Format:
Online-Ressource
,
illustrations (some color)
Edition:
Online-Ausg.
ISBN:
9783319135816
Series Statement:
Current cardiovascular therapy
Content:
This book offers highly practical information on pharmaceutical options in pulmonary hypertension and is designed to establish the baseline level of knowledge that a cardiovascular professional needs to know on a day-to-day basis. Treatment of Pulmonary Hypertension allows readers to learn quickly and with certainty the mode of action, the possible adverse effects, and the management of patients prescribed these drugs. The emphasis is on current practice, but with an eye to the near-future direction of treatment. Written in a quick-access, no-nonsense format and with an emphasis on a just-the-facts clinical approach, this book will be of value to trainees, recertifying physicians, practicing physicians and other professional staff in internal medicine, cardiology, emergency medicine, thrombosis, hematology, pathology, and clinical pharmacology
Note:
Includes bibliographical references and index
,
""Contents""; ""Contributors""; ""Chapter 1: The Pathophysiology, Presentation and Diagnostic Investigation of Pulmonary Hypertension""; ""Introduction""; "" Pulmonary Hypertension Pathophysiology""; ""Plexogenic Pulmonary Arteriopathy (PPA)""; ""Vasoconstriction""; "" Cellular Proliferation and Thrombosis""; "" Mechanisms of Disease""; "" Pulmonary Veno-occlusive Disease and Pulmonary Capillary Haemangiomatosis""; "" The Pathophysiology of Other Clinical Groups""; ""Left Heart Disease""; "" Chronic Lung Disease""; "" Chronic Thromboembolic Pulmonary Hypertension""
,
"" Right Ventricular Failure"""" Clinical Presentation""; ""Symptoms""; "" Functional Classification""; "" Physical Examination""; "" Diagnosis""; ""Right Heart Catheterisation""; "" Non invasive Investigations""; "" Echocardiography""; "" Other Routine Investigations""; "" Six Minute Walk Distance""; "" Disease Classification""; "" Survival""; "" Key Learning Points""; ""References""; ""Chapter 2: Molecular Biological Aspects, Therapeutic Targets and New Treatment Strategies""; ""Introduction""; "" Definition of Pulmonary Arterial Hypertension""; "" Histology of PAH""
,
"" Pathogenesis of PAH""""Endothelial Dysfunction""; ""ET-1""; "" NO""; "" PGI2""; "" Genetic Predisposition""; "" Blood Flow""; "" Drugs and Toxins""; "" Viruses and Parasites""; ""Viruses""; "" Parasites""; "" Inflammation""; "" Evidence for Inflammatory Cells""; ""T Cells""; ""B Cells""; ""Mast Cells""; ""Monocytes/Macrophages and Dendritic Cells (DC)""; ""Endothelial Progenitor Cells""; "" Evidence for Cytokines/Chemokines""; ""Cytokines""; ""Interleukin (IL)-1-β""; ""IL-6""; ""IL-13""; ""Chemokines""; ""Monocyte Chemoattractant Protein(MCP-1)""
,
""Regulated on Activation, Normal T-cell Expressed and Secreted (RANTES)""""Fractalkine (CX3CL1)""; ""Platelet Derived Growth Factor (PDGF)""; ""Epidermal Growth Factor (EGF)""; ""Vascular Endothelial Growth Factor (VEGF)""; ""Fibroblast Growth Factor 2 (FGF2)""; ""Serotonin (5-hydroxytryptamine, 5-HT)""; "" Evidence for Autoantibodies/Autoimmune Phenomenon""; "" Current Treatment of PAH""; "" Future Therapeutic Targets""; ""PDGF/Tyrosine Kinase Inhibitors""; "" Epigenetic Modulators""; ""DNA Methylation""; "" Histone Methylation and Acetylation""; "" MicroRNAs (miRNAs)""
,
"" Anti-Inflammatory/Immunosuppressive Treatments"""" Novel Vasoactive Factors""; ""Apelin""; ""Vasoactive Intestinal Peptide (VIP)""; ""Endothelial Nitric Oxide Synthase (eNOS) Couplers""; ""IP Receptor Agonists""; "" Serotonin Receptor Antagonism""; "" Rho-kinases""; "" Peroxisome Proliferator-Activated Receptor-γ (PPARγ)""; "" Cell Therapy""; "" Summary""; ""References""; ""Chapter 3: Current Treatment Strategies, Guidelines and New Therapies""; ""Endothelin Receptor Antagonists""; ""Bosentan""; "" Ambrisentan""; "" Macitentan""; "" Phosphodiesterase-5 Inhibitors""; ""Sildenafil""
,
"" Tadalafil""
Additional Edition:
3319135813
Additional Edition:
9783319135809
Additional Edition:
9783319135816
Additional Edition:
Print version Treatment of Pulmonary Hypertension
Language:
English
URL:
Volltext
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