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  • 1
    Language: English
    In: Science, 13 September 2012, Vol.337
    Description: Despite the growing importance of fluorinated organic compounds in drug development, there are no direct protocols for the fluorination of aliphatic C-H bonds using conveniently handled fluoride salts. We have discovered that a manganese porphyrin comptex catalyzes alkyl fluorination by fluoride ion under mild conditions in conjunction with stoichiometric oxidation by iodosylbenzene. Simple alkanes, terpenoids, and even steroids were selectively fluorinated at otherwise inaccessible sites in 50 to 60% yield. Decalin was fluorinated predominantly at the C2 and C3 methylene positions. Bornyl acetate was converted to exo-5-fluoro-bornyl acetate, and 5[alpha]-androstan-17-one was fluorinated selectively in the A ring. Mechanistic analysis suggests that the regioselectivity for C-H bond cleavage is directed by an oxomanganese(V) catalytic intermediate followed by F delivery via an unusual manganese(IV) fluoride that has been isolated and structurally characterized. 10.1126/science.1222327
    Keywords: Catalysis (Homogeneous), Catalysis (Heterogeneous), Bio-Inspired, Hydrogen and Fuel Cells, Materials and Chemistry By Design, Synthesis (Novel Materials)
    ISSN: 00368075
    E-ISSN: 10959203
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  • 2
    Language: English
    In: Journal of the American College of Cardiology, 13 October 2015, Vol.66(15), pp.B106-B107
    Description: Methods A total of 704 patients treated with primary angioplasty by drug eluting stents for ST-elevation myocardial infarction with MVD were enrolled from January 2009 to December 2012 and were divided into two groups. 425 patients underwent PCI of the infarct-related artery only (Infarct vessel PCI group); 279 patients underwent same time or stage PCI of non-target vessel and achieved complete revascularization within seven days of primary PCI at index admission (Multivessel PCI).
    Keywords: Medicine
    ISSN: 0735-1097
    E-ISSN: 1558-3597
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  • 3
    Language: English
    In: Tetrahedron Letters, 02 December 2015, Vol.56(48), pp.6800-6802
    Description: Palladium-catalyzed allylic sulfonations of the linear allylic carbonates with sodium sulfite (Na SO ) were accomplished under mild conditions. This method gave allylic sulfonic acids in good to excellent yields with high level of regioselectivities.
    Keywords: Regioselectivity ; Allylation ; Na2so3 ; Palladium ; Sulfonic Acid ; Chemistry
    ISSN: 0040-4039
    E-ISSN: 1873-3581
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  • 4
    Language: English
    In: Biochemical and Biophysical Research Communications, 25 October 2013, Vol.440(3), pp.388-392
    Description: The discovery of regulation relationship of protein interactions is crucial for the mechanism research in signaling network. Bioinformatics methods can be used to accelerate the discovery of regulation relationship between protein interactions, to distinguish the activation relations from inhibition relations. In this paper, we describe a novel method to predict the regulation relations of protein interactions in the signaling network. We detected 4,417 domain pairs that were significantly enriched in the activation or inhibition dataset. Three machine learning methods, logistic regression, support vector machines(SVMs), and naïve bayes, were explored in the classifier models. The prediction power of three different models was evaluated by 5-fold cross-validation and the independent test dataset. The area under the receiver operating characteristic curve for logistic regression, SVM, and naïve bayes models was 0.946, 0.905 and 0.809, respectively. Finally, the logistic regression classifier was applied to the human proteome-wide interaction dataset, and 2,591 interactions were predicted with their regulation relations, with 2,048 in activation and 543 in inhibition. This model based on domains can be used to identify the regulation relations between protein interactions and furthermore reconstruct signaling pathways.
    Keywords: Regulation Relationship ; Protein Interaction ; Signaling Network ; Logistic Regression ; Biology ; Chemistry ; Anatomy & Physiology
    ISSN: 0006-291X
    E-ISSN: 1090-2104
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  • 5
    Language: English
    In: Gastroenterology, November 2014, Vol.147(5), pp.e1-e2
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1053/j.gastro.2014.05.042 Byline: Wei Liu, Xinming Yang Author Affiliation: Department of Otolaryngology-Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China Article Note: (footnote) Conflicts of interest The authors disclose no conflicts.
    Keywords: Medicine
    ISSN: 0016-5085
    E-ISSN: 1528-0012
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  • 6
    Language: English
    In: Journal of Membrane Science, August 1, 2012, Vol.409-410, p.113(14)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.memsci.2012.03.041 Byline: Wei Liu, Nathan Canfield Keywords: Membrane support; Inorganic membrane; Porous metal sheet; Nickel alloy; Tape casting; Pore size; Permeability; Micro-filtration Abstract: a* Thin (25-200[mu]m) porous Ni alloy sheets of sub-micrometer pores are prepared with uniform pore structures. a* Inexpensive metal oxide powder is used as the metal precursor. a* The preparation process is versatile for tailoring of sheet chemical and physical properties. a* The 50[mu]m-thick sheet shows gas permeance of 1.0x10.sup.-4 mol/(m.sup.2 Pas) and water permeability of 10,000L/m.sup.2/h/bar. Author Affiliation: Pacific Northwest National Laboratory, Energy and Environment Directorate, Richland, WA 99354, USA Article History: Received 18 August 2011; Revised 18 February 2012; Accepted 16 March 2012
    Keywords: Permeability ; Alloys ; Nickel Alloys ; Sheet Metal
    ISSN: 0376-7388
    Source: Cengage Learning, Inc.
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  • 7
    Language: English
    In: Angewandte Chemie International Edition, June 3, 2013, Vol.52(23), p.6024(4)
    Description: Byline: Wei Liu, John T. Groves Keywords: C-H fluorination; manganese; porphyrins; positron emission tomography; synthetic methods ***** No abstract is available for this article. ***** Author Affiliation: Department of Chemistry, Princeton University, Princeton, NJ 08544 (USA) Department of Chemistry, Princeton University, Princeton, NJ 08544 (USA) Article Note: This research was supported by the Center for Catalytic Hydrocarbon Functionalization, an Energy Frontier Research Center, U.S. Department of Energy, Office of Science, Basic Energy Sciences, under award no. DE SC0001298. Fluorination of biomolecules was supported by the US National Science Foundation (CHE-1148597). We also thank Lotus Separations LLC and Prof. A. Doyle for chiral analyses and Prof. D. Fiedler for flash column chromatography. Supporting information: Additional Supporting Information may be found in the online version of this article As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
    Keywords: Porphyrins -- Analysis
    ISSN: 1433-7851
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  • 8
    Language: English
    In: Proceedings of the National Academy of Sciences of the United States of America, 28 January 2014, Vol.111(4), pp.1293-7
    Description: Electrochemical (EC) reactions are crucial in many applications, yet most EC analytical tools lack the sensitivity to access molecular-level information of reactants and products. By combining sum-frequency vibrational spectroscopy and surface plasmon resonance at EC interfaces, we demonstrate the feasibility of measuring in situ and real-time vibrational spectra during EC reactions at noble metal electrodes. Application of the technique to EC reactions at a gold surface helps in understanding how the surface in a basic solution is oxidized and reduced during a cyclic voltammetry cycle. Study of desorption of a thiol self-assembled monolayer from gold through EC reactions in a basic solution shows that the desorbed thiols by reductive reaction remain as an ordered layer near the gold interface, but do diffuse away if they are desorbed oxidatively from gold.
    Keywords: Buried Interface ; Field Enhancement ; Spectroelectrochemistry
    ISSN: 00278424
    E-ISSN: 1091-6490
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  • 9
    Language: English
    In: International Journal of Nursing Studies, August 2012, Vol.49(8), pp.941-952
    Description: Communication is central to safe medication management. Handover is a routine communication forum where nurses provide details about how patients’ medications are managed. Previous studies have investigated handover processes as general communication forums without specific focus on medication information exchange. The effects of social, environmental and organisational contexts on handover communication and medication safety have not been explored. To examine dominant and submissive forms of communication and power relations surrounding medication communication among nurses, and between nurses and patients during handover. A critical ethnographic approach was utilised to unpack the social and power struggles embedded in handover practices. The study was conducted in two medical wards of a metropolitan teaching hospital in Melbourne, Australia from January to November 2010. All registered nurses employed in the medical wards during the study time were eligible for participation. Patients were eligible if they were able to communicate with nurses about how their medications were managed. In total, 76 nurses and 27 patients were recruited for the study after giving written consent for participation. Participant observations, field interviews, video-recordings and video reflexive focus groups were conducted. Fairclough's critical discourse analytic framework guided data analysis. Nurse coordinators’ group handovers in private spaces prioritised organisational and biomedical discourses, with little emphasis on evaluating the effectiveness of medication treatment. The ward spatial structure provided an added complexity to how staff allocation occurred. Handovers involving patients in the public spaces at the bedside facilitated a partnership model in medication communication. Nurses exercised discretion during bedside handovers by discussing sensitive information away from the bedside. Handovers across different wards during patient transfers caused communication breakdowns because information was not exchanged between bedside nurses. Nurse coordinators need to relinquish organisational control of the handover practice and appreciate the contribution of bedside nurses to patient information exchange. Bedside nurses need to be provided with opportunities to raise questions during the group handover. Designated meeting spaces need to be provided to reduce interruptions to the group handover process.
    Keywords: Critical Ethnography ; Handover ; Medication Communication ; Video-Recording ; Nursing
    ISSN: 0020-7489
    E-ISSN: 1873-491X
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  • 10
    Language: English
    In: Journal of the American College of Cardiology, 20 October 2015, Vol.66(16), pp.C120-C120
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jacc.2015.06.466 Byline: Wei Liu, Fuyong Chu, Hongxu Liu Author Affiliation: Department of Cardiology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China
    Keywords: Medicine
    ISSN: 0735-1097
    E-ISSN: 1558-3597
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