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  • 1
    Language: English
    In: Annals of the New York Academy of Sciences, June 2017, Vol.1398(1), pp.30-36
    Description: Plants have provided the basis of traditional medicine systems throughout the world for thousands of years and continue to yield molecules for new remedies. We analyzed studies published from 2009 to 2016 on the Annona species (Annonaceae), including A. coriacea, A. crassifolia, A. hypoglauca, A. muricata, A. squamosa, A. sylvatica, and A. vepretorum, as sources of potential antitumor agents. Here, we report and discuss the mechanisms of action and structure-activity relationships of the most active Annona constituents. Annonaceous acetogenins are one of the most promising classes of natural products, owing to their potential antitumor activity. However, their neurotoxicity should not be underestimated.
    Keywords: Annona ; Mechanisms ; Natural Compounds ; Tumor ; Acetogenins -- Therapeutic Use ; Annonaceae -- Chemistry ; Antineoplastic Agents, Phytogenic -- Therapeutic Use ; Neoplasms -- Drug Therapy
    ISSN: 00778923
    E-ISSN: 1749-6632
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  • 2
    In: Journal of the Science of Food and Agriculture, August 2014, Vol.94(11), pp.2179-2186
    Description: To purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1002/jsfa.6533/abstract Byline: Monica R Loizzo, Marco Bonesi, Alessandro Pugliese, Francesco Menichini, Rosa Tundis Keywords: Ficus carica; dried fruits; honey; SPME/GC-MS; antioxidant properties; cholinesterase inhibition Abstract BACKGROUND The aim of this study is to evaluate, for the first time, the chemical profile, antioxidant properties and cholinesterase inhibitory activity of dried fruits and honey of Ficus carica (fig) cultivars Dottato, Citrullara, and San Francesco. RESULTS Gas chromatography-mass spectrometry (GC-MS) analysis of fig extracts identified terpenes, sterols and fatty acids as major constituents. The aroma profile of honey obtained from a mixture of the three cultivars was investigated by solid-phase micro-extraction/GC-MS. 5-(Hydroxymethyl)-2-furancarboxaldehyde, 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one and 1,3-dihydroxy-2-propanone were the main compounds. Total phenol, flavonoid and anthocyanin content are also reported. The San Francesco cultivar is characterised by the highest phenol and flavonoid content, while Dottato showed the major anthocyanin content. The Dottato cultivar exhibited the best radical scavenging activity against both 2,2a[sup.2]-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) and 2,2-diphenyl-1-picrylhydrazyl radicals (IC.sub.50 values of 5.4 and 22.6 A[micro]g mL.sub.-1, respectively). This cultivar also showed the highest inhibitory activity against both acetylcholinesterase and butyrylcholinesterase, with IC.sub.50 values of 26.9 and 31.8 A[micro]g mL.sub.-1, respectively. CONCLUSION Dried figs are a convenient source of bioactive compounds that demonstrated potential neuroprotection and antioxidant effects. Therefore, the addition of figs to the human diet should be recommended by dieticians and nutritionists. [c] 2013 Society of Chemical Industry
    Keywords: Ficus Carica ; Dried Fruits ; Honey ; Spme/Gc‐Ms ; Antioxidant Properties ; Cholinesterase Inhibition
    ISSN: 0022-5142
    E-ISSN: 1097-0010
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  • 3
    Language: English
    In: Food Chemistry, Jan 15, 2015, Vol.167, p.475(9)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.foodchem.2014.06.123 Byline: Paolo Lucci, Deborah Pacetti, Monica R. Loizzo, Natale G. Frega Abstract: acents Punica granatum seed ethanolic extract (PSEE) was investigated. acents PSEE had anti-proliferative activity against prostate and human breast cancer cells. acents PSEE exhibited promising antioxidant activity trough different mechanism of action. acents Punic acid resulted the main fatty acid of PSEE lipid fraction. acents PSEE represents a good source of phospholipids rich in essential fatty acids. Article History: Received 25 February 2014; Revised 21 May 2014; Accepted 30 June 2014
    Keywords: Fatty Acids ; Blood Lipids ; Antioxidants (Nutrients)
    ISSN: 0308-8146
    Source: Cengage Learning, Inc.
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  • 4
    Language: English
    In: Food Chemistry, 15 January 2015, Vol.167, pp.475-483
    Description: This paper aims to provide a solid base for the utilisation of pomegranate whole seed ethanolic extract (PSEE) as a nutraceutical/functional food ingredient. PSEE was tested for its antioxidant and antiproliferative activities against different human cancer cell lines. Bioactive lipid compounds were identified by studying the PSEE lipid portion. PSEE exhibited a protection of lipid peroxidation threefold higher than a positive control. PSEE showed a promising antiproliferative activity against hormone dependent prostate carcinoma LNCaP, with an IC value 3 times lower than the positive control vinblastine, and against human breast cancer cell lines (IC = 9.6 μg/ml). PSEE contained lipid bioactive compounds, such as neutral lipids, consisting of 72.8% punicic acid, glycolipids and phospholipids rich in essential fatty acids (α-linoleic and α-linolenic acids). Due the presence of bioactive compounds and the remarkable antiproliferative activity, the use of PSEE as a value-added ingredient in formulations of products aimed to prevent diseases, especially cancer, could be promoted.
    Keywords: Conjugated Linolenic Fatty Acid ; Functional Ingredient ; Phospholipid Molecular Species ; Seed ; Chemistry ; Diet & Clinical Nutrition ; Economics
    ISSN: 0308-8146
    E-ISSN: 1873-7072
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  • 5
    Language: English
    In: Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(6), pp.1990-1993
    Description: The synthesis and the ACE inhibitory activity of chalcones ( – ) and pyrazoles ( – ) are reported. A series of chalcones ( ) and pyrazoles ( ) was prepared to investigate their potential activity as Angiotensin I-Converting Enzyme (ACE) inhibitors. Their structures were verified by elemental analysis, UV, IR, MS, H NMR, C NMR, and 2D NMR experiments. Among tested compounds, chalcone exerted the highest activity with an IC value of 0.219 mM, while the most potent pyrazole was (IC value of 0.213 mM).
    Keywords: Chalcones ; Pyrazole Derivatives ; Hypertension ; ACE ; Medicine ; Chemistry ; Anatomy & Physiology
    ISSN: 0960-894X
    E-ISSN: 1464-3405
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  • 6
    Language: English
    In: Industrial Crops & Products, 2014, Vol.53, p.289(7)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.indcrop.2013.12.049 Byline: Monica R. Loizzo, Khaled Rashed, Ataa Said, Marco Bonesi, Francesco Menichini, Rosa Tundis Abstract: acents Alhagi maurorum, a legume used as natural sweetener, was investigated. acents Analyzed non-polar extracts were promising in phytochemicals composition. acents DE extract showed antioxidant and melanoma antiproliferative activities. acents Based on these properties A. maurorum can be used for the development of functional products. Author Affiliation: (a) Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy (b) Pharmacognosy Department, National Research Centre, Dokki, Giza, Egypt Article History: Received 7 October 2013; Revised 27 December 2013; Accepted 30 December 2013
    Keywords: Melanoma – Analysis ; Legumes – Analysis ; Antioxidants (Nutrients) – Analysis
    ISSN: 0926-6690
    Source: Cengage Learning, Inc.
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  • 7
    Language: English
    Description: In the present study, we assessed for the first time the changes in the antioxidant capacity, total phenolic content, and polyphenolic composition of interspecific hybrid palm oil extracted from Elaeis oleifera x Elaeis guineensis (O×G, Coari × La Mé cultivar) during the fruit ripening process 18, 20, 22, and 24 weeks after anthesis. A progressive decrease (p〈0.05) of phenolic content occurred during fruit development together with marked changes in polyphenol profiles. Significant negative correlations were established between antioxidant activity measured by TEAC (R = -0.954, p〈0.05) and ORAC (R = -0.745, p〈0.05) and fruits ripening stage while positive correlation between total phenolic content was found using either the TEAC assay or the ORAC assay. Highest DPPH radicals scavenging activity was also obtained with oils extracted at 18 WAA. These results highlight that O×G fruits of early ripeness represent a better source of phenolic compounds and may provide extracts with higher antioxidant activities when hybrid palm oil is aimed to be used as functional ingredient for the development of food or food products with antioxidant properties.
    Keywords: Polifenols ; Olis Vegetals ; Oli De Palma ; Polyphenols ; Vegetable Oils ; Palm Oil
    ISSN: 0021-8561
    Source: Universitat de Barcelona
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  • 8
    Language: English
    In: Journal of agricultural and food chemistry, 03 February 2016, Vol.64(4), pp.852-9
    Description: In the present study, we assessed for the first time the changes in the antioxidant capacity, total phenolic content, and polyphenolic composition of interspecific hybrid palm oil extracted from Elaeis oleifera × Elaeis guineensis (O × G, Coari × La Mé cultivar) during the fruit ripening process 18, 20, 22, and 24 weeks after anthesis. A progressive decrease (p 〈 0.05) of phenolic content occurred during fruit development together with marked changes in polyphenol profiles. Significant negative correlations were established between antioxidant activity measured by TEAC (R = -0.954; p 〈 0.05) and ORAC (R = -0.745; p 〈 0.05) and the fruit ripening stage, while a positive correlation between total phenolic content was found using either the TEAC assay or the ORAC assay. The highest DPPH radical scavenging activity was also obtained with oils extracted at 18 WAA. These results highlight that O × G fruits of early ripeness represent a better source of phenolic compounds and may provide extracts with higher antioxidant activities when hybrid palm oil is aimed to be used as a functional ingredient for the development of food or food products with antioxidant properties.
    Keywords: Hplc-Esi-MS/MS ; Dietary Antioxidants ; Interspecific Hybrid Palm ; Phenols ; Ripening ; Antioxidants -- Chemistry ; Arecaceae -- Chemistry ; Fruit -- Growth & Development ; Phenols -- Chemistry ; Plant Extracts -- Chemistry ; Plant Oils -- Chemistry ; Polyphenols -- Chemistry
    ISSN: 00218561
    E-ISSN: 1520-5118
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  • 9
    Language: English
    In: Food Chemistry, 2011, Vol.124(3), pp.1083-1089
    Description: This study evaluated the inhibition of carbohydrate-hydrolysing enzymes, the stimulation of insulin secretion, and the metabolic effects in mice of L. cv Diamante peel extract. The quantitative analysis of selected phytochemicals were determined to investigate their relationship with the biological activities. extract exhibited an inhibitory activity against both α-amylase and α-glucosidase with IC values of 258.7 and 263.2 μg/ml, respectively. Measurements of the effects of peel extract on the mouse insulinoma MIN6 β-cells indicated that it did exert direct stimulatory effects on the exocytotic release of insulin in a concentration-dependent manner. The supplementation of the cv Diamante was able to reduce plasma glucose (GLU) concentration and lowered the levels of plasma cholesterol (COL) and triglycerides (TG). The obtained results underline the potential health benefits as a result of consuming cv Diamante and suggest that it could be used as new potential source with functional properties for food or nutraceutical products.
    Keywords: Α-Amylase ; Α-Glucosidase ; Citrus Medica Cv Diamante ; Insulin Secretion ; Phenolics ; Chemistry ; Diet & Clinical Nutrition ; Economics
    ISSN: 0308-8146
    E-ISSN: 1873-7072
    Source: ScienceDirect Journals (Elsevier)
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  • 10
    In: Journal of Food Science, May 2013, Vol.78(5), pp.C703-C708
    Description: A traditional sweet dessert wine from Saracena (Italy), made with nonmacerated local white grapes (Guarnaccia, Malvasia and Moscato), was analyzed for phenolics and aroma profile and antioxidant activities. The most abundant classes of phenols identified by high‐performance liquid chromatography were hydroxybenzoic acids and flavan‐3‐ols, where gallic acid showed the highest content (376.5 mg/L). The analysis by solid phase microextraction‐gas chromatography‐mass spectrometry revealed the presence of superior alcohols (from ‐butanol and ‐amyl alcohol up to 2‐phenylethanol) and their ethyl esters, terpenes (such as linalool), furfuryl compounds, and free fatty acids (up to palmitic acid) as the key odorants of this wine. The antioxidant activity, evaluated by different assays 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH), 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulphonic acid (ABTS), and ‐carotene bleaching test), showed that passito wine had a radical scavenging activity (IC value of 0.03 v/v against DPPH·) and inhibited linoleic acid oxidation with an IC value of 0.4 v/v after 30 min of incubation. It is well known that moderate consumption of wine is actually recommended since it appears associated with a decreased incidence of several diseases. Passito of Saracena, a well‐appreciated Italian dessert wine, demonstrated an interesting antioxidant activity. Moreover, the aroma profile contributed and defined the chemical markers of the quality of this wine and their quantitative ranges, which are needed to assess the authenticity of local niche production claiming a quality designation.
    Keywords: Aroma ; Antioxidant Activity ; Dessert Wine ; Phenolics ; Hplc Tandem Ms ; Spme‐Gc‐Ms
    ISSN: 0022-1147
    E-ISSN: 1750-3841
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