Format:
1 Online-Ressource (xxii, 900 Seiten)
,
Illustrationen, Diagramme
ISBN:
9783527814527
Content:
Intro -- Table of Contents -- Title Page -- Title Page -- Copyright -- Preface -- Foreword -- References -- Volume 1 -- Part I: Nucleic Acid Catalysis: Principles, Strategies and Biological Function -- 1 The Chemical Principles of RNA Catalysis -- 1.1 RNA Catalysis -- 1.2 Rates of Chemical Reactions and Transition State Theory -- 1.3 Phosphoryl Transfer Reactions in the Ribozymes -- 1.4 Catalysis of Phosphoryl Transfer -- 1.5 General Acid-Base Catalysis in Nucleolytic Ribozymes -- 1.6 pKa Shifting of General Acids and Bases in Nucleolytic Ribozymes -- 1.7 Catalytic Roles of Metal Ions in Ribozymes -- 1.8 The Choice Between General Acid-Base Catalysis and the Use of Metal Ions -- 1.9 The Limitations to RNA Catalysis -- Acknowledgment -- References -- 2 Biological Roles of Self‐Cleaving Ribozymes -- 2.1 Introduction -- 2.2 Use of Self‐cleaving Ribozymes for Replication -- 2.3 Self‐cleaving Ribozymes as Part of Transposable Elements -- 2.4 Hammerhead Ribozymes with Suggested Roles in mRNA Biogenesis -- 2.5 The glmS Ribozyme Regulates Glucosamine‐6‐phosphate Levels in Bacteria -- 2.6 The Biological Roles of Many Ribozymes Are Unknown -- 2.7 Conclusion -- Acknowledgments -- References -- Part II: Naturally Occurring Ribozymes -- 3 Chemical Mechanisms of the Nucleolytic Ribozymes -- 3.1 The Nucleolytic Ribozymes -- 3.2 Some Nucleolytic Ribozymes Are Widespread -- 3.3 Secondary Structures of Nucleolytic Ribozymes - Junctions and Pseudoknots -- 3.4 Catalytic Players in the Nucleolytic Ribozymes -- 3.5 The Hairpin and VS Ribozymes: The G Plus A Mechanism -- 3.6 The Twister Ribozyme: A G Plus A Variant -- 3.7 The Hammerhead Ribozyme: A 2′‐Hydroxyl as a Catalytic Participant -- 3.8 The Hepatitis Delta Virus Ribozyme: A Direct Role for a Metal Ion -- 3.9 The Twister Sister (TS) Ribozyme: Another Metallo‐Ribozyme
Note:
2 Volume Set
Additional Edition:
Erscheint auch als Druck-Ausgabe, Hardcover ISBN 978-3-527-34454-3
Language:
English
Subjects:
Chemistry/Pharmacy
,
Biology
Keywords:
Ribozym
DOI:
10.1002/9783527814527
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9783527814527
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