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  • 1
    Language: English
    In: Generations (San Francisco, California), Winter, 2010, Vol.34(4), p.89-96
    Description: According to a Georgetown University study (Martin et al., 2009), between 1989 and 2009, about 11,000 foreigntrained registered nurses entered the United States under temporary H-1A (1989-1995) and H-1C (1999-2009) visas, issued when employers could show they were in areas of nurse shortages. [...] the public sector and the industry need to monitor developments in the "gray" or underground market, particularly in homecare settings.
    Keywords: Long Term Care -- Management ; Community Services -- Social Aspects ; Community Services -- Health Aspects ; Health Care Industry -- Services ; Health Care Industry -- Management ; Medical Personnel -- Emigration And Immigration ; Medical Personnel -- Human Resource Management
    ISSN: 0738-7806
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  • 2
    In: The Gerontologist, 2010, Vol. 50(3), pp.340-351
    Description: Purpose:  To investigate how a partnership between labor and management works to change the organization and focus of nursing home frontline work, supporting a transition toward person-centered care (PCC) in participating nursing homes.  Design and Methods:  Using a participatory research approach, we conducted case studies of 2 nursing homes participating in a partnership between a labor union and a provider coalition. The study was designed to reveal whether and how the labor–management partnership supported PCC and to identify challenges to overcome in the future.  Results:  The partnership provided training and follow-up support to member homes to implement PCC. Management and worker participants used the partnership as a learning collaborative to acquire PCC knowledge and to share implementation experience. Key elements of the implementation in each nursing home were translation of the larger labor–management partnership to each member nursing home, management innovations that developed and supported PCC, and conduct of union actors in each nursing home that supported PCC while maintaining traditional union protections. Frontline workers exhibited strong engagement in PCC practices.  Implications:  A partnership between labor and management can foster changes in the organization of frontline work aimed at improving nursing home residents’ quality of life and care.
    Keywords: 〈Kwd〉〈Italic〉Management〈/Italic〉〈/Kwd〉 ; 〈Kwd〉〈Italic〉Labor Unions〈/Italic〉〈/Kwd〉 ; 〈Kwd〉〈Italic〉Qualitative Research〈/Italic〉〈/Kwd〉 ; 〈Kwd〉〈Italic〉Workforce〈/Italic〉〈/Kwd〉
    ISSN: 0016-9013
    E-ISSN: 1758-5341
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  • 3
    In: PLoS ONE, 2013, Vol.8(6)
    Description: The transcription factor C/EBPβ controls differentiation, proliferation, and functionality of many cell types, including innate immune cells. A detailed molecular understanding of how C/EBPβ directs alternative cell fates remains largely elusive. A multitude of signal-dependent post-translational modifications (PTMs) differentially affect the protean C/EBPβ functions. In this study we apply an assay that converts primary mouse B lymphoid progenitors into myeloid cells in order to answer the question how C/EBPβ regulates (trans-) differentiation and determines myeloid cell fate. We found that structural alterations and various C/EBPβ PTMs determine the outcome of trans-differentiation of lymphoid into myeloid cells, including different types of monocytes/macrophages, dendritic cells, and granulocytes. The ability of C/EBPβ to recruit chromatin remodeling complexes is required for the granulocytic trans-differentiation outcome. These novel findings reveal that PTMs and structural plasticity of C/EBPβ are adaptable modular properties that integrate and rewire epigenetic functions to direct differentiation to diverse innate immune system cells, which are crucial for the organism survival.
    Keywords: Research Article ; Biology ; Medicine
    E-ISSN: 1932-6203
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  • 4
    Language: English
    In: Zeitschrift fur Psychodrama und Soziometrie, June, 2014, Vol.13(1), p.19(3)
    Description: Byline: Grete A. Leutz (1) Author Affiliation: (1) Uhlandstr. 8, 88662, Uberlingen, Deutschland Article History: Registration Date: 26/03/2014 Online Date: 14/05/2014
    ISSN: 1619-5507
    Source: Cengage Learning, Inc.
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  • 5
    Language: English
    In: Journal of Autism and Developmental Disorders, 2014, Vol.44(4), pp.903-914
    Description: This study investigated families’ experience of choice within a participant-directed Medicaid waiver program for young children with autism. Fourteen parents or grandparents participated in in-depth interviews about their experience of choosing personnel, directing in-home services, and managing the $25,000 annual allocation. Key findings included families’ preference to hire providers with whom they have a prior relationship, parent empowerment and differences of opinion about parents as teachers. Professionals implementing participant directed service models could benefit from understanding the strong value parents’ placed on the personalities and interpersonal skills of providers. Parents’ descriptions of directing rather than merely accepting autism services revealed increased confidence in their ability to choose and manage the multiple components of their children’s HCBS autism waiver program.
    Keywords: Participant direction ; Choice ; Medicaid home and community-based services ; Autism waiver
    ISSN: 0162-3257
    E-ISSN: 1573-3432
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  • 6
    In: Oncogene, 2015
    Description: Post-transcriptional control has emerged as a major regulatory event In gene expression and often occurs at the level of translation Initiation. Although overexpression or constitutive activation of tyrosine kinases (TKs) through gene amplification, translocation or mutation are well-characterized oncogenic events, current knowledge about translational mechanisms of TK activation is scarce. Here, we report the presence of translational cis-regulatory upstream open reading frames (uORFs) in the majority of transcript leader sequences of human TK mRNAs. Genetic ablation of uORF initiation codons in TK transcripts resulted in enhanced translation of the associated downstream main protein-coding sequences (CDSs) in all cases studied. Similarly, experimental removal of uORF start codons in additional non-TK proto-oncogenes, and naturally occurring loss-of-uORF alleles of the c-met proto-oncogene (MET) and the kinase insert domain receptor (KDR), was associated with increased CDS translation. Based on genome-wide sequence analyses we identified polymorphisms in 15.9% of all human genes affecting uORF initiation codons, associated Kozak consensus sequences or uORF-related termination codons. Together, these data suggest a comprehensive role of uORF-mediated translational control and delineate how aberrant induction of proto-oncogenes through loss-of-function mutations at uORF initiation codons may be involved in the etiology of cancer. We provide a detailed map of uORFs across the human genome to stimulate future research on the pathogenic role of uORFs. Oncogene (2016) 35, 1736-1742; doi: 10.1038/onc.2015.233; published online 22 June 2015
    Keywords: Open Reading Frames -- Properties ; Phosphotransferases -- Properties ; Translation (Genetics) -- Health Aspects ; Carcinogenesis -- Genetic Aspects;
    ISSN: 0950-9232
    E-ISSN: 14765594
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  • 7
    Article
    Article
    Language: German
    In: Zeitschrift für Psychodrama und Soziometrie, 2013, Vol.12(2), pp.305-317
    Description: Der Artikel befasst sich mit Doppeln als der variantenreichsten Technik des Psychodramas, seiner entwicklungspsychologischen Grundlage sowie der Bedeutung von Empathie für das doppelnde Hilfs-Ich. Verschiedene Formen dieser Technik, ihre Ausübungsweisen und Anwendungsmöglichkeiten werden beschrieben und durch Beispiele illustriert. This article deals with the double-technique of psychodrama, its various types and applications. Further, it focusses on the developmental basis of the technique, the auxiliary ego, on the significance of empathy and the double situation as such.
    Keywords: Psychodrama ; Double-technique ; Auxiliary ego ; Empathy ; Double ego ; Double situation
    ISSN: 1619-5507
    E-ISSN: 1862-2526
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  • 8
    In: Journal of Intellectual Disability Research, December 2014, Vol.58(12), pp.1091-1104
    Keywords: Autism Waiver Program ; Parenting Stress ; Participant Direction ; Relational Coordination
    ISSN: 0964-2633
    E-ISSN: 1365-2788
    Source: John Wiley & Sons, Inc.
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  • 9
    Language: English
    In: Journal of intellectual disability research : JIDR, December 2014, Vol.58(12), pp.1091-104
    Description: Massachusetts is one of a very limited number of states exclusively employing participant-direction to deliver autism waiver services to children. A crucial element of this waiver program is the work conducted by the state's Department of Developmental Services (DDS) staff and state-approved providers with waiver families to facilitate the implementation of the participant-direction model. Our study investigates the effect of the collaboration between state providers and family caregivers on family well-being. We conducted a survey of 74 families who have been utilising waiver services for at least 6 months. Participants were asked to rate the coordination with providers as well as to report on parenting stress and impact of waiver services on family functioning. Data from in-home child and family assessments conducted by the state were also abstracted from program records. After controlling for a host of variables hypothesised to affect the outcomes of interest, we found that the family's view of how well they coordinated with formal providers is significantly associated all of the outcomes. Families who reported greater coordination with state providers experienced lower parenting stress and reported a more positive impact on family functioning. Child externalising behavioural problems and caregiver's health rating also contributed to parenting stress and family functioning. Our findings highlight the importance of establishing a collaborative partnership with waiver families in promoting family well-being. These results suggest that training and/or resources that foster team building and communication can positively impact family functioning among families with young children with autism.
    Keywords: Autism Waiver Program ; Parenting Stress ; Participant Direction ; Relational Coordination ; Professional-Family Relations ; Child Development Disorders, Pervasive -- Nursing ; Community Health Services -- Methods ; Family -- Psychology ; Stress, Psychological -- Psychology
    ISSN: 09642633
    E-ISSN: 1365-2788
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  • 10
    Language: English
    In: Biochimica et Biophysica Acta. Gene Regulatory Mechanisms, 2016, Vol.1859(7), p.841(7)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.bbagrm.2016.04.008 Byline: Elisabeth Kowenz-Leutz, Anja Schuetz, Qingbin Liu, Maria Knoblich, Udo Heinemann, Achim Leutz Abstract: The transcription factor CCAAT/enhancer-binding protein [alpha] (C/EBP[alpha]) regulates cell cycle arrest and terminal differentiation of neutrophils and adipocytes. Mutations in the basic leucine zipper domain (bZip) of C/EBP[alpha] are associated with acute myeloid leukemia. A widely used murine transforming C/EBP[alpha] basic region mutant (BRM2) entails two bZip point mutations (I294A/R297A). BRM2 has been discordantly described as defective for DNA binding or defective for interaction with E2F. We have separated the two BRM2 mutations to shed light on the intertwined reciprocity between C/EBP[alpha]-E2F-DNA interactions. Both, C/EBP[alpha] I294A and R297A retain transactivation capacity and interaction with E2F-DP. The C/EBP[alpha] R297A mutation destabilized DNA binding, whereas the C/EBP[alpha] I294A mutation enhanced binding to DNA. The C/EBP[alpha] R297A mutant, like BRM2, displayed enhanced interaction with E2F-DP but failed to repress E2F-dependent transactivation although both mutants were readily suppressed by E2F1 for transcription through C/EBP cis-regulatory sites. In contrast, the DNA binding enhanced C/EBP[alpha] I294A mutant displayed increased repression of E2F-DP mediated transactivation and resisted E2F-DP mediated repression. Thus, the efficient repression of E2F dependent S-phase genes and the activation of differentiation genes reside in the balanced DNA binding capacity of C/EBP[alpha]. Article History: Received 12 June 2015; Revised 24 March 2016; Accepted 19 April 2016
    Keywords: DNA Binding ; DNA Binding Proteins ; Protein Binding ; DNA ; Gene Mutation ; Leukemia
    ISSN: 1874-9399
    E-ISSN: 18764320
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