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  • 1
    Language: English
    In: Journal of the American Chemical Society, 22 February 2012, Vol.134(7), pp.3322-5
    Description: Reversible plasmonic circular dichroism (CD) responses are realized for the first time based on temperature-dependent assembly and disassembly of Au nanorod (Au NR) and DNA hybrids. Compared with the conventional UV-vis absorption spectra, the changes in both intensity and line shape of plasmonic CD signals are much more pronounced, leading to a preliminary detection limit of DNA as low as 75 nM. The mechanism and influence factors of reversible plasmonic CD responses are explored.
    Keywords: DNA -- Chemistry ; Gold -- Chemistry ; Nanotubes -- Chemistry
    ISSN: 00027863
    E-ISSN: 1520-5126
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  • 2
    Language: English
    In: Chemical reviews, 11 May 2011, Vol.111(5), pp.3358-406
    Description: Wen et al discuss organic thin film fabrication for field-effect transistors.
    Keywords: Thin Films ; Transistors;
    ISSN: 00092665
    E-ISSN: 1520-6890
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  • 3
    Language: English
    In: Cancer Research, 07/01/2018, Vol.78(13 Supplement), pp.2268-2268
    ISSN: 0008-5472
    E-ISSN: 1538-7445
    Source: CrossRef
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  • 4
    Language: English
    In: Tetrahedron Letters, 06 May 2015, Vol.56(19), pp.2393-2396
    Description: A domino palladium-catalyzed hydrogenation reaction was developed to construct 6 -benzo[ ]chromene scaffold. Using Pd/C catalyst under H balloon, 6 -benzo[ ]chromenes were obtained in nearly quantitative yields. However, using Pd(PhCN) Cl /DPEphos/AgBF as the catalytic system, spiro[benzo[ ]chromene-6,2′-chroman]s were obtained in up to 91% yields.
    Keywords: 6h-Benzo[C]Chromene Scaffold ; Spiroacetal ; Domino Palladium-Catalyzed Reaction ; Cationic Palladium Catalyzed Hydrogenation ; Chemistry
    ISSN: 0040-4039
    E-ISSN: 1873-3581
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  • 5
    Language: English
    In: Current Biology, 12 September 2016, Vol.26(17), pp.2351-2357
    Description: Forgetting is a universal feature for most types of memories. The best-defined and extensively characterized behaviors that depict forgetting are natural memory decay and interference-based forgetting [ ]. Molecular mechanisms underlying the active forgetting remain to be determined for memories in vertebrates. Recent progress has begun to unravel such mechanisms underlying the active forgetting [ ] that is induced through the behavior-dependent activation of intracellular signaling pathways. In , training-induced activation of the small G protein Rac1 mediates natural memory decay and interference-based forgetting of aversive conditioning memory [ ]. In mice, the activation of photoactivable-Rac1 in recently potentiated spines in a motor learning task erases the motor memory [ ]. These lines of evidence prompted us to investigate a role for Rac1 in time-based natural memory decay and interference-based forgetting in mice. The inhibition of Rac1 activity in hippocampal neurons through targeted expression of a dominant-negative Rac1 form extended object recognition memory from less than 72 hr to over 72 hr, whereas Rac1 activation accelerated memory decay within 24 hr. Interference-induced forgetting of this memory was correlated with Rac1 activation and was completely blocked by inhibition of Rac1 activity. Electrophysiological recordings of long-term potentiation provided independent evidence that further supported a role for Rac1 activation in forgetting. Thus, Rac1-dependent forgetting is evolutionarily conserved from invertebrates to vertebrates. Y. Liu et al. discovered a forgetting mechanism that causes natural memory decay and interference-induced forgetting in mice. Inhibition of Rac1 activity blocks forgetting, whereas an increase of Rac1 activity speeds up forgetting. This could relate to the human conditions since it is conserved evolutionarily.
    Keywords: Active Forgetting ; Rac1 ; Hippocampus ; Novel Object Recognition Memory ; Retroactive Interference ; Memory Decay ; Biology
    ISSN: 0960-9822
    E-ISSN: 1879-0445
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  • 6
    In: Journal of Materials Chemistry, 2012, Vol.22(45), pp.23821-23829
    Description: Periodically stacked graphene and its insulating isomorph provide a fascinating structural element in implementing highly functional superlattices at the atomic scale, which offers possibilities in designing nanoelectronic and photonic devices. Using density functional theory (DFT) calculations, we demonstrate that various types of superlattices can be obtained by stacking two-dimensional (2D) materials alternately, namely, graphene, hexagonal boron nitride ( h -BN), hydrogenated graphene, and fluorinated graphene. The energy band in layer-stacked superlattices is found to be more sensitive to the barrier width than that in conventional IIIV semiconductor superlattices. When adding more than one atomic layer to the barrier in each period, the coupling of electronic wavefunctions in neighboring potential wells can be significantly reduced, which leads to the degeneration of continuous subbands into quantized energy levels. When varying the well width, the energy levels in the potential wells along the L-M direction behave distinctly from those along the K-H direction. Our results indicate that the quantized energy states in atomic-layered superlattices can be effectively tuned by modifying each individual barrier/well layer, enabling atomic-scale material engineering.
    Keywords: Barriers ; Energy Levels ; Graphene ; Nanostructure ; Semiconductors ; Superlattices ; Two Dimensional ; Wells ; Thin Films, Surfaces, and Interfaces (So) ; Chemical and Electrochemical Properties (MD) ; Chemical and Electrochemical Properties (Ep) ; Chemical and Electrochemical Properties (Ed) ; Chemical and Electrochemical Properties (EC);
    ISSN: 0959-9428
    E-ISSN: 1364-5501
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  • 7
    Language: English
    In: PLoS ONE, 2011, Vol.6(3), p.e17498
    Description: It is well established that in adults, long-term repopulating hematopoietic stem cells (HSC) are mitotically quiescent cells that reside in specialized bone marrow (BM) niches that maintain the dormancy of HSC. Our laboratory demonstrated that the engraftment potential of human HSC (CD34 + cells) from BM and mobilized peripheral blood (MPB) is restricted to cells in the G0 phase of cell cycle but that in the case of umbilical cord blood (UCB) -derived CD34 + cells, cell cycle status is not a determining factor in the ability of these cells to engraft and sustain hematopoiesis. We used this distinct in vivo behavior of CD34 + cells from these tissues to identify genes associated with the engraftment potential of human HSC. CD34 + cells from BM, MPB, and UCB were fractionated into G0 and G1 phases of cell cycle and subjected in parallel to microarray and proteomic analyses. A total of 484 target genes were identified to be associated with engraftment potential of HSC. System biology modeling indicated that the top four signaling pathways associated with these genes are Integrin signaling, p53 signaling, cytotoxic T lymphocyte-mediated apoptosis, and Myc mediated apoptosis signaling. Our data suggest that a continuum of functions of hematopoietic cells directly associated with cell cycle progression may play a major role in governing the engraftment potential of stem cells. While proteomic analysis identified a total of 646 proteins in analyzed samples, a very limited overlap between genomic and proteomic data was observed. These data provide a new insight into the genetic control of engraftment of human HSC from distinct tissues and suggest that mitotic quiescence may not be the requisite characteristic of engrafting stem cells, but instead may be the physiologic status conducive to the expression of genetic elements favoring engraftment.
    Keywords: Research Article ; Biology ; Medicine ; Genetics And Genomics ; Cell Biology ; Hematology ; Biochemistry
    E-ISSN: 1932-6203
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  • 8
    Language: English
    In: Ocean Engineering, Jan 1, 2014, Vol.75, p.46(7)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.oceaneng.2013.11.008 Byline: Yunlong Liu, Aman Zhang, Zhaoli Tian Abstract: On the basis of boundary element method, this paper constructs a numerical model of underwater explosion bubble, and then develops singularities approximation method of bubble induced flow field from the view point of potential flow theory. A point source is adopted to simulate bubble pulsation, and meanwhile a point dipole is applied to simulate asymmetry caused by both the migration and deformation of the bubble. Through the analysis of the relationship between the strength of equivalent singularities and dimensionless parameters, we find that strength parameter has few effects on equivalent point source. And with the increase of buoyancy parameter, considerable strength is added to point dipole instead of point source. Through the comparison with the numerical results of point dipole strength under the traditional spherical hypothesis, the traditional method is revised to consider non-spherical deformation in order to shed some light on research on underwater explosion bubble dynamics and anti-shock performance of ships. Author Affiliation: (a) College of Shipbuilding Engineering, Harbin Engineering University, Harbin 150001, China (b) Wuhan 2nd Ship Design and Research Institute, 430064, China Article History: Received 27 October 2012; Accepted 2 November 2013
    Keywords: Explosions – Analysis
    ISSN: 0029-8018
    Source: Cengage Learning, Inc.
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  • 9
    Language: English
    In: Angewandte Chemie International Edition, 18 May 2015, Vol.54(21), pp.6222-6226
    Description: By creating two triplet excitons from one photo‐excited singlet exciton, singlet fission in organic semiconductors has drawn tremendous attention for its potential applications in boosting the efficiency of solar conversion. Here, we show that this carrier‐multiplication effect can also be used to dramatically improve the nonlinear optical response in organic materials. We have observed large optical nonlinearity with a magnitude of up to 10 esu in pentacene films, which is further shown to be a result of singlet fission by monitoring the temporal dynamics. The potential application of such efficient nonlinear optical response has been demonstrated with a singlet‐fission‐induced polarization rotation. singlet‐fission‐induced nonlinear optical response with a magnitude of nonlinear susceptibility up to 10 esu is observed. Such efficient nonlinear optical response has been successfully applied to demonstrate ultrafast optical switching.
    Keywords: Nonlinear Optics ; Pentacene ; Singlet Fission ; Time‐Resolved Spectroscopy
    ISSN: 1433-7851
    E-ISSN: 1521-3773
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  • 10
    Language: English
    In: Biosensors and Bioelectronics, 15 June 2017, Vol.92, pp.596-601
    Description: Aberrations of gene methylation in stool DNA (sDNA) is an effective biomarker for non-invasive colorectal cancer diagnosis. However, it is challenging to accurately quantitate the gene methylation levels in sDNA due to the low abundance and degradation of sDNA. In this study, a digital quantification strategy was proposed by combining emulsion PCR (emPCR) with hydrogel immobilized bead-array. The assay includes following steps: bisulfite conversion of sDNA, pre-amplification by PCR with specific primers containing 5′ universal sequences, emPCR of pre-amplicons with beaded primers to achieve single-molecular amplification and identification of hydrogel embedding beads coated with amplicons. The sensitivity and the specificity of the method are high enough to pick up 0.05% methylated targets from unmethylated DNA background. The successful detection of hypermethylated gene in clinical stool samples suggests that the proposed method should be a potential tool for non-invasive colorectal cancer screening.
    Keywords: Hydrogel Immobilized Bead-Array ; Emulsion Pcr ; Gene Methylation ; Stool DNA ; Engineering ; Biology
    ISSN: 0956-5663
    E-ISSN: 1873-4235
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