Format:
Online-Ressource
ISSN:
1614-7065
Content:
Abstract: A novel oridonin derivative substituted with 3‐((2,3‐dihydroxypropyl) dithio)‐propionyl group at 14‐O position was synthesized through a two‐step procedure: Esterification of oridonin with 3‐(2‐pyridyldithio) propanoic acid and the subsequent thiol‐disul?de exchange reaction with 3‐mercapto‐1,2‐propanediol. The bioreduction‐responsive disulfide bond in the compound leads to high leaving ability of the 14‐O acyl moiety when treated with glutathione as monitored by reverse phase high‐performance liquid chromatography.
In:
volume:32
In:
number:5
In:
year:2014
In:
pages:448-453
In:
extent:6
In:
Chinese journal of chemistry, Weinheim : Wiley-VCH, 1983-, 32, Heft 5 (2014), 448-453 (gesamt 6), 1614-7065
Language:
English
DOI:
10.1002/cjoc.201300761
URN:
urn:nbn:de:101:1-2023010106272341216469
URL:
https://doi.org/10.1002/cjoc.201300761
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023010106272341216469
URL:
https://d-nb.info/1276966210/34
URL:
https://doi.org/10.1002/cjoc.201300761
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