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  • 1
    Language: English
    In: International Journal of Pharmaceutics, 01 May 2013, Vol.448(1), pp.28-43
    Description: Recent innovations and developments in nanotechnology have revolutionized cancer therapeutics. Engineered nanomaterials are the current workhorses in the emerging field of cancer nano-therapeutics. Lipid vesicles bearing anti-tumor drugs have turned out to be a clinically feasible and promising nano-therapeutic approach to treat cancer. Efficient entrapment of therapeutics, biocompatibility, biodegradability, low systemic toxicity, low immunogenicity and ability to bypass multidrug resistance mechanisms has made liposomes a versatile drug/gene delivery system in cancer chemotherapy. The present review attempts to explore the recent key advances in liposomal research and the vast arsenal of liposomal formulations currently being utilized in treatment and diagnosis of cancer.
    Keywords: Liposomes ; Cancer Therapeutics ; Drug Delivery ; Second Generation ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 0378-5173
    E-ISSN: 1873-3476
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  • 2
    Language: English
    In: Cancer Research, 08/01/2015, Vol.75(15 Supplement), pp.3685-3685
    ISSN: 0008-5472
    E-ISSN: 1538-7445
    Source: CrossRef
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  • 3
    Language: English
    In: Cancer Research, 04/15/2013, Vol.73(8 Supplement), pp.1044-1044
    ISSN: 0008-5472
    E-ISSN: 1538-7445
    Source: CrossRef
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  • 4
    Language: English
    In: Sensors & Actuators: B. Chemical, March 31, 2014, Vol.193, p.478(6)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.snb.2013.12.003 Byline: Rangadhar Pradhan, Mahitosh Mandal, Analava Mitra, Soumen Das Abstract: The present work reports the impedimetric characterization of cellular activities of T47D cells treated with anticancer drug ZD6474 using impedance sensing devices. Four types of devices with different dimensions are fabricated by micromachining technology. Real time impedance monitoring data reveals spreading stage completes within 5h. The frequency response characteristics of drug treated cells are studied to evaluate cytotoxic effect of ZD6474 along with the sensitivity variation for different designs. Compared to control data, a significant decrease in impedance data is observed for drug treated samples above 10[mu]M dose due to predominant cell death and detachment from the electrode surfaces. The quantitative relation developed between cell impedance and drug dose indicates that the magnitude of cell impedance varies inversely with the drug dose. Author Affiliation: School of Medical Science and Technology, Indian Institute of Technology, Kharagpur 721302, India Article History: Received 3 September 2013; Revised 30 November 2013; Accepted 3 December 2013
    ISSN: 0925-4005
    Source: Cengage Learning, Inc.
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  • 5
    Language: English
    In: Cancer Research, 10/01/2014, Vol.74(19 Supplement), pp.38-38
    ISSN: 0008-5472
    E-ISSN: 1538-7445
    Source: CrossRef
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  • 6
    Language: English
    In: Cancer Research, 10/01/2014, Vol.74(19 Supplement), pp.4594-4594
    Keywords: Medicine;
    ISSN: 0008-5472
    E-ISSN: 1538-7445
    Source: CrossRef
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  • 7
    Language: English
    In: Journal of Colloid And Interface Science, 01 April 2017, Vol.491, pp.98-110
    Description: Recent endeavors in exploiting vast array of natural phytochemicals to ameliorate colorectal cancer led us to investigate apigenin, a naturally occurring dietary flavone as a potential chemo-therapeutic agent. The present study focuses on establishing apigenin as a potential chemotherapeutic agent for alleviating colorectal cancer and reports the development of a stable liposomal nanocarrier with high encapsulation of the hydrophobic flavone apigenin for enhanced chemotherapeutic effects. The enhanced pharmacological activity of apigenin has been assigned to its ability to interact and subsequently influence membrane properties which also resulted in optimal yield of a stable, rigidified, non-leaky nano-carrier with ideal release kinetics. Extensive testing of drug and its liposomal counterpart for potential clinical chemotherapeutic applications yielded hemocompatibility and cytocompatibility with normal fibroblast cells while enhanced antineoplastic activity was observed in tumor xenograft model. The increased chemotherapeutic potential of liposomal apigenin highlights the clinical potential of apigenin-based vesicles.
    Keywords: Apigenin ; Liposomes ; Membrane ; Apoptosis ; Drug Delivery ; Cellular Arrest ; Engineering ; Chemistry
    ISSN: 0021-9797
    E-ISSN: 1095-7103
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  • 8
    Language: English
    In: Biosensors and Bioelectronics, May 15, 2014, Vol.55, p.44(7)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.bios.2013.11.060 Byline: Rangadhar Pradhan, Shashi Rajput, Mahitosh Mandal, Analava Mitra, Soumen Das Abstract: The present work reports the impedance characteristics of MCF-7 cell lines treated with anticancer drug ZD6474 to evaluate the cytotoxic effect on cellular electrical behaviour using miniature impedance sensors. Four types of impedance sensing devices with different electrode geometries are fabricated by microfabrication technology. The frequency response characteristics of drug treated cells are studied to evaluate cytotoxic effect of ZD6474 and also to assess the frequency dependent sensitivity variation with electrode area. A significant variation in magnitude of measured impedance data is obtained for drug treated samples above 10A[micro]M dose indicating prominent effect of ZD6474 which results in suppression of cell proliferation and induction of apoptosis process. The results obtained by impedimetric method are correlated well with conventional in vitro assays such as flow cytometry, cell viability assays and microscopic imaging. Finally an empirical relation between cell impedance, electrode area and drug dose is established from impedance data which exhibits a negative correlation between drug doses and impedance of cancer cells. Author Affiliation: School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur 721302, India Article History: Received 21 August 2013; Revised 8 November 2013; Accepted 20 November 2013
    Keywords: Breast Cancer -- Drug Therapy ; Breast Cancer -- Electric Properties ; Antineoplastic Agents -- Electric Properties
    ISSN: 0956-5663
    Source: Cengage Learning, Inc.
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  • 9
    Language: English
    In: International Journal of Pharmaceutics, 2010, Vol.396(1), pp.17-22
    Description: is one of the most common pathogens responsible for hospital-acquired infections. In this study, was exposed to 13.56 MHz radiofrequency (RF) plasma generated by two different gases namely nitrogen and nitrogen–oxygen mixture and their sterilization efficacies were compared. Nitrogen plasma had a significant effect on sterilization due to generation of ultraviolet (UV) radiation. However, the addition of 2% oxygen showed enhanced effect on the sterilization of bacteria through nitric oxide (NO) emission and various reactive species. The presence of these reactive species was confirmed by optical emission spectroscopy (OES). Scanning electron microscopy (SEM) analysis was carried out to study the morphological changes of bacteria after plasma treatment. From the SEM results, it was observed that the bacterial cells treated by N –O mixture plasma were severely damaged. As a result, a log reduction factor of 6 was achieved using N –O plasma after 5 min treatment with 100 W RF power.
    Keywords: Plasma Sterilization ; Staphylococcus Aureus ; Radio Frequency ; Optical Emission Spectroscopy ; Scanning Electron Microscopy ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 0378-5173
    E-ISSN: 1873-3476
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  • 10
    Language: English
    In: Biomaterials, March 2011, Vol.32(8), pp.2149-2159
    Description: 3D model systems that are able to mimic the microenvironment are now highly sought after in cancer research. silk fibroin protein matrices were investigated as potential biomaterial for tumor modeling. We compared the characteristics of MDA-MB-231 cells on , silk matrices, Matrigel, and tissue culture plates. The attachment and morphology of the MDA-MB-231 cell line on silk matrices was found to be better than on matrices and comparable to Matrigel and tissue culture plates. The cells grown in all 3D cultures showed more MMP-9 activity, indicating a more invasive potential. In comparison to fibroin, fibroin not only provided better cell adhesion, but also improved cell viability and proliferation. Yield coefficient of glucose consumed to lactate produced by cells on 3D fibroin was found to be similar to that of cancer cells . LNCaP prostate cancer cells were also cultured on 3D fibroin and they grew as clumps in long term culture. The results indicate that fibroin scaffold can provide an easily manipulated microenvironment system to investigate individual factors such as growth factors and signaling peptides, as well as evaluation of anticancer drugs.
    Keywords: Silk ; Fibroin ; Cell Culture ; Tumour ; Medicine ; Engineering
    ISSN: 0142-9612
    E-ISSN: 1878-5905
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