UID:
almafu_9961445053102883
Format:
1 online resource (192 pages)
ISBN:
9781394276639
,
139427663X
Series Statement:
Biology series. Nucleic acids set ; volume 2
Content:
Behind the neologism "ribozymes" lies a family of fascinating molecules, ribo-enzymes, which have been relatively little studied. These catalytically active RNAs are found in all strata of life, from viruses to the human genome. At the end of the 1970s, the discovery of a catalytic RNA nestled in an intron, followed by another involved in the maturation of transfer RNAs, led to the discovery of new ribozymes and the transition from a strictly "proteocentric" vision, inherited from the dogma of molecular biology, to a more "nucleocentric" one. Since then, a variety of ribozymes have been identified in genomes, where their functions often remain mysterious. Looking at Ribozymes traces the discovery of these molecules and presents a picture of their functional diversity, catalytic mechanisms and distribution within the tree of life.
Note:
Foreword -- Preface -- Chapter 1 Fundamentals of RNA and Ribozyme Structure -- 1.1 Sequences and secondary structures -- 1.2 RNA folding, tertiary structures and 3D -- 1.2.1 Secondary structures and RNA folding -- 1.2.2 The pseudoknot -- 1.2.3 The loop E -- 1.2.4 The k-turn -- 1.2.5 Tetra-loop receptors -- 1.2.6 The A-minor pattern -- 1.2.7 Comparative analysis of sequences -- Chapter 2 Ribozymes and the "Central Dogma" of Molecular Biology -- 2.1 The discovery of RNA catalysis and the central dogma of molecular biology -- 2.2 In search of the primordial polymerase -- Chapter 3 The Discovery of Ribozymes -- 3.1 The discovery of catalysis by autocatalytic introns -- 3.2 The discovery of RNA catalysis of RNase P -- 3.3 The first consequences of these discoveries -- 3.3.1 The ribosome, a long-ignored ribozyme -- 3.3.2 The modified bases -- 3.4 The spliceosome, another ribozyme -- 3.4.1 Nucleolytic ribozymes -- Chapter 4 Ribozyme Engineering and the RNA World -- 4.1 Classification of ribozymes -- 4.2 Classification of ribozymes according to catalytic mechanism -- Chapter 5 Structures of Ribozymes -- 5.1 Structures and catalytic mechanisms of ribozymes -- 5.1.1 Hammerhead ribozymes -- 5.1.2 The example of the hairpin ribozyme -- 5.1.3 The example of the glmS ribozyme -- 5.2 An example of catalysis control: lariat-capping ribozyme -- Chapter 6 Evolution of the Vision of the Catalytic Mechanisms of Ribozymes, the Hammerhead Ribozyme -- 6.1 Chemistry and catalysis: between general acid/base and metal cations -- 6.2 Difficulties in interpreting catalysis data -- Chapter 7 The Distribution of Ribozymes in Living Organisms and Molecular Adaptations during Evolution -- 7.1 Ubiquitous ribozymes -- 7.2 Selection pressures at work in ribozyme shaping -- 7.3 Ribozymes in cellular processes: from viroids to eukaryotes -- 7.4 Very human ribozymes -- Conclusion -- References -- Index.
Language:
English
DOI:
10.1002/9781394276639
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9781394276639
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9781394276639
Bookmarklink
