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  • 1
    Article
    Article
    Language: English
    In: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 17 April 2012, Vol.184(7), pp.789
    Description: A 69-year-old man presented with a 40-year history of recurrent asymptomatic rashes on the left side of his body. Examination showed linear scaly plaques on his left arm ([Figure 1A][1]), the left side of his chest and abdomen, the left flank ([Figure 1B][1]) and the left leg, distributed along
    Keywords: Anti-Inflammatory Agents -- Therapeutic Use ; Betamethasone -- Analogs & Derivatives ; Psoriasis -- Diagnosis ; Skin Diseases -- Diagnosis
    ISSN: 08203946
    E-ISSN: 1488-2329
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  • 2
    Language: English
    In: Modern Language Journal, Sept, 2011, Vol.95, p.370(15)
    Description: To authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1540-4781.2011.01209.x Byline: LI WEI (1) Abstract: This article examines the multilingual and multimodal practices of British Chinese children in complementary school classes from a multicompetence perspective. Using classroom interaction data from a number of Chinese complementary schools in 3 different cities in England, the article argues that the multicompetence perspective enables a holistic look at codeswitching and modeswitching by multilingual children of minority ethnic background and helps to highlight creativity and criticality-2 important and closely related concepts that have hitherto been underexplored in multilingualism research. Author Affiliation: (1)University of London,Birkbeck CollegeDepartment of Applied Linguistics & Communication30 Russell Square, BloomsburyLondon WC1B 5DT, United KingdomEmail:li.wei@bbk.ac.uk
    Keywords: Schools
    ISSN: 0026-7902
    Source: Cengage Learning, Inc.
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  • 3
    Language: English
    In: Marine Pollution Bulletin, April 2012, Vol.64(4), pp.699-703
    Description: ► could show avoidance behavior when exposure to lower pH. ► Respiration rates were enhanced under high CO (1000 μatm) condition. ► Feeding rates increased with prolonged exposure under the high CO condition. Climate change mediates marine chemical and physical environments and therefore influences marine organisms. While increasing atmospheric CO level and associated ocean acidification has been predicted to stimulate marine primary productivity and may affect community structure, the processes that impact food chain and biological CO pump are less documented. We hypothesized that copepods, as the secondary marine producer, may respond to future changes in seawater carbonate chemistry associated with ocean acidification due to increasing atmospheric CO concentration. Here, we show that the copepod, , was able to perceive the chemical changes in seawater induced under elevated CO concentration (〉1700 μatm, pH 〈 7.60) with avoidance strategy. The copepod’s respiration increased at the elevated CO (1000 μatm), associated acidity (pH 7.83) and its feeding rates also increased correspondingly, except for the initial acclimating period, when it fed less. Our results imply that marine secondary producers increase their respiration and feeding rate in response to ocean acidification to balance the energy cost against increased acidity and CO concentration.
    Keywords: Behavior ; Centropages Tenuiremis ; Copepod ; Feeding ; Ocean Acidification ; Respiration ; Environmental Sciences ; Oceanography
    ISSN: 0025-326X
    E-ISSN: 1879-3363
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  • 4
    Language: English
    In: Proceedings of the National Academy of Sciences of the United States of America, 16 October 2012, Vol.109(42), pp.17087-92
    Description: Dysfunction of the neurotrophin brain-derived neurotrophic factor (BDNF) is implicated in Rett syndrome (RTT), but the state of its releasable pool and downstream signaling in mice lacking methyl-CpG-binding protein-2 (Mecp2) is unknown. Here, we show that membrane currents and dendritic Ca(2+) signals evoked by recombinant BDNF or an activator of diacylglycerol (DAG)-sensitive transient receptor potential canonical (TRPC) channels are impaired in CA3 pyramidal neurons of symptomatic Mecp2 mutant mice. TRPC3 and TRPC6 mRNA and protein levels are lower in Mecp2 mutant hippocampus, and chromatin immunoprecipitation (ChIP) identified Trpc3 as a target of MeCP2 transcriptional regulation. BDNF mRNA and protein levels are also lower in Mecp2 mutant hippocampus and dentate gyrus granule cells, which is reflected in impaired activity-dependent release of endogenous BDNF estimated from TRPC currents and dendritic Ca(2+) signals in CA3 pyramidal neurons. These results identify the gene encoding TRPC3 channels as a MeCP2 target and suggest a potential therapeutic strategy to boost impaired BDNF signaling in RTT.
    Keywords: Brain-Derived Neurotrophic Factor -- Metabolism ; Hippocampus -- Cytology ; Methyl-Cpg-Binding Protein 2 -- Genetics ; Pyramidal Cells -- Physiology ; Rett Syndrome -- Metabolism ; Signal Transduction -- Physiology ; Trpc Cation Channels -- Metabolism
    ISSN: 00278424
    E-ISSN: 1091-6490
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  • 5
    Language: English
    In: Applied Surface Science, Jan 30, 2014, Vol.290, p.240(6)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.apsusc.2013.11.057 Byline: Wei Li, Minfang Chen Abstract: acents Mixed stabilizers and reductants resulted in reduced the size of Cu particles. acents Refined Cu NPs exhibited an enhanced density upon sintering. acents The enhanced particle density decreased the resistivity of the Cu pattern. Author Affiliation: (a) School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China (b) School of Materials Science and Engineering, Tianjin University of Technology, Tianjin 300384, China Article History: Received 15 August 2013; Revised 18 September 2013; Accepted 14 November 2013
    ISSN: 0169-4332
    Source: Cengage Learning, Inc.
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  • 6
    Language: English
    In: Tetrahedron Letters, 28 September 2011, Vol.52(39), pp.5070-5072
    Description: A simple and highly efficient route to the FKBP-binding domain (FKBD) from the natural product rapamycin has been developed, which entails a sequence of ozonolysis/Baeyer–Villiger/Wittig reactions. The newly synthesized FKBD may serve as a core to assemble hybrid macrocyclic libraries for the discovery of novel probes of protein function and to synthesize new ligands for the FKBP family of proteins.
    Keywords: Fkbp ; Rapamycin ; Fkbp-Binding Domain ; Chemistry
    ISSN: 0040-4039
    E-ISSN: 1873-3581
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  • 7
    Language: English
    In: The Journal of Urology, April 2015, Vol.193(4), pp.e556-e556
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.juro.2015.02.1532 Byline: Wei Li Author Affiliation: Shanghai, China, People's Republic of Article Note: (footnote) Source of Funding: The work was partially supported by grants from the National Natural Science Foundation (No. 81000311 and No. 81270831), People's Republic of China.
    Keywords: Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
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  • 8
    Language: English
    In: Journal of Hydrology, March 14, 2014, Vol.510, p.124(13)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jhydrol.2013.12.029 Byline: Wei-Li Liang, Taro Uchida Abstract: acents Subsurface saturation develops fragmentarily at the soil-bedrock interface firstly. acents Soil depth and bedrock topographic wetness index control subsurface saturation. acents Subsurface saturation shows an "upper-lower" and "fragment-integration" process. Article History: Received 3 July 2013; Revised 30 November 2013; Accepted 17 December 2013 Article Note: (miscellaneous) This manuscript was handled by Corrado Corradini, Editor-in-Chief, with the assistance of Rao S. Govindaraju, Associate Editor
    ISSN: 0022-1694
    Source: Cengage Learning, Inc.
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  • 9
    Language: English
    In: Angewandte Chemie International Edition, 29 July 2013, Vol.52(31), pp.8079-8083
    Description: : Silicon nanowires that contain multiple, dimensionally controlled, axially registered doped regions were synthesized and investigated by angle‐dependent mid‐infrared spectroscopy (see picture; =partial pressure). The wires support mid‐infrared multimodal localized surface plasmon resonances.
    Keywords: Doping ; Nanowires ; Semiconductor Plasmonics ; Silicon ; Surface Plasmon Resonances
    ISSN: 1433-7851
    E-ISSN: 1521-3773
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  • 10
    Language: English
    In: Li, Gene-Wei and X. Sunney Xie. 2012. Central dogma at the single-molecule level in living cells. Nature 475(7356): 308-315.
    Description: Gene expression originates from individual DNA molecules within living cells. Like many single-molecule processes, gene expression and regulation are stochastic, that is, sporadic in time. This leads to heterogeneity in the messenger RNA and protein copy numbers in a population of cells with identical genomes. With advanced single-cell fluorescence microscopy, it is now possible to quantify transcriptomes and proteomes with single-molecule sensitivity. Dynamic processes such as transcription factor binding, transcription and translation can be monitored in real time, providing quantitative descriptions of gene expression and regulation, and the demonstration that a single-molecule event can determine the phenotype of a cell.
    Keywords: Cell Survival–Metabolism ; Cells–Methods ; Gene Expression Profiling–Metabolism ; Gene Expression Regulation–Metabolism ; Humans–Metabolism ; Molecular Imaging–Metabolism ; Transcription Factors–Metabolism ; Drug Resistance ; Proteins ; Bacteria ; Enzymes ; Transcription Factors;
    ISSN: 0028-0836
    E-ISSN: 14764687
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