulation by Th1 and Treg Lymphocytes -- Childhood Asthma -- Early Childhood: Transient vs Persistent Asthma -- Asthma from Childhood to Adulthood -- Risk Factors for Persistent Asthma -- Allergy -- Gender -- Parental History of Asthma -- Lower Respiratory Tract Infections -- Environmental Tobacco Smoke Exposure -- Asthma- and Allergy-Protective Influences -- Breastfeeding -- Microbial Exposures -- Pet Ownership -- Vitamin D -- Childhood Asthma Phenotypes -- Atopic Dermatitis -- Allergic Rhinitis -- Food Allergy -- Anaphylaxis -- Gene-Environment Interactions -- Prevention Studies -- Avoidance versus Early Introduction of Allergenic Foods -- Inhalant Allergen Elimination/Reduction -- Breastfeeding -- Environmental Tobacco Smoke Elimination/Reduction -- Pharmacologic Intervention -- Antihistamines. , Conventional 'Controller' Pharmacotherapy for Asthma -- Allergen-Specific Immunotherapy -- Probiotics -- Conclusions -- Acknowledgment -- Key References -- References -- 3 The Genetics of Allergic Disease and Asthma -- Key Points -- Why Undertake Genetic Studies of Allergic Disease? -- Approaches to Genetic Studies of Complex Genetic Diseases -- What is a Complex Genetic Disease? -- How to Identify Genes Underlying Complex Disease -- Inheritance -- Phenotype -- Population -- Genetic Markers -- Approaches to Analysis -- Identify Gene -- Allergy and Asthma as Complex Genetic Diseases -- Phenotypes for Allergy and Allergic Disease: What Should We Measure? -- The Heritability of Atopic Disease: Are Atopy and Atopic Disease Heritable Conditions? -- Molecular Regulation of Atopy and Atopic Disease, I: Susceptibility Genes -- Positional Cloning by Genome-Wide Screens -- Genes Identified by Genome-Wide Association Studies -- Candidate Gene/Gene Region Studies -- An Example of a Candidate Gene: Interleukin-13 -- An Example of a Candidate Gene: Interleukin-33 -- Analysis of Clinically Defined Subgroups -- Filaggrin -- Molecular Regulation of Atopy and Atopic Disease, II: Disease-Modifying Genes -- Genetic Influences on Disease Severity -- Genetic Regulation of Response to Therapy: Pharmacogenetics -- Epigenetics and Allergic Disease -- Conclusions -- Key References -- References -- 4 Regulation and Biology of Immunoglobulin E -- Key Points -- Components of the Immune Response -- Immunoglobulin E Protein Structure and Gene Organization -- Regulation of IgE Isotype Switching -- ε-Germline Transcription Precedes Isotype Switch Recombination -- Regulation of Germline Transcription, The Iε Promoter -- Cytokines IL-4 and IL-13 Activate STAT-6 -- CD40/CD154 Provides Second Signal for Isotype Switch Recombination. , Alternative Second Signals for Isotype Switch Recombination -- Cytokine-Stimulated Germline Transcripts and CD40-Induced AID Collaborate to Execute Switch Recombination -- Regulation of Allergen-Specific T Cell Responses -- Th2 Helper T Cell Development -- Genetic Influences on Th2 Development -- Antigen-Presenting Cell Function in Th Differentiation -- Microbial Products and Dendritic Cell Phenotype -- Non-T Cell Sources of IL-4: Mast Cells, Basophils, NKT Cells and NK Cells -- Sites of IgE Class Switch Recombination and Mechanisms of IgE Memory -- IgE Receptors -- FcεRI Structure -- CD23 Expression and Structure -- Principles of IgE-Mediated Disease Mechanisms -- Mast Cell Activation and Homeostasis -- FcεRI Signaling -- Antigen-Independent IgE Signaling via FcεRI and IgE Effects on Mast Cell Homeostasis -- Regulation of IgE Receptors by IgE -- CD23 Function: Antigen Capture -- CD23 Function: IgE Regulation -- Conclusions -- Key References -- References -- 5 Inflammatory and Effector Cells/Cell Migration -- Key Points -- Introduction -- Myelocytes -- Eosinophils -- Mast Cells -- Basophils -- Macrophages -- Neutrophils -- Dendritic Cells -- Lymphocytes -- T Cells -- B Cells -- Natural Killer Cells -- Natural Killer T Cells -- γ/δ T Cells -- Innate Lymphoid Cells -- Leukocyte Recruitment -- Chemokine and Chemokine Receptor Families -- Chemokine Receptor Signal Transduction -- Regulation of Chemokine and Chemokine Receptor Expression -- Cellular Receptor Expression -- Chemokine Regulation of Leukocyte Effector Function -- Chemoattraction -- Cellular Activation -- Hematopoiesis -- Modulation of T Cell Immune Responses -- Conclusion -- Key References -- References -- 6 The Developing Immune System and Allergy -- Key Points -- Immune Function during Fetal Life -- Resistance to Infection during Infancy -- Surface Phenotype of T Cells in Early Life. , Functional Phenotype of T Cells during Infancy and Early Childhood -- Innate Immunity in Neonates -- B Cell Function in Early Life -- Antigen-Presenting Cell Populations -- Granulocyte Populations -- Postnatal Maturation of Immune Functions and Allergic Sensitization -- Conclusions -- Key References -- References -- B Immunologic Diseases -- 7 Approach to the Child with Recurrent Infections Including Molecular Diagnostics -- Key Points -- Definition of Recurrent Infections -- The Clinical Presentation of Underlying Disorders -- Allergy -- Immunodeficiency -- Infection -- Autoimmune/Chronic Inflammatory Disease -- Syndrome Complexes -- Cystic Fibrosis -- Abnormalities of Airway Anatomy and Physiology -- Disorders of Ciliary Structure and Function -- Secondary Immunodeficiency -- Laboratory Tests for Underlying Disorders -- Immunodeficiency -- Examination of the Peripheral Blood Smear -- Evaluation of Humoral Immunity -- Evaluation of Cell-Mediated Immunity -- Evaluation of the Complement System -- Evaluation of Phagocytic Cells -- Evaluation of Cilia -- Cystic Fibrosis -- Evaluation for Human Immunodeficiency Virus and Other Immunosuppressive Virus Infections -- Molecular Diagnostics -- Conclusions -- Helpful Website -- Key References -- References -- 8 Antibody Deficiency -- Key Points -- X-Linked Agammaglobulinemia -- Autosomal Agammaglobulinemia -- Common Variable Immunodeficiency -- IgA Deficiency -- IgG Subclass Deficiency -- Specific Antibody Deficiency With Normal Immunoglobulins -- Transient Hypogammaglobulinemia of Infancy -- Hyper-IgM Syndromes -- Differential Diagnosis -- Evaluation -- Treatment -- Conclusions -- Helpful Websites -- Key References -- References -- 9 T Cell Immunodeficiencies -- Key Points -- Severe Combined Immunodeficiency -- Etiology -- SCID Caused by Adenosine Deaminase Deficiency -- Reticular Dysgenesis. , X-Linked Severe Combined Immunodeficiency (SCIDX1, γc Deficiency) -- JAK-3 Deficiency -- IL-7Rα Deficiency -- T− B− SCID Caused by Defective VDJ Recombination -- CD3/TCR Deficiencies -- CD45 Deficiency -- Other Combined Immunodeficiencies -- Omenn Syndrome and Other Conditions Associated with Hypomorphic RAG Mutations -- Nucleoside Phosphorylase Deficiency -- TCRα Constant Chain (TRAC) Gene Defect -- Defects of TCR Signaling -- DOCK8 Deficiency -- Human 'Nude' Phenotype (FOXN1 Defect) -- Coronin-1A Deficiency -- Major Histocompatibility Complex (MHC) Class II Deficiency -- MHC Class I Deficiency -- Deficiency of Calcium-Release Activated Channels (CRAC) and of Magnesium Flux -- Immunodeficiency with Immune Dysregulation due to Impaired IL-2 Signaling -- IL-21 Receptor (IL-21R) Deficiency -- CD27 Deficiency -- T cell Defects with Impaired NF-κB Activation -- Immunodeficiency due to Activating PI3K-δ Mutations -- Cytidine 5′ Triphosphate Synthase 1 (CTPS1) Deficiency -- Differential Diagnosis of SCID and Other Combined Immunodeficiencies -- Evaluation and Management -- Treatment -- DiGeorge Syndrome -- Syndromes with Significant T Cell Deficiency -- Immuno-Osseous Syndromes -- Cartilage Hair Hypoplasia -- Schimke Syndrome -- Combined Immunodeficiency with Multiple Intestinal Atresias -- Immunodeficiency Syndromes with Defective DNA Repair -- Wiskott-Aldrich Syndrome -- Hyper-IgM Syndromes due to CD40 Ligand (CD40L) or to CD40 Deficiency -- Conclusions -- Helpful Websites -- Key References -- References -- 10 Complement Deficiencies -- Key Points -- Pathophysiology of Increased Susceptibility to Infection -- Pathophysiology of Systemic Autoimmune Disorders -- Pathophysiology of Atypical Hemolytic Uremic Syndrome (HUS) -- Inherited Complement Deficiencies -- C1q Deficiency -- C1r/C1s Deficiency -- C4 Deficiency -- C2 Deficiency -- C3 Deficiency. , C5 Deficiency. , English

Additional Edition: ISBN 0-323-29875-3

Language: English

UID:

Format: 1 online resource (727 p.)

Edition: 3rd ed.

ISBN: 0-323-33946-8

Content: The third edition of Pediatric Allergy continues this title's steadfast tradition of providing comprehensive, authoritative guidance on the day-to-day diagnosis and management of pediatric allergic and immunologic diseases. You'll have the most up-to-date research at hand thanks to an easily accessible full-color format that highlights a host of new chapters, extensive updates, and clinically focused coverage. Whether you're a student, resident, pediatrician or allergist, you'll appreciate this user-friendly and versatile source for providing optimal care! Includes diagnostic tests available

Note: Description based upon print version of record. , Front cover -- Half title page -- Dedication -- Pediatric Allergy: Principles and Practice -- Copyright page -- Table of Contents -- List of Contributors -- Preface -- A General Concepts -- 1 Epidemiology of Allergic Diseases -- Key Points -- Introduction -- Prevalence of Childhood Asthma and Allergies -- Western versus Developing Countries -- The East-West Gradient across Europe -- Differences between Rural and Urban Populations -- Inner City Areas of the USA -- Time Trends in the Prevalence of Allergic Diseases -- Environmental Risk Factors for Allergic Diseases -- Air Pollution -- Environmental Tobacco Smoke -- Water Hardness and Dampness -- Nutrition -- Allergen Exposure -- Family Size, Infections and Hygiene -- Gene-Environment Interactions -- Conclusions -- Key References -- References -- 2 Natural History of Allergic Diseases and Asthma -- Key Points -- Allergic March of Childhood -- Early Immune Development Underlying Allergies -- Total Serum IgE Levels -- Allergen-Specific IgE -- Allergen-Specific Th2 Lymphocytes, and Their Regulation by Th1 and Treg Lymphocytes -- Childhood Asthma -- Early Childhood: Transient vs Persistent Asthma -- Asthma from Childhood to Adulthood -- Risk Factors for Persistent Asthma -- Allergy -- Gender -- Parental History of Asthma -- Lower Respiratory Tract Infections -- Environmental Tobacco Smoke Exposure -- Asthma- and Allergy-Protective Influences -- Breastfeeding -- Microbial Exposures -- Pet Ownership -- Vitamin D -- Childhood Asthma Phenotypes -- Atopic Dermatitis -- Allergic Rhinitis -- Food Allergy -- Anaphylaxis -- Gene-Environment Interactions -- Prevention Studies -- Avoidance versus Early Introduction of Allergenic Foods -- Inhalant Allergen Elimination/Reduction -- Breastfeeding -- Environmental Tobacco Smoke Elimination/Reduction -- Pharmacologic Intervention -- Antihistamines. , Conventional 'Controller' Pharmacotherapy for Asthma -- Allergen-Specific Immunotherapy -- Probiotics -- Conclusions -- Acknowledgment -- Key References -- References -- 3 The Genetics of Allergic Disease and Asthma -- Key Points -- Why Undertake Genetic Studies of Allergic Disease? -- Approaches to Genetic Studies of Complex Genetic Diseases -- What is a Complex Genetic Disease? -- How to Identify Genes Underlying Complex Disease -- Inheritance -- Phenotype -- Population -- Genetic Markers -- Approaches to Analysis -- Identify Gene -- Allergy and Asthma as Complex Genetic Diseases -- Phenotypes for Allergy and Allergic Disease: What Should We Measure? -- The Heritability of Atopic Disease: Are Atopy and Atopic Disease Heritable Conditions? -- Molecular Regulation of Atopy and Atopic Disease, I: Susceptibility Genes -- Positional Cloning by Genome-Wide Screens -- Genes Identified by Genome-Wide Association Studies -- Candidate Gene/Gene Region Studies -- An Example of a Candidate Gene: Interleukin-13 -- An Example of a Candidate Gene: Interleukin-33 -- Analysis of Clinically Defined Subgroups -- Filaggrin -- Molecular Regulation of Atopy and Atopic Disease, II: Disease-Modifying Genes -- Genetic Influences on Disease Severity -- Genetic Regulation of Response to Therapy: Pharmacogenetics -- Epigenetics and Allergic Disease -- Conclusions -- Key References -- References -- 4 Regulation and Biology of Immunoglobulin E -- Key Points -- Components of the Immune Response -- Immunoglobulin E Protein Structure and Gene Organization -- Regulation of IgE Isotype Switching -- ε-Germline Transcription Precedes Isotype Switch Recombination -- Regulation of Germline Transcription, The Iε Promoter -- Cytokines IL-4 and IL-13 Activate STAT-6 -- CD40/CD154 Provides Second Signal for Isotype Switch Recombination. , Alternative Second Signals for Isotype Switch Recombination -- Cytokine-Stimulated Germline Transcripts and CD40-Induced AID Collaborate to Execute Switch Recombination -- Regulation of Allergen-Specific T Cell Responses -- Th2 Helper T Cell Development -- Genetic Influences on Th2 Development -- Antigen-Presenting Cell Function in Th Differentiation -- Microbial Products and Dendritic Cell Phenotype -- Non-T Cell Sources of IL-4: Mast Cells, Basophils, NKT Cells and NK Cells -- Sites of IgE Class Switch Recombination and Mechanisms of IgE Memory -- IgE Receptors -- FcεRI Structure -- CD23 Expression and Structure -- Principles of IgE-Mediated Disease Mechanisms -- Mast Cell Activation and Homeostasis -- FcεRI Signaling -- Antigen-Independent IgE Signaling via FcεRI and IgE Effects on Mast Cell Homeostasis -- Regulation of IgE Receptors by IgE -- CD23 Function: Antigen Capture -- CD23 Function: IgE Regulation -- Conclusions -- Key References -- References -- 5 Inflammatory and Effector Cells/Cell Migration -- Key Points -- Introduction -- Myelocytes -- Eosinophils -- Mast Cells -- Basophils -- Macrophages -- Neutrophils -- Dendritic Cells -- Lymphocytes -- T Cells -- B Cells -- Natural Killer Cells -- Natural Killer T Cells -- γ/δ T Cells -- Innate Lymphoid Cells -- Leukocyte Recruitment -- Chemokine and Chemokine Receptor Families -- Chemokine Receptor Signal Transduction -- Regulation of Chemokine and Chemokine Receptor Expression -- Cellular Receptor Expression -- Chemokine Regulation of Leukocyte Effector Function -- Chemoattraction -- Cellular Activation -- Hematopoiesis -- Modulation of T Cell Immune Responses -- Conclusion -- Key References -- References -- 6 The Developing Immune System and Allergy -- Key Points -- Immune Function during Fetal Life -- Resistance to Infection during Infancy -- Surface Phenotype of T Cells in Early Life. , Functional Phenotype of T Cells during Infancy and Early Childhood -- Innate Immunity in Neonates -- B Cell Function in Early Life -- Antigen-Presenting Cell Populations -- Granulocyte Populations -- Postnatal Maturation of Immune Functions and Allergic Sensitization -- Conclusions -- Key References -- References -- B Immunologic Diseases -- 7 Approach to the Child with Recurrent Infections Including Molecular Diagnostics -- Key Points -- Definition of Recurrent Infections -- The Clinical Presentation of Underlying Disorders -- Allergy -- Immunodeficiency -- Infection -- Autoimmune/Chronic Inflammatory Disease -- Syndrome Complexes -- Cystic Fibrosis -- Abnormalities of Airway Anatomy and Physiology -- Disorders of Ciliary Structure and Function -- Secondary Immunodeficiency -- Laboratory Tests for Underlying Disorders -- Immunodeficiency -- Examination of the Peripheral Blood Smear -- Evaluation of Humoral Immunity -- Evaluation of Cell-Mediated Immunity -- Evaluation of the Complement System -- Evaluation of Phagocytic Cells -- Evaluation of Cilia -- Cystic Fibrosis -- Evaluation for Human Immunodeficiency Virus and Other Immunosuppressive Virus Infections -- Molecular Diagnostics -- Conclusions -- Helpful Website -- Key References -- References -- 8 Antibody Deficiency -- Key Points -- X-Linked Agammaglobulinemia -- Autosomal Agammaglobulinemia -- Common Variable Immunodeficiency -- IgA Deficiency -- IgG Subclass Deficiency -- Specific Antibody Deficiency With Normal Immunoglobulins -- Transient Hypogammaglobulinemia of Infancy -- Hyper-IgM Syndromes -- Differential Diagnosis -- Evaluation -- Treatment -- Conclusions -- Helpful Websites -- Key References -- References -- 9 T Cell Immunodeficiencies -- Key Points -- Severe Combined Immunodeficiency -- Etiology -- SCID Caused by Adenosine Deaminase Deficiency -- Reticular Dysgenesis. , X-Linked Severe Combined Immunodeficiency (SCIDX1, γc Deficiency) -- JAK-3 Deficiency -- IL-7Rα Deficiency -- T− B− SCID Caused by Defective VDJ Recombination -- CD3/TCR Deficiencies -- CD45 Deficiency -- Other Combined Immunodeficiencies -- Omenn Syndrome and Other Conditions Associated with Hypomorphic RAG Mutations -- Nucleoside Phosphorylase Deficiency -- TCRα Constant Chain (TRAC) Gene Defect -- Defects of TCR Signaling -- DOCK8 Deficiency -- Human 'Nude' Phenotype (FOXN1 Defect) -- Coronin-1A Deficiency -- Major Histocompatibility Complex (MHC) Class II Deficiency -- MHC Class I Deficiency -- Deficiency of Calcium-Release Activated Channels (CRAC) and of Magnesium Flux -- Immunodeficiency with Immune Dysregulation due to Impaired IL-2 Signaling -- IL-21 Receptor (IL-21R) Deficiency -- CD27 Deficiency -- T cell Defects with Impaired NF-κB Activation -- Immunodeficiency due to Activating PI3K-δ Mutations -- Cytidine 5′ Triphosphate Synthase 1 (CTPS1) Deficiency -- Differential Diagnosis of SCID and Other Combined Immunodeficiencies -- Evaluation and Management -- Treatment -- DiGeorge Syndrome -- Syndromes with Significant T Cell Deficiency -- Immuno-Osseous Syndromes -- Cartilage Hair Hypoplasia -- Schimke Syndrome -- Combined Immunodeficiency with Multiple Intestinal Atresias -- Immunodeficiency Syndromes with Defective DNA Repair -- Wiskott-Aldrich Syndrome -- Hyper-IgM Syndromes due to CD40 Ligand (CD40L) or to CD40 Deficiency -- Conclusions -- Helpful Websites -- Key References -- References -- 10 Complement Deficiencies -- Key Points -- Pathophysiology of Increased Susceptibility to Infection -- Pathophysiology of Systemic Autoimmune Disorders -- Pathophysiology of Atypical Hemolytic Uremic Syndrome (HUS) -- Inherited Complement Deficiencies -- C1q Deficiency -- C1r/C1s Deficiency -- C4 Deficiency -- C2 Deficiency -- C3 Deficiency. , C5 Deficiency. , English

Additional Edition: ISBN 0-323-29875-3

Language: English

UID:

Format: 1 online resource (727 p.)

Edition: 3rd ed.

ISBN: 0-323-33946-8

Content: The third edition of Pediatric Allergy continues this title's steadfast tradition of providing comprehensive, authoritative guidance on the day-to-day diagnosis and management of pediatric allergic and immunologic diseases. You'll have the most up-to-date research at hand thanks to an easily accessible full-color format that highlights a host of new chapters, extensive updates, and clinically focused coverage. Whether you're a student, resident, pediatrician or allergist, you'll appreciate this user-friendly and versatile source for providing optimal care! Includes diagnostic tests available

Note: Description based upon print version of record. , Front cover -- Half title page -- Dedication -- Pediatric Allergy: Principles and Practice -- Copyright page -- Table of Contents -- List of Contributors -- Preface -- A General Concepts -- 1 Epidemiology of Allergic Diseases -- Key Points -- Introduction -- Prevalence of Childhood Asthma and Allergies -- Western versus Developing Countries -- The East-West Gradient across Europe -- Differences between Rural and Urban Populations -- Inner City Areas of the USA -- Time Trends in the Prevalence of Allergic Diseases -- Environmental Risk Factors for Allergic Diseases -- Air Pollution -- Environmental Tobacco Smoke -- Water Hardness and Dampness -- Nutrition -- Allergen Exposure -- Family Size, Infections and Hygiene -- Gene-Environment Interactions -- Conclusions -- Key References -- References -- 2 Natural History of Allergic Diseases and Asthma -- Key Points -- Allergic March of Childhood -- Early Immune Development Underlying Allergies -- Total Serum IgE Levels -- Allergen-Specific IgE -- Allergen-Specific Th2 Lymphocytes, and Their Regulation by Th1 and Treg Lymphocytes -- Childhood Asthma -- Early Childhood: Transient vs Persistent Asthma -- Asthma from Childhood to Adulthood -- Risk Factors for Persistent Asthma -- Allergy -- Gender -- Parental History of Asthma -- Lower Respiratory Tract Infections -- Environmental Tobacco Smoke Exposure -- Asthma- and Allergy-Protective Influences -- Breastfeeding -- Microbial Exposures -- Pet Ownership -- Vitamin D -- Childhood Asthma Phenotypes -- Atopic Dermatitis -- Allergic Rhinitis -- Food Allergy -- Anaphylaxis -- Gene-Environment Interactions -- Prevention Studies -- Avoidance versus Early Introduction of Allergenic Foods -- Inhalant Allergen Elimination/Reduction -- Breastfeeding -- Environmental Tobacco Smoke Elimination/Reduction -- Pharmacologic Intervention -- Antihistamines. , Conventional 'Controller' Pharmacotherapy for Asthma -- Allergen-Specific Immunotherapy -- Probiotics -- Conclusions -- Acknowledgment -- Key References -- References -- 3 The Genetics of Allergic Disease and Asthma -- Key Points -- Why Undertake Genetic Studies of Allergic Disease? -- Approaches to Genetic Studies of Complex Genetic Diseases -- What is a Complex Genetic Disease? -- How to Identify Genes Underlying Complex Disease -- Inheritance -- Phenotype -- Population -- Genetic Markers -- Approaches to Analysis -- Identify Gene -- Allergy and Asthma as Complex Genetic Diseases -- Phenotypes for Allergy and Allergic Disease: What Should We Measure? -- The Heritability of Atopic Disease: Are Atopy and Atopic Disease Heritable Conditions? -- Molecular Regulation of Atopy and Atopic Disease, I: Susceptibility Genes -- Positional Cloning by Genome-Wide Screens -- Genes Identified by Genome-Wide Association Studies -- Candidate Gene/Gene Region Studies -- An Example of a Candidate Gene: Interleukin-13 -- An Example of a Candidate Gene: Interleukin-33 -- Analysis of Clinically Defined Subgroups -- Filaggrin -- Molecular Regulation of Atopy and Atopic Disease, II: Disease-Modifying Genes -- Genetic Influences on Disease Severity -- Genetic Regulation of Response to Therapy: Pharmacogenetics -- Epigenetics and Allergic Disease -- Conclusions -- Key References -- References -- 4 Regulation and Biology of Immunoglobulin E -- Key Points -- Components of the Immune Response -- Immunoglobulin E Protein Structure and Gene Organization -- Regulation of IgE Isotype Switching -- ε-Germline Transcription Precedes Isotype Switch Recombination -- Regulation of Germline Transcription, The Iε Promoter -- Cytokines IL-4 and IL-13 Activate STAT-6 -- CD40/CD154 Provides Second Signal for Isotype Switch Recombination. , Alternative Second Signals for Isotype Switch Recombination -- Cytokine-Stimulated Germline Transcripts and CD40-Induced AID Collaborate to Execute Switch Recombination -- Regulation of Allergen-Specific T Cell Responses -- Th2 Helper T Cell Development -- Genetic Influences on Th2 Development -- Antigen-Presenting Cell Function in Th Differentiation -- Microbial Products and Dendritic Cell Phenotype -- Non-T Cell Sources of IL-4: Mast Cells, Basophils, NKT Cells and NK Cells -- Sites of IgE Class Switch Recombination and Mechanisms of IgE Memory -- IgE Receptors -- FcεRI Structure -- CD23 Expression and Structure -- Principles of IgE-Mediated Disease Mechanisms -- Mast Cell Activation and Homeostasis -- FcεRI Signaling -- Antigen-Independent IgE Signaling via FcεRI and IgE Effects on Mast Cell Homeostasis -- Regulation of IgE Receptors by IgE -- CD23 Function: Antigen Capture -- CD23 Function: IgE Regulation -- Conclusions -- Key References -- References -- 5 Inflammatory and Effector Cells/Cell Migration -- Key Points -- Introduction -- Myelocytes -- Eosinophils -- Mast Cells -- Basophils -- Macrophages -- Neutrophils -- Dendritic Cells -- Lymphocytes -- T Cells -- B Cells -- Natural Killer Cells -- Natural Killer T Cells -- γ/δ T Cells -- Innate Lymphoid Cells -- Leukocyte Recruitment -- Chemokine and Chemokine Receptor Families -- Chemokine Receptor Signal Transduction -- Regulation of Chemokine and Chemokine Receptor Expression -- Cellular Receptor Expression -- Chemokine Regulation of Leukocyte Effector Function -- Chemoattraction -- Cellular Activation -- Hematopoiesis -- Modulation of T Cell Immune Responses -- Conclusion -- Key References -- References -- 6 The Developing Immune System and Allergy -- Key Points -- Immune Function during Fetal Life -- Resistance to Infection during Infancy -- Surface Phenotype of T Cells in Early Life. , Functional Phenotype of T Cells during Infancy and Early Childhood -- Innate Immunity in Neonates -- B Cell Function in Early Life -- Antigen-Presenting Cell Populations -- Granulocyte Populations -- Postnatal Maturation of Immune Functions and Allergic Sensitization -- Conclusions -- Key References -- References -- B Immunologic Diseases -- 7 Approach to the Child with Recurrent Infections Including Molecular Diagnostics -- Key Points -- Definition of Recurrent Infections -- The Clinical Presentation of Underlying Disorders -- Allergy -- Immunodeficiency -- Infection -- Autoimmune/Chronic Inflammatory Disease -- Syndrome Complexes -- Cystic Fibrosis -- Abnormalities of Airway Anatomy and Physiology -- Disorders of Ciliary Structure and Function -- Secondary Immunodeficiency -- Laboratory Tests for Underlying Disorders -- Immunodeficiency -- Examination of the Peripheral Blood Smear -- Evaluation of Humoral Immunity -- Evaluation of Cell-Mediated Immunity -- Evaluation of the Complement System -- Evaluation of Phagocytic Cells -- Evaluation of Cilia -- Cystic Fibrosis -- Evaluation for Human Immunodeficiency Virus and Other Immunosuppressive Virus Infections -- Molecular Diagnostics -- Conclusions -- Helpful Website -- Key References -- References -- 8 Antibody Deficiency -- Key Points -- X-Linked Agammaglobulinemia -- Autosomal Agammaglobulinemia -- Common Variable Immunodeficiency -- IgA Deficiency -- IgG Subclass Deficiency -- Specific Antibody Deficiency With Normal Immunoglobulins -- Transient Hypogammaglobulinemia of Infancy -- Hyper-IgM Syndromes -- Differential Diagnosis -- Evaluation -- Treatment -- Conclusions -- Helpful Websites -- Key References -- References -- 9 T Cell Immunodeficiencies -- Key Points -- Severe Combined Immunodeficiency -- Etiology -- SCID Caused by Adenosine Deaminase Deficiency -- Reticular Dysgenesis. , X-Linked Severe Combined Immunodeficiency (SCIDX1, γc Deficiency) -- JAK-3 Deficiency -- IL-7Rα Deficiency -- T− B− SCID Caused by Defective VDJ Recombination -- CD3/TCR Deficiencies -- CD45 Deficiency -- Other Combined Immunodeficiencies -- Omenn Syndrome and Other Conditions Associated with Hypomorphic RAG Mutations -- Nucleoside Phosphorylase Deficiency -- TCRα Constant Chain (TRAC) Gene Defect -- Defects of TCR Signaling -- DOCK8 Deficiency -- Human 'Nude' Phenotype (FOXN1 Defect) -- Coronin-1A Deficiency -- Major Histocompatibility Complex (MHC) Class II Deficiency -- MHC Class I Deficiency -- Deficiency of Calcium-Release Activated Channels (CRAC) and of Magnesium Flux -- Immunodeficiency with Immune Dysregulation due to Impaired IL-2 Signaling -- IL-21 Receptor (IL-21R) Deficiency -- CD27 Deficiency -- T cell Defects with Impaired NF-κB Activation -- Immunodeficiency due to Activating PI3K-δ Mutations -- Cytidine 5′ Triphosphate Synthase 1 (CTPS1) Deficiency -- Differential Diagnosis of SCID and Other Combined Immunodeficiencies -- Evaluation and Management -- Treatment -- DiGeorge Syndrome -- Syndromes with Significant T Cell Deficiency -- Immuno-Osseous Syndromes -- Cartilage Hair Hypoplasia -- Schimke Syndrome -- Combined Immunodeficiency with Multiple Intestinal Atresias -- Immunodeficiency Syndromes with Defective DNA Repair -- Wiskott-Aldrich Syndrome -- Hyper-IgM Syndromes due to CD40 Ligand (CD40L) or to CD40 Deficiency -- Conclusions -- Helpful Websites -- Key References -- References -- 10 Complement Deficiencies -- Key Points -- Pathophysiology of Increased Susceptibility to Infection -- Pathophysiology of Systemic Autoimmune Disorders -- Pathophysiology of Atypical Hemolytic Uremic Syndrome (HUS) -- Inherited Complement Deficiencies -- C1q Deficiency -- C1r/C1s Deficiency -- C4 Deficiency -- C2 Deficiency -- C3 Deficiency. , C5 Deficiency. , English

Additional Edition: ISBN 0-323-29875-3

Language: English

UID:

Format: XV, 688 S. : , Ill., graph. Darst.

Edition: 2. ed.

ISBN: 978-1-4377-0271-2 , 1-4377-0271-6

Note: Includes bibliographical references and index

Language: English

Subjects: Medicine

Keywords: Allergie ; Kind

URL: Inhaltsverzeichnis

URL: Klappentext

UID:

Format: 226 S. : , Ill., graph. Darst.

ISBN: 3-540-60407-3

Series Statement: Medical intelligence unit

Subjects: Medicine

Keywords: Endogenes Ekzem ; Aufsatzsammlung

UID:

Format: xiv, 633 p. : , ill.

Edition: Electronic reproduction. Ann Arbor, MI : ProQuest, 2015. Available via World Wide Web. Access may be limited to ProQuest affiliated libraries.

Language: English

Keywords: Electronic books.

URL: Click to View

UID:

Format: 1 online resource (649 p.)

ISBN: 0-429-22142-8 , 1-135-55855-8 , 1-280-20830-9 , 9786610208302 , 0-203-90887-2 , 0-8247-4453-5

Series Statement: NIH publication ; no. 09-4272

Content: This reference explores the epidemiology, etiology, management, and pathophysiological mechanisms of atopic dermatitis and identifies potential genetic and environmental factors associated with allergic skin immune responses-compiling the latest research, diagnostic procedures, and therapeutic strategies for the prevention, control, and treatment of this chronic inflammatory disease.Written by leading experts in the field, Atopic Dermatitis addressesthe clinical features of atopic dermatitis (AD) the role of antigen-presenting cells, T-cells, and keratinocytes in pathogenesis food hypersensiti

Note: Description based upon print version of record. , Front Cover; Preface; Contents; Contributors; Chapter 1. Definition and Diagnosis of Intrinsic Versus Extrinsic Atopic Dermatitis; Chapter 2. Epidemiology; Chapter 3. Psychoimmunology and Evaluation of Therapeutic Approaches; Chapter 4. Socioeconomic Impact of Atopic Dermatitis; Chapter 5. Genetics of Atopic Dermatitis; Chapter 6. Risk Factors for Atopic Dermatitis; Chapter 7. Epidermal Barrier in Atopic Dermatitis; Chapter 8. Mechanisms of Allergic Skin In.ammation; Chapter 9. Animal Models of Atopic Dermatitis; Chapter 10 .Pathophysiology of Pruritus , Chapter 11. Cellular Aspects of Atopic Dermatitis: OverviewChapter 12. Keratinocytes; Chapter 13. T Cells in Atopic Dermatitis; Chapter 14. Antigen-Presenting Cells; Chapter 15. Mast Cells and Basophils; Chapter 16. Eosinophils and Atopic Dermatitis; Chapter 17. Aeroallergens; Chapter 18. Atopic Dermatitis and Foods; Chapter 19. Role of Staphylococcus aureus in Atopic Dermatitis; Chapter 20. Fungal Allergens; Chapter 21. Allergy Diagnosis in Atopic Eczema with the Atopy Patch Test; Chapter 22. Conventional Topical Treatment of Atopic Dermatitis , Chapter 23. Special Aspects in Pediatric PatientsChapter 24. Role of Cyclic Nucleotide Phosphodiesterases in Atopic Dermatitis; Chapter 25. Phototherapy for Atopic Dermatitis; Chapter 26. The Psychological Aspects of Atopic Dermatitis; Chapter 27. Topical Macrolide Immunomodulators for Therapy of Atopic Dermatitis; Chapter 28. Chinese Herbal Therapy in Atopic Dermatitis; Chapter 29. Systemic Pharmacotherapy; Chapter 30. Future Perspectives in Atopic Dermatitis; Index; Back Cover , English

Additional Edition: ISBN 0-8247-0742-7

Language: English

DOI: 10.3109/9780203908877

UID:

Format: 1 online resource (649 p.)

ISBN: 0-429-22142-8 , 1-135-55855-8 , 1-280-20830-9 , 9786610208302 , 0-203-90887-2 , 0-8247-4453-5

Series Statement: NIH publication ; no. 09-4272

Content: This reference explores the epidemiology, etiology, management, and pathophysiological mechanisms of atopic dermatitis and identifies potential genetic and environmental factors associated with allergic skin immune responses-compiling the latest research, diagnostic procedures, and therapeutic strategies for the prevention, control, and treatment of this chronic inflammatory disease.Written by leading experts in the field, Atopic Dermatitis addressesthe clinical features of atopic dermatitis (AD) the role of antigen-presenting cells, T-cells, and keratinocytes in pathogenesis food hypersensiti

Note: Description based upon print version of record. , Front Cover; Preface; Contents; Contributors; Chapter 1. Definition and Diagnosis of Intrinsic Versus Extrinsic Atopic Dermatitis; Chapter 2. Epidemiology; Chapter 3. Psychoimmunology and Evaluation of Therapeutic Approaches; Chapter 4. Socioeconomic Impact of Atopic Dermatitis; Chapter 5. Genetics of Atopic Dermatitis; Chapter 6. Risk Factors for Atopic Dermatitis; Chapter 7. Epidermal Barrier in Atopic Dermatitis; Chapter 8. Mechanisms of Allergic Skin In.ammation; Chapter 9. Animal Models of Atopic Dermatitis; Chapter 10 .Pathophysiology of Pruritus , Chapter 11. Cellular Aspects of Atopic Dermatitis: OverviewChapter 12. Keratinocytes; Chapter 13. T Cells in Atopic Dermatitis; Chapter 14. Antigen-Presenting Cells; Chapter 15. Mast Cells and Basophils; Chapter 16. Eosinophils and Atopic Dermatitis; Chapter 17. Aeroallergens; Chapter 18. Atopic Dermatitis and Foods; Chapter 19. Role of Staphylococcus aureus in Atopic Dermatitis; Chapter 20. Fungal Allergens; Chapter 21. Allergy Diagnosis in Atopic Eczema with the Atopy Patch Test; Chapter 22. Conventional Topical Treatment of Atopic Dermatitis , Chapter 23. Special Aspects in Pediatric PatientsChapter 24. Role of Cyclic Nucleotide Phosphodiesterases in Atopic Dermatitis; Chapter 25. Phototherapy for Atopic Dermatitis; Chapter 26. The Psychological Aspects of Atopic Dermatitis; Chapter 27. Topical Macrolide Immunomodulators for Therapy of Atopic Dermatitis; Chapter 28. Chinese Herbal Therapy in Atopic Dermatitis; Chapter 29. Systemic Pharmacotherapy; Chapter 30. Future Perspectives in Atopic Dermatitis; Index; Back Cover , English

Additional Edition: ISBN 0-8247-0742-7

Language: English

DOI: 10.3109/9780203908877