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  • 1
    Language: English
    In: Journal of the American Chemical Society, 06 April 2011, Vol.133(13), pp.4710-3
    Description: The enantioselectivity of a chiral catalyst can be determined from its racemic form by mass spectrometric screening of a nonequal mixture of two mass-labeled quasienantiomeric substrates. The presented method opens up new possibilities for evaluating catalyst structures that are not readily available in enantiomerically pure form.
    Keywords: Organometallic Compounds -- Chemistry
    ISSN: 00027863
    E-ISSN: 1520-5126
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  • 2
    Language: English
    In: Proceedings of the National Academy of Sciences of the United States of America, 2011, Vol.108(52), pp.21276-21281
    Description: High Gleason score is currently the best prognostic indicator for poor prognosis in prostate cancer. However, a significant number of patients with low Gleason scores develop aggressive disease as well. In an effort to understand molecular signatures associated with poor outcome in prostate cancer, we analyzed a microarray dataset characterizing 281 prostate cancers from a Swedish watchful-waiting cohort. Patients were classified on the basis of their mRNA microarray signature profiles indicating embryonic stem cell expression patterns (stemness), inactivation of the tumor suppressors p53 and PTEN, activation of several oncogenic pathways, and the TMPRSS2–ERG fusion. Unsupervised clustering identified a subset of tumors manifesting stem-like signatures together with p53 and PTEN inactivation, which had very poor survival outcome, a second group with intermediate survival outcome, characterized by the TMPRSS2–ERG fusion, and three groups with benign outcome. The stratification was validated on a second independent dataset of 150 tumor and metastatic samples from a clinical cohort at Memorial Sloan–Kettering Cancer Center. This classification is independent of Gleason score and therefore provides useful unique molecular profiles for prostate cancer prognosis, helping to predict poor outcome in patients with low or average Gleason scores. ; p. 21276-21281.
    Keywords: Data Collection ; Patients ; Microarray Technology ; Messenger Rna ; Stem Cells ; Metastasis ; Prostatic Neoplasms ; Prognosis
    ISSN: 0027-8424
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  • 3
    Language: English
    In: International Journal of Hydrogen Energy, May 5, 2014, Vol.39(14), p.7356(9)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ijhydene.2014.02.166 Byline: Frank Markert, Daniele Melideo, Daniele Baraldi Abstract: Evaluations of the performance of simplified engineering and CFD models are important to improve risk assessment tools e.g. to predict accurately releases from various types of hydrogen storages. These tools have to predict releases from a wide range of storage pressures (up to 80 MPa) and temperatures (down to 20 K), e.g. cryogenic compressed gas storage covers pressures up to 35 MPa and temperatures between 33 K and 338 K. Accurate calculations of high pressure releases require real gas EOS. This paper compares a number of EOS to predict hydrogen properties typical in different storage types. The vessel dynamics are modeled using a simplified engineering and a CFD model to evaluate the performance of various EOS to predict vessel pressures, temperatures mass flow rates and jet flame lengths. It is shown that the chosen EOS and the chosen specific heat capacity correlation are important to model accurately hydrogen releases at low temperatures. Author Affiliation: (a) Department of Management Engineering, Technical University of Denmark, Produktionstorvet 424, DK-2800 Kongens Lyngby, Denmark (b) Institute for Energy and Transport, Joint Research Centre European Commission, Westerduinweg 3, P.O. Box 2, 1755 ZG Petten, The Netherlands Article History: Received 6 January 2014; Revised 15 February 2014; Accepted 27 February 2014
    Keywords: Hydrogen -- Analysis
    ISSN: 0360-3199
    Source: Cengage Learning, Inc.
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  • 4
    Language: English
    In: JAMA, The Journal of the American Medical Association, Nov 14, 2012, Vol.308(18), p.1918(2)
    Description: The article discusses about the classification of gliomas into low grade and malignant gliomas, making a comparison between the role of early resection vs biopsy for the management of low grade gliomas. Results from the study show that at the hospitals favouring resection, patients are found to show marked improvement in survival over time when compared to patients treated at the hospial favouring biopsy alone.
    Keywords: Gliomas -- Diagnosis ; Gliomas -- Care And Treatment ; Gliomas -- Research ; Excision (Surgery) -- Comparative Analysis ; Excision (Surgery) -- Health Aspects
    ISSN: 0098-7484
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  • 5
    Language: English
    In: JAMA, 14 November 2012, Vol.308(18), pp.1918-9
    Description: Markert discusses the role of early resection versus biopsy in the management of Low-Grade Gliomas (LGGs). Gliomas are primary tumors of the central nervous system and are classified into grades I to IV according to histologic criteria. Grades I and II are low-grade gliomas and grades III and IV are considered malignant gliomas. Low-grade gliomas affect both children and adults. However, the predominant histologic type of glioma found in children is a grade I tumor, juvenile pilocytic astrocytoma, and is curable by complete surgical resection.
    Keywords: Watchful Waiting ; Brain Neoplasms -- Surgery ; Glioma -- Surgery
    ISSN: 00987484
    E-ISSN: 1538-3598
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  • 6
    Language: English
    In: Proceedings of the National Academy of Sciences of the United States of America, 16 July 2013, Vol.110(29), pp.11672-3
    Description: Author contributions: R.J.W. and J.M.M. wrote the paper.
    Keywords: Disease Models, Animal ; Glioblastoma -- Therapy ; Immunotherapy -- Methods ; Interleukin-12 -- Metabolism ; Oncolytic Virotherapy -- Methods ; Simplexvirus -- Metabolism
    ISSN: 00278424
    E-ISSN: 1091-6490
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  • 7
    Language: English
    In: Journal of the American Chemical Society, 14 December 2011, Vol.133(49), pp.19664-7
    Description: Different derivatives of Guanine (G) and Cytosine (C), which sterically enforce the Watson-Crick (WC) conformer, have been studied in CHCl(3) by means of broad-band transient absorption spectroscopy. Our experiments rule out the involvement of an Excited State Proton Transfer (ESPT), which dominates the excited state decay of GC in the gas phase. Instead, the ultrafast dynamics via internal conversion occurs in a polar environment mainly by relaxation in the monomer moieties. Time-dependent density functional theory (TD-DFT) calculations in solution indeed indicate that population transfer from the bright excited states toward the charge transfer state is not effective in CHCl(3) and a noticeable energy barrier is associated with the ESPT reaction. ESPT is therefore not expected to be a main deactivation route for GC pairs within DNA.
    Keywords: Protons ; Cytosine -- Chemistry ; Guanine -- Chemistry
    ISSN: 00027863
    E-ISSN: 1520-5126
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  • 8
    Language: English
    In: Journal of the American Chemical Society, 31 January 2018, Vol.140(4), pp.1327-1336
    Description: Supramolecular self-assembly at the solid-solid interface enables the deposition and monolayer formation of insoluble organic semiconductors under ambient conditions. The underlying process, termed as the organic solid-solid wetting deposition (OSWD), generates two-dimensional adsorbates directly from dispersed three-dimensional organic crystals. This straightforward process has important implications in various fields of research and technology, such as in the domains of low-dimensional crystal engineering, the chemical doping and band gap engineering of graphene, and in the area of field-effect transistor fabrication. However, to date, lack of an in-depth understanding of the physicochemical basis of the OSWD prevented the identification of important parameters, essential to achieve a better control of the growth of monolayers and supramolecular assemblies with defined structures, sizes, and coverage areas. Here we propose a detailed model for the OSWD, derived from experimental and theoretical results that have been acquired by using the organic semiconductor quinacridone as an example system. The model reveals the vital role of the ζ potential and includes Casimir-like fluctuation-induced forces and the effect of dewetting in hydrophobic nanoconfinements. Based on our results, the OSWD of insoluble organic molecules can hence be applied to environmental friendly and low-cost dispersing agents, such as water. In addition, the model substantially enhances the ability to control the OSWD in terms of adsorbate structure and substrate coverage.
    Keywords: Physics - Chemical Physics ; Condensed Matter - Mesoscale And Nanoscale Physics ; Condensed Matter - Materials Science;
    ISSN: 00027863
    E-ISSN: 1520-5126
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  • 9
    In: Medicine & Science in Sports & Exercise, 2017, Vol.49(5S Suppl 1), pp.948-948
    ISSN: 0195-9131
    Source: Copyright © 2013 Lippincott Williams & Wilkins. All rights reserved.〈img src=http://exlibris-pub.s3.amazonaws.com/LWW%20logo.png style="vertical-align:middle;margin-left:7px"〉
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  • 10
    In: Biotechnology and Bioengineering, January 2017, Vol.114(1), pp.113-121
    Description: The authors developed a unique automated screening system for animal suspension cell culture to carry out unsupervised batch or fed‐batch processes with integrated miniaturized analytics based on off‐the‐shelf commercial laboratory automation equipment. It is fully automated and handles plate transport, seeding/feeding of cells, daily sampling, cell counting and metabolite assays. More than 600 fed‐batch cultivations can be handled in parallel enabling enhanced process development. Main application areas in late stage cell culture operation are media development and product quality optimization.
    Keywords: Biopharmaceutical Drug Development ; Fed‐Batch Cho Suspension Cultures ; High‐Throughput Process Optimization ; Shaken Microtiter Plate ; Industrial Cell Culture Automation ; Scale Up Prediction
    ISSN: 0006-3592
    E-ISSN: 1097-0290
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