Tetrahedron, March 4, 2013, Vol.69(9), p.2131(6)
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.tet.2013.01.011 Byline: Jean-Pierre Uttaro, Sylvie Broussous, Christophe Mathe, Christian Perigaud Abstract: Racemic synthesis of novel 3'-methyl-5'-norcarbocyclic nucleoside phosphonates 1a-c and 2 was performed using 4-hydroxy-2-methylcyclo-pent-2-enone as starting material. Direct coupling of the heterocyclic base involved a Mitsunobu reaction as key step. The compounds were evaluated for their antiviral properties, but none of them showed significant activity. Author Affiliation: Institut des Biomolecules Max Mousseron (IBMM), UMR 5247 CNRS-UM 1-UM 2, cc 1705, Universite Montpellier 2, Place Eugene Bataillon, 34095 Montpellier cedex 5, France Article History: Received 5 October 2012; Revised 17 December 2012; Accepted 4 January 2013
Phosphonates ; Anti-hiv Agents ; Substitution Reactions ; Nucleosides
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