UID:
edoccha_9961426828402883
Format:
1 streaming video file (30 min.) :
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digital, mono, SWF file, sound, color
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002956
Note:
Retrieved April 16, 2024, from https://hstalks.com/bs/1272/.
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Introduction -- The cell cycle -- Somatic cell cycles -- Negative regulation of G1 progression by Cdk -- The "Rb pathway" in human cancer -- Two groups of Ink4 proteins -- Two groups of CIP/KIP proteins -- Expression of INK4 genes during embryogenesis -- Expression of Ink4 genes in tissues of young mice -- Testicular atrophy, fertility in Ink4d-null male mice -- Ink4c/Ink4d double deficient male mice are sterile -- Conclusion (1) -- Role of Cdk inhibitors in the CNS (1) -- Hypothesis (1) -- Role of Cdk inhibitors in the CNS (2) -- Sensory hair cell loss in Ink4d -/- mice, deafness -- Ink4d and postmitotic state of sensory hair cells -- Postnatal development in Ink4d, Kip1-null mice -- Conclusions (2) -- Role of the Rb pathway in cerebellar development -- Medulloblastoma -- Childhood medulloblastoma -- Cerebellum - little brain -- Postnatal cerebellar development -- Cerebellar development in the mouse -- The SHH/PATCHED signaling pathway -- Rb-dependent cell cycle exit and differentiation -- Ink4c expression in the mouse cerebellum -- p27Kip1 expression in the IGL -- N-Myc in GNP proliferation -- Partial rescue in adult cerebellum -- Hypothesis (2) -- Mice lacking Ink4c, p53 develop medulloblastoma -- Ink4c loss increases medulloblastoma -- p18INK4C and human medulloblastoma -- p18Ink4C/CDKN2C expression in medulloblastoma -- Conclusions (3) -- Phenotype of Ink4d- or Ink4c- deficient mice -- Acknowledgments.
Language:
English
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